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  1. Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2023  Volume 15, Issue 6, Page(s) 2358–2360

    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cangfudaotan decoction inhibits mitochondria-dependent apoptosis of granulosa cells in rats with polycystic ovarian syndrome.

    Jiang, Xiao-Lin / Tai, He / Xiao, Xuan-Si / Zhang, Shi-Yu / Cui, Shi-Chao / Qi, Shu-Bo / Hu, Dan-Dan / Zhang, Li-Na / Kuang, Jin-Song / Meng, Xian-Sheng / Li, Shun-Min

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 962154

    Abstract: Polycystic ovary syndrome (PCOS) is a universal endocrine and metabolic disorder prevalent in reproductive aged women. PCOS is often accompanied with insulin resistance (IR) which is an essential pathological factor. Although there is no known cure for ... ...

    Abstract Polycystic ovary syndrome (PCOS) is a universal endocrine and metabolic disorder prevalent in reproductive aged women. PCOS is often accompanied with insulin resistance (IR) which is an essential pathological factor. Although there is no known cure for PCOS, cangfudaotan (CFDT) decoction is widely used for the treatment of PCOS; nevertheless, the underlying mechanism is not clear. In this study, 40 Sprague-Dawley (SD) rats (female) were randomized to 4 groups, namely the control group, PCOS group, PCOS+CFDT group, and PCOS+metformin group. The rats in the control group were fed a normal-fat diet, intraperitoneally injected with 0.5% carboxymethyl cellulose (CMC, 1 mL/kg/d) for 21 days and orally given saline (1 mL/kg/d) for the next 4 weeks. The rats in the PCOS group, PCOS+CFDT group, and PCOS+Metformin group were fed a high-fat diet (HFD) and intraperitoneally injected with letrozole (1.0 mg/kg) for 21 days. During this period, we recorded the body weight, estrous cycles, and rate of pregnancy in all rats. We also observed the ovarian ultrastructure. Blood glucose indices, serum hormones, and inflammatory factors were also recorded. Then, we detected apoptotic and mitochondrial function, and observed mitochondria in ovarian granular cells by transmission electron microscopy. We also detected genes of ASK1/JNK pathway at mRNA and protein levels. The results showed that CFDT alleviated pathohistological damnification and apoptosis in PCOS rat model. In addition, CFDT improved ovarian function, reduced inflammatory response, inhibited apoptosis of granular cells, and inhibited the operation of ASK1/JNK pathway. These findings demonstrate the occurrence of ovary mitochondrial dysfunction and granular cell apoptosis in PCOS. CFDT can relieve mitochondria-dependent apoptosis by inhibiting the ASK1/JNK pathway in PCOS rats.
    MeSH term(s) Female ; Pregnancy ; Humans ; Rats ; Animals ; Polycystic Ovary Syndrome/drug therapy ; Rats, Sprague-Dawley ; Granulosa Cells ; Mitochondria ; Apoptosis ; Metformin/pharmacology
    Chemical Substances Metformin (9100L32L2N)
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.962154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2022  Volume 14, Issue 20, Page(s) 8321–8345

    Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD). ...

    Abstract As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
    MeSH term(s) Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
    Chemical Substances Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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