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Article: Varietal responses of root characteristics to low nitrogen application explain the differing nitrogen uptake and grain yield in two rice varieties.

Liu, Lei / Cui, Kehui / Qi, Xiaoli / Wu, Yu / Huang, Jianliang / Peng, Shaobing

2023 Volume 14, Page(s) 1244281

Abstract: Rice root characteristics are tightly associated with high-efficient nitrogen uptake. To understand the relationship of root plastic responses with nitrogen uptake when reducing nitrogen application for green rice production, a hydroponic experiment and ... ...

Abstract	Rice root characteristics are tightly associated with high-efficient nitrogen uptake. To understand the relationship of root plastic responses with nitrogen uptake when reducing nitrogen application for green rice production, a hydroponic experiment and a soil pot experiment were conducted under high (HN) and low (LN) nitrogen applications, using two rice (
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1244281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Uncovering the relationship between floating marine litter and human activities in watersheds.

Luo, Jianing / Luan, Bo / Xue, Fei / Qi, Xiaoli / Zhu, Mingjian / Xu, Peng / Zhang, Lan

Marine pollution bulletin

2023 Volume 198, Page(s) 115893

Abstract: Rivers serve as the primary pathway for transporting floating marine litter (FML) from land to sea. However, the complex dynamics of transboundary rivers pose a significant obstacle when examining the impact of watershed-based human activities on FML ... ...

Abstract	Rivers serve as the primary pathway for transporting floating marine litter (FML) from land to sea. However, the complex dynamics of transboundary rivers pose a significant obstacle when examining the impact of watershed-based human activities on FML distribution. This study conducts year-long monthly monitoring of FML using trawl and visual surveys in the coastal water of a peninsula dominated by indigenous rivers in south China. Overall, small pieces debris dominates FML in the nearshore waters of the peninsula, with meso-sized (0.5 cm-2.5 cm) FML accounting for 73.93 % of the total. The density of FML is more profoundly influenced by human activities within watersheds rather than its composition. Moreover, the association between human activity and FML density exhibits greater significant compared to variations based on geography and seasonality. This study provides a scientific basis for coastal protection and contributes for understanding of the mechanisms of marine litter transfer from land to sea.
MeSH term(s)	Humans ; Plastics ; Fluorometholone ; Environmental Monitoring ; Waste Products/analysis ; Geography
Chemical Substances	Plastics ; Fluorometholone (SV0CSG527L) ; Waste Products
Language	English
Publishing date	2023-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115893
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genome-wide Identification and Expression Analysis of

Xu, Binjie / Chen, Bang / Qi, Xiaoli / Liu, Shunli / Zhao, Yibing / Tang, Ce / Meng, Xianli

Frontiers in genetics

2022 Volume 13, Page(s) 831611

Abstract: Modern research has proved that the main medicinal component ... ...

Abstract	Modern research has proved that the main medicinal component of
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.831611
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surface modification of fibroblasts with peroxiredoxin-1-loaded polymeric microparticles increases cell mobility, resistance to oxidative stress and collagen I production.

Shen, Ningfei / Qi, Xiaoli / Bagrov, Dmitry V / Krechetov, Sergey P / Sharapov, Mars G / Durymanov, Mikhail O

Colloids and surfaces. B, Biointerfaces

2022 Volume 219, Page(s) 112834

Abstract: Modification of the cell surface with artificial nano- and microparticles (also termed "cellular backpacks") containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some ... ...

Abstract	Modification of the cell surface with artificial nano- and microparticles (also termed "cellular backpacks") containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some cases, using cells as delivery vehicles leads to improved pharmacokinetics due to extended circulation time of cell-immobilized formulations. Another rationale for particle attachment to cells is augmentation of desirable cellular functions and cell proliferation in response to release of the particle contents. In this study, we conjugated poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with multifunctional antioxidant enzyme peroxiredoxin-1 (Prx1) to the surface of fibroblasts. The obtained microparticles were uniform in size and demonstrated sustained protein release. We found that the released Prx1 maintains its signaling activity resulting in macrophage activation, as indicated by TNFα upregulation and increase in ROS generation. Functionalization of fibroblasts with PLGA/Prx1 microparticles via EDC/sulfo-NHS coupling reaction did not affect cell viability but increased cell migratory properties and collagen I production. Moreover, PLGA/Prx1 backpacks increased resistance of fibroblasts to oxidative stress and attenuated cell senescence. In summary, we have developed a novel approach of fibroblast modification to augment their biological properties, which can be desirable for wound repair, cosmetic dermatology, and tissue engineering.
MeSH term(s)	Polylactic Acid-Polyglycolic Acid Copolymer/metabolism ; Polyglycolic Acid ; Lactic Acid/metabolism ; Fibroblasts/metabolism ; Collagen Type I/metabolism ; Oxidative Stress ; Particle Size
Chemical Substances	Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT) ; Collagen Type I
Language	English
Publishing date	2022-09-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112834
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Quantification of glutathione with high throughput live-cell imaging.

Qi, Xiaoli / Chen, Jianwei / Jiang, Xiqian / Lu, Dong / Yu, Xin / Lin, Hanfeng / Monroy, Erika Y / Wang, Meng C / Wang, Jin

bioRxiv : the preprint server for biology

2023

Abstract: Reduction oxidation (redox) reactions are central in life and altered redox state is associated with a spectrum of human diseases. Glutathione (GSH) is the most abundant antioxidant in eukaryotic cells and plays critical roles in maintaining redox ... ...

Abstract	Reduction oxidation (redox) reactions are central in life and altered redox state is associated with a spectrum of human diseases. Glutathione (GSH) is the most abundant antioxidant in eukaryotic cells and plays critical roles in maintaining redox homeostasis. Thus, measuring intracellular GSH level is an important method to assess the redox state of organism. The currently available GSH probes are based on irreversible chemical reactions with glutathione and can't monitor the real-time glutathione dynamics. Our group developed the first reversible reaction based fluorescent probe for glutathione, which can measure glutathione levels at high resolution using a confocal microscope and in the bulk scale with a flow cytometry. Most importantly it can quantitatively monitor the real-time GSH dynamics in living cells. Using the 2
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.07.11.548586
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Article: Metal-Organic Framework-Based Nanomedicines for the Treatment of Intracellular Bacterial Infections.

Qi, Xiaoli / Shen, Ningfei / Al Othman, Aya / Mezentsev, Alexandre / Permyakova, Anastasia / Yu, Zhihao / Lepoitevin, Mathilde / Serre, Christian / Durymanov, Mikhail

Pharmaceutics

2023 Volume 15, Issue 5

Abstract: Metal-organic frameworks (MOFs) are a highly versatile class of ordered porous materials, which hold great promise for different biomedical applications, including antibacterial therapy. In light of the antibacterial effects, these nanomaterials can be ... ...

Abstract	Metal-organic frameworks (MOFs) are a highly versatile class of ordered porous materials, which hold great promise for different biomedical applications, including antibacterial therapy. In light of the antibacterial effects, these nanomaterials can be attractive for several reasons. First, MOFs exhibit a high loading capacity for numerous antibacterial drugs, including antibiotics, photosensitizers, and/or photothermal molecules. The inherent micro- or meso-porosity of MOF structures enables their use as nanocarriers for simultaneous encapsulation of multiple drugs resulting in a combined therapeutic effect. In addition to being encapsulated into an MOF's pores, antibacterial agents can sometimes be directly incorporated into an MOF skeleton as organic linkers. Next, MOFs contain coordinated metal ions in their structure. Incorporation of Fe
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15051521
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Longitudinal Changes in Refractive Development in Highly Hyperopic Children: A 2.6-11.2 Year Follow-up of Preschoolers Diagnosed with High Hyperopia.

Sun, Ling / Qi, Xiaoli / Song, Linlin / Ning, Yuxian / Zeng, Xiaoyu / Ding, Gang / Li, Xue / Li, Jing / Wei, Nan / Hua, Ning / Qian, Xuehan

Current eye research

2024 , Page(s) 1–8

Abstract: Purpose: This study aims to elucidate the longitudinal refractive and ocular biometric alterations in preschool children with high hyperopia who underwent early interventions.: Methods: We conducted a retrospective analysis of preschool children ... ...

Abstract	Purpose: This study aims to elucidate the longitudinal refractive and ocular biometric alterations in preschool children with high hyperopia who underwent early interventions. Methods: We conducted a retrospective analysis of preschool children diagnosed with high hyperopia at Tianjin Medical University Eye Hospital between 2011 and 2023. Inclusion criteria required an initial examination with cycloplegic refraction, bilateral spherical equivalent power (SE) ≥ +5.00D with a difference <1.00D, a minimum two-year follow-up, and at least three ocular biometric measurements. The annual axial growth rate evaluated emmetropization in highly hyperopic children. We applied Restricted Cubic Spline (RCS) models to explore potential nonlinear relationships between age and spherical equivalent, axial length, corneal curvature, and axial length-to-corneal curvature ratio. Additionally, Mixed-effects models were employed to investigate factors associated with changes in refractive error and axial length. Results: The study enrolled 60 eligible subjects, with a median initial diagnosis age of 3.5 years (IQR, 2.8-4.9 years) and a median last visit age of 9.3 years (IQR, 8.1-10.8 years). The average follow-up duration was 5.7 years. RCS analysis revealed notable nonlinear changes in spherical equivalent power, axial length, and axial length-to-corneal curvature ratio, although corneal curvature displayed no statistically significant nonlinear trend. Factors affecting SE changes included the presence of strabismus, the use of cycloplegia, baseline SE, and age. Conversely, changes in axial length solely correlated with baseline axial length and age. Conclusion: Highly hyperopic preschool children undergoing early intervention display a marked emmetropization tendency, though most still remain moderately to highly hyperopic, with the progression of refractive changes showing non-uniform patterns with respect to age.
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	82079-9
ISSN	1460-2202 ; 0271-3683
ISSN (online)	1460-2202
ISSN	0271-3683
DOI	10.1080/02713683.2024.2336162
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity.

Yu, Xin / Lu, Dong / Qi, Xiaoli / Lin, Hanfeng / Holloman, Bryan L / Jin, Feng / Xu, Longyong / Ding, Lang / Peng, Weiyi / Wang, Meng C / Chen, Xi / Wang, Jin

bioRxiv : the preprint server for biology

2024

Abstract: The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and has emerged as a promising target for improving cancer immunotherapies. To address the ... ...

Abstract	The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and has emerged as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain, we harnessed proteolysis targeting chimera (PROTAC) technology to develop a first-in-class RIPK1 degrader, LD4172. LD4172 exhibited potent and selective RIPK1 degradation both
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.25.586133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity.

Wang, Jin / Lu, Dong / Yu, Xin / Qi, Xiaoli / Lin, Hanfeng / Holloman, Bryan L / Jin, Feng / Xu, Longyong / Ding, Lang / Peng, Weiyi / Wang, Meng / Chen, Xi

Research square

2024

Abstract	The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and has emerged as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain, we harnessed proteolysis targeting chimera (PROTAC) technology to develop a first-in-class RIPK1 degrader, LD4172. LD4172 exhibited potent and selective RIPK1 degradation both
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-4156736/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Surface modification of fibroblasts with peroxiredoxin-1-loaded polymeric microparticles increases cell mobility, resistance to oxidative stress and collagen I production

Shen, Ningfei / Qi, Xiaoli / Bagrov, Dmitry V. / Krechetov, Sergey P. / Sharapov, Mars G. / Durymanov, Mikhail O.

Colloids and surfaces. 2022 Nov., v. 219

2022

Abstract: Modification of the cell surface with artificial nano- and microparticles (also termed “cellular backpacks”) containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some ... ...

Abstract	Modification of the cell surface with artificial nano- and microparticles (also termed “cellular backpacks”) containing biologically active payloads usually enables drug targeting via harnessing intrinsic cell tropism to the sites of injury. In some cases, using cells as delivery vehicles leads to improved pharmacokinetics due to extended circulation time of cell-immobilized formulations. Another rationale for particle attachment to cells is augmentation of desirable cellular functions and cell proliferation in response to release of the particle contents. In this study, we conjugated poly(lactic-co-glycolic acid) (PLGA) microparticles loaded with multifunctional antioxidant enzyme peroxiredoxin-1 (Prx1) to the surface of fibroblasts. The obtained microparticles were uniform in size and demonstrated sustained protein release. We found that the released Prx1 maintains its signaling activity resulting in macrophage activation, as indicated by TNFα upregulation and increase in ROS generation. Functionalization of fibroblasts with PLGA/Prx1 microparticles via EDC/sulfo-NHS coupling reaction did not affect cell viability but increased cell migratory properties and collagen I production. Moreover, PLGA/Prx1 backpacks increased resistance of fibroblasts to oxidative stress and attenuated cell senescence. In summary, we have developed a novel approach of fibroblast modification to augment their biological properties, which can be desirable for wound repair, cosmetic dermatology, and tissue engineering.
Keywords	antioxidant enzymes ; cell proliferation ; cell senescence ; cell viability ; collagen ; drugs ; fibroblasts ; macrophage activation ; migratory behavior ; oxidative stress ; pharmacokinetics ; polymers
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112834
Database	NAL-Catalogue (AGRICOLA)

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