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Article ; Online: METTL3 is aberrantly expressed in endometriosis and suppresses proliferation, invasion, and migration of endometrial stromal cells

Qian‐Chen Zhang

Kaohsiung Journal of Medical Sciences, Vol 39, Iss 3, Pp 266-

2023 Volume 277

Abstract: Abstract Endometriosis (EM) is one of the leading gynecological disorders, and associated with excessive functioning of endometrial stromal cells (ESCs). The current study was conducted to determine the expression and role of methyltransferase‐like 3 ( ... ...

Abstract	Abstract Endometriosis (EM) is one of the leading gynecological disorders, and associated with excessive functioning of endometrial stromal cells (ESCs). The current study was conducted to determine the expression and role of methyltransferase‐like 3 (METTL3) in the proliferation, invasion, and migration of ESCs in EM. The documented expression levels of METTL3, microRNA (miR)‐21‐5p, and WNT inhibitory factor 1 (WIF1) in eutopic (Eut) and ectopic (Ect) endometrial tissues and ESCs were determined by a combination of real‐time quantitative polymerase chain reaction and Western blot assay. After transfection with pcDNA3.1‐METTL3, miR‐21‐5p mimic, and WIF1 small interfering RNA, cell counting kit‐8, colony formation, and Transwell assays were performed in the Ect ESCs (Ect‐ESCs). Subsequently, the binding of miR‐21‐5p to METTL3 was analyzed, along with quantification of the N6‐methyladenosine (m6A) level, the enrichments of METTL3 and m6A on WIF1, and the mRNA stability of WIF1. In our findings, METTL3 was downregulated in the EM tissues and cells. METTL3 overexpression intrinsically reduced the proliferation, invasion, and migration of Ect‐ESCs. miR‐21‐5p inhibited the METTL3 expression while METTL3 enhanced the mRNA stability and expression of WIF1 via m6A modification. Additionally, a negative correlation of METTL3 was identified with miR‐21‐5p along with a positive correlation with the WIF1 mRNA in EM tissues. The miR‐21‐5p overexpression or WIF1 downregulation enhanced the proliferation, invasion, and migration of Ect‐ESCs. Collectively, miR‐21‐5p inhibited the METTL3‐mediated m6A modification and mRNA stability of WIF1, thereby facilitating the proliferation, invasion, and migration of Ect‐ESCs.
Keywords	endometrial stromal cells ; endometriosis ; m6A modification ; METTL3 ; WIF1 ; Medicine (General) ; R5-920
Subject code	500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: METTL3 is aberrantly expressed in endometriosis and suppresses proliferation, invasion, and migration of endometrial stromal cells.

Zhang, Qian-Chen

The Kaohsiung journal of medical sciences

2022 Volume 39, Issue 3, Page(s) 266–277

Abstract: Endometriosis (EM) is one of the leading gynecological disorders, and associated with excessive functioning of endometrial stromal cells (ESCs). The current study was conducted to determine the expression and role of methyltransferase-like 3 (METTL3) in ... ...

Abstract	Endometriosis (EM) is one of the leading gynecological disorders, and associated with excessive functioning of endometrial stromal cells (ESCs). The current study was conducted to determine the expression and role of methyltransferase-like 3 (METTL3) in the proliferation, invasion, and migration of ESCs in EM. The documented expression levels of METTL3, microRNA (miR)-21-5p, and WNT inhibitory factor 1 (WIF1) in eutopic (Eut) and ectopic (Ect) endometrial tissues and ESCs were determined by a combination of real-time quantitative polymerase chain reaction and Western blot assay. After transfection with pcDNA3.1-METTL3, miR-21-5p mimic, and WIF1 small interfering RNA, cell counting kit-8, colony formation, and Transwell assays were performed in the Ect ESCs (Ect-ESCs). Subsequently, the binding of miR-21-5p to METTL3 was analyzed, along with quantification of the N6-methyladenosine (m6A) level, the enrichments of METTL3 and m6A on WIF1, and the mRNA stability of WIF1. In our findings, METTL3 was downregulated in the EM tissues and cells. METTL3 overexpression intrinsically reduced the proliferation, invasion, and migration of Ect-ESCs. miR-21-5p inhibited the METTL3 expression while METTL3 enhanced the mRNA stability and expression of WIF1 via m6A modification. Additionally, a negative correlation of METTL3 was identified with miR-21-5p along with a positive correlation with the WIF1 mRNA in EM tissues. The miR-21-5p overexpression or WIF1 downregulation enhanced the proliferation, invasion, and migration of Ect-ESCs. Collectively, miR-21-5p inhibited the METTL3-mediated m6A modification and mRNA stability of WIF1, thereby facilitating the proliferation, invasion, and migration of Ect-ESCs.
MeSH term(s)	Female ; Humans ; Endometriosis/genetics ; Endometriosis/metabolism ; Cell Movement/genetics ; Endometrium/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Stromal Cells ; Cell Proliferation/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism
Chemical Substances	MicroRNAs ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2022-12-22
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12626
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Article ; Online: Greening the BRI countries through economic and political reforms

Qian Chen / Ghulam Rasool Madni

PLoS ONE, Vol 18, Iss

2023 Volume 11

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative analysis of neutrophil-to-lymphocyte ratio and remnant cholesterol in predicting cardiovascular events and mortality in general adult population.

Wang, Qian-Chen / Wang, Zhen-Yu

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22362

Abstract: This study aimed to investigate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and Remnant Cholesterol (Remnant-C) in relation to cardiovascular events and all-cause mortality in the general population. A population-based study. We ... ...

Abstract	This study aimed to investigate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and Remnant Cholesterol (Remnant-C) in relation to cardiovascular events and all-cause mortality in the general population. A population-based study. We conducted a retrospective cohort study analyzing data from the National Health and Nutrition Examination Survey (NHANES) spanning the years of 2011-2018, with follow-up for mortality status until December 31, 2019. Kaplan‒Meier and Cox proportional hazards regression analyses were used to evaluate the associations between NLR, Remnant-C, and cardiovascular events as well as all-cause mortality. Overall, 9409 individuals with both complete blood count and blood lipids were included in the analysis. Baseline NLR and Remnant-C were calculated. During the follow-up (median, 59.3 months), 177 cardiovascular events and 561 all-cause mortality occurred. In fully adjusted model, people with NLR > 2.26 were significantly associated with higher risk of cardiovascular events (HR 2.14, 95% CI 1.30-3.52, P < 0.001) and all-cause mortality (HR 1.66, 95% CI 1.30-2.12, P < 0.001). NLR exhibited a positive correlation with Remnant-C (r = 0.04, P < 0.001). Elevated NLR levels shown stronger association with cardiovascular events (HR 1.21, 95% CI 1.14-2.28, P < 0.001) compared with Remnant-C (HR 1.02, 95% CI 1.00-1.04, P = 0.020). Our findings suggest that NLR and Remnant-C are potential predictive markers for cardiovascular events in the general population. We observed a correlation between NLR and Remnant-C, and high NLR levels demonstrate a stronger association with the prediction of cardiovascular events and all-cause mortality compared with Remnant-C.
MeSH term(s)	Adult ; Humans ; Neutrophils ; Nutrition Surveys ; Retrospective Studies ; Lymphocytes ; Cardiovascular Diseases/epidemiology ; Prognosis
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-49403-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ab Initio Molecular Dynamics Investigation of the Solvation States of Hydrated Ions in Confined Water.

Qian, Chen / Zhou, Ke

Inorganic chemistry

2023 Volume 62, Issue 43, Page(s) 17756–17765

Abstract: Ionic transport in nanoscale channels with a critical size comparable to that of ions and solutes exhibits exceptional performance in water desalination, ion separation, electrocatalysts, and supercapacitors. However, the solvation states (SSs), i.e., ... ...

Abstract	Ionic transport in nanoscale channels with a critical size comparable to that of ions and solutes exhibits exceptional performance in water desalination, ion separation, electrocatalysts, and supercapacitors. However, the solvation states (SSs), i.e., the hydration structures and probability distribution, of hydrated ions in nanochannels differ from those in the bulk and the perspective of continuum theory. In this work, we conduct ab initio enhanced-sampling atomistic simulations to investigate the ion-specific SSs of monovalent ions (including Li
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c02443
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Wearable teleoperation controller with 2-DoF robotic arm and haptic feedback for enhanced interaction in virtual reality.

Zhang, Zheyuan / Qian, Chen

Frontiers in neurorobotics

2023 Volume 17, Page(s) 1228587

Abstract: Introduction: Teleoperation is an essential component in fields such as medicine and manufacturing, enabling human operators to interact with remote robotic systems. A wearable device has been designed and manufactured to enhance sensitivity, ... ...

Abstract	Introduction: Teleoperation is an essential component in fields such as medicine and manufacturing, enabling human operators to interact with remote robotic systems. A wearable device has been designed and manufactured to enhance sensitivity, wearability, and synchronization, providing users with the ability to experience the sensation of grasping virtual objects. Methods: The device incorporates a 2-DoF robotic arm, haptic sensors for finger gestures, and a Unity-powered virtual scene system. Its effectiveness was evaluated through user experiments, where participants were asked to rank the weights of three virtual balls and identify the direction of force applied to a virtual ball in separate tests. Additionally, the device's ability to render various shapes was also examined. Results: The experiments showed that 73.3% of participants accurately ranked the balls by mass, and an overall correctness rate of 87.3% was achieved for force direction identification. For shape rendering, the device yielded more accurate results for simple objects like spheres, whereas rendering more complex objects such as cups and cones was challenging. Discussion: The findings indicate that this wearable device has potential applications in haptic feedback and virtual reality contexts. Despite the challenges with complex shape rendering, the device shows promising capability in enhancing the user's immersive experience in virtual environments.
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2453002-5
ISSN	1662-5218
ISSN	1662-5218
DOI	10.3389/fnbot.2023.1228587
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Applications and challenges of biomaterial mediated mRNA delivery

Huapan Fang / Qian Chen

Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 4, Pp 428-

2022 Volume 444

Abstract: With the rapid development of gene therapy technology and the outbreak of coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) therapeutics have attracted more and more attention, and the COVID-19 mRNA vaccine has been approved by the Food and Drug ... ...

Abstract	With the rapid development of gene therapy technology and the outbreak of coronavirus disease 2019 (COVID-19), messenger RNA (mRNA) therapeutics have attracted more and more attention, and the COVID-19 mRNA vaccine has been approved by the Food and Drug Administration (FDA) for emergency authorization. To improve the delivery efficiency of mRNA in vitro and in vivo, researchers have developed a variety of mRNA carriers and explored different administration routes. This review will systematically introduce the types of mRNA vectors, routes of administration, storage methods, safety of mRNA therapeutics, and the type of diseases that mRNA drugs are applied for. Finally, some suggestions are supplied on the development direction of mRNA therapeutic agents in the future.
Keywords	messenger rna therapeutics ; delivery efficiency ; messenger rna vectors ; routes of administration ; storage methods ; safety ; Internal medicine ; RC31-1245
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Open Exploration Publishing Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Thesis ; Online: Individual differences matter

Qian, Chen

personality traits and preferences in smallholders’ farm management

2021

Abstract: Individual differences in personality traits and economic preferences have been found to be powerful in explaining key labour market success. Yet, much of their impact on agricultural production decisions in the rural context remains unclear. This thesis ...

Abstract	Individual differences in personality traits and economic preferences have been found to be powerful in explaining key labour market success. Yet, much of their impact on agricultural production decisions in the rural context remains unclear. This thesis aims to provide more insights into the contribution of personality traits and economic preferences to smallholders’ economic decisions in agricultural production and farm management, using available data sets from China. It starts with an investigation of smallholders’ perception of land tenure security from perspectives of both cognitive-consequentialist and risk-as-feelings. The subsequent two chapters centre on the roles of personality traits and preferences in two important input decisions regarding smallholders’ agricultural production: land renting and fertilizer use. This thesis further examines if human personality has direct impact on smallholder farmers’ overall farm management performance. Unravelling the mysterious role that personality traits play in smallholder farmers’ decision-making processes is vital for designing policies aimed at increasing agricultural production and alleviating rural poverty.
Keywords	Life Science
Language	English
Publisher	Wageningen University
Publishing country	nl
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Refined Estimation of Potential GDP Exposure in Low-Elevation Coastal Zones (LECZ) of China Based on Multi-Source Data and Random Forest

Feixiang Li / Liwei Mao / Qian Chen / Xuchao Yang

Remote Sensing, Vol 15, Iss 1285, p

2023 Volume 1285

Abstract: With climate change and rising sea levels, the residents and assets in low-elevation coastal zones (LECZ) are at increasing risk. The application of high-resolution gridded population datasets in recent years has highlighted the threats faced by people ... ...

Abstract	With climate change and rising sea levels, the residents and assets in low-elevation coastal zones (LECZ) are at increasing risk. The application of high-resolution gridded population datasets in recent years has highlighted the threats faced by people living in LECZ. However, the potential exposure of gross domestic product (GDP) within LECZ remains unknown, due to the absence of refined GDP datasets and corresponding analyzes for coastal regions. The climate-related risks faced by LECZ may still be underestimated. In this study, we estimated the potential exposure of GDP in the LECZ across China by overlying DEM with new gridded GDP datasets generated by random forest models. The results show that 24.02% and 22.7% of China’s total GDP were located in the LECZ in 2010 and 2019, respectively, while the area of the LECZ only accounted for 1.91% of China’s territory. Significant variability appears in the spatial-temporal pattern and the volume of GDP across sectors, which impedes disaster prevention and mitigation efforts within administrative regions. Interannual comparisons reveal a rapid increase in GDP within the LECZ, but a decline in its share of the country. Policy reasons may have driven the slow shift of China’s economy to regions far from the LECZ.
Keywords	low elevation coastal zones ; GDP ; climate change ; multi-source data ; random forest ; China ; Science ; Q
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The usage of spatial econometric approach to explore the determinants of ecological footprint in BRI countries

Qian Chen / Ghulam Rasool Madni / Adnan Ali Shahzad

PLoS ONE, Vol 18, Iss

2023 Volume 10

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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