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Article ; Online: Mitochondria: A Potential Rejuvenation Tool against Aging.

Phua, Qian Hua / Ng, Shi Yan / Soh, Boon-Seng

2024 Volume 15, Issue 2, Page(s) 503–516

Abstract: Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related ... ...

Abstract	Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related diseases. In response to the remarkable increase in human life expectancy, there has been a substantial rise in research focusing on the development of anti-aging therapies and pharmacological interventions. Mitochondrial dysfunction, a critical factor in the aging process, significantly impacts overall cellular health. In this extensive review, we will explore the contemporary landscape of anti-aging strategies, placing particular emphasis on the promising potential of mitotherapy as a ground-breaking approach to counteract the aging process. Moreover, we will investigate the successful application of mitochondrial transplantation in both animal models and clinical trials, emphasizing its translational potential. Finally, we will discuss the inherent challenges and future possibilities of mitotherapy within the realm of aging research and intervention.
MeSH term(s)	Animals ; Humans ; Rejuvenation/physiology ; Aging/physiology ; Mitochondria/metabolism ; Proteomics
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2023.0712
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health risk assessment of airborne bacteria and fungi in different-type buildings in Kunming, a typical temperate Chinese city

Wang Shengqi / Qian Hua

E3S Web of Conferences, Vol 356, p

2022 Volume 05073

Abstract: The risk assessment of airborne bacteria and fungi between different-type buildings located in temperate climate zone is still unclear. We applied the culturable method to characterize the airborne bacteria and fungi in 10 residences, 1 school, 2 office ... ...

Abstract	The risk assessment of airborne bacteria and fungi between different-type buildings located in temperate climate zone is still unclear. We applied the culturable method to characterize the airborne bacteria and fungi in 10 residences, 1 school, 2 office buildings, 1 hospital, and 1 library during winter in Kunming, China. In a total of 79 rooms, 152 culturable microbial samples were investigated. Results showed that there were significant disparities in bacterial concentrations among various types of buildings. The highest culturable bacterial concentration was found in residences, while the lowest was in the library. In contrast, the fungal concentrations showed little difference. The risk assessment indicated that occupants in different types of buildings in Kunming had an acceptable exposure risk (hazard index < 1) for bioaerosols. The exposure risk for bacteria in residence was significantly higher than in the others, while the mean hazard index of fungi in residence was significantly higher than in schools, hospitals, and libraries. Ventilation could reduce the HI of bioaerosols in rooms. This study is helpful to give practical implications for assessing microbial characteristics in different types of buildings and highlight the significance of evaluating the microbial concentrations in residence in temperate climate zone in China.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Uncertainty analysis of facemasks in mitigating SARS-CoV-2 transmission.

Liu, Fan / Qian, Hua

Environmental pollution (Barking, Essex : 1987)

2022 Volume 303, Page(s) 119167

Abstract: In the context of global spread of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2), there is a controversial issue on whether the use of facemasks is promising to control or mitigate the COVID-19 transmission. This study ... ...

Abstract	In the context of global spread of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2), there is a controversial issue on whether the use of facemasks is promising to control or mitigate the COVID-19 transmission. This study modeled the SARS-CoV-2 transmission process and analyzed the ability of surgical mask and N95 in reducing the infection risk with Sobol's analysis. Two documented outbreaks of COVID-19 with no involvers wearing face masks were reviewed in a restaurant in Guangzhou (China) and a choir rehearsal in Mount Vernon (USA), suggesting that the proposed model can be well validated when airborne transmission is assumed to dominate the virus transmission indoors. Subsequently, the uncertainty analysis of the protection efficiency of N95 and surgical mask were conducted with Monte Carlo simulations, with three main findings: (1) the uncertainty in infection risk is primarily apportioned by respiratory activities, virus dynamics, environment factors and individual exposures; (2) wearing masks can effectively reduce the SARS-CoV-2 infection risk to an acceptable level (< 10
MeSH term(s)	COVID-19/prevention & control ; Humans ; Masks ; Pandemics/prevention & control ; SARS-CoV-2 ; Uncertainty
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119167
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Article: Uncertainty analysis of facemasks in mitigating SARS-CoV-2 transmission

Liu, Fan / Qian, Hua

Environmental pollution. 2022 June 15, v. 303

2022

Abstract	In the context of global spread of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2), there is a controversial issue on whether the use of facemasks is promising to control or mitigate the COVID-19 transmission. This study modeled the SARS-CoV-2 transmission process and analyzed the ability of surgical mask and N95 in reducing the infection risk with Sobol's analysis. Two documented outbreaks of COVID-19 with no involvers wearing face masks were reviewed in a restaurant in Guangzhou (China) and a choir rehearsal in Mount Vernon (USA), suggesting that the proposed model can be well validated when airborne transmission is assumed to dominate the virus transmission indoors. Subsequently, the uncertainty analysis of the protection efficiency of N95 and surgical mask were conducted with Monte Carlo simulations, with three main findings: (1) the uncertainty in infection risk is primarily apportioned by respiratory activities, virus dynamics, environment factors and individual exposures; (2) wearing masks can effectively reduce the SARS-CoV-2 infection risk to an acceptable level (< 10⁻³) by at least two orders of magnitude; (3) faceseal leakage can reduce protection efficiency by approximately 4% when the infector is speaking or coughing, and by approximately 28% when the infector is sneezing. This work indicates the effectiveness of non-pharmaceutical interventions during the pandemic, and implies the importance of the synergistic studies of medicine, environment, social policies and strategies, etc., on reducing hazards and risks of the pandemic.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; airborne transmission ; face ; medicine ; models ; pandemic ; pollution ; restaurants ; risk ; uncertainty ; uncertainty analysis ; virus transmission ; viruses ; China
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119167
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Article ; Online: Potential contribution of anti-p200 autoantibodies to mucosal lesions in anti-p200 pemphigoid.

Gao, Yangmin / Qian, Hua / Hashimoto, Takashi / Li, Xiaoguang

Frontiers in immunology

2023 Volume 14, Page(s) 1118846

Abstract: Anti-p200 pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, ... ...

Abstract	Anti-p200 pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, with occasional involvement of mucosal lesions. The mechanism of mucosal lesions involved in anti-p200 pemphigoid is still unclear. In the present study, we aimed to analyze published data on cases and case series of anti-p200 pemphigoid with mucosal lesions and explored the potential contribution of anti-p200 autoantibodies to mucosal lesions. A total of 32 papers that comprised 52 anti-p200 pemphigoid patients with various mucosal lesions were included in this review. Oral lesions were involved in 75.0% patients, followed by genital lesions (26.9%) and ocular lesions (11.54%). Only one patient had psoriasis, 26.9% patients had multiple mucosal lesions, and 30.8% cases had comorbidity of other AIBDs, particularly anti-laminin (LM) 332-type mucous membrane pemphigoid (MMP). In comparison with anti-LM332-type MMP, anti-BP180-type MMP and epidermolysis bullosa acquisita, higher frequency of genital lesions was identified as a unique character of anti-p200 pemphigoid with mucosal lesions. These results indicated that anti-p200 autoantibodies might contribute to mucosal lesions in a pattern different from other MMP-related autoantibodies, although its pathogenetic mechanisms are still unclear.
MeSH term(s)	Humans ; Pemphigoid, Bullous ; Autoantibodies ; Epidermolysis Bullosa Acquisita ; Skin Diseases, Vesiculobullous ; Psoriasis
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1118846
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Article: Impact of thermal stratification on airborne transmission risk of SARS-CoV-2 in various indoor environments.

Liu, Fan / Luo, Zhiwen / Qian, Hua

Building simulation

2023 , Page(s) 1–14

Abstract: There exist various vertical temperature gradients in different-type buildings. A holistic understanding of the impact of different temperature-stratified indoor environments on infection risk is necessary. In this work, the airborne transmission risk of ...

Abstract	There exist various vertical temperature gradients in different-type buildings. A holistic understanding of the impact of different temperature-stratified indoor environments on infection risk is necessary. In this work, the airborne transmission risk of SARS-CoV-2 in different thermally stratified indoor environments is assessed using our previously developed airborne infection risk model. Results show that the vertical temperature gradients in office building, hospital, classroom, etc. are within the range of -0.34 to 3.26 °C/m. In large space such as coach station, airport terminal, and sport hall, the average temperature gradient ranges within 0.13-2.38 °C/m in occupied zone (0-3 m); in ice rink with special requirements of indoor environment, the temperature gradient is higher than those in the above indoor spaces. The existence of temperature gradients causes multi-peaks of the transmission risk of SARS-CoV-2 with distancing, and our results show that in office, hospital ward and classroom, the second peak of the transmission risk is higher than 10 Electronic supplementary material: the Appendix is available in the online version of this article at 10.1007/s12273-023-1021-5.
Language	English
Publishing date	2023-05-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2422327-X
ISSN	1996-8744 ; 1996-3599
ISSN (online)	1996-8744
ISSN	1996-3599
DOI	10.1007/s12273-023-1021-5
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Article ; Online: CAV-1 Overexpression Exacerbates the Manifestation in EPAC-1-Induced Chronic Postsurgical Pain in Rats

Qian Hua / Shiren Shen / Yibin Qin / Su Cao

Pain Research and Management, Vol

2022 Volume 2022

Abstract: Purpose. Caveolae (CAV) are an invaginated microcapsule with the shape of Ω on the surface of the cell membrane. Caveolin-1 (CAV-1) is involved in neuropathic pain, and adenosine monophosphate (AMP)-exchange protein directly activated by cAMP1 (EPAC-1) ... ...

Abstract	Purpose. Caveolae (CAV) are an invaginated microcapsule with the shape of Ω on the surface of the cell membrane. Caveolin-1 (CAV-1) is involved in neuropathic pain, and adenosine monophosphate (AMP)-exchange protein directly activated by cAMP1 (EPAC-1) is a potential therapeutic target for chronic pain. However, whether EPAC-1 promotes chronic postsurgical pain (CPSP) through CAV-1 has not been reported. Here, we aim to investigate the underlying mechanism of CAV in CPSP. Methods. All the rats were divided into 9 groups, including the Naive group, Sham group, skin/muscle incision and retraction (SMIR) group, SMIR + CAV-1 siRNA group, SMIR + control siRNA group, SMIR (7 days)+Saline group, SMIR (7 days)+CE3F4 group, 8-PCPT group, and Saline group. The CPSP rat model was established after SMIR. A mechanical withdrawal threshold (MWT) was recorded to evaluate the animal’s behavior. Western blotting and immunofluorescent were performed to detect the protein expression levels of EPAC-1 and P-CAV-1. Results. EPAC-1 and CAV-1 were both overexpressed after operation, particularly in astrocytes, microglia, and neurons of spinal marrow (all P<0.05). Interestingly, CAV-1 siRNA can partly reverse the SMIR-induced hypersensitivity, but there was no effect on EPAC-1. Besides, EPAC-1 blockage partly reversed the SMIR-induced hypersensitivity and CAV-1 overexpression, and EPAC-1 activation promoted CAV-1 overexpression and hypersensitivity in normal rats (all P<0.05). Conclusion. CAV-1 mediates the functional coupling of microglia, astrocytes, and neurons, and thus EPAC-1/CAV-1 plays an important role in CPSP exacerbation.
Keywords	Medicine (General) ; R5-920
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research on hydrogen leakage and dispersion characteristics in indoor thermal stratification environment

Shu Zhiyong / Liang Wenqing / Zheng Xiaohong / Qian Hua

E3S Web of Conferences, Vol 356, p

2022 Volume 02018

Abstract: The leakage of hydrogen in a room is a key issue of hydrogen safety, and ventilation plays an important role in hydrogen dispersion. The hydrogen leakage usually builds a thermal stratification environment due to the low temperature of liquid hydrogen or ...

Abstract	The leakage of hydrogen in a room is a key issue of hydrogen safety, and ventilation plays an important role in hydrogen dispersion. The hydrogen leakage usually builds a thermal stratification environment due to the low temperature of liquid hydrogen or throttling effect. This study attempts to develop a fast-computational theoretical model of hydrogen dispersion motion in an indoor thermal stratification environment based on the classical buoyant jet model and to carry out an experimental to verify model. The research results show that the developed theoretical model can well predict the trajectory of slowly releasing hydrogen leakage. The motion trajectory of the hydrogen leak oscillates in the thermally stratified environment at a certain height, called as the “lock height”. The smaller the leak port in the uniform environment the larger the horizontal diffusion distance, and the smaller the leak port in the thermally stratified environment the higher the locking height. The research results are expected to predict the hydrogen leakage safety prediction problem and the formulation of related standards and help make ventilation strategies to ensure the hydrogen safety.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Various pathogen-laden aerosol deposition in the realistic human airway during inhalation

Luo Danting / Zheng Xiaohong / Qian Hua

E3S Web of Conferences, Vol 356, p

2022 Volume 05003

Abstract: Studying the deposition of different pathogens with various sizes and shapes is vital for understanding various respiratory infectious diseases. Few studies focus on the deposition of pathogen-laden aerosol during inhalation, especially for different ... ...

Abstract	Studying the deposition of different pathogens with various sizes and shapes is vital for understanding various respiratory infectious diseases. Few studies focus on the deposition of pathogen-laden aerosol during inhalation, especially for different respiratory infectious pathogens. This paper studied the depositions of H3N2, SAR-CoV-2, Ebola virus, Escherichia coli, and different sizes of droplets in the realistic human respiratory airway during inhalation. And results show that large droplets are mainly deposited in the upper respiratory tract, while most of the small particles, especially viruses, will transmit to somewhere further than bronchi-G7 and be deposited into the deep lobes of the lungs. Over 90% of single virus particles will inhale into lobes. The deposition efficiency of pathogens in the right lobes is significantly higher than that in the left, and this phenomenon is more obvious in the superior lobes, which may also explain why lung carcinomas are more likely to develop in the right lung. Compared with other viruses, SARS-CoV-2 is more inhaled into the right superior lobe, which should be paid attention to. This paper may help learn about various respiratory infectious diseases and provide references for treatment methods and drug delivery locations.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Magnetic resonance imaging-based radiomics was used to evaluate the level of prognosis-related immune cell infiltration in breast cancer tumor microenvironment.

Qian, Hua / Ren, Xiaojing / Xu, Maosheng / Fang, Zhen / Zhang, Ruixin / Bu, Yangyang / Zhou, Changyu

BMC medical imaging

2024 Volume 24, Issue 1, Page(s) 31

Abstract: Purpose: The tumor immune microenvironment is a valuable source of information for predicting prognosis in breast cancer (BRCA) patients. To identify immune cells associated with BRCA patient prognosis from the Cancer Genetic Atlas (TCGA), we ... ...

Abstract	Purpose: The tumor immune microenvironment is a valuable source of information for predicting prognosis in breast cancer (BRCA) patients. To identify immune cells associated with BRCA patient prognosis from the Cancer Genetic Atlas (TCGA), we established an MRI-based radiomics model for evaluating the degree of immune cell infiltration in breast cancer patients. Methods: CIBERSORT was utilized to evaluate the degree of infiltration of 22 immune cell types in breast cancer patients from the TCGA database, and both univariate and multivariate Cox regressions were employed to determine the prognostic significance of immune cell infiltration levels in BRCA patients. We identified independent prognostic factors for BRCA patients. Additionally, we obtained imaging features from the Cancer Imaging Archive (TCIA) database for 73 patients who underwent preoperative MRI procedures, and used the Least Absolute Shrinkage and Selection Operator (LASSO) to select the best imaging features for constructing an MRI-based radiomics model for evaluating immune cell infiltration levels in breast cancer patients. Results: According to the results of Cox regression analysis, M2 macrophages were identified as an independent prognostic factor for BRCA patients (HR = 32.288, 95% CI: 3.100-357.478). A total of nine significant features were selected to calculate the radiomics-based score. We established an intratumoral model with AUCs (95% CI) of 0.662 (0.495-0.802) and 0.678 (0.438-0.901) in the training and testing cohorts, respectively. Additionally, a peritumoral model was created with AUCs (95% CI) of 0.826 (0.710-0.924) and 0.752 (0.525-0.957), and a combined model was established with AUCs (95% CI) of 0.843 (0.723-0.938) and 0.744 (0.491-0.965). The peritumoral model demonstrated the highest diagnostic efficacy, with an accuracy, sensitivity, and specificity of 0.773, 0.727, and 0.818, respectively, in its testing cohort. Conclusion: The MRI-based radiomics model has the potential to evaluate the degree of immune cell infiltration in breast cancer patients, offering a non-invasive imaging biomarker for assessing the tumor microenvironment in this disease.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Radiomics ; Tumor Microenvironment ; Prognosis ; Magnetic Resonance Imaging
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2061975-3
ISSN	1471-2342 ; 1471-2342
ISSN (online)	1471-2342
ISSN	1471-2342
DOI	10.1186/s12880-024-01212-9
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