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  1. Article ; Online: Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis.

    He, Tao / Qian, Weiqing

    Zeitschrift fur Rheumatologie

    2024  

    Abstract: Reactive arthritis (ReA) is defined as arthritis resulting from infections in other body parts, such as the gastrointestinal and urogenital tracts. The primary clinical manifestations involve acute-onset and self-limiting asymmetric large joint ... ...

    Title translation Immunologische Störung durch intestinale Dysbiose und Stress als wesentliche Grundlage der reaktiven Arthritis.
    Abstract Reactive arthritis (ReA) is defined as arthritis resulting from infections in other body parts, such as the gastrointestinal and urogenital tracts. The primary clinical manifestations involve acute-onset and self-limiting asymmetric large joint inflammation in the lower limbs. Although bacterial or chlamydia infections have long been recognized as playing a pivotal role in its pathogenesis, recent studies suggest that antibiotic treatment may perpetuate rather than eradicate chlamydia within the host, indicating an involvement of other mechanisms in Reactive arthritis. Reactive arthritis is currently believed to be associated with infection, genetic marker (HLA-B27), and immunologic derangement. As an autoimmune disease, increasing attention has been given to understanding the role of the immune system in Reactive arthritis. This review focuses on elucidating how the immune system mediates reactive arthritis and explores the roles of intestinal dysbiosis-induced immune disorders and stress-related factors in autoimmune diseases, providing novel insights into understanding reactive arthritis.
    Language English
    Publishing date 2024-02-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-024-01480-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Translational control of SOG1 expression in response to replication stress in Arabidopsis.

    Li, Jinchao / Qian, Weiqiang

    Stress biology

    2023  Volume 3, Issue 1, Page(s) 28

    Abstract: DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage ... ...

    Abstract DNA damage, which may arise from cellular activities or be induced by genotoxic stresses, can cause genome instability and significantly affect plant growth and productivity. In response to genotoxic stresses, plants activate the cellular DNA damage response (DDR) to sense the stresses and activate downstream processes. The transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a functional counterpart of mammalian p53, is a master regulator of the DDR in plants. It is activated by various types of DNA lesions and can activate the transcription of hundreds of genes to trigger downstream processes, including cell cycle arrest, DNA repair, endoreplication, and apoptosis. Since SOG1 plays a crucial role in DDR, the activity of SOG1 must be tightly regulated. A recent study published in Plant Cell (Chen et al., Plant Cell koad126, 2023) reports a novel mechanism by which the ATR-WEE1 kinase module promotes SOG1 translation to fine-tune replication stress response.
    Language English
    Publishing date 2023-07-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-0450
    ISSN (online) 2731-0450
    DOI 10.1007/s44154-023-00112-2
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  3. Article ; Online: From Self-Assembly of Colloidal Crystals toward Ordered Porous Layer Interferometry.

    Wan, Yi-Zhen / Qian, Weiping

    Biosensors

    2023  Volume 13, Issue 7

    Abstract: Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many ... ...

    Abstract Interferometry-based, reflectometric, label-free biosensors have made significant progress in the analysis of molecular interactions after years of development. The design of interference substrates is a key research topic for these biosensors, and many studies have focused on porous films prepared by top-down methods such as porous silicon and anodic aluminum oxide. Lately, more research has been conducted on ordered porous layer interferometry (OPLI), which uses ordered porous colloidal crystal films as interference substrates. These films are made using self-assembly techniques, which is the bottom-up approach. They also offer several advantages for biosensing applications, such as budget cost, adjustable porosity, and high structural consistency. This review will briefly explain the fundamental components of self-assembled materials and thoroughly discuss various self-assembly techniques in depth. We will also summarize the latest studies that used the OPLI technique for label-free biosensing applications and divide them into several aspects for further discussion. Then, we will comprehensively evaluate the strengths and weaknesses of self-assembly techniques and discuss possible future research directions. Finally, we will outlook the upcoming challenges and opportunities for label-free biosensing using the OPLI technique.
    MeSH term(s) Porosity ; Interferometry ; Biosensing Techniques/methods ; Silicon/chemistry ; Aluminum Oxide/chemistry
    Chemical Substances Silicon (Z4152N8IUI) ; Aluminum Oxide (LMI26O6933)
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13070730
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  4. Article ; Online: Identification of cell-type-specific genes in multimodal single-cell data using deep neural network algorithm.

    Qian, Weiye / Yang, Zhiyuan

    Computers in biology and medicine

    2023  Volume 166, Page(s) 107498

    Abstract: The emergence of single-cell RNA sequencing (scRNA-seq) technology makes it possible to measure DNA, RNA, and protein in a single cell. Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-seq) is a powerful multimodal single-cell ... ...

    Abstract The emergence of single-cell RNA sequencing (scRNA-seq) technology makes it possible to measure DNA, RNA, and protein in a single cell. Cellular Indexing of Transcriptomes and Epitopes by sequencing (CITE-seq) is a powerful multimodal single-cell research innovation, allowing researchers to capture RNA and surface protein expression on the same cells. Currently, identification of cell-type-specific genes in CITE-seq data is still challenging. In this study, we obtained a set of CITE-seq datasets from Kaggle database, which included the sequencing dataset of seven cell types during bone marrow stem cell differentiation. We used Student's t-test to analyze these transcription RNAs and pick out 133 significantly differentially expressed genes (DEGs) among all cell types. Functional enrichment revealed that these DEGs were strongly associated with blood-related diseases, providing important insights into the cellular heterogeneity within bone marrow stem cells. The relation between RNA and protein levels was performed by deep neural network (DNN) model and achieved a high prediction score of 0.867. Based on their coefficients in the DNN model, three genes (LGALS1, CENPV, TRIM24) were identified as cell-type-specific genes in erythrocyte progenitor. Our works provide a novel perspective regarding the differentiation of stem cells in the bone marrow and provide valuable insights for further research in this field.
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2023.107498
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    Zs.A 653: Show issues Location:
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  5. Article: Exploring the Influential Factors of Personal Media Bloggers on Followers' Continuous Following Intention Based on Relationship Marketing Theory.

    Qian, Wenjie / Mao, Jianhua

    Behavioral sciences (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: The use of personal media has become increasingly popular in recent years. However, gaining and retaining followers has become increasingly challenging, given the fierce competition among bloggers and the constant changes in personal media. In this ... ...

    Abstract The use of personal media has become increasingly popular in recent years. However, gaining and retaining followers has become increasingly challenging, given the fierce competition among bloggers and the constant changes in personal media. In this context, this study aims to explore the factors that influence followers' continued usage intentions toward personal media bloggers and strategies to improve their loyalty. Drawing upon the theory of relationship marketing, a structural model is constructed to examine the impacts and mechanisms of personal media bloggers' attributes and communication on social presence, fanship, intention to use, and word of mouth. This research focuses on two dimensions of personal media bloggers' attributes: expertise and attractiveness. A sample of 155 highly active personal media users in China was collected through a questionnaire for analysis and validation. The findings reveal that expertise and communication have positive impacts on followers' intentions to continue following a blogger, while attractiveness has a significant, positive, and direct impact on word of mouth. Furthermore, this study shows that social presence and fanship play mediating roles in the effects of expertise and communication on followers' usage intentions and word of mouth. The research results provide valuable insights for personal media operators and marketers seeking to improve followers' loyalty and encourage potential users to become more loyal fans.
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651997-5
    ISSN 2076-328X
    ISSN 2076-328X
    DOI 10.3390/bs13050416
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  6. Article: [Research progress on clinical and mechanisms of chronic pruritus with anxiety and depression].

    Qian, W L / Cai, T

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2023  Volume 57, Issue 5, Page(s) 778–784

    Abstract: Chronic pruritus seriously affects the quality of life of patients, which is closely related to stress, anxiety and depression. Prolonged and repeated pruritus can induce negative emotions such as anxiety and depression, while continued increased ... ...

    Abstract Chronic pruritus seriously affects the quality of life of patients, which is closely related to stress, anxiety and depression. Prolonged and repeated pruritus can induce negative emotions such as anxiety and depression, while continued increased negative emotions can also promote exacerbation of pruritus, which drives the itch scratch cycle, thereby further aggravating skin damage. More and more studies have explored the mechanism of pruritus, anxiety and depression. This article mainly reviews the clinical relationship between pruritus and anxiety, depression and the new progress of its possible mechanism, providing reference for the prevention, control and effective treatment of chronic pruritus, anxiety and depression.
    MeSH term(s) Humans ; Pruritus/psychology ; Quality of Life ; Depression ; Anxiety ; Chronic Disease
    Language Chinese
    Publishing date 2023-04-25
    Publishing country China
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.cn112150-20220522-00516
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    Zs.B 2487: Show issues Location:
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  7. Article ; Online: Gastric fundus bronchogenic cyst with elevated CA72-4: A case report and literature review.

    Qian, Wenxiu / Xu, Guofu

    Asian journal of surgery

    2023  Volume 46, Issue 10, Page(s) 4507–4508

    MeSH term(s) Humans ; Gastric Fundus ; Bronchogenic Cyst/diagnostic imaging ; Bronchogenic Cyst/surgery ; Stomach Neoplasms
    Language English
    Publishing date 2023-05-11
    Publishing country Netherlands
    Document type Review ; Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.04.133
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    Zs.B 2831: Show issues Location:
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  8. Article ; Online: Expression and diagnostic significance of integrin beta-2 in synovial fluid of patients with osteoarthritis.

    Qian, Weiwei / Li, Zhen

    Journal of orthopaedic surgery (Hong Kong)

    2023  Volume 31, Issue 2, Page(s) 10225536221147213

    Abstract: Objective: Osteoarthritis (OA) is characterized by synovial cartilage degeneration and is the leading cause of disability and pain worldwide. This study sought to investigate the expression of integrin beta-2 (ITGB2) in synovial fluid of OA patients and ...

    Abstract Objective: Osteoarthritis (OA) is characterized by synovial cartilage degeneration and is the leading cause of disability and pain worldwide. This study sought to investigate the expression of integrin beta-2 (ITGB2) in synovial fluid of OA patients and its clinical significance.
    Methods: A total of 110 OA patients were enrolled, who were classified into grade I (
    Results: The content of red blood cells, white blood cells, PINP, BGP, and BALP was lowered in OA patients, while β-CTX was elevated. ITGB2 was highly-expressed in OA patients, negatively-correlated with PINP, BGP, and BALP, but positively-correlated with β-CTX. ITGB2 level increased with the elevation of OA grade. The ITGB2 level >1.375 had certain diagnostic values for OA. ITGB2 level is related to OA severity and may be a biomarker for OA classification. ITGB2 was an independent risk factor for OA.
    Conclusion: High expression of ITGB2 in synovial fluid can assist OA diagnosis and may be a biomarker for OA grade.
    MeSH term(s) Humans ; Synovial Fluid/chemistry ; Osteoarthritis, Knee/diagnosis ; Osteoarthritis, Knee/metabolism ; Biomarkers/metabolism ; Integrins/analysis ; Integrins/metabolism ; Severity of Illness Index
    Chemical Substances Procollagen Type I ; Biomarkers ; Integrins
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1493368-8
    ISSN 2309-4990 ; 1022-5536
    ISSN (online) 2309-4990
    ISSN 1022-5536
    DOI 10.1177/10225536221147213
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    Zs.A 5104: Show issues Location:
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  9. Article: [Paying more attention to burn induced coagulopathy].

    Luo, G X / Zhang, Q R / Qian, W / Li, H S

    Zhonghua shao shang yu chuang mian xiu fu za zhi

    2023  Volume 39, Issue 5, Page(s) 401–406

    Abstract: Burn induced coagulopathy (BIC) is one of the common complications after burn injury. The types and clinical manifestations of BIC vary dramatically, which frequently leads serious consequences. However, at present BIC does not attract enough attention ... ...

    Abstract Burn induced coagulopathy (BIC) is one of the common complications after burn injury. The types and clinical manifestations of BIC vary dramatically, which frequently leads serious consequences. However, at present BIC does not attract enough attention in clinic. In order to prevent and treat BIC more effectively, the authors suggest that it is necessary to strengthen coagulation surveillance, operation management, infection control, rational application of drugs, prevention and treatment of deep vein thrombosis, relative clinical and basic research, and others.
    MeSH term(s) Humans ; Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/therapy ; Burns/complications ; Burns/therapy
    Language Chinese
    Publishing date 2023-10-05
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2097-1109
    ISSN 2097-1109
    DOI 10.3760/cma.j.cn501225-20221223-00545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Advancements and Prospects of Flexoelectricity.

    Xia, Yanlong / Qian, Weiqi / Yang, Ya

    ACS applied materials & interfaces

    2024  Volume 16, Issue 8, Page(s) 9597–9613

    Abstract: The flexoelectric effect, as a novel form of the electromechanical coupling phenomenon, has attracted significant attention in the fields of materials science and electronic devices. It refers to the interaction between strain gradients and electric ... ...

    Abstract The flexoelectric effect, as a novel form of the electromechanical coupling phenomenon, has attracted significant attention in the fields of materials science and electronic devices. It refers to the interaction between strain gradients and electric dipole moments or electric field intensity gradients and strain. In contrast to the traditional piezoelectric effect, the flexoelectric effect is not limited by material symmetry or the Curie temperature and exhibits a stronger effect at the nanoscale. The flexoelectric effect finds widespread applications ranging from energy harvesting to electronic device design. Utilizing the flexoelectric effect, enhanced energy harvesters, sensitive sensors, and high-performance wearable electronic devices can be developed. Additionally, the flexoelectric effect can be utilized to modulate the optoelectronic properties and physical characteristics of materials, holding the potential for significant applications in areas such as optoelectronic devices, energy storage devices, and flexible electronics. This review provides a comprehensive overview of the historical development, measurement of flexoelectric coefficients, enhancement mechanisms, and current research progress of the flexoelectric effect. Additionally, it offers a perspective on future prospects of the flexoelectric effect.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c16727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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