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Article ; Online: A Network Sampling Strategy Inspired by Epidemic Spreading

Qiang Dong / En-Yu Yu / Wen-Jun Li

Security and Communication Networks, Vol

2022 Volume 2022

Abstract: Nowadays, network sampling has become an indispensable premise and foundation for large-scale network analysis, and its effectiveness determines to a large extent the reliability and practicability of the subsequent network analysis results. In this ... ...

Abstract	Nowadays, network sampling has become an indispensable premise and foundation for large-scale network analysis, and its effectiveness determines to a large extent the reliability and practicability of the subsequent network analysis results. In this paper, we propose a network sampling algorithm inspired by an epidemic spreading model named the contact process. The contact process is similar to the random walk process but different from it in two key points. First, at each time step, a randomly selected sampled node rather than the latest sampled node is responsible for recruiting a new node from its neighborhood. Second, the responsible node recruits one of its neighbor nodes with a probability inversely proportional to the degree of this neighbor node, instead of equal probability. Experiments on nine indiscriminately selected real-world networks show that our proposed sampling algorithm has a significant advantage in preserving two basic network properties, the degree distributions and clustering coefficient distributions of original networks, compared with seven classical sampling methods.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment

Shasha Chen / Weina Shen / Yuhuan Liu / Qiang Dong / Yongquan Shi / Jinjiao Li / Yuanyuan Ji

Chinese Medical Journal, Vol 136, Iss 14, Pp 1690-

A randomized controlled trial

2023 Volume 1698

Abstract: Abstract. Background:. With the development of traditional Chinese medicine research, berberine has shown good efficacy and safety in the eradication of Helicobacter pylori (H. pylori). The present study aimed to evaluate the efficacy and safety of ... ...

Abstract	Abstract. Background:. With the development of traditional Chinese medicine research, berberine has shown good efficacy and safety in the eradication of Helicobacter pylori (H. pylori). The present study aimed to evaluate the efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for the initial treatment of H. pylori. Methods:. This study was a single-center, open-label, parallel, randomized controlled clinical trial. Patients with H. pylori infection were randomly (1:1:1) assigned to receive berberine triple therapy (berberine 500 mg, amoxicillin 1000 mg, vonoprazan 20 mg, A group), vonoprazan quadruple therapy (vonoprazan 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg, colloidal bismuth tartrate 220 mg, B group), or rabeprazole quadruple therapy (rabeprazole 10 mg, amoxicillin 1000 mg, clarithromycin 500 mg, colloidal bismuth tartrate 220 mg, C group). The drugs were taken twice daily for 14 days. The main outcome was the H. pylori eradication rate. The secondary outcomes were symptom improvement rate, patient compliance, and incidence of adverse events. Furthermore, factors affecting the eradication rate of H. pylori were further analyzed. Results:. A total of 300 H. pylori-infected patients were included in this study, and 263 patients completed the study. An intention-to-treat (ITT) analysis showed that the eradication rates of H. pylori in berberine triple therapy, vonoprazan quadruple therapy, and rabeprazole quadruple therapy were 70.0% (70/100), 77.0% (77/100), and 69.0% (69/100), respectively. The per-protocol (PP) analysis showed that the eradication rates of H. pylori in these three groups were 81.4% (70/86), 86.5% (77/89), and 78.4% (69/88), respectively. Both ITT analysis and PP analysis showed that the H. pylori eradication rate did not significantly differ among the three groups (P >0.05). In addition, the symptom improvement rate, overall adverse reaction rate, and patient compliance were similar among the three groups (P >0.05). Conclusions:. The ...
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Second malignant tumors and non-tumor causes of death for patients with localized and regional kidney cancer after diagnosis

Luchen Yang / Xiaotian Wu / Jing Zhou / Pan Song / Zhenghuan Liu / Junhao Chen / Qiang Dong

European Journal of Medical Research, Vol 28, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Background To evaluate the second malignant tumors (SMTs) and non-tumor causes of death among patients diagnosed with localized and regional kidney cancer. Methods Patients diagnosed with kidney cancer between 2000 and 2017 in the Surveillance, ... ...

Abstract	Abstract Background To evaluate the second malignant tumors (SMTs) and non-tumor causes of death among patients diagnosed with localized and regional kidney cancer. Methods Patients diagnosed with kidney cancer between 2000 and 2017 in the Surveillance, Epidemiology, and End Results (SEER) program database were identified. All causes of death for patients during the follow-up and standardized mortality ratio (SMR) were analyzed. Result 113,734 patients with localized kidney cancer with 30,390 cases of death were analyzed. 60.4% of the death cases were due to non-tumor caused and 23.6% were second malignant tumors (SMTs). Main SMTs included cancers of lung and bronchus [n = 1,283, SMR: 1.00 (0.95–1.06)] and pancreas [n = 393, SMR: 1.27 (1.15–1.41)]. Causes of death for non-tumor mainly included heart diseases [n = 6,161, SMR: 1.25 (1.21–1.28)] and chronic obstructive pulmonary disease (COPD) [n = 1,185, SMR: 0.99 (0.94–1.05)]. 14,437 of 29,602 patients with regional kidney cancer died. 14.6% of all deaths were due to SMTs and 23.6% due to non-tumor causes. Main SMTs contained bladder cancer [n = 371, SMR: 10.90 (9.81–12.06)] and lung and bronchus cancer [n = 346, SMR: 1.21 (1.08–1.34)]. The main non-tumor death was heart disease [n = 1,424, SMR: 1.26 (1.2–1.33)]. When stratified by pathological types, patients with clear cell renal cell carcinoma (RCC) did not have increased mortality risks of bladder cancer and lung cancer but patients with non-clear cell RCC did. Conclusion SMTs and non-tumor diseases including lung and bronchus cancer, bladder cancer, pancreas cancer, diseases of heart, COPD, and cerebrovascular diseases are the leading causes of death besides kidney cancer and should be paid more attention during patients’ survival period.
Keywords	Kidney cancer ; SMT ; Non-tumor causes of death ; Localized ; Regional ; SEER ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phosphorus and carbohydrate metabolism contributes to low phosphorus tolerance in cotton

Iqbal, Asif / Qiang, Dong / Xiangru, Wang / Huiping, Gui / Hengheng, Zhang / Xiling, Zhang / Meizhen, Song

BMC Plant Biol. 2023 Dec., v. 23, no. 1 p.97-97

2023

Abstract: Low phosphorus (P) is one of the limiting factors in sustainable cotton production. However, little is known about the performance of contrasting low P tolerant cotton genotypes that might be a possible option to grow in low P condition. In the current ... ...

Abstract	Low phosphorus (P) is one of the limiting factors in sustainable cotton production. However, little is known about the performance of contrasting low P tolerant cotton genotypes that might be a possible option to grow in low P condition. In the current study, we characterized the response of two cotton genotypes, Jimian169 a strong low P tolerant, and DES926 a weak low P tolerant genotypes under low and normal P conditions. The results showed that low P greatly inhibited growth, dry matter production, photosynthesis, and enzymatic activities related to antioxidant system and carbohydrate metabolism and the inhibition was more in DES926 as compared to Jimian169. In contrast, low P improved root morphology, carbohydrate accumulation, and P metabolism, especially in Jimian169, whereas the opposite responses were observed for DES926. The strong low P tolerance in Jimian169 is linked with a better root system and enhanced P and carbohydrate metabolism, suggesting that Jimian169 is a model genotype for cotton breeding. Results thus indicate that the Jimian169, compared with DES926, tolerates low P by enhancing carbohydrate metabolism and by inducing the activity of several enzymes related to P metabolism. This apparently causes rapid P turnover and enables the Jimian169 to use P more efficiently. Moreover, the transcript level of the key genes could provide useful information to study the molecular mechanism of low P tolerance in cotton.
Keywords	antioxidants ; carbohydrates ; cotton ; dry matter accumulation ; genotype ; growth retardation ; phosphorus ; photosynthesis ; root systems
Language	English
Dates of publication	2023-12
Size	p. 97.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04100-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Differential responses of contrasting low phosphorus tolerant cotton genotypes under low phosphorus and drought stress

Iqbal, Asif / Huiping, Gui / Qiang, Dong / Xiangru, Wang / Hengheng, Zhang / Xiling, Zhang / Meizhen, Song

BMC Plant Biol. 2023 Dec., v. 23, no. 1 p.168-168

2023

Abstract: BACKGROUND: Drought is one of the main reasons for low phosphorus (P) solubility and availability. AIMS: The use of low P tolerant cotton genotypes might be a possible option to grow in drought conditions. METHODS: This study investigates the tolerance ... ...

Abstract	BACKGROUND: Drought is one of the main reasons for low phosphorus (P) solubility and availability. AIMS: The use of low P tolerant cotton genotypes might be a possible option to grow in drought conditions. METHODS: This study investigates the tolerance to drought stress in contrasting low P-tolerant cotton genotypes (Jimian169; strong tolerant to low P and DES926; weak tolerant to low P). In hydroponic culture, the drought was artificially induced with 10% PEG in both cotton genotypes followed by low (0.01 mM KH₂PO₄) and normal (1 mM KH₂PO₄) P application. RESULTS: The results showed that under low P, PEG-induced drought greatly inhibited growth, dry matter production, photosynthesis, P use efficiency, and led to oxidative stress from excessive malondialdehyde (MDA) and higher accumulation of reactive oxygen species (ROS), and these effects were more in DES926 than Jimian169. Moreover, Jimian169 alleviated oxidative damage by improving the antioxidant system, photosynthetic activities, and an increase in the levels of osmoprotectants like free amino acids, total soluble proteins, total soluble sugars, and proline. CONCLUSIONS: The present study suggests that the low P-tolerant cotton genotype can tolerate drought conditions through high photosynthesis, antioxidant capacity, and osmotic adjustment.
Keywords	antioxidant activity ; cotton ; drought ; dry matter accumulation ; genotype ; growth retardation ; hydroponics ; malondialdehyde ; osmotolerance ; oxidative stress ; phosphorus ; photosynthesis ; proline ; reactive oxygen species ; solubility ; water stress
Language	English
Dates of publication	2023-12
Size	p. 168.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04171-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phosphorus and carbohydrate metabolism contributes to low phosphorus tolerance in cotton.

Iqbal, Asif / Qiang, Dong / Xiangru, Wang / Huiping, Gui / Hengheng, Zhang / Xiling, Zhang / Meizhen, Song

BMC plant biology

2023 Volume 23, Issue 1, Page(s) 97

Abstract	Low phosphorus (P) is one of the limiting factors in sustainable cotton production. However, little is known about the performance of contrasting low P tolerant cotton genotypes that might be a possible option to grow in low P condition. In the current study, we characterized the response of two cotton genotypes, Jimian169 a strong low P tolerant, and DES926 a weak low P tolerant genotypes under low and normal P conditions. The results showed that low P greatly inhibited growth, dry matter production, photosynthesis, and enzymatic activities related to antioxidant system and carbohydrate metabolism and the inhibition was more in DES926 as compared to Jimian169. In contrast, low P improved root morphology, carbohydrate accumulation, and P metabolism, especially in Jimian169, whereas the opposite responses were observed for DES926. The strong low P tolerance in Jimian169 is linked with a better root system and enhanced P and carbohydrate metabolism, suggesting that Jimian169 is a model genotype for cotton breeding. Results thus indicate that the Jimian169, compared with DES926, tolerates low P by enhancing carbohydrate metabolism and by inducing the activity of several enzymes related to P metabolism. This apparently causes rapid P turnover and enables the Jimian169 to use P more efficiently. Moreover, the transcript level of the key genes could provide useful information to study the molecular mechanism of low P tolerance in cotton.
MeSH term(s)	Phosphorus/metabolism ; Plant Breeding ; Carbohydrate Metabolism ; Photosynthesis ; Genotype
Chemical Substances	Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04100-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential responses of contrasting low phosphorus tolerant cotton genotypes under low phosphorus and drought stress.

Iqbal, Asif / Huiping, Gui / Qiang, Dong / Xiangru, Wang / Hengheng, Zhang / Xiling, Zhang / Meizhen, Song

BMC plant biology

2023 Volume 23, Issue 1, Page(s) 168

Abstract: Background: Drought is one of the main reasons for low phosphorus (P) solubility and availability.: Aims: The use of low P tolerant cotton genotypes might be a possible option to grow in drought conditions.: Methods: This study investigates the ... ...

Abstract	Background: Drought is one of the main reasons for low phosphorus (P) solubility and availability. Aims: The use of low P tolerant cotton genotypes might be a possible option to grow in drought conditions. Methods: This study investigates the tolerance to drought stress in contrasting low P-tolerant cotton genotypes (Jimian169; strong tolerant to low P and DES926; weak tolerant to low P). In hydroponic culture, the drought was artificially induced with 10% PEG in both cotton genotypes followed by low (0.01 mM KH Results: The results showed that under low P, PEG-induced drought greatly inhibited growth, dry matter production, photosynthesis, P use efficiency, and led to oxidative stress from excessive malondialdehyde (MDA) and higher accumulation of reactive oxygen species (ROS), and these effects were more in DES926 than Jimian169. Moreover, Jimian169 alleviated oxidative damage by improving the antioxidant system, photosynthetic activities, and an increase in the levels of osmoprotectants like free amino acids, total soluble proteins, total soluble sugars, and proline. Conclusions: The present study suggests that the low P-tolerant cotton genotype can tolerate drought conditions through high photosynthesis, antioxidant capacity, and osmotic adjustment.
MeSH term(s)	Antioxidants/metabolism ; Droughts ; Oxidative Stress ; Genotype ; Phosphorus ; Stress, Physiological/genetics
Chemical Substances	Antioxidants ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2059868-3
ISSN	1471-2229 ; 1471-2229
ISSN (online)	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-023-04171-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrative physiological, transcriptome and metabolome analysis reveals the involvement of carbon and flavonoid biosynthesis in low phosphorus tolerance in cotton.

Iqbal, Asif / Qiang, Dong / Xiangru, Wang / Huiping, Gui / Hengheng, Zhang / Xiling, Zhang / Meizhen, Song

Plant physiology and biochemistry : PPB

2023 Volume 196, Page(s) 302–317

Abstract: Phosphorus (P) is an essential nutrient controlling plant growth and development through the regulation of basic metabolic processes; however, the molecular details of these pathways remain largely unknown. In this study, physiological, transcriptome, ... ...

Abstract	Phosphorus (P) is an essential nutrient controlling plant growth and development through the regulation of basic metabolic processes; however, the molecular details of these pathways remain largely unknown. In this study, physiological, transcriptome, and metabolome analysis were compared for two cotton genotypes with different low P tolerance under P starvation and resupply. The results showed that the glucose, fructose, sucrose, and starch contents increased by 18.2%, 20.4%, 20.2%, and 14.3% in the roots and 18.3%, 23.3%, 11.0%, and 13.6% in the shoot of Jimian169 than DES926, respectively. Moreover, the activities of enzymes related to carbon and phosphorus metabolism were higher in the roots and shoots of Jimian169 than DES926. In addition, transcriptome analysis revealed that the number of differentially expressed genes (DEGs) was higher in both roots (830) and shoots (730) under P starvation and the DEGs drastically reduced upon P resupply. The KEGG analysis indicated that DEGs were mainly enriched in phenylpropanoid biosynthesis, carbon metabolism, and photosynthesis. The metabolome analysis showed the enrichment of phenylpropanoid, organic acids and derivatives, and lipids in all the pairs at a given time point. The combined transcriptome and metabolome analysis revealed that carbon metabolism and flavonoid biosynthesis are involved in the P starvation response in cotton. Moreover, co-expression network analysis identified 3 hub genes in the roots and shoots that regulate the pathways involved in the P starvation response. This study provides the foundation for understanding the mechanisms of low P tolerance and the hub genes as a potential target for the development of low P tolerant genotypes.
MeSH term(s)	Transcriptome ; Carbon/metabolism ; Gene Expression Profiling ; Metabolome/physiology ; Flavonoids/metabolism ; Phosphorus/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	Carbon (7440-44-0) ; Flavonoids ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-01-28
Publishing country	France
Document type	Journal Article
ZDB-ID	742978-2
ISSN	1873-2690 ; 0981-9428
ISSN (online)	1873-2690
ISSN	0981-9428
DOI	10.1016/j.plaphy.2023.01.042
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Deep Scale-Variant Network for Femur Trochanteric Fracture Classification with HP Loss

Yuxiang Kang / Zhipeng Ren / Yinguang Zhang / Aiming Zhang / Weizhe Xu / Guokai Zhang / Qiang Dong

Journal of Healthcare Engineering, Vol

2022 Volume 2022

Abstract: Achieving automatic classification of femur trochanteric fracture from the edge computing device is of great importance and value for remote diagnosis and treatment. Nevertheless, designing a highly accurate classification model on 31A1/31A2/31A3 ... ...

Abstract	Achieving automatic classification of femur trochanteric fracture from the edge computing device is of great importance and value for remote diagnosis and treatment. Nevertheless, designing a highly accurate classification model on 31A1/31A2/31A3 fractures from the X-ray is still limited due to the failure of capturing the scale-variant and contextual information. As a result, this paper proposes a deep scale-variant (DSV) network with a hybrid and progressive (HP) loss function to aggregate more influential representations of the fracture regions. More specifically, the DSV network is based on the ResNet and integrated with the designed scale-variant (SV) layer and HP loss, where the SV layer aims to enhance the representation ability to extract the scale-variant features, and HP loss is intended to force the network to condense more contextual clues. Furthermore, to evaluate the effect of the proposed DSV network, we carry out a series of experiments on the real X-ray images for comparison and evaluation, and the experimental results demonstrate that the proposed DSV network could outperform other classification methods on this classification task.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Subject code	006
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MRI-guided thrombolysis for lenticulostriate artery stroke within 12 h of symptom onset

Jianying Zhang / Qingke Bai / Zhenguo Zhao / Yiting Mao / Qiang Dong / Wenjie Cao

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 7

Abstract: Abstract Stroke thrombolysis treatment is generally administered within 4.5 h, but a greater time window may be permitted depending upon the ischemic penumbra on neuroimaging. This observational cohort study investigated the outcomes of thrombolysis ... ...

Abstract	Abstract Stroke thrombolysis treatment is generally administered within 4.5 h, but a greater time window may be permitted depending upon the ischemic penumbra on neuroimaging. This observational cohort study investigated the outcomes of thrombolysis given within 12 h after symptom onset of lenticulostriate artery stroke. The population comprised 160 patients. Thrombolysis was administered via tissue plasminogen activator, alteplase (TPA). Thrombolysis was indicated by a mismatch between diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI), that is, an acute ischemic lesion on DWI without a corresponding lesion on T2WI. Demographics and medical history were compared with the modified Rankin scale (mRS) score, to reflect outcome. Patients with a favorable clinical outcome (mRS 0–1) had significantly lower hypertension, baseline NIH Stroke Scale (NIHSS) score, and admission systolic/diastolic blood pressure compared with patients with mRS 2–6. Lower admission systolic blood pressure and NIHSS score were significantly associated with favorable outcome. In patients either with IV-TPA within 4.5 h, or between 4.5 and 12 h, lower admission systolic blood pressure and/or NIHSS score similarly independently predict favorable outcome. However, in all groups, the onset-to-treatment time did not significantly influence the outcomes. We conclude that in our cohort higher admission systolic blood pressure and higher baseline NIHSS and not time were associated with poor outcome in patients with magnetic resonance-guided thrombolysis within 12 h of isolated lenticulostriate artery stroke, therefore loosening the traditionally perceived dependency of outcome on time.
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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