Article ; Online: A secreted fungal effector suppresses rice immunity through host histone hypoacetylation.
2022 Volume 235, Issue 5, Page(s) 1977–1994
Abstract: Histone acetylation is a critical epigenetic modification that regulates plant immunity. Fungal pathogens secrete effectors that modulate host immunity and facilitate infection, but whether fungal pathogens have evolved effectors that directly target ... ...
| Abstract | Histone acetylation is a critical epigenetic modification that regulates plant immunity. Fungal pathogens secrete effectors that modulate host immunity and facilitate infection, but whether fungal pathogens have evolved effectors that directly target plant histone acetylation remains unknown. Here, we identified a secreted protein, UvSec117, from the rice false smut fungus, Ustilaginoidea virens, as a key effector that can target the rice histone deacetylase OsHDA701 and negatively regulates rice broad-spectrum resistance against rice pathogens. UvSec117 disrupts host immunity by recruiting OsHDA701 to the nucleus and enhancing OsHDA701-modulated deacetylation, thereby reducing histone H3K9 acetylation levels in rice plants and interfering with defense gene activation. Host-induced gene silencing of UvSec117 promotes rice resistance to U. virens, thus providing an alternative way for developing rice false smut-resistant plants. This is the first direct evidence demonstrating that a fungal effector targets a histone deacetylase to suppress plant immunity. Our data provided insight into a counter-defense mechanism in a plant pathogen that inactivates host defense responses at the epigenetic level. |
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| MeSH term(s) | Histone Deacetylases ; Histones ; Oryza/genetics ; Oryza/microbiology ; Plant Diseases/microbiology ; Plant Immunity | |||||
| Chemical Substances | Histones ; Histone Deacetylases (EC 3.5.1.98) | |||||
| Language | English | |||||
| Publishing date | 2022-06-08 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 208885-x | |||||
| ISSN | 1469-8137 ; 0028-646X | |||||
| ISSN (online) | 1469-8137 | |||||
| ISSN | 0028-646X | |||||
| DOI | 10.1111/nph.18265 | |||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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