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Article ; Online: Scapular dislocation following radical surgical excision of lung sarcomatoid carcinoma: A rare case report.

Wu, Qiang / Qiao, Kun / Liu, Jixian / Zhen, Shuo / Zhou, Zizi

2024 Volume 103, Issue 2, Page(s) e36884

Abstract: Rationale: Scapular prolapse is a rare complication of thoracotomy. Only a few cases of scapular prolapse after thoracotomy have been reported. Here, we report the case of a 52-year-old male patient who underwent standard posterior thoracotomy for lung ... ...

Abstract	Rationale: Scapular prolapse is a rare complication of thoracotomy. Only a few cases of scapular prolapse after thoracotomy have been reported. Here, we report the case of a 52-year-old male patient who underwent standard posterior thoracotomy for lung sarcomatoid carcinoma invading the left upper chest wall. Patient concerns: The surgery was performed to remove some ribs and chest wall muscles; however, no reconstruction or repair of the chest wall defect was performed. The patient experienced a sharp pain and severe limitation of movement of the left shoulder within 1 month of receiving adjuvant therapy. Diagnoses: The patient was diagnosed with left intrathoracic scapular prolapse after careful consideration of medical history, physical examination, and chest radiography. Interventions: We performed closed manual reduction because the patient refused to undergo surgery. Outcomes: The patient's shoulder pain and movement limitation were significantly relieved, but the symptoms relapsed. After repeated closed manual reduction, the patient was instructed not to abduct the shoulder joint above 90°. The patient did not relapse during a 1-year observation period. Conclusion: If scapular prolapse occurs, manual or surgical reduction can be selected based on the needs. If a patient refuses to undergo surgery, manual reduction can be an effective treatment method.
MeSH term(s)	Male ; Humans ; Middle Aged ; Neoplasm Recurrence, Local ; Joint Dislocations ; Thoracic Wall ; Carcinoma, Non-Small-Cell Lung ; Lung Neoplasms/surgery ; Carcinoma ; Prolapse ; Lung
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036884
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Article ; Online: Insight on immune cells in rejection and infection postlung transplant.

Liao, Mingfeng / Wang, Chaoxi / Zhang, Mingxia / Qiao, Kun

Immunity, inflammation and disease

2023 Volume 11, Issue 7, Page(s) e868

Abstract: Objective: The aim of this study is to provide a concise overview of the role of immune cells in rejection and infection after lung transplantation.: Methods: Based on previous clinical and basic studies, the role of various types of immune cells in ... ...

Abstract	Objective: The aim of this study is to provide a concise overview of the role of immune cells in rejection and infection after lung transplantation. Methods: Based on previous clinical and basic studies, the role of various types of immune cells in the development of rejection and infection after lung transplantation is summarized. Results: Immune cell functional status is strongly associated with common complications after lung transplantation, such as primary graft dysfunction, infection and occlusive bronchitis syndrome. Targeted balancing of immune cell tolerance and rejection is an important tool for successful lung transplantation. Conclusion: A comprehensive understanding of immune cell function and the mechanisms that balance immune tolerance and immune rejection may be a crucial factor in improving survival after lung transplantation.
MeSH term(s)	Humans ; Bronchiolitis Obliterans/etiology ; Lung Transplantation/adverse effects ; Graft Rejection
Language	English
Publishing date	2023-07-28
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.868
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hispidulin targets PTGS2 to improve cyclophosphamide-induced cystitis by suppressing NLRP3 inflammasome.

Liu, Songlin / Li, Shuhang / Dong, Yuping / Qiao, Kun / Zhao, Yang / Yu, Jianyong

Naunyn-Schmiedeberg's archives of pharmacology

2024

Abstract: Interstitial cystitis (IC) is a chronic bladder inflammation. Inhibition of prostaglandin G/H synthase 2 (PTGS2) is the most common method for controlling inflammation-related diseases. This study aimed to analyze the effects of hispidulin on the PTGS2 ... ...

Abstract	Interstitial cystitis (IC) is a chronic bladder inflammation. Inhibition of prostaglandin G/H synthase 2 (PTGS2) is the most common method for controlling inflammation-related diseases. This study aimed to analyze the effects of hispidulin on the PTGS2 and NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammation in experimental IC models. A binding activity between hispidulin and PTGS2 was measured using molecular docking. Human urothelial cells (SV-HUC-1) were stimulated by 2 ng/mL of interleukin (IL)-1β for 24 h and cultured in a medium with different concentrations of hispidulin (2.5, 5, 10, 20 µM) for 24 h to observe the expressions of PTGS2 and NLRP3 protein. Cells overexpressing PTGS2 were established by PTGS2 cDNA transfection. In the IL-1β-treated cells, the NLRP3 inflammasome was measured after 20 µM hispidulin treatment. In rats, animals were performed with three injections of 40 mg/kg cyclophosphamide (CYP) and orally treated with 50 mg/kg/day hispidulin or ibuprofen for 3 days. The bladder pain was measured using Von Frey filaments, and the bladder pathology was observed using hematoxylin and eosin (H&E) staining. The expressions of PTGS2 and NLRP3 inflammasome were also observed in the bladder tissues. A good binding activity was found between hispidulin and PTGS2 (score = - 8.9 kcal/mol). The levels of PTGS2 and NLRP3 inflammasome were decreased with the hispidulin dose increase in the IL-1β-treated cells (p < 0.05). Cells overexpressing PTGS2 weakened the protective effects of hispidulin in the IL-1β-treated cells (p < 0.01). In the CYP-treated rats, hispidulin treatment improved the bladder pain through decreasing the nociceptive score (p < 0.01) and suppressed the bladder inflammation through suppressing the expressions of PTGS2 and NLRP3 inflammasome in bladder tissues (p < 0.01). Additionally, the results of ibuprofen treatment were similar to the effects of hispidulin in the CYP-treated rats. This study demonstrates that hispidulin may be a new alternative drug for the IC treatment that binds PTGS2 to perform its functions.
Language	English
Publishing date	2024-02-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-024-02987-y
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Ud II Zs.5: Show issues

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Article ; Online: Correction to "Performance Improvement with an Ultrathin p-Type Interfacial Layer in n-Type Vertical Organic Field-Effect Transistors Based on Reduced Graphene Oxide Electrode".

Qiao, Kun / Arakaki, Shun / Suzuki, Mitsuharu / Nakayama, Ken-Ichi

ACS omega

2023 Volume 8, Issue 50, Page(s) 48584–48585

Abstract: This corrects the article DOI: 10.1021/acsomega.2c02085.]. ...

Abstract	[This corrects the article DOI: 10.1021/acsomega.2c02085.].
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Published Erratum
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c08085
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Article ; Online: Camera-based Respiratory Imaging for Thoracic Asymmetry in Thoracic Surgery Patients.

Zhang, Yiling / Tao, Xiaoting / Lu, Hongzhou / Qiao, Kun / Wang, Wenjin

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–5

Abstract: The current tool for assessing thoracic asymmetry of thoracic surgery patients is inappropriate for timely or frequent clinical routines due to its dependency on empirical physical examinations or specialized machines. This study investigates the camera- ... ...

Abstract	The current tool for assessing thoracic asymmetry of thoracic surgery patients is inappropriate for timely or frequent clinical routines due to its dependency on empirical physical examinations or specialized machines. This study investigates the camera-based respiratory imaging for screening thoracic asymmetry, in an intelligent and convenient way. The respiratory heatmaps are generated based on the respiratory magnitudes, phases and angles extracted from the chest video, and bilateral chest region of interest are compared statistically. Due to the variability of chest respiratory direction, spatial enhancement (SDR and SPCA) algorithms are proposed to magnify the respiratory energy. The proposed framework was validated in a clinical trial involving 31 patients, recorded by a smartphone camera. A high correlation was found between the camera measurements and patients' thoracic status in both the visual imaging and quantified indices. The respiratory imaging of camera shows a clear potential for assessing chest abnormalities of thoracic surgery patients.
MeSH term(s)	Humans ; Thoracic Surgery ; Thorax/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Thoracic Surgical Procedures ; Imaging, Three-Dimensional/methods
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Populus euphratica plant cadmium resistance 2 mediates Cd tolerance by root efflux of Cd ions in poplar.

Lv, Fuling / Shan, Qinghua / Qiao, Kun / Zhang, Haizhen / Zhou, Aimin

Plant cell reports

2023 Volume 42, Issue 11, Page(s) 1777–1789

Abstract: Key message: Populus euphratica PePCR2 increases Cd resistance by functioning as a Cd extrusion pump and by mediating the expression of genes encoding other transporters. Cadmium (Cd) is a non-essential, toxic metal that negatively affects plant growth. ...

Abstract	Key message: Populus euphratica PePCR2 increases Cd resistance by functioning as a Cd extrusion pump and by mediating the expression of genes encoding other transporters. Cadmium (Cd) is a non-essential, toxic metal that negatively affects plant growth. Plant cadmium resistance (PCR) proteins play key roles in the response to heavy metal stress. In this study, we isolated the gene PePCR2 encoding a plant PCR from Populus euphratica. PePCR2 gene transcription was induced by Cd, and its transcript level peaked at 24 h after exposure, at a level approximately 18-fold higher than that at 0 h. The PePCR2 protein was localized to the plasma membrane. Compared with yeast cells harboring the empty vector, yeast cells expressing PePCR2 showed enhanced Cd tolerance and a lower Cd content. Compared with wild-type (WT) plants, poplar overexpressing PePCR2 showed higher Cd resistance. Net Cd
Language	English
Publishing date	2023-09-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8397-5
ISSN	1432-203X ; 0721-085X ; 0721-7714
ISSN (online)	1432-203X
ISSN	0721-085X ; 0721-7714
DOI	10.1007/s00299-023-03065-y
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Article ; Online: Populus euphratica plant cadmium tolerance PePCR3 improves cadmium tolerance.

Qiao, Kun / Shan, Qinghua / Zhang, Haizhen / Lv, Fuling / Zhou, Aimin

Tree physiology

2023 Volume 43, Issue 11, Page(s) 1950–1963

Abstract: Contamination of soils with toxic heavy metals is a major environmental problem. Growing crop plants that can promote the efflux of heavy metals is an effective strategy in contaminated soils. The plant cadmium resistance (PCR) protein is involved in the ...

Abstract	Contamination of soils with toxic heavy metals is a major environmental problem. Growing crop plants that can promote the efflux of heavy metals is an effective strategy in contaminated soils. The plant cadmium resistance (PCR) protein is involved in the translocation of heavy metals, specifically zinc and cadmium (Cd). In this study, yeast expressing Populus euphratica PCR3 (PePCR3) showed enhanced Cd tolerance and decreased Cd accumulation under Cd treatment. Real-time quantitative PCR analyses revealed up-regulation of PePCR3 in poplar seedlings under Cd stress. Localization analysis revealed that PePCR3 localizes at the plasma membrane. The plant growth and biomass were greater in PePCR3-overexpressing (OE) transgenic hybrid poplar lines than in wild type (WT). Physiological parameters analyses indicated that, compared with WT, PePCR3-OE transgenic lines were more tolerant to Cd. In addition, more Cd was excreted in the roots of the PePCR3-OE transgenic lines than in those of WT, but the remaining Cd in transgenic lines was more translocated into the stems and leaves. Eight genes encoding transporters showed increased transcript levels in PePCR3-OE transgenic lines under Cd treatment, implying that PePCR3 interacts with other transporters to translocate Cd. Thus, PePCR3 may be an important genetic resource for generating new lines that can enhance Cd translocation to phytoremediation in contaminated soils.
MeSH term(s)	Cadmium/metabolism ; Populus/metabolism ; Metals, Heavy/metabolism ; Zinc/metabolism ; Saccharomyces cerevisiae ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Roots/genetics ; Plant Roots/metabolism ; Biodegradation, Environmental ; Soil
Chemical Substances	Cadmium (00BH33GNGH) ; Metals, Heavy ; Zinc (J41CSQ7QDS) ; Plant Proteins ; Soil
Language	English
Publishing date	2023-08-23
Publishing country	Canada
Document type	Journal Article
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpad103
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Article ; Online: Therapeutic effect of intravitreal anti-VEGF drugs on retinal neovascularization in diabetic retinopathy.

Jiang, Guangwei / Han, Xue / Qiao, Kun / Liu, Shu

Minerva medica

2022

Language	English
Publishing date	2022-07-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.22.07943-5
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Article ; Online: Physical Activity Patterns and Cognitive Function in Patients With Breast Cancer.

Ning, Shipeng / Qiao, Kun / Pan, Linghui

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 8, Page(s) 915–916

MeSH term(s)	Breast Neoplasms/drug therapy ; Cognition ; Exercise ; Female ; Humans ; Prospective Studies
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.21.02073
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Article ; Online: Sep2, a light-harvesting complex-like protein, is involved in light stress response by binding to free chlorophylls

Ren, Lulu / Ma, Hongping / Chao, Donghui / Zhang, Haizhen / Qiao, Kun / Feng, Shuang / Zhou, Aimin

Environmental and Experimental Botany. 2023 Sept., v. 213 p.105429-

2023

Abstract: The light-harvesting complex (LHC) protein superfamily includes the LHC family and LHC-like family, each of which contains one or two conserved chlorophyll (Chl)-binding motifs. The LHC-like family includes early light-inducible proteins (Elips), light ... ...

Abstract	The light-harvesting complex (LHC) protein superfamily includes the LHC family and LHC-like family, each of which contains one or two conserved chlorophyll (Chl)-binding motifs. The LHC-like family includes early light-inducible proteins (Elips), light harvesting-like3 (Lil3s), one-helix proteins (Ohps), and stress-enhanced proteins (Seps). Currently, only the Chl-binding ability and biological function of Elips, Lil3s, and Ohps have been reported. However, the role of Seps remains unknown. In the present study, we investigated and compared the functions of two Arabidopsis (Arabidopsis thaliana) Sep proteins, Sep1 and Sep2, in Chl breakdown and in response to light stress. Our results showed that Sep1 and Sep2 contained a conserved Chl-binding motif and were localized within chloroplasts. The expression of Sep1 and Sep2 in leaves was mainly induced by light stress. Overexpression of Sep2 caused a decrease in the levels of Chl by promoting Chl breakdown, whereas Sep1 overexpression did not. Moreover, reduced accumulation of reactive oxygen species was observed in the Sep2-overexpressing Arabidopsis leaves compared with that in wild-type leaves under long-term light stress. The Sep2-induced Chl breakdown was compromised when the conserved residue (glutamic acidatposition105) of the Chl-binding motif was mutated. However, neither wild-type Sep1 nor mutant Sep1 caused Chl breakdown in Arabidopsis leaves. These findings suggested that Sep2, as a member of the LHC-like family, might regulate the levels of free Chl by binding to Chl, thereby participating in light-stress response.
Keywords	Arabidopsis thaliana ; botany ; chlorophyll ; chloroplasts ; light harvesting complex ; mutants ; reactive oxygen species ; stress response ; Light-harvesting complex ; Stress-enhanced protein ; Chlorophyll binding ; Chlorophyll breakdown ; Light stress response
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	195968-2
ISSN	0098-8472
ISSN	0098-8472
DOI	10.1016/j.envexpbot.2023.105429
Database	NAL-Catalogue (AGRICOLA)

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