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  1. Article: Bibliometric Analysis on GABA-A Receptors Research Based on CiteSpace and VOSviewer.

    Yu, Xufeng / Gao, Zhan / Gao, Mingzhou / Qiao, Mingqi

    Journal of pain research

    2023  Volume 16, Page(s) 2101–2114

    Abstract: Background: GABA-A receptors are the primary mediators of brain inhibitory neurotransmission. In the past years, many studies focused on this channel to decipher the pathogenesis of related diseases but lacked bibliometric analysis research. This study ... ...

    Abstract Background: GABA-A receptors are the primary mediators of brain inhibitory neurotransmission. In the past years, many studies focused on this channel to decipher the pathogenesis of related diseases but lacked bibliometric analysis research. This study aims to explore the research status and identify the research trends of GABA-A receptor channels.
    Methods: Publications related to GABA-A receptor channels were retrieved from the Web of Science Core Collection from 2012 to 2022. After screening, the VOSviewer 1.6.18 and Citespace 5.8 R3 were used for bibliometric analysis from journals, countries, institutions, authors, co-cited references and keywords.
    Results: We included 12,124 publications in the field of GABA-A receptor channels for analysis. The data shows that although there was a slight decrease in annual publications from 2012 to 2021, it remained at a relatively high level. Most publications were in the domain of neuroscience. Additionally, the United States was the most prolific country, followed by China. Univ Toronto was the most productive institution, and James M Cook led essential findings in this field. Furthermore, brain activation, GABAAR subunits expression, modulation mechanism in pain and anxiety behaviors and GABA and dopamine were paid attention to by researchers. And top research frontiers were molecular docking, autoimmune encephalitic series, obesity, sex difference, diagnosis and management, EEG and KCC2.
    Conclusion: Taken together, academic attention on GABA-A receptor channels was never neglected since 2012. Our analysis identified key information, such as core countries, institutions and authors in this field. Molecular docking, autoimmune encephalitic series, obesity, sex difference, diagnosis and management, EEG and KCC2 will be the future research direction.
    Language English
    Publishing date 2023-06-19
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S409380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Research progress of traditional Chinese medicine compound "Xiaochaihu Decoction" in the treatment of depression.

    Sun, Chunyan / Gao, Mingzhou / Qiao, Mingqi

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 159, Page(s) 114249

    Abstract: Depression is a common psychiatric disorder under the category of depression syndrome in Traditional Chinese Medicine (TCM) theory. Meanwhile, Xiaochaihu Decoction is a classical TCM formulation regulating Qi, resolving and dissipating stagnation. ... ...

    Abstract Depression is a common psychiatric disorder under the category of depression syndrome in Traditional Chinese Medicine (TCM) theory. Meanwhile, Xiaochaihu Decoction is a classical TCM formulation regulating Qi, resolving and dissipating stagnation. Clinically, the formulation has long been adopted to treat Shaoyang stagnation syndrome for depression syndrome. In this review, potential targets of action and the corresponding pathways of Xiaochaihu Decoction are explored for depression treatment via network pharmacology. The article also systematically summarizes the active components and pharmacological mechanisms of seven Chinese herbal medicine components in Xiaochaihu Decoction and guides the future study direction of Xiaochaihu Decoction, which may serve a promising treatment for depression.
    MeSH term(s) Humans ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; Depression/drug therapy ; Mental Disorders/drug therapy
    Chemical Substances xiaochaihu ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-01-20
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy and safety of Shugan Jieyu Decoction in the treatment of coronary heart disease complicated with depression.

    Li, Zhenzhen / Zhang, Jianying / Qiao, Mingqi / Wang, Xiaojin / Guo, Yinghui / Wang, Haijun

    Medicine

    2023  Volume 102, Issue 11, Page(s) e33176

    Abstract: Background: Coronary heart disease combined with depression is 1 of the 2 major diseases affecting physical and mental health. It has become a hot spot at the intersection of psychiatry and internal medicine. Most doctors call double heart medicine, ... ...

    Abstract Background: Coronary heart disease combined with depression is 1 of the 2 major diseases affecting physical and mental health. It has become a hot spot at the intersection of psychiatry and internal medicine. Most doctors call double heart medicine, which has a high incidence rate and a low diagnostic rate. Clinical research shows that Shugan Jieyu Decoction (SJD) has a better curative effect, increased safety, and fewer adverse reactions, but it lacks systematic evaluation. This study aims to integrate clinical data through network meta-analysis and provide more evidence-based medical evidence for clinical medication.
    Methods: We searched 8 electronic databases: China knowledge network database, Wanfang, VIP, SinoMed, PubMed, Embase, WebofScience, Cochrane Library, and selected 22 randomized controlled trials from January 2012 to January 2022. The common primary endpoint was the relief of angina pectoris and the improvement of depression. Two researchers used Endnote9.1 software to conduct literature screening and information extraction according to the developed nano-passage standard, used Cochrane collaborative tool to evaluate the bias risk in the experiment, and then used RevMan5.3 software to assess the literature and data analysis synthesis.
    Results: In 1908 patients with coronary heart disease and depression, the total effective rate of SJD in the treatment of angina pectoris was 3.49 (95% confidence interval, 1.93-6.29), as well as the network meta-analysis of improving depressive symptoms, anxiety, depression scores (SAS, SDS) and quality of life scores (HAMD), and reducing the indicators related to CPR and homocysteine.
    Conclusion: The analysis of this study shows that SJD can reduce the frequency of angina pectoris in patients with coronary heart disease and depression, alleviate anxiety and depression, provide a reference basis for clinical treatment, and select more effective intervention therapy.
    MeSH term(s) Humans ; Angina Pectoris/complications ; Angina Pectoris/drug therapy ; Coronary Disease/complications ; Coronary Disease/drug therapy ; Depression/complications ; Depression/drug therapy ; Drugs, Chinese Herbal ; Quality of Life ; Network Meta-Analysis
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000033176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Network meta-analysis of 6 kinds of Chinese patent medicines combined with mifepristone in the treatment of uterine fibroids: A protocol for systematic review and network meta-analysis.

    Bi, Chenhao / Qiao, Mingqi / Jia, Yuqi / Wang, Haijun

    Medicine

    2021  Volume 100, Issue 42, Page(s) e27523

    Abstract: Background: Uterine fibroids are benign. They belong to the category of "abdominal mass" in traditional Chinese medicine, and pathogenesis is mainly caused by weakness of the body, qi stagnation, and blood stasis. Drug therapy is the preferred treatment ...

    Abstract Background: Uterine fibroids are benign. They belong to the category of "abdominal mass" in traditional Chinese medicine, and pathogenesis is mainly caused by weakness of the body, qi stagnation, and blood stasis. Drug therapy is the preferred treatment of uterine fibroids in clinical practice, and mifepristone is the most commonly used drug. In the past decade, a large number of clinical randomized controlled trials have proven that Chinese patent medicine combined with mifepristone in the treatment of uterine fibroids has a better curative effect, fewer adverse reactions, and higher safety than mifepristone alone. However, there is a lack of evidence-based research. This study aims to integrate clinical data through network meta-analysis to provide more evidence-based medical evidence for clinical medication.
    Methods: The comprehensive search included Chinese and other-language databases, such as MEDLINE (PubMed), Web of Science, The Cochrane Library, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Scientific Journal Database, and China Biomedical Literature Database. Clinical randomized controlled trials of 6 Chinese patent medicines combined with mifepristone for the treatment of uterine fibroids, including Guizhi Fuling Capsule, Gongliuxiao Capsule, Gongliuqing Capsule, Danbie Capsule, Gongliuning Capsule, and Xiaojiean Capsule were retrieved. The search period was from January 2010 to April 2021. Two researchers screened the literature through EndNote and used Excel to extract data. RevMan 5.3 was used to evaluate the quality of the literature. Treatment measures were analyzed in R language, and a forest map and probability ranking map of various interventions were drawn. The network evidence map and correction comparison funnel map of various interventions were drawn by STATA 14.0 software.
    Results: This study provides the clinical efficacy and safety of network meta-analysis of 6 kinds of Chinese patent medicines combined with mifepristone in the treatment of uterine fibroids will be systematically evaluated or descriptively analyzed.
    Conclusion: This study's purpose is to provide a reference for the clinical treatment of uterine fibroids to choose more effective intervention therapies.
    MeSH term(s) Drug Therapy, Combination ; Hormone Antagonists/administration & dosage ; Hormone Antagonists/adverse effects ; Hormone Antagonists/therapeutic use ; Humans ; Leiomyoma/drug therapy ; Leiomyoma/pathology ; Medicine, Chinese Traditional/adverse effects ; Medicine, Chinese Traditional/methods ; Mifepristone/administration & dosage ; Mifepristone/adverse effects ; Mifepristone/therapeutic use ; Network Meta-Analysis ; Randomized Controlled Trials as Topic ; Research Design ; Meta-Analysis as Topic ; Systematic Review as Topic
    Chemical Substances Hormone Antagonists ; Mifepristone (320T6RNW1F)
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000027523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Global and regional prevalence and burden for premenstrual syndrome and premenstrual dysphoric disorder: A study protocol for systematic review and meta-analysis.

    Gao, Mingzhou / Zhang, Hao / Gao, Zhan / Cheng, Xunshu / Sun, Ya / Qiao, Mingqi / Gao, Dongmei

    Medicine

    2022  Volume 101, Issue 1, Page(s) e28528

    Abstract: Introduction: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are becoming common mental diseases in women impairing daily functioning. Estimation of the epidemiological burden of PMS/PMDD can serve as scientific basis for ... ...

    Abstract Introduction: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are becoming common mental diseases in women impairing daily functioning. Estimation of the epidemiological burden of PMS/PMDD can serve as scientific basis for prevention and management of premenstrual disorders. Herein, we firstly provide a protocol to perform estimation on the prevalence and risk factors for PMS/PMDD in the general population globally and regionally.
    Methods/design: The PubMed, Web of Science, Chinese National Knowledge Infrastructure, the Cochrane Central Register of Controlled Trials (Cochrane Library), Chinese VIP Information, EMBASE, Wanfang Database, as well as the Chinese Biomedical Literature Database will be queried to find related studies containing information on the prevalence of PMDD (2011-2021). Two independent reviewers will comb the literature and abstract the data characteristics. Disparities will be reconciled via consents. The primary outcome will be the global prevalence. The random-effect model will be employed to pool the assessments. The standard χ2 tests, as well as the I2 statistic will be used to determine heterogeneity. Furthermore, the meta-regression analysis will be employed to estimate the differences in study-level characteristics. All the statistical analyses will be carried out in the software Stata v 15.0 (Stata Corporation, College Station, TX), as well as the R (v R 3.5.1, R Foundation for Statistical Computing, Vienna, Austria) software.
    Discussion: Based on existing evidence, our study will offer a high-quality synthesis for global and regional prevalence, burden, and risk factors of PMS/PMDD. Effective strategies will be made for prevention and management of epidemiological burden on the PMS/PMDD, even premenstrual disorders.
    Ethics and dissemination: This study does not involve the specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.
    Inplasy registration number: INPLASY2021120065.
    MeSH term(s) Female ; Humans ; Meta-Analysis as Topic ; Premenstrual Dysphoric Disorder/epidemiology ; Premenstrual Dysphoric Disorder/psychology ; Premenstrual Syndrome/epidemiology ; Premenstrual Syndrome/psychology ; Prevalence ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acupuncture combined with SSRIs in the treatment of perimenopausal depressive disorder: A protocol for systematic review and meta-analysis.

    Gao, Zhan / Wang, Jieqiong / Gao, Mingzhou / Song, Tingting / Gao, Xiangju / Qiao, Mingqi / Gao, Jie

    Medicine

    2022  Volume 101, Issue 3, Page(s) e28558

    Abstract: Background: Perimenopausal depressive disorder (PDD) is an affective disorder involving endocrine, neurological, immune, which seriously endangers the physical and mental health of human. Selective serotonin reuptake inhibitors (SSRIs) are the current ... ...

    Abstract Background: Perimenopausal depressive disorder (PDD) is an affective disorder involving endocrine, neurological, immune, which seriously endangers the physical and mental health of human. Selective serotonin reuptake inhibitors (SSRIs) are the current first-line clinical treatment, have limited efficacy and serious side effects. Acupuncture combined with SSRIs therapy has been widely used clinically because it increases efficacy and reduces side effects. There is a lack of high-quality evidence to assess its efficacy and safety. This study evaluated the effectiveness and safety of acupuncture combined with SSRIs in the treatment of PDD by meta-analysis.
    Methods: All randomized controlled trials articles about acupuncture combined with SSRIs treatment of PDD will be searched in databases, such as PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan Fang, Wei Pu from the construction of the library to December 16, 2021. According to Cochrane 5.1 Handbook criteria, two researchers independently screened the literature, extracted data, and evaluated the quality of included studies. Meta-analysis was performed by using RevMan 5.4 and STATA 16.0 software.
    Results: This study will summarize the current evidence to evaluate the effectiveness and safety of acupuncture combined with SSRIs for the treatment of PDD.
    Conclusion: The results of this study will provide clinicians with new treatment ideas and bring benefits to most patients.
    Registration number: INPLASY2021120080 (DOI number: 10.37766/inplasy2021.12.0080).
    MeSH term(s) Acupuncture Therapy ; Depressive Disorder/complications ; Depressive Disorder/therapy ; Humans ; Meta-Analysis as Topic ; Perimenopause ; Research Design ; Serotonin Uptake Inhibitors/therapeutic use ; Systematic Reviews as Topic
    Chemical Substances Serotonin Uptake Inhibitors
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Profiling GABA(A) Receptor Subunit Expression in the Hippocampus of PMDD Rat Models Based on TCM Theories.

    Zhang, Hao / Gao, Zhan / Sun, Ya / Lu, Tian / Wang, Zhenzhen / Gao, Dongmei / Wang, Jieqiong / Qiao, Mingqi / Gao, Mingzhou

    Molecular neurobiology

    2023  Volume 60, Issue 8, Page(s) 4418–4428

    Abstract: γ-Aminobutyric acid type A receptors (GABAARs) play an important role in cognitive and emotional regulation and are related to the hippocampus. However, little is known regarding patterns of hippocampal GABAAR subunit expression in rat models of ... ...

    Abstract γ-Aminobutyric acid type A receptors (GABAARs) play an important role in cognitive and emotional regulation and are related to the hippocampus. However, little is known regarding patterns of hippocampal GABAAR subunit expression in rat models of premenstrual dysphoric disorder (PMDD). This study investigated the above changes by establishing two PMDD rat models based on Traditional Chinese Medicine (TCM) theories, namely, PMDD liver-qi invasion syndrome (PMDD-LIS) and PMDD liver-qi depression syndrome (PMDD-LDS). Behavioral tests were used to detect depression and irritability emotion. Western blot analysis was used to investigate protein levels of GABAAR α1, α2, α4, α5, β2, β3, and δ subunits, whereas ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis was performed to determine gamma-aminobutyric acid (GABA) and glutamate (Glu) levels in the hippocampus across each group. Concurrently, behavioral data indicated that the PMDD-LDS and PMDD-LIS rat models had been successfully established. GABAAR α2, α5, β2, and δ subunit was significantly upregulated, whereas α4 was significantly downregulated (P < 0.05) in PMDD-LDS rat models relative to controls. On the other hand, GABAAR α1, α2, and β3 were significantly downregulated while α4 and β2 were significantly upregulated in PMDD-LIS rat models relative to the control group (P < 0.05). Moreover, GABA levels significantly decreased, while Glu and the ratio of glutamate to GABA increased in PMDD-LIS rat models (P < 0.05). Conversely, GABA and Glu levels significantly decreased, whereas the ratio of glutamate to GABA increased in PMDD-LIS rat models (P < 0.05). Conclusively, our results revealed differential expression of GABAAR α1, α2, α4, α5, β2, β3, and δ subunits between PMDD-LIS and PMDD-LDS rat models, suggesting that they may be biomarkers in the pathogenesis of PMDD.
    MeSH term(s) Humans ; Female ; Rats ; Animals ; Receptors, GABA-A/metabolism ; Rats, Sprague-Dawley ; Premenstrual Dysphoric Disorder/metabolism ; Medicine, Chinese Traditional ; Tandem Mass Spectrometry ; gamma-Aminobutyric Acid/metabolism ; Hippocampus/metabolism ; Glutamates/metabolism
    Chemical Substances Receptors, GABA-A ; gamma-Aminobutyric Acid (56-12-2) ; Glutamates
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-023-03354-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus.

    Zhang, Hao / Qiao, Mingqi / Gao, Dongmei / Wang, Jieqiong / Sun, Chunyan / Sun, Ya / Zhang, Yang / Liu, Huayuan / Zhang, Zhen / Gao, Mingzhou

    Asian journal of psychiatry

    2023  Volume 90, Page(s) 103800

    Abstract: To reveal the exact changes of allopregnanolone-mediated γ-aminobutyric acid A receptor pathways and its specific therapeutic targets by Shuyu Capsule treating premenstrual depression, female Wistar rat models of premenstrual depression was established ... ...

    Abstract To reveal the exact changes of allopregnanolone-mediated γ-aminobutyric acid A receptor pathways and its specific therapeutic targets by Shuyu Capsule treating premenstrual depression, female Wistar rat models of premenstrual depression was established by Forced swimming test (FST). Behavioral tests, enzyme-linked immunosorbent assay (ELISA), interference knockdown adenovirus, and overexpressed vector adenovirus of GABA
    MeSH term(s) Rats ; Female ; Animals ; Receptors, GABA-A ; Rats, Wistar ; Pregnanolone/metabolism ; Pregnanolone/therapeutic use ; Hippocampus/metabolism ; gamma-Aminobutyric Acid ; Metabolic Networks and Pathways
    Chemical Substances Receptors, GABA-A ; Pregnanolone (BXO86P3XXW) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-10-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2023.103800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Traditional Chinese medicine on treating premenstrual syndrome and premenstrual dysphoric disorder: A protocol for systematic review and meta-analysis.

    Gao, Mingzhou / Sun, Hui / Sun, Wenjun / Gao, Dongmei / Qiao, Mingqi

    Medicine

    2020  Volume 99, Issue 42, Page(s) e22694

    Abstract: Background: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are common disorders that manifest themselves in the late luteal phase, and significantly interfere with an individual's daily activities. Clinical evidence suggests that ...

    Abstract Background: Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are common disorders that manifest themselves in the late luteal phase, and significantly interfere with an individual's daily activities. Clinical evidence suggests that traditional Chinese medicine (TCM) may ease PMS/PMDD symptoms. Here, we review a protocol for exploring the effectiveness and safety of TCM in PMS/PMDD management.
    Methods: We will conduct a literature search for randomized controlled trials (RCT) for TCM use in PMS/PMDD on PubMed, web of science, EMBASE, the Cochrane central register of controlled trials (Cochrane Library), Chinese national knowledge infrastructure, Chinese VIP Information, Wanfang, as well as Chinese biomedical literature database. The search included all relevant reports for up to June 1, 2020. The search results were independently analyzed by 2 reviewers who extracted the data. RCT quality will be assessed using the risk-of-bias tool. The evidence will be inspected using the grading of recommendations assessment development and evaluation (GRADE). We will utilize Stata and Revman for systematic review and meta-analysis and analysis of direct and indirect evidence.
    Results: Based on current evidence, this study will elucidate the rationale for the utilization of TCM in PMS/PMDD treatment.
    Conclusion: Conclusions from this study will inform about the effectiveness and safety of TCM in PMS/PMDD management.
    Trial registration number: CRD42020192822.
    Ethics and dissemination: Since all data utilized in this systematic review and meta-analysis are published, ethical approval is not needed. Additionally, in the trial of the review process, all data will be evaluated anonymously.
    MeSH term(s) Databases, Factual ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Medicine, Chinese Traditional ; Premenstrual Dysphoric Disorder/drug therapy ; Premenstrual Syndrome/drug therapy ; Randomized Controlled Trials as Topic ; Meta-Analysis as Topic ; Systematic Review as Topic
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000022694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinary tract infections.

    Zhao, Fei / Yang, Huanxin / Bi, Dezhong / Khaledi, Azad / Qiao, Mingqi

    Microbial pathogenesis

    2020  Volume 144, Page(s) 104196

    Abstract: Urinary tract infection (UTI) is caused by the invasion of the pathogen in the urinary system that can manifest as symptomatic or asymptomatic bacteriuria. This study was conducted to investigate antibiotic resistance patterns, and the correlation ... ...

    Abstract Urinary tract infection (UTI) is caused by the invasion of the pathogen in the urinary system that can manifest as symptomatic or asymptomatic bacteriuria. This study was conducted to investigate antibiotic resistance patterns, and the correlation between biofilm formations with virulence factors in uropathogenic E. coli isolates retrieved from UTI. We searched Scopus and Google Scholar, PubMed, Web of sciences for studies published in the English language between 1st 2005 to 31st December 2019. The Mesh terms and text words included "biofilms", OR "biofilm formation", AND "antibiotic resistance", OR "drug-resistance", OR "antimicrobial drug resistance", AND "urinary tract infections", OR "UTI", AND "biofilm related-genes", AND "virulence factors" AND "correlation", AND "Uropathogenic Escherichia coli", OR "Uropathogenic E. coli" AND "prevalence" AND "Iran". Data analyzed using Comprehensive Meta-Analysis (CMA) software. The random-effects model was used to calculate the pooled prevalence with 95% confidence interval (CI). The combined rates of biofilm formation in Uropathogenic E. coli (UPEC) isolates were achieved as 84.6% (95% CI: 72.7-91.9). Also, 24.8%, 26.1% and 44.6% of UPEC isolates were able to create strong, moderate and weak biofilm, respectively. The highest pooled antibiotic resistance was against Ampicillin followed by Tetracycline with resistance rates of 74.6% and 64.9%, respectively. Accordingly, some studies reported that biofilm production was significantly associated with antibiotic resistance and virulence genes (p < 0.05). This study showed a high tendency among UPEC isolates to form biofilm (more than 84%), also, most studies included in the present review reported a significant correlation between biofilm formation with antibiotic resistance and virulence factors.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Biofilms/drug effects ; Biofilms/growth & development ; Databases, Factual ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Escherichia coli Infections/epidemiology ; Humans ; Iran/epidemiology ; Microbial Sensitivity Tests ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Uropathogenic Escherichia coli/drug effects ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/isolation & purification ; Virulence/genetics ; Virulence Factors/genetics
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2020.104196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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