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Article ; Online: Synthesis of lipophilic antioxidant tyrosol laurate using imidazolium ionic liquid [Bmim]HSO

Wang, Yimei / Zhang, Yaoyao / Qiao, Xing / Sun, Shangde

2024 Volume 442, Page(s) 138418

Abstract: Tyrosol is a natural phenolic compound with potent antioxidant properties in the field of food manufacturing. However, the low lipophilicity of tyrosol limited its application. Therefore, the construction of tyrosol laurate (Tyr-L) could effectively ... ...

Abstract	Tyrosol is a natural phenolic compound with potent antioxidant properties in the field of food manufacturing. However, the low lipophilicity of tyrosol limited its application. Therefore, the construction of tyrosol laurate (Tyr-L) could effectively overcome the limitations of tyrosol. In this work, four ionic liquids (ILs) were applied for TYr-L preparation. Among them, the 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO
MeSH term(s)	Antioxidants ; Ionic Liquids/chemistry ; Laurates ; Catalysis ; Phenylethyl Alcohol/analogs & derivatives
Chemical Substances	Antioxidants ; Ionic Liquids ; Laurates ; 4-hydroxyphenylethanol (1AK4MU3SNX) ; Phenylethyl Alcohol (ML9LGA7468)
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.138418
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Article ; Online: Role of NF-κB in cardiac changes of obstructive sleep apnoea rabbits treated by mandibular advancement device.

Kang, Wenjing / Zhu, Dechao / Zhang, Shilong / Qiao, Xing / Liu, Jie / Liu, Chunyan / Lu, Haiyan

Journal of oral rehabilitation

2024 Volume 51, Issue 6, Page(s) 962–969

Abstract: Background: Obstructive sleep apnoea (OSA) is an independent risk factor for cardiovascular diseases. We aimed to investigate the role of nuclear factor-kappa B (NF-κB) in the changes of cardiac structures in OSA rabbits treated by mandibular ... ...

Abstract	Background: Obstructive sleep apnoea (OSA) is an independent risk factor for cardiovascular diseases. We aimed to investigate the role of nuclear factor-kappa B (NF-κB) in the changes of cardiac structures in OSA rabbits treated by mandibular advancement device (MAD). Methods: Eighteen male New Zealand white rabbits aged 6 months were randomly divided into three groups: control group, group OSA and group MAD. Hyaluronate gel was injected into the soft palate of the rabbits in group OSA and group MAD to induce OSA. The cone beam computer tomography (CBCT) of the upper airway and polysomnography (PSG) was performed to ensure successful modelling. CBCT and PSG were applied again to detect the effects of MAD treatment. All animals were induced to sleep in a supine position for 4-6 h a day for 8 weeks. Then the levels of NF-κB, Interleukin 6 (IL-6), Interleukin 10 (IL-10) and the proportion of myocardial fibrosis (MF) were detected. Results: The higher activation of NF-κB, IL-6 and IL-10 were found in the OSA group than in the control group, leading to the increase of collagen fibres compared with the control group. Furthermore, the apnoea-hypopnea index (AHI) was positively correlated with the above factors. There were no significant differences between group MAD and the control group. Conclusion: The NF-κB pathway was activated in the myocardium of OSA rabbits, which accelerated the development of MF. Early application of MAD could reduce the activation of NF-κB in the myocardium and prevent the development of MF.
MeSH term(s)	Animals ; Rabbits ; Sleep Apnea, Obstructive/therapy ; Male ; Mandibular Advancement/instrumentation ; NF-kappa B/metabolism ; Disease Models, Animal ; Interleukin-6/metabolism ; Polysomnography ; Cone-Beam Computed Tomography ; Interleukin-10/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; Fibrosis
Chemical Substances	NF-kappa B ; Interleukin-6 ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	187079-8
ISSN	1365-2842 ; 0305-182X
ISSN (online)	1365-2842
ISSN	0305-182X
DOI	10.1111/joor.13666
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Article ; Online: Dietary astaxanthin: an excellent carotenoid with multiple health benefits

Cao, Yunrui / Yang, Lu / Qiao, Xing / Xue, Changhu / Xu, Jie

Critical Reviews in Food Science and Nutrition. 2023 July 15, v. 63, no. 18 p.3019-3045

2023

Abstract: Astaxanthin is a carotenoid widely found in marine organisms and microorganisms. With extensive use in nutraceuticals, cosmetics, and animal feed, astaxanthin will have the largest share in the global market for carotenoids in the near future. Owing to ... ...

Abstract	Astaxanthin is a carotenoid widely found in marine organisms and microorganisms. With extensive use in nutraceuticals, cosmetics, and animal feed, astaxanthin will have the largest share in the global market for carotenoids in the near future. Owing to its unique molecular features, astaxanthin has excellent antioxidant activity and holds promise for use in biochemical studies. This review focuses on the observed health benefits of dietary astaxanthin, as well as its underlying bioactivity mechanisms. Recent studies have increased our understanding of the role of isomerization and esterification in the structure–function relationship of dietary astaxanthin. Gut microbiota may involve the fate of astaxanthin during digestion and absorption; thus, further knowledge is needed to establish accurate recommendations for dietary intake of both healthy and special populations. Associated with the regulation of redox balance and multiple biological mechanisms, astaxanthin is proposed to affect oxidative stress, inflammation, cell death, and lipid metabolism in humans, thus exerting benefits for skin condition, eye health, cardiovascular system, neurological function, exercise performance, and immune response. Additionally, preclinical trials predict its potential effects such as intestinal flora regulation and anti-diabetic activity. Therefore, astaxanthin is worthy of further investigation for boosting human health, and wide applications in the food industry.
Keywords	absorption ; antioxidant activity ; astaxanthin ; athletic performance ; cardiovascular system ; cell death ; cosmetics ; digestion ; esterification ; eyes ; feeds ; food industry ; food intake ; food science ; glycemic effect ; human health ; immune response ; inflammation ; intestinal microorganisms ; isomerization ; lipid metabolism ; oxidative stress ; structure-activity relationships ; world markets ; digestive tract absorption ; biological mechanism ; health benefits ; human trial
Language	English
Dates of publication	2023-0715
Size	p. 3019-3045.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2021.1983766
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.

Fan, Deng-Ying / Zhai, Hao-Yan / Zhao, Yuan / Qiao, Xing / Zhu, De-Chao / Liu, Hui-Juan / Liu, Chunyan

BMC oral health

2024 Volume 24, Issue 1, Page(s) 23

Abstract: Background: The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.: Methods: Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2: ...

Abstract	Background: The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement. Methods: Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2 Results: The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P < 0.0001) and bone resorption on the compression area in CB2 Conclusions: CB2 modulated OTM and bone remodeling through regulating osteoclast activity and RANKL/OPG balance.
MeSH term(s)	Animals ; Male ; Mice ; Bone Remodeling/physiology ; Bone Resorption ; Osteoclasts ; Tooth Movement Techniques ; Receptor, Cannabinoid, CB2/genetics
Chemical Substances	Cnr2 protein, mouse ; Receptor, Cannabinoid, CB2
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091511-1
ISSN	1472-6831 ; 1472-6831
ISSN (online)	1472-6831
ISSN	1472-6831
DOI	10.1186/s12903-023-03810-5
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Article: [Effects of Biochar on Growth and Pollutant Accumulation of Lettuce in Soil Co-contaminated with Tetracycline and Copper].

Zheng, Chen-Ge / Pei, Huan-Huan / Zhang, Ya-Shan / Li, Jia-Xin / Liu, Fen-Wu / Qiao, Xing-Xing / Qin, Jun-Mei

Huan jing ke xue= Huanjing kexue

2024 Volume 45, Issue 5, Page(s) 3037–3046

Abstract: Through lettuce potting experiments, the effects of different types of biochar (apple branch, corn straw, and modified sorghum straw biochar with phosphoric acid modification) on lettuce growth under tetracycline (TC) and copper (Cu) co-pollution were ... ...

Abstract	Through lettuce potting experiments, the effects of different types of biochar (apple branch, corn straw, and modified sorghum straw biochar with phosphoric acid modification) on lettuce growth under tetracycline (TC) and copper (Cu) co-pollution were investigated. The results showed that compared with those under CK, the addition of biochar treatment significantly increased the plant height, root length, shoot fresh weight, and root fresh weight of lettuce (
MeSH term(s)	Copper ; Lactuca ; Environmental Pollutants/analysis ; Soil ; Catalase ; Nitrates/analysis ; Anti-Bacterial Agents ; Tetracycline/analysis ; Charcoal ; Soil Pollutants/analysis ; Chlorophyll/analysis ; Malondialdehyde ; Nitrogen/analysis ; Proline
Chemical Substances	Copper (789U1901C5) ; biochar ; Environmental Pollutants ; Soil ; Catalase (EC 1.11.1.6) ; Nitrates ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Charcoal (16291-96-6) ; Soil Pollutants ; Chlorophyll (1406-65-1) ; Malondialdehyde (4Y8F71G49Q) ; Nitrogen (N762921K75) ; Proline (9DLQ4CIU6V)
Language	Chinese
Publishing date	2024-04-17
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202306155
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Article ; Online: Retinal microvasculature features in patients with Behcet’s disease

Kai-bao Ji / Zhe Hu / Qing-lin Zhang / Hai-feng Mei / Yi-qiao Xing

Scientific Reports, Vol 12, Iss 1, Pp 1-

a systematic review and meta-analysis

2022 Volume 12

Abstract: Abstract This meta-analysis aimed to analyze retinal microvasculature features in eyes with Behçet’s disease (BD) using optical coherence tomography angiography (OCTA). Electronic databases, including PubMed, Web of Science, Embase, and Cochrane Library, ...

Abstract	Abstract This meta-analysis aimed to analyze retinal microvasculature features in eyes with Behçet’s disease (BD) using optical coherence tomography angiography (OCTA). Electronic databases, including PubMed, Web of Science, Embase, and Cochrane Library, were comprehensively searched for published studies comparing retinal microvasculature characteristics between eyes with BD and controls. Continuous variables were calculated using the mean difference (MD) with 95% confidence interval (CI). Review Manager software (version 5.30) was used to conduct statistical analysis. A total of 13 eligible studies involving 599 eyes with BD and 622 control eyes were included in the meta-analysis. The pooled results showed that the macular whole enface superficial and deep vessel density (VD) values measured by OCTA were significantly lower in eyes with BD than in control eyes (superficial VD: MD = − 3.05, P < 0.00001; deep VD: MD = − 4.05, P = 0.0004). The foveal superficial and deep VD values were also significantly lower in the BD group than in the control group (superficial VD: MD = − 1.50, P = 0.009; deep VD: MD = − 4.25, − = 0.03). Similarly, the analysis revealed a significant reduction in the parafoveal superficial and deep VD in eyes with BD than in control eyes (superficial VD: MD = − 3.68, P < 0.00001; deep VD: MD = − 4.95, P = 0.0007). In addition, the superficial and deep foveal avascular zones (FAZs) were significantly larger in patients with BD than in controls (superficial FAZ: MD = 0.06, P = 0.02; deep FAZ: MD = 0.12, P = 0.03). The present meta-analysis found that macular whole enface VD, foveal VD, and parafoveal VD were lower in eyes with BD, and the FAZ was larger in patients with BD. The findings suggest that OCTA can assist clinicians in diagnosing and monitoring the status of patients with BD.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Stability and bioavailability of protein matrix‐encapsulated astaxanthin ester microcapsules

Yang, Lu / Li, Fei / Cao, Xinyu / Qiao, Xing / Xue, Changhu / Xu, Jie

Journal of the science of food and agriculture. 2022 Mar. 30, v. 102, no. 5

2022

Abstract: BACKGROUND: Astaxanthin ester derived from Haematococcus pluvialis is often used as a functional and nutritional ingredient in foods. However, its utilization is currently limited as a result of its chemical instability and low bioavailability. Food ... ...

Abstract	BACKGROUND: Astaxanthin ester derived from Haematococcus pluvialis is often used as a functional and nutritional ingredient in foods. However, its utilization is currently limited as a result of its chemical instability and low bioavailability. Food matrix microcapsules are becoming increasingly popular because of their safety and high encapsulation efficiency. In the present study, the effect of protein matrixes on the properties of microcapsules was evaluated. RESULTS: We investigated the effects of storage on astaxanthin ester microcapsules and the corresponding rehydration solution at 40 °C under a nitrogen atmosphere, as well as in darkness. The results showed that the stability of products prepared based on whey protein (WP) and corn‐gluten was superior to that of products prepared based on lactoferrin, soy protein and sodium caseinate. The bioavailability of astaxanthin ester microcapsules encapsulated with different proteins and examined by means of astaxanthin concentrations in the serum and liver after oral administration was compared. All five protein wall materials could significantly improve the bioavailability of astaxanthin ester. The microcapsules prepared based on WP had the highest bioavailability, with a value of 10.69 ± 0.75 μg·h mL⁻¹, which was 3.15 times higher compared to that of the control group. CONCLUSION: The results of the present study showed that protein encapsulation, especially WP encapsulation, could effectively improve the stability, water solubility and bioavailability of astaxanthin esters. Thus, WP can be used as the main wall material in delivery systems. © 2021 Society of Chemical Industry.
Keywords	Haematococcus pluvialis ; agriculture ; astaxanthin ; bioavailability ; blood serum ; corn gluten ; encapsulation ; food matrix ; ingredients ; lactoferrin ; liver ; nitrogen ; oral administration ; rehydration ; sodium caseinate ; soy protein ; water solubility ; whey protein
Language	English
Dates of publication	2022-0330
Size	p. 2144-2152.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11556
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of microencapsulation in dairy matrix on the quality characteristics and bioavailability of docosahexaenoic acid astaxanthin

Gao, Qun / Qiao, Xing / Yang, Lu / Cao, Yunrui / Li, Zhaojie / Xu, Jie / Xue, Changhu

Journal of the science of food and agriculture. 2022 Oct., v. 102, no. 13

2022

Abstract: BACKGROUND: Compared with free astaxanthin (Asta), docosahexaenoic acid astaxanthin monoester (Asta‐C22:6) has higher stability and bioavailability. However, Asta‐E is still unable to be used in the water system. Hence it is necessary to build a water‐ ... ...

Abstract	BACKGROUND: Compared with free astaxanthin (Asta), docosahexaenoic acid astaxanthin monoester (Asta‐C22:6) has higher stability and bioavailability. However, Asta‐E is still unable to be used in the water system. Hence it is necessary to build a water‐soluble delivery system. In this study, Asta‐C22:6 microemulsion and microcapsule using whey protein isolate (WPI) and hydroxypropyl‐β‐cyclodextrin (HPβ‐CD) as composite wall material were prepared. They were added to three dairy products (milk powder, yogurt and flavored dairy product). A dairy product rich in Asta‐C22:6 with high bioavailability was designed by measuring quality characteristics, sensory evaluation and in vivo experiments. RESULTS: Compared with spray drying, the freeze‐drying microcapsule had a higher encapsulation efficiency (72.5%), water content (4%) and better solubility, and Asta‐C22:6 microcapsule (1 g L⁻¹) yogurt had the best quality. The bioavailability of Asta‐C22:6 microcapsule yogurt was further evaluated. After a single oral dose in mice, the bioavailability of Asta‐C22:6 microcapsule in yogurt was significantly increased (Cₘₐₓ = 0.31 μg mL⁻¹, AUC₀–T = 3.20 h μg mL⁻¹). CONCLUSION: We successfully prepared Asta‐C22:6 microcapsule yogurt, which improved the stability and bioavailability of Asta. The present research is meaningful for delivering unstable bioactive small molecules based on WPI and HPβ‐CD. It provides an experimental basis for the application of Asta‐C22:6 and the development of functional dairy products. © 2022 Society of Chemical Industry.
Keywords	agriculture ; astaxanthin ; bioavailability ; docosahexaenoic acid ; dried milk ; emulsions ; freeze drying ; microencapsulation ; oral administration ; sensory evaluation ; water content ; water solubility ; whey protein isolate ; yogurt
Language	English
Dates of publication	2022-10
Size	p. 5711-5719.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11919
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Article ; Online: Dietary astaxanthin: an excellent carotenoid with multiple health benefits.

Cao, Yunrui / Yang, Lu / Qiao, Xing / Xue, Changhu / Xu, Jie

Critical reviews in food science and nutrition

2021 Volume 63, Issue 18, Page(s) 3019–3045

Abstract	Astaxanthin is a carotenoid widely found in marine organisms and microorganisms. With extensive use in nutraceuticals, cosmetics, and animal feed, astaxanthin will have the largest share in the global market for carotenoids in the near future. Owing to its unique molecular features, astaxanthin has excellent antioxidant activity and holds promise for use in biochemical studies. This review focuses on the observed health benefits of dietary astaxanthin, as well as its underlying bioactivity mechanisms. Recent studies have increased our understanding of the role of isomerization and esterification in the structure-function relationship of dietary astaxanthin. Gut microbiota may involve the fate of astaxanthin during digestion and absorption; thus, further knowledge is needed to establish accurate recommendations for dietary intake of both healthy and special populations. Associated with the regulation of redox balance and multiple biological mechanisms, astaxanthin is proposed to affect oxidative stress, inflammation, cell death, and lipid metabolism in humans, thus exerting benefits for skin condition, eye health, cardiovascular system, neurological function, exercise performance, and immune response. Additionally, preclinical trials predict its potential effects such as intestinal flora regulation and anti-diabetic activity. Therefore, astaxanthin is worthy of further investigation for boosting human health, and wide applications in the food industry.
MeSH term(s)	Animals ; Humans ; Carotenoids ; Xanthophylls/pharmacology ; Xanthophylls/chemistry ; Xanthophylls/metabolism ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Dietary Supplements
Chemical Substances	astaxanthine (8XPW32PR7I) ; Carotenoids (36-88-4) ; Xanthophylls ; Antioxidants
Language	English
Publishing date	2021-09-28
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2021.1983766
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Article ; Online: Effects of microencapsulation in dairy matrix on the quality characteristics and bioavailability of docosahexaenoic acid astaxanthin.

Gao, Qun / Qiao, Xing / Yang, Lu / Cao, Yunrui / Li, Zhaojie / Xu, Jie / Xue, Changhu

Journal of the science of food and agriculture

2022 Volume 102, Issue 13, Page(s) 5711–5719

Abstract: Background: Compared with free astaxanthin (Asta), docosahexaenoic acid astaxanthin monoester (Asta-C22:6) has higher stability and bioavailability. However, Asta-E is still unable to be used in the water system. Hence it is necessary to build a water- ... ...

Abstract	Background: Compared with free astaxanthin (Asta), docosahexaenoic acid astaxanthin monoester (Asta-C22:6) has higher stability and bioavailability. However, Asta-E is still unable to be used in the water system. Hence it is necessary to build a water-soluble delivery system. In this study, Asta-C22:6 microemulsion and microcapsule using whey protein isolate (WPI) and hydroxypropyl-β-cyclodextrin (HPβ-CD) as composite wall material were prepared. They were added to three dairy products (milk powder, yogurt and flavored dairy product). A dairy product rich in Asta-C22:6 with high bioavailability was designed by measuring quality characteristics, sensory evaluation and in vivo experiments. Results: Compared with spray drying, the freeze-drying microcapsule had a higher encapsulation efficiency (72.5%), water content (4%) and better solubility, and Asta-C22:6 microcapsule (1 g L Conclusion: We successfully prepared Asta-C22:6 microcapsule yogurt, which improved the stability and bioavailability of Asta. The present research is meaningful for delivering unstable bioactive small molecules based on WPI and HPβ-CD. It provides an experimental basis for the application of Asta-C22:6 and the development of functional dairy products. © 2022 Society of Chemical Industry.
MeSH term(s)	2-Hydroxypropyl-beta-cyclodextrin ; Animals ; Biological Availability ; Capsules ; Docosahexaenoic Acids ; Mice ; Water ; Xanthophylls
Chemical Substances	Capsules ; Xanthophylls ; Water (059QF0KO0R) ; 2-Hydroxypropyl-beta-cyclodextrin (1I96OHX6EK) ; Docosahexaenoic Acids (25167-62-8) ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2022-04-18
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.11919
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