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Article ; Online: Targeting HDACs for diffuse large B-cell lymphoma therapy

Chunyan Wu / Qiao Song / Sophie Gao / Shaoling Wu

Scientific Reports, Vol 14, Iss 1, Pp 1-

2024 Volume 11

Abstract: Abstract Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical ... ...

Abstract	Abstract Histone deacetylases (HDACs) are involved in tumorigenesis and progression, however, their role in diffuse large B-cell lymphoma (DLBCL) is not well understood. In this study, we examined the expression levels, mutations, and clinical significance of HDACs in DLBCL. Additionally, we investigated the therapeutic potential of Chidamide, a novel HDAC inhibitor, to provide scientific evidence for targeting HDACs in DLBCL patients. We extracted transcriptome data of DLBCLs––including 47 lymph node samples and 337 whole-blood-cell controls––from The Cancer Genome Atlas. Bioinformatic analyses of HDAC expression, mutation, and correlation with the clinical significance of DLBCL patients were performed with the Gene Expression Profiling Interactive Analysis, GENEMANIA, and web-based software including cBioPortal and WebGestalt. To examine the therapeutic effect of Chidamide, DLBCL cell lines (WSU-DLCL-2 and DB cells) were employed. Cell proliferation and apoptosis were analyzed with Cell Counting Kit-8 and flow cytometry assays. The impact of Chidamide treatment was also analyzed by RNA sequencing of treated DB cells. Western blot was used to explore the molecular mechanism of the cytotoxicity of Chidamide on DLBCL cell lines. The expression of some HDACs (HDAC1, 2, 3, 4, 6, 7, 8, and 9) were significantly higher in the lymph node samples of DLBCL than that in whole-blood-cell controls. Moreover, we found that the mutation rate of HDACs was also higher in DLBCL tissues, although the overall survival of DLBCL patients was not associated with HDAC expression. Chidamide was found to have a cytotoxic effect on DLBCL cells in a dose-dependent manner, while transcriptome analysis and western blot revealed that using it for treatment impacted several biological processes, including PI3K/AKT signaling, mTOR signaling, the cell cycle, and apoptosis pathways. Alterations of HDAC genes, including enhanced expression and mutations, are positively related to DLBCL. Targeting HDACs with specific inhibitors such as Chidamide ...
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ringing cancellation in Carr-Purcell-Meiboom-Gill-type sequences

Shin Utsuzawa / Marcus Donaldson / Yi-Qiao Song

Magnetic Resonance Letters, Vol 2, Iss 4, Pp 233-

2022 Volume 242

Abstract: We propose a four-step phase cycling scheme that can cancel ringings from both the excitation and the refocusing pulses in Carr-Purcell-Meiboom-Gill (CPMG) measurements. It allows accurate measurements of the first echo with short echo spacing tE, ... ...

Abstract	We propose a four-step phase cycling scheme that can cancel ringings from both the excitation and the refocusing pulses in Carr-Purcell-Meiboom-Gill (CPMG) measurements. It allows accurate measurements of the first echo with short echo spacing tE, yielding improved precision of porosity, permeability, and fluid type identification in porous media study, at a cost of ∼25% signal reduction. In our example, we achieved tE = 100 μs on a 6.8 MHz unilateral NMR sensor without using a Q-switch. These methods can be integrated in all nuclear magnetic resonance (NMR) protocols using CPMG, such as relaxation (T1, T2) and diffusion measurements, and do not require additional hardware (e.g., Q-switches) to cancel ringing (although it can be used with a Q-switch to further reduce residual ringing).
Keywords	CPMG ; Ringing cancellation ; Phase cycling ; Physical and theoretical chemistry ; QD450-801 ; Analytical chemistry ; QD71-142
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	KeAi Communications Co. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research Progress on the Relationship Between Inflammation and Colorectal Cancer.

Zhang, Feng / Qiao, Song

Annals of gastroenterological surgery

2021 Volume 6, Issue 2, Page(s) 204–211

Abstract: Colorectal cancer is one of the common malignant tumors. Relevant epidemiology and a large number of experimental studies have proved that chronic inflammation is highly correlated with the occurrence and development of colorectal cancer. And ... ...

Abstract	Colorectal cancer is one of the common malignant tumors. Relevant epidemiology and a large number of experimental studies have proved that chronic inflammation is highly correlated with the occurrence and development of colorectal cancer. And inflammatory bowel disease has been proven to be an independent risk factor for colorectal cancer. Various inflammatory cells participate in the establishment of the chronic inflammatory intestinal microenvironment required for the onset of colorectal cancer. The abnormal signal pathways mediated by various inflammatory factors and inflammatory mediators promote the occurrence of tumors, which are related to colorectal cancer and pathogenesis-related inflammation mechanisms. At the gene level, miRNAs can also affect the pathogenesis of colorectal cancer by regulating mesenchymal epithelial transformation. This article reviews the relationship between inflammation and colorectal cancer as well as the related inflammatory mechanisms.
Language	English
Publishing date	2021-11-10
Publishing country	Japan
Document type	Journal Article ; Review
ISSN	2475-0328
ISSN (online)	2475-0328
DOI	10.1002/ags3.12517
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Optimal timing of GnRH antagonist initiation in IVF-ET: a retrospective cohort study on advanced maternal age women.

Han, Qiao-Song / Zhou, Yue / Xu, Ying / Ai, Kai-Liang / Song, Jing-Yan / Sun, Zhen-Gao

Frontiers in endocrinology

2024 Volume 15, Page(s) 1340230

Abstract: Background: Several studies have compared the effects of fixed and flexible gonadotropin releasing hormone antagonist (GnRH-ant) protocols during : Methods: In this retrospective cohort study, a total of 472 infertile women aged ≥ 35 years old ... ...

Abstract	Background: Several studies have compared the effects of fixed and flexible gonadotropin releasing hormone antagonist (GnRH-ant) protocols during Methods: In this retrospective cohort study, a total of 472 infertile women aged ≥ 35 years old undergoing their first IVF cycle from August 2015 to September 2021 at a tertiary academic medical center were recruited, of whom 136 followed fixed GnRH-ant protocol and 336 followed flexible GnRH-ant protocol. The primary outcomes measured were the cumulative live birth rate (CLBR) per IVF cycle and the time to live birth (TTLB) from the date of oocyte retrieval. Cox proportional models were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) of CLBR regarding GnRH-ant timing. Results: No significant difference in CLBR was found between the fixed and flexible GnRH-ant groups (27.9% vs 20.5%, p=0.105). The TTLB was also comparable between groups (10.56 vs 10.30 months, p=0.782). The Kaplan-Meier analysis for CLBR also showed comparable results between groups (P=0.351, HR=0.83; 95%CI: 0.56-1.23). After establishing a multiple Cox proportional hazard model, the fixed GnRH-ant group still had comparable CLBR with the flexible GnRH-ant group (HR=0.85; 95%CI: 0.53-1.38; P=0.518). Subgroup and sensitivity analyses also demonstrated similar results. Conclusion: GnRH-ant protocols can be tailored to the needs of AMA women, and timing of GnRH-ant initiation can be adjusted flexibly.
MeSH term(s)	Adult ; Female ; Humans ; Pregnancy ; Fertilization in Vitro/methods ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Infertility, Female/drug therapy ; Maternal Age ; Ovulation Induction/methods ; Pregnancy Rate ; Retrospective Studies
Chemical Substances	Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2024-02-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1340230
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Realtime optimization of multidimensional NMR spectroscopy on embedded sensing devices

Yiqiao Tang / Yi-Qiao Song

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 6

Abstract: Abstract The increasingly ubiquitous use of embedded devices calls for autonomous optimizations of sensor performance with meager computing resources. Due to the heavy computing needs, such optimization is rarely performed, and almost never carried out ... ...

Abstract	Abstract The increasingly ubiquitous use of embedded devices calls for autonomous optimizations of sensor performance with meager computing resources. Due to the heavy computing needs, such optimization is rarely performed, and almost never carried out on-the-fly, resulting in a vast underutilization of deployed assets. Aiming at improving the measurement efficiency, we show an OED (Optimal Experimental Design) routine where quantities of interest of probable samples are partitioned into distinctive classes, with the corresponding sensor signals learned by supervised learning models. The trained models, digesting the compressed live data, are subsequently executed at the constrained device for continuous classification and optimization of measurements. We demonstrate the closed-loop method with multidimensional NMR (Nuclear Magnetic Resonance) relaxometry, an analytical technique seeing a substantial growth of field applications in recent years, on a wide range of complex fluids. The realtime portion of the procedure demands minimal computing load, and is ideally suited for instruments that are widely used in remote sensing and IoT networks.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article ; Online: The role of Erzhi Tiangui formula in expected poor ovarian responders undergoing in vitro fertilization-embryo transfer: A multicenter, randomized, double-blind, placebo-controlled trial.

Han, Qiao-Song / Zhou, Yue / Chen, Wen / Song, Jing-Yan / Sun, Zhen-Gao

Medicine

2023 Volume 102, Issue 27, Page(s) e34088

Abstract: Introduction: Advanced age is one of the primary risk factors for infertility. Poor ovarian response (POR) to exogenous gonadotropin is a prominent characteristic of advanced-age women undergoing in vitro fertilization and embryo transfer (IVF-ET), ... ...

Abstract	Introduction: Advanced age is one of the primary risk factors for infertility. Poor ovarian response (POR) to exogenous gonadotropin is a prominent characteristic of advanced-age women undergoing in vitro fertilization and embryo transfer (IVF-ET), which results in fewer retrieved oocytes and poor pregnancy outcomes. Traditional Chinese medicine (TCM) has been shown to improve female fertility. Erzhi Tiangui (EZTG) formula, in the form of granules with 10 herbal ingredients, demonstrated potential benefits in improving oocyte and embryo quality and ovarian reserve. Thus, this study aims to evaluate the efficacy and safety of EZTG formula. Method: The study is a multicenter, double-blind, placebo-controlled, randomized controlled trial (RCT), which will be conducted at 10 reproductive centers of tertiary hospitals. This study will enroll 480 women with expected POR of advanced age (≥35 years old) who fulfill the 2011 Bologna criteria. Participants will be assigned to either the EZTG group or the placebo group at random in an equal ratio. Each individual will receive conventional IVF-ET with EZTG granules or placebo as a complementary treatment. The primary outcome is the number of oocytes retrieved. Adverse events and safety assessments will be also conducted. Discussion: This study aims to provide robust evidence of the efficacy and safety of EZTG formula as a complementary treatment for advanced-age women with expected POR undergoing IVF-ET.
MeSH term(s)	Pregnancy ; Female ; Humans ; Pregnancy Rate ; Ovulation Induction/methods ; Embryo Transfer ; Fertilization in Vitro/methods
Chemical Substances	erzhi tiangui
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034088
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Article ; Online: Prevalence and factors of discordance attitudes toward advance care planning between older patients and their family members in the primary medical and healthcare institution.

Ye, Ling / Jin, Genhong / Chen, Min / Xie, Xingyuan / Shen, Shanshan / Qiao, Song

Frontiers in public health

2023 Volume 11, Page(s) 1013719

Abstract: Background: This study aimed at investigating the prevalence and factors of the discordant attitudes toward advance care planning (ACP) among older patients and their family members toward patients' engagement in ACP in the primary medical and ... ...

Abstract	Background: This study aimed at investigating the prevalence and factors of the discordant attitudes toward advance care planning (ACP) among older patients and their family members toward patients' engagement in ACP in the primary medical and healthcare institution. Methods: In a cross-sectional study, a total of 117 older patients and 117 family members from Jinhua Fifth Hospital in China were enrolled. The questionnaire included sociodemographic characteristics, functional capacity assessment, and attitudes toward patients' engagement in ACP. Functional capacity assessment scales included the Modified Barthel Index (MBI), the Short-Form Mini-Nutritional Assessment (MNA-SF), the 15-item Geriatric Depression Scale (GDS-15), the Mini-Mental State Examination (MMSE), the Clinical Frailty Scale (CFS), and the SARC-F questionnaire. Results: The discordance attitudes toward patients' engagement in ACP between patients and family members accounted for 41(35.0%). In the multivariate logistic analysis, factors associated with higher odds of discordance attitudes toward patients' engagement in ACP included greater age differences between patients and family members ( Conclusion: Older patients and their family members had little ACP knowledge, and factors that influence discordance attitudes toward patients' engagement in ACP included the age gaps between patients and family members, family members' educational level, patients' depressive symptoms, and patients' nutritional status.
MeSH term(s)	Humans ; Aged ; Cross-Sectional Studies ; Prevalence ; Advance Care Planning ; Attitude ; Patient Participation ; Family
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1013719
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Article ; Online: Analysis of Alterations of the Gut Microbiota in Moderate to Severe Psoriasis Patients Using 16S rRNA Gene Sequencing.

Wang, Xiaomeng / Chen, Zheng / Qiao, Song / Zhu, Qiming / Zuo, Zongbao / Guo, Birong

Indian journal of dermatology

2023 Volume 67, Issue 5, Page(s) 495–503

Abstract: Background: Psoriasis is an inflammatory skin disease. The correlation between intestinal microbiota and immune-mediated diseases makes scientists pay attention to the pathogenic role of microbiota.: Objective: The aim of this study was to identify ... ...

Abstract	Background: Psoriasis is an inflammatory skin disease. The correlation between intestinal microbiota and immune-mediated diseases makes scientists pay attention to the pathogenic role of microbiota. Objective: The aim of this study was to identify the gut microbial composition of patients with psoriasis. Methods: 16S rRNA gene sequencing method was used to analyse the faecal samples which was collected from 28 moderately severe psoriasis patients and 21 healthy controls and was followed by the analysing of informatics methods. Results: No visible differences can be observed in the diversity of gut microbiota between the psoriasis and the healthy patients, but the composition of the gut microbiota illustrate significant distinction between these two groups. At the phylum level, compared to the healthy control group, the psoriasis group shows higher relative abundance of Conclusion: This study identified the intestinal microecological environment of patients with psoriasis and healthy people, proving that psoriasis patients have a remarkably disturbed microbiome, and found several biomarkers of intestinal microorganisms in patients with psoriasis.
Language	English
Publishing date	2023-01-30
Publishing country	India
Document type	Journal Article
ZDB-ID	416069-1
ISSN	1998-3611 ; 0019-5154
ISSN (online)	1998-3611
ISSN	0019-5154
DOI	10.4103/ijd.ijd_297_22
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Article: T-Cell Non-Hodgkin Lymphoma of the Ileum Presenting as Perforation and Peritonitis: A Case Report.

Tian, Yong / Li, Chuanfang / Tian, Rusong / Tian, Qingming / Qiao, Song

Frontiers in surgery

2022 Volume 9, Page(s) 810360

Abstract: Background: Non-Hodgkin lymphoma (NHL) of the ileum, presenting as perforation and peritonitis, is a rare disease, derived from intestinal intraepithelial T lymphocytes. The degree of malignancy is extremely high. The pathogenesis of ileal perforation ... ...

Abstract	Background: Non-Hodgkin lymphoma (NHL) of the ileum, presenting as perforation and peritonitis, is a rare disease, derived from intestinal intraepithelial T lymphocytes. The degree of malignancy is extremely high. The pathogenesis of ileal perforation caused by NHL remains unclear, as well as the chromosome and immune system abnormalities, which may be related to NHL, and are indistinguishable from other benign and malignant conditions and are clinically nonspecific. Case report: We describe an 84-year-old man with abdominal pain for 4 days, which was aggravated for 3 h. The pain was in the upper abdominal region and was initially considered to be due to gastrointestinal perforation. He had persistent insidious pain, accompanied by nausea, vomiting, and fever. Physical examination indicated that the patient had pain all over the abdomen; also, rebound pain and muscle tension, and bowel sounds were reduced on auscultation. An abdominal CT scan showed free gas in the abdominal cavity. The patient was diagnosed with peritonitis due to hollow viscus perforation. A prompt exploratory laparotomy was performed. Intraoperative findings showed perforations in the ileum that are approximately 40 cm from the ileocecal region, which were 3-8 mm in size. A segmental distribution was observed, and the intestinal contents overflowed with purulent discharge around the perforation surface. Resection and ileostomy were performed, and the clinical histopathological examination confirmed T-cell lymphoma. The patient was advised to visit the Oncology Department for further chemotherapy. Conclusion: Timely emergency surgery is the key to the treatment of ileal perforation caused by T-cell lymphoma. Resection and ileostomy were performed as intervention measures, and subsequent histopathological examination manifested T-cell lymphoma.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.810360
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Article ; Online: One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Qiao Song / Sheng Wang / Xiangui Lei / Yan Liu / Xin Wen / Zhouyu Wang

Molecules, Vol 27, Iss 4698, p

2022 Volume 4698

Abstract: Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, ... ...

Abstract	Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts, highly toxic reaction reagents or hazardous reaction conditions. Herein, an efficient route from halogenated amides to piperidines and pyrrolidines was disclosed. In this method, amide activation, reduction of nitrile ions, and intramolecular nucleophilic substitution were integrated in a one-pot reaction. The reaction conditions were mild and no metal catalysts were used. The synthesis of a variety of N-substituted and some C-substituted piperidines and pyrrolidines became convenient, and good yields were obtained.
Keywords	piperidine ; pyrrolidine ; synthesis ; one-pot route ; amide activation ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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