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  1. Article ; Online: The impact of preoperative parameters on postoperative foveal displacement in idiopathic macular hole.

    Qin, Hecong / Zhao, Jinsong / Jin, Siyan / Zhang, Hui

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3755

    Abstract: This study examined the effect of vitrectomy combined with internal limiting membrane (ILM) peeling on foveal displacement in 42 eyes with idiopathic macular hole (IMH). A retrospective analysis was conducted to measure various macular hole parameters ... ...

    Abstract This study examined the effect of vitrectomy combined with internal limiting membrane (ILM) peeling on foveal displacement in 42 eyes with idiopathic macular hole (IMH). A retrospective analysis was conducted to measure various macular hole parameters before surgery, including basal diameter, minimum diameter, hole height, and areas affected by traction such as macular hole area (MHA), macular hole cystoid space area (MHCSA), macular hole retinal area (MHRA), and total area (TA). The results showed a postoperative shift of the fovea towards the optic disc in all cases. Notably, the extent of foveal displacement was significantly linked to the preoperative basal diameter (r
    MeSH term(s) Humans ; Retinal Perforations/surgery ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Fovea Centralis ; Retina ; Vitrectomy/methods ; Basement Membrane/surgery ; Epiretinal Membrane/surgery
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54417-x
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  2. Article: Factors Associated with Anatomic Failure and Hole Reopening after Macular Hole Surgery.

    Li, Yutong / Jin, Siyan / Shi, Lijun / Qin, Hecong / Zhao, Jinsong

    Journal of ophthalmology

    2021  Volume 2021, Page(s) 7861180

    Abstract: A macular hole (MH), particularly an idiopathic macular hole (IMH), is a common cause of central vision loss. Risk factors for nonidiopathic MH include high myopia, cystoid macular edema, inflammation, and trauma. MH is primarily diagnosed using slit- ... ...

    Abstract A macular hole (MH), particularly an idiopathic macular hole (IMH), is a common cause of central vision loss. Risk factors for nonidiopathic MH include high myopia, cystoid macular edema, inflammation, and trauma. MH is primarily diagnosed using slit-lamp microscopy and optical coherence tomography (OCT). Half of the patients with stage I MHs are treated conservatively and may show spontaneous resolution. The main treatment methods for MHs currently include vitrectomy and stripping of the internal limiting membrane (ILM). However, in some patients, surgery does not lead to anatomical closure. In this review, we summarize the factors influencing the anatomical closure of MHs and analyze the potential underlying mechanisms.
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2021/7861180
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  3. Article ; Online: Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [

    Alanizi, Aryn A / Sorlin, Alexandre M / Parker, Matthew F L / López-Álvarez, Marina / Qin, Hecong / Lee, Sang Hee / Blecha, Joseph / Rosenberg, Oren S / Engel, Joanne / Ohliger, Michael A / Flavell, Robert R / Wilson, David M

    Bioconjugate chemistry

    2024  Volume 35, Issue 4, Page(s) 517–527

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Animals ; Mice ; Azides/chemistry ; Tissue Distribution ; Peptidoglycan ; Positron-Emission Tomography ; Bacteria ; Amino Acids ; Alanine ; Fluorine Radioisotopes/chemistry
    Chemical Substances Azides ; Peptidoglycan ; Amino Acids ; Alanine (OF5P57N2ZX) ; Fluorine Radioisotopes
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.4c00024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3400: Show issues Location:
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  4. Article: Defining the Magnetic Resonance Features of Renal Lesions and Their Response to Everolimus in a Transgenic Mouse Model of Tuberous Sclerosis Complex.

    Agarwal, Shubhangi / Decavel-Bueff, Emilie / Wang, Yung-Hua / Qin, Hecong / Santos, Romelyn Delos / Evans, Michael J / Sriram, Renuka

    Frontiers in oncology

    2022  Volume 12, Page(s) 851192

    Abstract: Tuberous sclerosis complex (TSC) is an inherited genetic disorder characterized by mutations ... ...

    Abstract Tuberous sclerosis complex (TSC) is an inherited genetic disorder characterized by mutations in
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.851192
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  5. Article: Deuterium Metabolic Imaging-Rediscovery of a Spectroscopic Tool.

    Polvoy, Ilona / Qin, Hecong / Flavell, Robert R / Gordon, Jeremy / Viswanath, Pavithra / Sriram, Renuka / Ohliger, Michael A / Wilson, David M

    Metabolites

    2021  Volume 11, Issue 9

    Abstract: The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium ( ...

    Abstract The growing demand for metabolism-specific imaging techniques has rekindled interest in Deuterium (
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo11090570
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  6. Article ; Online: Clinically Translatable Hyperpolarized

    Mu, Changhua / Liu, Xiaoxi / Kim, Yaewon / Riselli, Andrew / Korenchan, David E / Bok, Robert A / Delos Santos, Romelyn / Sriram, Renuka / Qin, Hecong / Nguyen, Hao / Gordon, Jeremy W / Slater, James / Larson, Peder E Z / Vigneron, Daniel B / Kurhanewicz, John / Wilson, David M / Flavell, Robert R

    ACS sensors

    2023  Volume 8, Issue 11, Page(s) 4042–4054

    Abstract: Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease progression is ...

    Abstract Solid tumors such as prostate cancer (PCa) commonly develop an acidic microenvironment with pH 6.5-7.2, owing to heterogeneous perfusion, high metabolic activity, and rapid cell proliferation. In preclinical prostate cancer models, disease progression is associated with a decrease in tumor extracellular pH, suggesting that pH imaging may reflect an imaging biomarker to detect aggressive and high-risk disease. Therefore, we developed a hyperpolarized carbon-13 MRI method to image the tumor extracellular pH (pH
    MeSH term(s) United States ; Male ; Animals ; Humans ; Bicarbonates/metabolism ; Reproducibility of Results ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Hydrogen-Ion Concentration ; Tumor Microenvironment
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2379-3694
    ISSN (online) 2379-3694
    DOI 10.1021/acssensors.3c00851
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  7. Article ; Online: Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [

    Liu, Xiaoxi / Tang, Shuyu / Mu, Changhua / Qin, Hecong / Cui, Di / Lai, Ying-Chieh / Riselli, Andrew M / Delos Santos, Romelyn / Carvajal, Lucas / Gebrezgiabhier, Daniel / Bok, Robert A / Chen, Hsin-Yu / Flavell, Robert R / Gordon, Jeremy W / Vigneron, Daniel B / Kurhanewicz, John / Larson, Peder E Z

    Magnetic resonance in medicine

    2022  Volume 88, Issue 3, Page(s) 1039–1054

    Abstract: Purpose: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and ... ...

    Abstract Purpose: This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with a metabolite-specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized
    Methods: A metabolite-specific bSSFP urea imaging sequence was designed using a urea-specific excitation pulse, optimized TR, and 3D stack-of-spiral readouts. Simulations and phantom studies were performed to validate the spectral response of the sequence. The image quality of urea data acquired by the 3D-bSSFP sequence and the 2D-GRE sequence was evaluated with 2 identical injections of co-hyperpolarized [1-
    Results: Simulations and phantom studies demonstrated that 3D-bSSFP sequence achieved urea-only excitation, while minimally perturbing other metabolites (<1%). An animal study demonstrated that compared to GRE, bSSFP sequence provided an ∼2.5-fold improvement in SNR without perturbing urea or pyruvate kinetics, and bSSFP approach with a shorter spiral readout reduced blurring artifacts caused by J-coupling of [
    Conclusion: The 3D-bSSFP urea sequence with a stack-of-spiral acquisition demonstrated significantly increased SNR and image quality for [
    MeSH term(s) Animals ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy ; Male ; Perfusion ; Pyruvic Acid/metabolism ; Rats ; Urea
    Chemical Substances Pyruvic Acid (8558G7RUTR) ; Urea (8W8T17847W)
    Language English
    Publishing date 2022-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.29266
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.

    Parker, Matthew F L / López-Álvarez, Marina / Alanizi, Aryn A / Luu, Justin M / Polvoy, Ilona / Sorlin, Alexandre M / Qin, Hecong / Lee, Sanghee / Rabbitt, Sarah J / Pichardo-González, Priamo A / Ordonez, Alvaro A / Blecha, Joseph / Rosenberg, Oren S / Flavell, Robert R / Engel, Joanne / Jain, Sanjay K / Ohliger, Michael A / Wilson, David M

    The Journal of infectious diseases

    2023  Volume 228, Issue Suppl 4, Page(s) S281–S290

    Abstract: Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel ... ...

    Abstract Background: Vertebral discitis-osteomyelitis (VDO) is a devastating infection of the spine that is challenging to distinguish from noninfectious mimics using computed tomography and magnetic resonance imaging. We and others have developed novel metabolism-targeted positron emission tomography (PET) radiotracers for detecting living Staphylococcus aureus and other bacteria in vivo, but their head-to-head performance in a well-validated VDO animal model has not been reported.
    Methods: We compared the performance of several PET radiotracers in a rat model of VDO. [11C]PABA and [18F]FDS were assessed for their ability to distinguish S aureus, the most common non-tuberculous pathogen VDO, from Escherichia coli.
    Results: In the rat S aureus VDO model, [11C]PABA could detect as few as 103 bacteria and exhibited the highest signal-to-background ratio, with a 20-fold increased signal in VDO compared to uninfected tissues. In a proof-of-concept experiment, detection of bacterial infection and discrimination between S aureus and E coli was possible using a combination of [11C]PABA and [18F]FDS.
    Conclusions: Our work reveals that several bacteria-targeted PET radiotracers had sufficient signal to background in a rat model of S aureus VDO to be potentially clinically useful. [11C]PABA was the most promising tracer investigated and warrants further investigation in human VDO.
    MeSH term(s) Humans ; Rats ; Animals ; Discitis/diagnostic imaging ; 4-Aminobenzoic Acid ; Escherichia coli ; Positron-Emission Tomography/methods ; Staphylococcal Infections/diagnostic imaging ; Osteomyelitis/microbiology ; Bacteria ; Staphylococcus aureus ; Radiopharmaceuticals
    Chemical Substances Carbon-11 ; 4-Aminobenzoic Acid (TL2TJE8QTX) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad159
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    Zs.MO 445: Show issues

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  9. Article ; Online: A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-

    Tang, Shuyu / Bok, Robert / Qin, Hecong / Reed, Galen / VanCriekinge, Mark / Delos Santos, Romelyn / Overall, William / Santos, Juan / Gordon, Jeremy / Wang, Zhen Jane / Vigneron, Daniel B / Larson, Peder E Z

    Magnetic resonance in medicine

    2020  Volume 84, Issue 3, Page(s) 1113–1125

    Abstract: Purpose: The balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized : Methods: Simulations were performed to evaluate the spectral response of the MS-3DSSFP sequence. ... ...

    Abstract Purpose: The balanced steady-state free precession sequence has been previously explored to improve the efficient use of nonrecoverable hyperpolarized
    Methods: Simulations were performed to evaluate the spectral response of the MS-3DSSFP sequence. Thermal
    Results: Simulations, phantom, and in vivo studies demonstrate that the MS-3DSSFP sequence achieved spectrally selective excitation on lactate while minimally perturbing other metabolites. Compared with MS-GRE sequences, the MS-3DSSFP sequence showed approximately a 2.5-fold SNR improvement for lactate imaging in rat kidneys, prostate tumors in a mouse model, and human kidneys.
    Conclusions: Improved lactate imaging using the MS-3DSSFP sequence in hyperpolarized [1-
    MeSH term(s) Animals ; Carbon Isotopes ; Humans ; Imaging, Three-Dimensional ; Lactic Acid ; Magnetic Resonance Imaging ; Male ; Phantoms, Imaging ; Pyruvic Acid
    Chemical Substances Carbon Isotopes ; Lactic Acid (33X04XA5AT) ; Pyruvic Acid (8558G7RUTR)
    Language English
    Publishing date 2020-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28204
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Hyperpolarized

    Korenchan, David E / Bok, Robert / Sriram, Renuka / Liu, Kristina / Santos, Romelyn Delos / Qin, Hecong / Lobach, Iryna / Korn, Natalie / Wilson, David M / Kurhanewicz, John / Flavell, Robert R

    Oncotarget

    2019  Volume 10, Issue 58, Page(s) 6096–6110

    Abstract: There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH ( ... ...

    Abstract There is an unmet clinical need for new and robust imaging biomarkers to distinguish indolent from aggressive prostate cancer. Hallmarks of aggressive tumors such as a decrease in extracellular pH (pH
    Language English
    Publishing date 2019-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27225
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