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  1. AU="Qin, Huixun"
  2. AU="Brunozzi, Denise"
  3. AU="Uthayasooriyan, Pavithra"
  4. AU="Yaffee, Robert"
  5. AU=Shao Miao AU=Shao Miao
  6. AU="Elghazoui, Anouar"
  7. AU="Álvarez Álvarez, Beatriz"
  8. AU=Morens David M AU=Morens David M
  9. AU="Victor, Virginia"
  10. AU="Spahr, Melissa"
  11. AU="Bruschi, Carlo"
  12. AU="Caplice, Noel M"
  13. AU="Muzi, Stefania"
  14. AU="Fried, Daniel"
  15. AU=Majidi Hadi
  16. AU="Kilpatrick, Laura E"
  17. AU="Cantero, Chloé"
  18. AU="Minatani, Shinobu"
  19. AU=Wang Yueying
  20. AU="Wagner, Holger"
  21. AU="Blinkey, Neil"
  22. AU=Jiang Yi

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  1. Artikel ; Online: Endovascular treatment for wake-up stroke and daytime unwitnessed stroke: A meta-analysis.

    Qin, Bin / Gao, Wen / Qin, Huixun / Zhao, Libo / Yang, Mingxiu

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2022  Band 101, Seite(n) 252–258

    Abstract: Background: Evidence from sources outside the typical clinical research setting, such as a real-world setting, may complement evidence from randomised controlled trials (RCTs). The aim of the present study was to carry out a meta-analysis of available ... ...

    Abstract Background: Evidence from sources outside the typical clinical research setting, such as a real-world setting, may complement evidence from randomised controlled trials (RCTs). The aim of the present study was to carry out a meta-analysis of available real-world evidence that focused on the efficacy and safety of endovascular treatment in patients with wake-up stroke (WUS) or daytime unwitnessed stroke (DUS) compared to that in patients treated ≤ 6 h after the onset of an ischemic stroke.
    Methods: Data mining was conducted on 1 May 2021 from PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials Cochrane Library. The study reviewed all published that assessed the effect of endovascular treatment in WUS and DUS compared to that received by patients with ischemic stroke. Relevant data were extracted and the narrative was reviewed and analysed. The results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs).
    Findings: The meta-analysis showed no significant differences between the two groups in the rates of functional independence (OR, 0.81; 95% CI, 0.65-1.02; P = 0.07), symptomatic intracerebral haemorrhage (OR, 0.86; 95% CI, 0.57-1.30; P = 0.470), and all-cause mortality (OR, 0.92; 95% CI, 0.73-1.16; P = 0.50). There was also no heterogeneity between the trials.
    Conclusion: The pooled analysis provided evidence to support the use of endovascular treatment in WUS and DUS with favourable perfusion imaging. The meta-analysis confirmed the main findings of RCTs of endovascular treatment in WUS and DUS in a real-world setting and therefore strengthens the validity of this treatment strategy.
    Mesh-Begriff(e) Brain Ischemia/complications ; Cerebral Hemorrhage/complications ; Endovascular Procedures/methods ; Humans ; Ischemic Stroke ; Stroke/etiology ; Stroke/surgery ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2022-05-31
    Erscheinungsland Scotland
    Dokumenttyp Journal Article ; Meta-Analysis
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2022.05.023
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3999: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel ; Online: Efficacy and Safety of the Soft Torqueable Catheter Optimized For Intracranial Access in the Endovascular Treatment of Acute Ischemic Stroke: A Meta-Analysis.

    Gao, Wen / Qin, Bin / Qin, Huixun / Qin, Cheng / Zhang, Jiede / Liang, Yumin / Qin, Chao

    World neurosurgery

    2022  Band 171, Seite(n) 167–174.e7

    Abstract: Objective: Acute ischemic stroke (AIS) is a severe, life-threatening type of stroke with poor prognosis and high recurrence rate, mainly attributed to large vessel occlusion (LVO). Improved understanding of the safety and effectiveness of the Soft ... ...

    Abstract Objective: Acute ischemic stroke (AIS) is a severe, life-threatening type of stroke with poor prognosis and high recurrence rate, mainly attributed to large vessel occlusion (LVO). Improved understanding of the safety and effectiveness of the Soft Torqueable Catheter Optimized For Intracranial Access (SOFIA) for LVO-AIS might guide practitioners. Therefore, we conducted this study focusing on neurological outcomes, procedure-related complications, and recanalization rates.
    Methods: We collected data in January 2022 from PubMed, Cochrane, Web of Science, and Embase. The study considered that assessed the effects of the SOFIA catheter in treatment of LVO-AIS. We extracted data narratively and expressed the results with the proportions and 95% confidence intervals (CI).
    Results: We included 17 studies reporting on 2106 patients treated with the SOFIA catheter. The successful recanalization rate was 77% (95% CI, 71%-83%) with the SOFIA catheter alone and the application of a rescue stent-retriever was observed in 28% (95% CI, 23%-33%) of cases, resulting in an overall successful recanalization rate of 90% (95% CI, 87%-92%). A pooled estimate of 45% (95% CI, 39%-51%) was observed for functional independence at 90 days, 15% (95% CI, 11%-20%) for mortality at 90 days, and 5% (95% CI, 3%-8%) for symptomatic intracranial hemorrhage.
    Conclusions: This meta-analysis revealed that aspiration thrombectomy with the SOFIA catheter is a safer and effective treatment modality for LVO-AIS.
    Mesh-Begriff(e) Humans ; Ischemic Stroke/etiology ; Brain Ischemia/etiology ; Retrospective Studies ; Stroke/etiology ; Thrombectomy/methods ; Catheters/adverse effects ; Treatment Outcome ; Endovascular Procedures/methods
    Sprache Englisch
    Erscheinungsdatum 2022-12-13
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.12.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1159: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Artikel: Effectiveness of high-frequency repetitive transcranial magnetic stimulation in patients with depression and Parkinson's disease: a meta-analysis of randomized, controlled clinical trials.

    Qin, Bin / Chen, Hong / Gao, Wen / Zhao, Li-Bo / Zhao, Ming-Jun / Qin, Hui-Xun / Yang, Ming-Xiu

    Neuropsychiatric disease and treatment

    2018  Band 14, Seite(n) 273–284

    Abstract: Aim: This meta-analysis aimed to assess the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for the treatment of depression in patients with Parkinson's disease (PD).: Methods: The design was a meta-analysis of ... ...

    Abstract Aim: This meta-analysis aimed to assess the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for the treatment of depression in patients with Parkinson's disease (PD).
    Methods: The design was a meta-analysis of randomized controlled trials (RCTs). The participants were patients with PD who suffered from depression. The interventions were HF-rTMS alone or in combination with other treatments compared with sham-rTMS, placebo, and anti-depressant treatments. The primary outcome measure was changes in depressive symptoms, defined as the mean change in the total depression score. The secondary outcome was changes in motor symptoms, defined by Unified Parkinson's Disease Rating Scale part III scores, and the acceptability, defined as the risk of all-cause discontinuation. These were expressed as mean differences (MDs), standardized mean differences (SMDs), or risk ratios (RRs) with 95% confidence intervals (CIs).
    Results: We identified nine suitable trials, with data from 332 participants. For the patients with depression in PD, HF-rTMS was not better than sham-rTMS (SMD =-0.33, 95% CI -0.83 to 0.17) or selective serotonin re-uptake inhibitors (SSRIs) (SMD =0.07, 95% CI -0.52 to 0.18) for the treatment of depressive symptoms. However, the motor benefits after treatment with HF-rTMS might be better than sham-rTMS (MD =-2.80, 95% CI -5.45 to -0.15) and SSRIs (MD =-2.70, 95% CI -4.51 to -0.90).
    Conclusion: This meta-analysis provides some evidence that in patients with PD with depression, HF-rTMS may lead to improvement in motor function but not in depression compared with sham-rTMS or SSRIs.
    Sprache Englisch
    Erscheinungsdatum 2018-01-11
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S156695
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6068: Hefte anzeigen Standort:
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  4. Artikel ; Online: Real-World Outcomes of Acute Ischemic Stroke Treatment with Intravenous Thrombolysis: A Systematic Review and Meta-Analysis.

    Qin, Bin / Zhao, Ming-Jun / Chen, Hong / Qin, Huixun / Zhao, Libo / Fu, Lin / Qin, Cheng / Yang, Mingxiu / Gao, Wen

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2018  Band 27, Heft 12, Seite(n) 3542–3548

    Abstract: Background: Evidence from outside the typical clinical research setting, such as the real-world setting, complements evidence coming from randomized controlled trials. The purpose of this study was to evaluate all available evidence from the real-world ... ...

    Abstract Background: Evidence from outside the typical clinical research setting, such as the real-world setting, complements evidence coming from randomized controlled trials. The purpose of this study was to evaluate all available evidence from the real-world observational trials about long-term outcomes of treatment with intravenous (IV) recombinant tissue-type plasminogen activator (rt-PA) compared with not treated with IV rt-PA (non-rt-PA) in patients with acute ischemic stroke.
    Methods: We searched PubMed and Embase until March 1, 2018 for observational studies reporting matched or adjusted results comparing IV rt-PA versus non-rt-PA in patients with acute ischemic stroke. Outcomes assessed included all-cause mortality, hospital readmission rates, and independence rates. Hazard ratios with 95% confidence intervals were used as a measure of comparing between patients treated with IV rt-PA and non-rt-PA.
    Results: Six observational trials with 16,399 participants were identified. The use of IV rt-PA in acute ischemic stroke patients was associated with a lower risk of mortality (hazard ratio .61; 95% confidence interval, .52-.70; P < .00001), and there was no heterogeneity across trials. There was no evidence of an effect on hospital readmission rates and independence rates.
    Conclusions: IV rt-PA is associated with reduced long-term mortality in acute ischemic stroke patients.
    Mesh-Begriff(e) Administration, Intravenous ; Brain Ischemia/drug therapy ; Humans ; Observational Studies as Topic ; Stroke/drug therapy ; Thrombolytic Therapy
    Sprache Englisch
    Erscheinungsdatum 2018-09-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2018.08.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3519: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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