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Article: [Psychological effect of physical function dependence on maintenance hemodialysis patients and their primary family caregivers].

Mo, J B / Huang, L / Qin, J J / Liang, B

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2023 Volume 39, Issue 1, Page(s) 13–19

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Male ; Female ; Caregivers ; Cross-Sectional Studies ; Renal Dialysis/psychology ; Hypertension ; Diabetes Mellitus
Language	Chinese
Publishing date	2023-02-13
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.cn441217-20220722-00730
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Article: [Effects of manipulator operation task and troubleshooting task on blood pressure indexes of oceanauts].

Qin, J J / Shi, L / Li, X Y / Li, Y Y / Yang, L / Yu, Z W

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2023 Volume 41, Issue 2, Page(s) 87–93

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Male ; Humans ; Blood Pressure ; Diving ; Workload
Language	Chinese
Publishing date	2023-03-07
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1050900-8
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.cn121094-20211109-00552
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Zs.A 7219: Show issues

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Article: [Optimization of perioperative treatment strategies for locally advanced esophageal squamous cell carcinoma from the perspective of tumor heterogeneity].

Kang, X Z / Zhang, R X / Wang, Z / Chen, X K / Qin, J J / Li, Y / Xue, Q / He, J

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2023 Volume 26, Issue 4, Page(s) 334–338

Abstract: Recent advances in multimodality treatment offer excellent opportunities to rethink the paradigm of perioperative management for locally advanced esophageal squamous cell carcinoma. One treatment clearly doesn't fit all in terms of a broad disease ... ...

Abstract	Recent advances in multimodality treatment offer excellent opportunities to rethink the paradigm of perioperative management for locally advanced esophageal squamous cell carcinoma. One treatment clearly doesn't fit all in terms of a broad disease spectrum. Individualized treatment of local control of bulky primary tumor burden (advanced T stage) or systemic control of nodal metastatic tumor burden (advanced N stage) is essential. Given that clinically applicable predictive biomarkers are still awaited, therapy selection guided by diverse phenotypes of tumor burden (T vs. N) is promising. Potential challenges regarding the use of immunotherapy may also boost this novel strategy in the future.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/surgery ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/pathology ; Combined Modality Therapy ; Immunotherapy
Language	Chinese
Publishing date	2023-04-18
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.cn441530-20221126-00494
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Article: [Advances of immunotherapy-related biomarker in esophageal carcinoma].

Zhang, R X / Kang, X Z / Zheng, Q F / Wang, Z / Chen, X K / Li, Y / Qin, J J

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2023 Volume 26, Issue 4, Page(s) 396–400

Abstract: Esophageal carcinoma is one of the most common malignant tumors in the world, with incidence and mortality rankings of 7th and 6th, respectively. In recent years, immunotherapy represented by immune checkpoint inhibitors of programmed death-1 and ... ...

Abstract	Esophageal carcinoma is one of the most common malignant tumors in the world, with incidence and mortality rankings of 7th and 6th, respectively. In recent years, immunotherapy represented by immune checkpoint inhibitors of programmed death-1 and programmed death ligand 1 (PD-L1) has been introduced into clinical practice and has changed the treatment status of esophageal cancer. Although immunotherapy has provided long-term survival benefits for patients with advanced esophageal cancer and high pathological response rates in the neoadjuvant therapy, only a few of the patients have satisfactory therapeutic outcomes. Therefore, effective biomarkers for predicting immunotherapeutic effects are urgently needed to identify those patients who could benefit from immunotherapy. In this paper, we mainly discuss recent research advances of biomarkers related to the immunotherapy of esophageal cancer and the clinical application prospects of these biomarkers.
MeSH term(s)	Humans ; Biomarkers ; Esophageal Neoplasms/therapy ; Immunotherapy ; B7-H1 Antigen ; Biomarkers, Tumor
Chemical Substances	Biomarkers ; B7-H1 Antigen ; Biomarkers, Tumor
Language	Chinese
Publishing date	2023-04-18
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.cn441530-20221213-00522
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Article ; Online: Fyn stimulates the progression of pancreatic cancer via Fyn-GluN2b-AKT axis.

Dong, W / Sun, S-J / Qin, J-J / Liu, G-M

European review for medical and pharmacological sciences

2020 Volume 24, Issue 1, Page(s) 109–121

Abstract: Objective: To assess the expression levels of Fyn in human tissue samples and pancreatic cancer cells and explore the potential mechanisms of Fyn in pancreatic cancer progression.: Materials and methods: Quantitative PCR and immunohistochemical (IHC) ...

Abstract	Objective: To assess the expression levels of Fyn in human tissue samples and pancreatic cancer cells and explore the potential mechanisms of Fyn in pancreatic cancer progression. Materials and methods: Quantitative PCR and immunohistochemical (IHC) assays were performed to detect the expression of Fyn in 30 cancer tissue samples from pancreatic cancer patients and corresponding adjacent normal tissues. In addition, the potential correlations between Fyn expression levels and clinical pathological features were assessed. We further detected the effects of Fyn on the proliferation, apoptosis, migration, and invasion of the pancreatic cancer cells through colony formation assay, flow cytometry (FCM) assay, wound healing assay, and transwell assay, respectively. The potential effects of Fyn on tumor growth were assessed using an animal model. Results: We demonstrated the possible involvement of Fyn in the progression of pancreatic cancer. We found that Fyn was upregulated in human pancreatic cancer tissues and cells, and we analyzed the correlations between Fyn expression and the clinicopathological features, including metastasis staging (p=0.010) and tumor size (p=0.025) of patients with pancreatic cancer. Our data further confirmed that Fyn affects cell proliferation, apoptosis, migration, and invasion of pancreatic cancer cells via the phosphorylation of GluN2b and regulation of AKT signaling pathway. We also demonstrated that Fyn promoted tumor growth of pancreatic cancer cells in vivo. Conclusions: We investigated the potential involvement of Fyn in the progression of pancreatic cancer, and therefore indicated Fyn as a possible therapeutic target for pancreatic cancer.
MeSH term(s)	Animals ; Apoptosis ; Cell Proliferation ; Disease Models, Animal ; Female ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-fyn/genetics ; Proto-Oncogene Proteins c-fyn/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Tumor Cells, Cultured
Chemical Substances	NR2B NMDA receptor ; Receptors, N-Methyl-D-Aspartate ; FYN protein, human (EC 2.7.10.2) ; Proto-Oncogene Proteins c-fyn (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-01-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202001_19900
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Zs.A 1887: Show issues

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Article: [Oligometastatic and oligoprogressive esophageal squamous cell carcinoma:clarifying conceptions and surgery perspectives].

Kang, X Z / Zhang, R X / Wang, Z / Zheng, Q F / Chen, X K / Li, Y / Qin, J J

Zhonghua wai ke za zhi [Chinese journal of surgery

2022 Volume 60, Issue 2, Page(s) 122–127

Abstract: The oligometastatic and oligoprogressive state has been a hot issue in cancer research. Its indolent tumor behavior, representing a novel therapeutic opportunity, has been identified as a clinical subtype in several malignancies. However, the clinical ... ...

Abstract	The oligometastatic and oligoprogressive state has been a hot issue in cancer research. Its indolent tumor behavior, representing a novel therapeutic opportunity, has been identified as a clinical subtype in several malignancies. However, the clinical implications of the oligometastatic and oligoprogressive state in esophageal squamous cell carcinoma (ESCC) have not been thoroughly elucidated. There are still controversies regarding the existence of the oligometastatic state in ESCC, if the solitary regional lymph node metastasis should be viewed as oligoprogressive disease after esophagectomy, and the role of surgery and radiotherapy in ESCC oligometastatic disease. Despite many exciting contributions to the literature on these, further exploration is warranted. Thus, fostering the advance of research and scientific knowledge on the biological and prognostic characteristics scrupulously would facilitate personalizing treatment strategy for better outcomes.
MeSH term(s)	Carcinoma, Squamous Cell/surgery ; Esophageal Neoplasms/surgery ; Esophageal Squamous Cell Carcinoma ; Esophagectomy ; Humans ; Neoplasm Staging ; Prognosis ; Retrospective Studies
Language	Chinese
Publishing date	2022-01-04
Publishing country	China
Document type	Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.cn112139-20210818-00378
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 218: Show issues

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Article: [Surgical treatment for esophageal cancer during the outbreak of COVID-19].

Li, Y / Qin, J J / Wang, Z / Yu, Y / Wen, Y Y / Chen, X K / Liu, W X

Zhonghua zhong liu za zhi [Chinese journal of oncology

2020 Volume 42, Issue 4, Page(s) 296–300

Abstract: Since December 2019, unexplained pneumonia has appeared in Wuhan City, Hubei Province, and a new type of coronavirus infection was confirmed as COVID-19. COVID-19 spread rapidly nationwide and abroad. The COVID-19 has brought huge impacts to all the ... ...

Abstract	Since December 2019, unexplained pneumonia has appeared in Wuhan City, Hubei Province, and a new type of coronavirus infection was confirmed as COVID-19. COVID-19 spread rapidly nationwide and abroad. The COVID-19 has brought huge impacts to all the people and walks of life, especially to the medical and health systems. It has also brought great challenges to the treatment of patients with cancer. Esophageal cancer is a common malignant tumor in China and most of the patients are in the middle and advanced stage when diagnosed, with immunosuppressive and poor prognosis. The selection of surgical procedures and perioperative managements of esophageal cancer require all thoracic surgeons work together to figure out a reasonable system of surgical treatment and emergency response.
MeSH term(s)	Betacoronavirus ; COVID-19 ; China ; Communicable Disease Control/methods ; Coronavirus/pathogenicity ; Coronavirus Infections/epidemiology ; Cross Infection/prevention & control ; Disease Outbreaks/prevention & control ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/therapy ; Humans ; Immunocompromised Host ; Pandemics/prevention & control ; Patient Care Planning ; Pneumonia, Viral/epidemiology ; Risk ; SARS-CoV-2
Keywords	covid19
Language	Chinese
Publishing date	2020-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.cn112152-20200226-00128
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Zs.B 2277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 321: Show issues

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Article: [Role of short-term starvation in alleviating hepatic ischemia-reperfusion injury in mice and possible mechanism of action].

Zhou, J J / Qin, J J / Lyu, L / Zhou, H M / Zhang, F

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2018 Volume 26, Issue 1, Page(s) 42–47

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Alanine Transaminase/metabolism ; Animals ; Aspartate Aminotransferases/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Reperfusion Injury/metabolism
Chemical Substances	Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	Chinese
Publishing date	2018-05-26
Publishing country	China
Document type	Journal Article
ISSN	1007-3418
ISSN	1007-3418
DOI	10.3760/cma.j.issn.1007-3418.2018.01.010
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Article: [Clinical application of LDLT after reconstruction of IVC using artificial blood vessel in the treatment of HCC beyond Milan Criteria].

Sun, B C / Li, G Q / Huang, X L / Qin, J J / Mu, X X

Zhonghua zhong liu za zhi [Chinese journal of oncology

2018 Volume 40, Issue 3, Page(s) 211–215

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Blood Vessel Prosthesis ; Carcinoma, Hepatocellular/surgery ; Humans ; Liver/blood supply ; Liver Neoplasms/surgery ; Liver Transplantation ; Living Donors ; Retrospective Studies ; Stents ; Tissue and Organ Harvesting/methods ; Vena Cava, Inferior/surgery
Language	Chinese
Publishing date	2018-03-23
Publishing country	China
Document type	Journal Article
ZDB-ID	603424-x
ISSN	0253-3766
ISSN	0253-3766
DOI	10.3760/cma.j.issn.0253-3766.2018.03.010
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Zs.B 2277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 321: Show issues

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Article: FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells.

Liu, B L / Qin, J J / Shen, W Q / Liu, C / Yang, X Y / Zhang, X N / Hu, F / Liu, G M

Journal of biological regulators and homeostatic agents

2019 Volume 33, Issue 4, Page(s) 1041–1050

Abstract: Gastric cancer (GC) is the fourth leading cause of gynecological malignancies worldwide. 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with GC following surgical resection. Many studies have indicated the cancer-type ... ...

Abstract	Gastric cancer (GC) is the fourth leading cause of gynecological malignancies worldwide. 5-fluorouracil (5-FU)-mediated chemotherapy is the adjuvant treatment for patients with GC following surgical resection. Many studies have indicated the cancer-type specific roles of forkhead box protein A1 (FOXA1) and keratin 7 (KRT7) in human malignancies. However, the potential mechanism underlying the involvement of FOXA1 and KRT7 in the pathogenesis and chemoresistance of GC are still not entirely clear. In our study, gain- and loss-of-function experiments proved that FOXA1 promoted cell proliferation, migration and invasion in AGS and SGC-7901 cells. Consequently, KRT7 was identified to be transcriptional activated by FOXA1 using Dual luciferase reporter assay. Our results also indicated that FOXA1 exerted its functions in enhancing viability and invasion of AGS and SGC-7901 cells through activating KRT7. Finally, interference of FOXA1 or KRT7 increased the chemosensitivity of AGS and SGC-7901 cells to 5-fluorouracil (5-Fu) treatment by suppressing cell proliferation. In conclusion, these data indicate that FOXA1 promoted proliferation, migration, invasion, and decreased chemosensitivity of GC cells to 5-Fu treatment through transcriptional activator KRT7. The present study provides a novel therapeutic strategy for the enhancement of efficacy in GC treatment and provides important insights into the molecular mechanism underlying 5-FU-mediated chemoresistance.
MeSH term(s)	Cell Line, Tumor ; Cell Proliferation ; Hepatocyte Nuclear Factor 3-alpha/metabolism ; Humans ; Keratin-7/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology
Chemical Substances	FOXA1 protein, human ; Hepatocyte Nuclear Factor 3-alpha ; KRT7 protein, human ; Keratin-7
Language	English
Publishing date	2019-07-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
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Zs.A 2270: Show issues

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