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  1. Article ; Online: Influence of glycemic control and hypoglycemia on the risk of fracture in patients with diabetes mellitus: a systematic review and meta-analysis of observational studies.

    Hidayat, K / Fang, Q-L / Shi, B-M / Qin, L-Q

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2021  Volume 32, Issue 9, Page(s) 1693–1704

    Abstract: Individuals with diabetes mellitus (DM) have an increased risk of fracture. Glycemic control is crucial to the management of DM, but there are concerns pertaining to hypoglycemia development in the course of glycemic control target achievement. The ... ...

    Abstract Individuals with diabetes mellitus (DM) have an increased risk of fracture. Glycemic control is crucial to the management of DM, but there are concerns pertaining to hypoglycemia development in the course of glycemic control target achievement. The extent to which glycemic control may affect the risk of fracture remains less defined. Hypoglycemia-induced falls have been suggested to contribute to an elevated risk of fracture in DM patients. In this meta-analysis of observational studies, we aimed to investigate the relative contribution of glycemic control, as measured by glycated hemoglobin (HbA1c), and hypoglycemia to the risk of fracture in DM. The PubMed and Web of Science databases were searched for relevant studies. A random-effects model was used to generate summary relative risks (RRs) and 95% confidence intervals (CIs). Both increased HbA1c levels (RR
    MeSH term(s) Diabetes Mellitus, Type 2 ; Glycated Hemoglobin/analysis ; Glycemic Control ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemic Agents/adverse effects ; Observational Studies as Topic
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents
    Language English
    Publishing date 2021-04-16
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-021-05934-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3163: Show issues Location:
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  2. Article ; Online: Dynapenic Abdominal Obesity and Risk of Heart Disease among Middle-Aged and Older Adults: A Prospective Cohort Study.

    Wang, X / Jiang, J / Hu, W / Hu, Y / Qin, L-Q / Hao, Y / Dong, J-Y

    The journal of nutrition, health & aging

    2023  Volume 27, Issue 9, Page(s) 752–758

    Abstract: Objectives: The vicious cycle of dynapenia and abdominal obesity may have synergistic detrimental impacts on health. We aim to investigate the prospective association between dynapenic abdominal obesity and the risk of heart disease among middle-aged ... ...

    Abstract Objectives: The vicious cycle of dynapenia and abdominal obesity may have synergistic detrimental impacts on health. We aim to investigate the prospective association between dynapenic abdominal obesity and the risk of heart disease among middle-aged and older adults.
    Design: A prospective cohort study.
    Setting: English Longitudinal Study of Ageing, 2002-2019.
    Participants: A total of 4734 participants aged 50 years and older were included.
    Measurements: Individuals were divided into non-dynapenia/non-abdominal obesity (ND/NAO), non-dynapenia/abdominal obesity (ND/AO), dynapenia/non-abdominal obesity (D/NAO), and dynapenia/abdominal obesity (D/AO) according to grip strength and waist circumference at baseline. The Cox proportional hazards models were used to obtain the hazard ratios (HRs) of incident heart disease associated with dynapenia and abdominal obesity after adjusting for potential confounding factors.
    Results: During a median follow-up of 9.5 years, 1040 cases of heart disease were recorded. Compared with ND/NAO group, the multivariable HRs were 1.05 (0.92, 1.21) for ND/AO group, 1.31 (0.96, 1.81) for D/NAO group, and 1.39 (1.03, 1.88) for D/AO group. The significant association of D/AO with incident heart disease was detected in women but not in men [HR = 1.55 (1.07, 2.24) and 1.06 (0.60, 1.88), respectively]. Among middle-aged adults, significant associations of D/NAO and D/AO with incident heart disease were observed [HR = 2.46 (1.42, 4.29) and 1.74 (1.02, 2.97), respectively].
    Conclusion: Both D/NAO and D/AO might increase the risk of developing heart disease, highlighting the importance of dynapenia and obesity early screening for heart disease prevention.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Aged ; Obesity, Abdominal/complications ; Obesity, Abdominal/epidemiology ; Longitudinal Studies ; Prospective Studies ; Obesity/complications ; Hand Strength ; Heart Diseases/complications ; Heart Diseases/epidemiology ; Risk Factors
    Language English
    Publishing date 2023-09-27
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2081921-3
    ISSN 1760-4788 ; 1279-7707
    ISSN (online) 1760-4788
    ISSN 1279-7707
    DOI 10.1007/s12603-023-1975-0
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  3. Article ; Online: Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence.

    Hidayat, K / Du, X / Shi, B-M / Qin, L-Q

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2020  Volume 31, Issue 8, Page(s) 1411–1425

    Abstract: In the present meta-analysis, reductions in the risk of hip fracture with milk consumption were only observed among American adults, but not among Scandinavian adults, possibly because milk products are more commonly fortified with vitamin D in the ... ...

    Abstract In the present meta-analysis, reductions in the risk of hip fracture with milk consumption were only observed among American adults, but not among Scandinavian adults, possibly because milk products are more commonly fortified with vitamin D in the former population than in Scandinavian countries. The reduction in the risk of hip fracture was also observed with yogurt consumption, which is often associated with healthy lifestyles and dietary patterns that contribute to improved bone health.
    Introduction: Although dairy products contain bone-beneficial nutrients, the association between dairy consumption and the risk of hip fracture remains equivocal. Fueling this uncertainty, the elevated risk of hip fracture in association with milk consumption was observed in a cohort of Swedish women. A systematic review and meta-analysis of prospective cohort studies was performed to critically evaluate the association, or lack thereof, between dairy consumption (milk, yogurt, and cheese) and the risk of hip fracture.
    Methods: A random effects model was used to generate the summary relative risks (RRs) with their 95% confidence intervals (CIs) for the associations of interest.
    Results: In the meta-analysis of the highest versus lowest category of consumption, higher consumption of yogurt (RR 0.78, 95% CI 0.68, 0.90), but not milk (RR 0.86, 95% CI 0.73, 1.02) or cheese (RR 0.85, 95% CI 0.66, 1.08), was associated with a lower risk of hip fracture. For milk, the reduced risk of fracture with higher milk consumption was observed in the USA (RR 0.75, 95% CI 0.65, 0.87), but not in Scandinavian countries (RR 1.00, 95% CI 0.85, 1.17). These findings were further supported by the fact that American studies (RR 0.93, 95% CI 0.88, 0.98; per 1 glass/day), but not Scandinavian studies (RR 1.01, 95% CI 0.95, 1.07; per 1 glass/day), demonstrated a linear association between milk consumption and the risk of hip fracture.
    Conclusions: The cumulative evidence from prospective cohort studies reassuringly suggests that the risk of hip fracture may not be elevated among people who consume milk, yogurt, and cheese, and that a greater consumption of milk or yogurt may even be associated with a lower risk of hip fracture depending on the factors that may differ across the population of interest.
    MeSH term(s) Adult ; Animals ; Dairy Products ; Diet ; Female ; Hip Fractures/epidemiology ; Hip Fractures/etiology ; Hip Fractures/prevention & control ; Humans ; Milk ; Prospective Studies ; Risk Factors ; Yogurt
    Language English
    Publishing date 2020-05-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-020-05383-3
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    Zs.A 3163: Show issues Location:
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  4. Article: [The status of preventive medicine funding supported by National Natural Science Foundation of China from 2010-2017].

    Qin, L Q / Dai, Y F / Zhang, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2018  Volume 52, Issue 8, Page(s) 869–872

    Language Chinese
    Publishing date 2018-07-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2018.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Analysis of funding of projects on occupational diseases and occupational health by National Natural Science Foundation of China].

    Dai, Y F / Qin, L Q / Zhang, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2018  Volume 52, Issue 7, Page(s) 769–772

    Language Chinese
    Publishing date 2018-08-27
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2018.07.018
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  6. Article: [Analysis of project results of preventive medicine from the National Natural Science Foundation of China in 2017].

    Chen, S Y / Dai, Y F / Cao, H L / Qin, L Q / Zhang, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2019  Volume 53, Issue 4, Page(s) 433–436

    Abstract: We analyzed the project results of preventive medicine from the National Natural Science Foundation of China (NSFC) finished in 2017 based on the project-ending reports and data on science fund sharing service network. A total of 406 projects in this ... ...

    Abstract We analyzed the project results of preventive medicine from the National Natural Science Foundation of China (NSFC) finished in 2017 based on the project-ending reports and data on science fund sharing service network. A total of 406 projects in this field were completed in 2017. A total of 3 122 published articles supported by these projects, including 1 789 articles in science citation index (SCI) journals and 525 articles in Chinese core journals. In addition, there were 224 patent application/software copyright and 589 trained postgraduates. The top three sub-disciplines of project were non-communicable disease epidemiology, human nutrition and hygienic toxicology, accounting for 45.32% of the total number of completed projects. There were 12 institutions which had more than 10 finished projects, accounting for 41.87%. During the recent 5 years, the number of SCI articles and patents/software copyrights per project showed a general uptrend. It should be noted that the number of articles in Chinese core journals and postgraduates decreased in recent two years. Our analyses demonstrated that the project results should be guided by the new era policy of science fund to promote sustainable development of scientific research.
    MeSH term(s) China ; Foundations ; Humans ; Natural Science Disciplines ; Preventive Medicine
    Language Chinese
    Publishing date 2019-04-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2019.04.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dietary calcium intake and risk of type 2 diabetes: possible confounding by magnesium.

    Dong, J-Y / Qin, L-Q

    European journal of clinical nutrition

    2012  Volume 66, Issue 3, Page(s) 408–410

    Abstract: This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. ... ...

    Abstract This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. Prospective cohort studies that reported relative risks (RR) with 95% confidence intervals (CI) of type 2 diabetes for dietary calcium intake were selected. Results were combined using either a fixed- or random-effects model. Six prospective cohort studies comprising 264268 participants and 11225 reported cases were included. All combined random-effects meta-analysis yielded a significant pooled RR of 0.85 (95% CI 0.75-0.97). However, a sensitivity analysis limited to four studies with control for magnesium yielded an attenuated, nonsignificant pooled RR of 0.94 (95% CI 0.85-1.05). In conclusion, dietary calcium intake was not independently associated with risk of type 2 diabetes. The inverse association in prior observational studies may be partially confounded by magnesium intake.
    MeSH term(s) Calcium/administration & dosage ; Calcium/deficiency ; Calcium/pharmacology ; Calcium, Dietary/administration & dosage ; Calcium, Dietary/pharmacology ; Confounding Factors (Epidemiology) ; Diabetes Mellitus, Type 2/etiology ; Diabetes Mellitus, Type 2/prevention & control ; Humans ; Magnesium/administration & dosage ; Magnesium/pharmacology ; Magnesium Deficiency/complications ; Risk Factors
    Chemical Substances Calcium, Dietary ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2012-03
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/ejcn.2012.5
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    Zs.A 1045: Show issues Location:
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  8. Article ; Online: Leptin levels and risk of type 2 diabetes: gender-specific meta-analysis.

    Chen, G-C / Qin, L-Q / Ye, J-K

    Obesity reviews : an official journal of the International Association for the Study of Obesity

    2014  Volume 15, Issue 2, Page(s) 134–142

    Abstract: This meta-analysis aimed to assess the gender-specific differences in the relationship between circulating leptin levels and risk of type 2 diabetes. Published prospective studies that reported the association of leptin levels with risk of type 2 ... ...

    Abstract This meta-analysis aimed to assess the gender-specific differences in the relationship between circulating leptin levels and risk of type 2 diabetes. Published prospective studies that reported the association of leptin levels with risk of type 2 diabetes for a certain gender or those that reported gender-specific associations were considered. Dose-response relationships were assessed by the generalized least squares trend estimation and summary relative risks (RRs) with 95% confidence interval (CI) were computed with the random-effects model. Stratified and sensitivity analyses were also performed to investigate potential sources of heterogeneity. Overall, 11 prospective studies were identified. The summary RR for an increment in leptin levels of 1-log ng mL(-1) was 1.37 (95% CI, 1.13-1.66) for men and 0.96 (95% CI, 0.90-1.03) for women. The differences between genders were statistically significant (P for interaction = 0.006). Subgroup and sensitivity analyses generally confirmed the robustness of these findings. Furthermore, the increased risk in men appeared non-linear, with a tendency to plateau at high levels (P for non-linearity = 0.03). Little evidence of publication bias was found. Collectively, higher leptin levels were found to be associated with elevated risk of type 2 diabetes in men but not in women.
    MeSH term(s) Biomarkers/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/prevention & control ; Female ; Humans ; Leptin/blood ; Male ; Obesity/blood ; Obesity/epidemiology ; Prospective Studies ; Risk Factors ; Sex Factors
    Chemical Substances Biomarkers ; Leptin
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2147980-X
    ISSN 1467-789X ; 1467-7881
    ISSN (online) 1467-789X
    ISSN 1467-7881
    DOI 10.1111/obr.12088
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    Zs.A 5908: Show issues Location:
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  9. Article: [Responding to national strategy demand for a new era, and grasping key problems of basic frontiers in preventive medicine--Shuangqing Forum (No. 192) of National Natural Science Foundation of China].

    Qin, L Q / Yu, C Q / Dai, Y F / Gu, A H / Zhang, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2017  Volume 52, Issue 1, Page(s) 113–116

    Language Chinese
    Publishing date 2017-12-24
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2018.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [The status of preventive medicine program of the National Natural Science Foundation of China in 2017].

    Wang, D P / Huang, X / Jin, H / Qin, L Q / Zhang, Z W

    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

    2017  Volume 51, Issue 12, Page(s) 1137–1141

    Language Chinese
    Publishing date 2017-12-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 604575-3
    ISSN 0253-9624
    ISSN 0253-9624
    DOI 10.3760/cma.j.issn.0253-9624.2017.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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