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  1. Book ; Thesis: Opposing effects of HIF1A and HIF2A on chromaffin cell phenotypic features and tumor cell proliferation

    Qin, Nan

    insights from max

    2014  

    Author's details von Nan Qin
    Language English
    Size 125 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2015
    HBZ-ID HT018677927
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Analysis of sterilization efficiency and application cost of three low temperature sterilization methods.

    Chen, Hui / Liu, Jiawei / Zeng, Aiying / Qin, Nian

    The Review of scientific instruments

    2024  Volume 95, Issue 4

    Abstract: Objective: This paper discusses the sterilization efficiency of three low temperature sterilization methods used in thermosensitive medical devices and makes a preliminary analysis of sterilization costs so as to provide the basis for reasonable ... ...

    Abstract Objective: This paper discusses the sterilization efficiency of three low temperature sterilization methods used in thermosensitive medical devices and makes a preliminary analysis of sterilization costs so as to provide the basis for reasonable selection of low temperature sterilizer in Central Sterile Supply Department.
    Methods: Medical devices compatible with the three sterilization methods were selected for sterilization, and two packaging materials were selected for the three low-temperature sterilization equipment according to the compatibility of the packaging materials. The equipment packed with the same packaging materials were sterilized for five times, and each low-temperature sterilizer was sterilized for a total of ten times. The sterilization effect, sterilization cycle time, energy consumption, and cost of the three sterilizers were compared.
    Results: The cycle time of ethylene oxide sterilizer was 393.6 min, and the cycle time of hydrogen peroxide low temperature plasma sterilizer was 56.1 min. The cycle time of low temperature steam and formaldehyde sterilizer was 105.7 min. The hydrogen peroxide low temperature plasma sterilizes single cycle power consumption at a maximum of 5 kWh. The single cycle energy consumption of compressed air ethylene oxide sterilizer is up to 12 l. In terms of sterilization application cost, hydrogen peroxide low temperature plasma sterilization has the highest cost, followed by ethylene oxide sterilization, and low temperature steam and formaldehyde sterilization is the lowest.
    Conclusion: The sterilization efficiency of hydrogen peroxide low temperature plasma sterilization is the highest, followed by low temperature steam and formaldehyde sterilization, and the lowest is ethylene oxide sterilization. The three low temperature sterilization methods can achieve effective sterilization of devices. Each hospital can choose an appropriate low temperature sterilization method according to the characteristics of thermosensitive instruments, turnover efficiency requirements, and financial status.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0175121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Placement of an artificial urethral sphincter for treatment of passive urinary incontinence after inadvertent prostatectomy and balloon dilation treatment for stricture formation in a 5-month-old dog.

    Qin, Nancy / Romine, Jessica F / Visser, Judith

    Journal of the American Veterinary Medical Association

    2024  Volume 262, Issue 4, Page(s) 1–5

    Abstract: Objective: Describe the management of incontinence with several therapies, culminating with the apparently successful treatment utilizing artificial sphincter placement following an inadvertent prostatectomy.: Animal: 5-month-old 7.5-kg male neutered ...

    Abstract Objective: Describe the management of incontinence with several therapies, culminating with the apparently successful treatment utilizing artificial sphincter placement following an inadvertent prostatectomy.
    Animal: 5-month-old 7.5-kg male neutered Miniature Schnauzer.
    Clinical presentation, progression, and procedures: The patient was referred for dysuria and persistent stranguria following an iatrogenic total prostatectomy and urethrectomy. An extra pelvic urethral anastomosis was performed, followed by hospitalization for 2 weeks with a urinary catheter. The patient was further investigated for persistent stranguria, and a contrast urethrogram revealed a urethral stricture at the anastomosis site, which was treated with fluoroscopic balloon dilation. The stranguria resolved, but an acute nocturnal grade 3 passive urinary incontinence occurred, which was nonresponsive to medical management of phenylpropanolamine hydrochloride and estriol. An artificial urethral sphincter was placed, leading to continence after 5 top-ups to a total volume of 0.9 mL. The patient remained continent for 5.5 weeks before abrupt incontinence recurred, which was resolved by another 0.1-mL top-up. No further signs of incontinence occurred in the 11 months following.
    Treatment and outcome: The placement of an artificial urethral sphincter successfully managed urinary incontinence in this patient. Continence was achieved with no significant complications other than a transient loss of continence. Long-term follow-up 14 months after sphincter placement revealed that the patient had remained continent since the final sphincter top-up. The owner reported a significant improvement in the patient's quality of life following successful incontinence management.
    Clinical relevance: This case highlighted the benefits of placing an artificial urethral sphincter in managing urinary incontinence after select cases of prostatectomy in dogs that are unresponsive to medical management.
    MeSH term(s) Humans ; Dogs ; Male ; Animals ; Urethra/surgery ; Constriction, Pathologic/surgery ; Constriction, Pathologic/veterinary ; Quality of Life ; Dilatation/veterinary ; Urinary Incontinence/etiology ; Urinary Incontinence/surgery ; Urinary Incontinence/veterinary ; Urethral Stricture/etiology ; Urethral Stricture/surgery ; Urethral Stricture/veterinary ; Prostatectomy/adverse effects ; Prostatectomy/veterinary ; Dog Diseases/etiology ; Dog Diseases/surgery
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
    DOI 10.2460/javma.23.11.0634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Low expression of

    Liu, Xiao / Cui, Qianqian / Qin, Nan

    Translational cancer research

    2024  Volume 13, Issue 3, Page(s) 1225–1240

    Abstract: Background: KLRB1: Methods: A dataset comprising 1,109 BRCA samples and 113 healthy samples was retrieved from The Cancer Genome Atlas (TCGA) database to establish the association between : Results: KLRB1: Conclusions: This research ... ...

    Abstract Background: KLRB1
    Methods: A dataset comprising 1,109 BRCA samples and 113 healthy samples was retrieved from The Cancer Genome Atlas (TCGA) database to establish the association between
    Results: KLRB1
    Conclusions: This research investigated the mechanism and potential therapeutic target of the
    Language English
    Publishing date 2024-03-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-1231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Association Between Dyadic Coping and Quality of Life in Breast Cancer Patients and Their Spouses: An Actor-partner Interdependence Mediation Model.

    Chen, Wei / Li, Hui / Cai, Jian-Zheng / Qin, Nan

    Asian nursing research

    2024  Volume 18, Issue 1, Page(s) 44–50

    Abstract: Purpose: This study aims to examine the relationship between dyadic coping (DC), intimate relationship, and quality of life (QOL), and to explore the mediating role of intimate relationship in patients with breast cancer (BC) and their spouses from a ... ...

    Abstract Purpose: This study aims to examine the relationship between dyadic coping (DC), intimate relationship, and quality of life (QOL), and to explore the mediating role of intimate relationship in patients with breast cancer (BC) and their spouses from a dyadic perspective.
    Methods: A cross-sectional design was used in this present study, and 205 dyads of BC patients and their spouses who completed a sociodemographic and clinical questionnaire and self-reported measures assessing their DC, intimate relationship, and QOL were recruited. The actor-partner interdependence mediation model (APIMeM) was adopted for dyadic distinguished data analysis. The paired t-test, Pearson's correlation coefficients, and the structural equation model were employed for data analysis by using SPSS 22.0 and Amos 24.0.
    Results: The current study revealed that, for BC patients and their spouses, intimate relationship mediates completely the actor effect of DC on QOL. That is to say, DC was positively related to intimate relationship and then improved QOL. It was interesting to find that, for both patients and their spouses, the intimate relationship could exert a partner-actor complete mediation effect between DC and QOL.
    Conclusions: The DC perceived by both BC patients and their spouses has significant actor effects on QOL by improving the level of an intimate relationship. Furthermore, intimate relationship has significant actor-actor and partner-actor complete mediation effects for both patients and their spouses. Given the vital role of patient-spouse dyads, nursing staff should take patients' spouses into account when conducting related psychosocial interventions aiming to improve the QOL of BC patients and their spouses.
    MeSH term(s) Humans ; Female ; Spouses/psychology ; Quality of Life/psychology ; Breast Neoplasms ; Cross-Sectional Studies ; Coping Skills ; Adaptation, Psychological
    Language English
    Publishing date 2024-02-02
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2481635-8
    ISSN 2093-7482 ; 2093-7482
    ISSN (online) 2093-7482
    ISSN 2093-7482
    DOI 10.1016/j.anr.2024.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sepsis-associated encephalopathy: Autophagy and miRNAs regulate microglial activation.

    Qin, Nannan / Miao, Yanmei / Xie, Leiyu / Ma, Xinglong / Xie, Peng

    Physiological reports

    2024  Volume 12, Issue 5, Page(s) e15964

    Abstract: Sepsis-associated encephalopathy (SAE) describes diffuse or multifocal cerebral dysfunction caused by the systemic inflammatory response to sepsis. SAE is a common neurological complication in patients in the middle and late stages of sepsis in the ... ...

    Abstract Sepsis-associated encephalopathy (SAE) describes diffuse or multifocal cerebral dysfunction caused by the systemic inflammatory response to sepsis. SAE is a common neurological complication in patients in the middle and late stages of sepsis in the intensive care unit. Microglia, resident macrophages of the central nervous system, phagocytose small numbers of neuronal cells and apoptotic cells, among other cells, to maintain the dynamic balance of the brain's internal environment. The neuroinflammatory response induced by activated microglia plays a central role in the pathogenesis of various central nervous system diseases. In this paper, we systematically describe the functions and phenotypes of microglia, summarize how microglia mediate neuroinflammation and contribute to the occurrence and development of SAE, and discuss recent progress in autophagy- and microRNA-mediated regulation of microglial activation to provide a theoretical basis for the prevention and treatment of SAE and identify related therapeutic targets.
    MeSH term(s) Humans ; MicroRNAs/genetics ; Sepsis-Associated Encephalopathy ; Microglia ; Autophagy ; Sepsis/complications
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic insights into lung function inform better management of respiratory diseases.

    Qin, Na / Wang, Cheng / Hu, Zhibin

    Cell reports. Medicine

    2023  Volume 4, Issue 5, Page(s) 101041

    Abstract: Shrine et al. ...

    Abstract Shrine et al.
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Respiratory Tract Diseases/genetics ; Respiratory Tract Diseases/therapy ; Lung
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Meta-Analysis ; Journal Article ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A comprehensive survey of reference materials for their use in quality assurance for the determination of Np-237 in environmental samples.

    Qin, Ning / Zheng, Jian / Guosheng Yang / Tagami, Keiko

    Journal of environmental radioactivity

    2023  Volume 271, Page(s) 107328

    Abstract: Neptunium-237 ( ...

    Abstract Neptunium-237 (
    MeSH term(s) Neptunium ; Environmental Pollutants ; Reference Standards ; Radiation Monitoring ; Soil
    Chemical Substances Neptunium-237 ; Neptunium (6200K977BQ) ; Environmental Pollutants ; Soil
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483112-0
    ISSN 1879-1700 ; 0265-931X
    ISSN (online) 1879-1700
    ISSN 0265-931X
    DOI 10.1016/j.jenvrad.2023.107328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Association between incubator standards and newborn nosocomial infection with machine-learning prediction.

    Jiang, Lingxia / Ma, Jun / Li, Fang / Qin, Na

    Translational pediatrics

    2023  Volume 12, Issue 4, Page(s) 655–662

    Abstract: Background: Newborns have a high incidence of nosocomial infection (NI). We conducted a logistic regression to analyze different incubator standards and other risk factors for newborn NI, which could better help clinical choice of incubator standard.: ...

    Abstract Background: Newborns have a high incidence of nosocomial infection (NI). We conducted a logistic regression to analyze different incubator standards and other risk factors for newborn NI, which could better help clinical choice of incubator standard.
    Methods: Newborns with complete necessary clinical data were included. We collected the demographic and incubator data of 76 patients (40 uninfected and 36 infected) at the Heping Hospital Affiliated to Changzhi Medical College. An analysis of variance, Pearson correlation matrix analysis, and logistic regression analysis were conducted to explore the different incubator standards and other risk factors for neonatal hospital infections. In addition, 4 machine-learning algorithms were used to predict neonatal hospital infections.
    Results: We found differences in the gestational age, incubator type, paternal age, and maternal age between the 2 groups. The correlation analysis only revealed a correlation between paternal age and maternal age. The logistic regression showed that gestational age [odds ratio (OR)= 0.77574, 95% confidence interval (CI): 0.583513-0.996354] and the new standard incubator (OR =0.011639, 95% CI: 0.000958-0.067897) may be protective factors for infant infection during hospitalization. Among the extreme gradient boosting (XGBoost), random forest (RF), support vector machine (SVM), and decision tree (DT) algorithms, XGBoost had the best performance in terms of accuracy, sensitivity, specificity, and precision.
    Conclusions: We found early gestational age and incubator standards may be risk factors for the NIs of newborns, which might help clinicians to improve the health and safety standards for incubators. XGBoost can be used to predict newborn NIs.
    Language English
    Publishing date 2023-04-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Adaptive Iterative Learning Control for a Class of Nonlinear Strict-Feedback Systems With Unknown State Delays.

    Chen, Yong / Huang, Deqing / Qin, Na / Zhang, Yanhui

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 9, Page(s) 6416–6427

    Abstract: In this article, an adaptive iterative learning control scheme is presented for a class of nonlinear parametric strict-feedback systems with unknown state delays, aiming to achieve the point-wise tracking of desired trajectory in a finite interval. The ... ...

    Abstract In this article, an adaptive iterative learning control scheme is presented for a class of nonlinear parametric strict-feedback systems with unknown state delays, aiming to achieve the point-wise tracking of desired trajectory in a finite interval. The appropriate Lyapunov-Krasovskii functions are established to compensate the influence of time-delay uncertainties on the control systems. As the main features, the proposed approach integrates the command filter into the backstepping procedure to avoid the differential explosion problem that may occur with the increase of system order, and introduces the hyperbolic tangent functions into the learning controller to handle the singularity problem thus maintaining the continuity of input signal. The results of theoretical analysis and numerical simulation demonstrate that the tracking errors at the entire period will converge to a compact set along the iteration axis. Compared with the existing works, the proposed control scheme is promising to manifest the better performance and practicability owing to the learning mechanism, the dynamic model, as well as the implementation of controller.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2021.3136644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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