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Article: [Diagnostic value of FNDC5 in patients with subclinical diabetic cardiomyopathy].

Qin, Z H / Huang, X L / Tao, L C / Hua, F

2021 Volume 49, Issue 7, Page(s) 687–693

Abstract: Objective: ...

Abstract	Objective:
Language	Chinese
Publishing date	2021-07-24
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20200624-00510
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Article: [Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].

Zhang, J H / Zhou, S J / Kuang, Z / Qin, Z H / Tan, L W / Shao, Y T

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2023 Volume 41, Issue 8, Page(s) 576–581

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; RNA, Circular ; NF-kappa B ; Interleukin-8 ; Soot/toxicity ; Toll-Like Receptor 4 ; Interleukin-6 ; Epithelial Cells ; Caspase 1
Chemical Substances	RNA, Circular ; NF-kappa B ; Interleukin-8 ; Soot ; Toll-Like Receptor 4 ; Interleukin-6 ; Caspase 1 (EC 3.4.22.36)
Language	Chinese
Publishing date	2023-09-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1050900-8
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.cn121094-20220501-00251
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Article: [Therapeutic effect of Prussian blue with hemoperfusion in treatment on five patients of acute thalliumpoisoning].

Liu, L P / Qin, Z H / Zou, W M

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2018 Volume 36, Issue 1, Page(s) 63–64

Language	Chinese
Publishing date	2018-02-23
Publishing country	China
Document type	Journal Article
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.issn.1001-9391.2018.01.012
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Article: [Efficacy and safety of total neoadjuvant therapy versus neoadjuvant chemoradiotherapy in the treatment of locally advanced rectal cancer: a meta-analysis].

Zhang, Y Q / Sun, K G / Lu, J Y / Ma, J / Yao, N / Qin, Z H / Yao, Y H

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

2022 Volume 25, Issue 6, Page(s) 531–538

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Chemoradiotherapy/methods ; Disease-Free Survival ; Humans ; Neoadjuvant Therapy/methods ; Neoplasm Staging ; Neoplasms, Second Primary/pathology ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Rectum/pathology ; Treatment Outcome
Language	Chinese
Publishing date	2022-06-27
Publishing country	China
Document type	Journal Article ; Meta-Analysis
ISSN	1671-0274
ISSN	1671-0274
DOI	10.3760/cma.j.cn441530-20210806-00311
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Article ; Online: DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX.

Guan, J-J / Zhang, X-D / Sun, W / Qi, L / Wu, J-C / Qin, Z-H

Cell death & disease

2015 Volume 6, Page(s) e1624

Abstract: DRAM1 (DNA damage-regulated autophagy modulator 1) is a TP53 target gene that modulates autophagy and apoptosis. We previously found that DRAM1 increased autophagy flux by promoting lysosomal acidification and protease activation. However, the molecular ... ...

Abstract	DRAM1 (DNA damage-regulated autophagy modulator 1) is a TP53 target gene that modulates autophagy and apoptosis. We previously found that DRAM1 increased autophagy flux by promoting lysosomal acidification and protease activation. However, the molecular mechanisms by which DRAM1 regulates apoptosis are not clearly defined. Here we report a novel pathway by which DRAM1 regulates apoptosis involving BAX and lysosomes. A549 or HeLa cells were treated with the mitochondrial complex II inhibitor, 3-nitropropionic acid (3NP), or an anticancer drug, doxorubicin. Changes in the protein and mRNA levels of BAX and DRAM1 and the role of DRAM1 in BAX induction were determined. The interaction between DRAM1 and BAX and its effect on BAX degradation, BAX lysosomal localization, the release of cathepsin B and cytochrome c by BAX and the role of BAX in 3NP- or doxorubicin-induced cell death were studied. The results showed that BAX, a proapoptotic protein, was induced by DRAM1 in a transcription-independent manner. BAX was degraded by autophagy under basal conditions; however, its degradation was inhibited when DRAM1 expression was induced. There was a protein interaction between DRAM1 and BAX and this interaction prolonged the half-life of BAX. Furthermore, upregulated DRAM1 recruited BAX to lysosomes, leading to the release of lysosomal cathepsin B and cleavage of BID (BH3-interacting domain death agonist). BAX mediated the release of mitochondrial cytochrome c, activation of caspase-3 and cell death partially through the lysosome-cathepsin B-tBid pathway. These results indicate that DRAM1 regulates apoptosis by inhibiting BAX degradation. In addition to mitochondria, lysosomes may also be involved in BAX-initiated apoptosis.
MeSH term(s)	Apoptosis ; Autophagy ; BH3 Interacting Domain Death Agonist Protein/metabolism ; Cathepsin B/metabolism ; Cell Line, Tumor ; Cytochromes c/metabolism ; Humans ; Lysosomes/metabolism ; Membrane Proteins/metabolism ; Models, Biological ; Protein Binding ; Protein Transport ; Proteolysis ; Transcription, Genetic ; bcl-2-Associated X Protein/metabolism
Chemical Substances	BH3 Interacting Domain Death Agonist Protein ; DRAM1 protein, human ; Membrane Proteins ; bcl-2-Associated X Protein ; Cytochromes c (9007-43-6) ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2015-01-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/cddis.2014.546
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Article: Geographical origin identification of propolis using GC–MS and electronic nose combined with principal component analysis

Cheng, H / Qin, Z.H / Guo, X.F / Hu, X.S / Wu, J.H

Food research international. 2013 May, v. 51, no. 2

2013

Abstract: Dynamic headspace sampling (DHS) coupled with gas chromatography–mass spectrometry and olfactometry (GC–MS–O) analysis have been applied for the determination of the characteristic volatile profile of propolis with the aim to differentiate the propolis ... ...

Abstract	Dynamic headspace sampling (DHS) coupled with gas chromatography–mass spectrometry and olfactometry (GC–MS–O) analysis have been applied for the determination of the characteristic volatile profile of propolis with the aim to differentiate the propolis from different regions of China. Acids, esters, alcohols, terpenes, aromatics represented the most abundant compounds in propolis among the ninety-nine volatile components identified by comparing with mass spectra and retention indices (RI) or from literature. In addition, principal component analysis (PCA) based on the data of DHS–GC–MS and electronic nose was used to study and obtain the important volatile compounds contributed to the differentiation of the propolis samples from different regions. Furthermore, a total of 28 odor-active compounds were detected and characterized by the trained panel of judges in the sniffing port of GC–O by using detection frequency analysis (DFA). In conclusion, GC–MS analysis and electronic nose combining with PCA could successfully distinguish the twelve representative raw propolis samples from 4 different geographical regions of China. The samples have been assigned to four large groups in accordance with their vegetal sampling location and we also have observed the volatile compounds resulting in the odor differentiation.
Keywords	acids ; alcohols ; aromatic compounds ; electronic nose ; esters ; gas chromatography ; headspace analysis ; mass spectrometry ; odor compounds ; odors ; olfactometry ; principal component analysis ; propolis ; provenance ; terpenoids ; China
Language	English
Dates of publication	2013-05
Size	p. 813-822.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1111695-x
ISSN	0963-9969
ISSN	0963-9969
DOI	10.1016/j.foodres.2013.01.053
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Article: [Features of peripheral nerve injuries in workers exposed to vibration: an analysis of 197 cases].

Situ, J / Lin, C M / Qin, Z H / Zhu, D X / Lin, H / Zhang, F F / Zhang, J J

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

2016 Volume 34, Issue 12, Page(s) 931–934

Abstract: Objective: ...

Abstract	Objective:
Language	Chinese
Publishing date	2016-12-20
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1001-9391
ISSN	1001-9391
DOI	10.3760/cma.j.issn.1001-9391.2016.12.012
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Article ; Online: Identification of the CAD gene from Eucalyptus urophylla GLU4 and its functional analysis in transgenic tobacco.

Chen, B W / Xiao, Y F / Li, J J / Liu, H L / Qin, Z H / Gai, Y / Jiang, X N

Genetics and molecular research : GMR

2016 Volume 15, Issue 4

Abstract: Cinnamyl alcohol dehydrogenase (CAD) catalyzes the final step in lignin biosynthesis. The genus Eucalyptus belongs to the family Myrtaceae, which is the main cultivated species in China. Eucalyptus urophylla GLU4 (GLU4) is widely grown in Guangxi. It is ... ...

Abstract	Cinnamyl alcohol dehydrogenase (CAD) catalyzes the final step in lignin biosynthesis. The genus Eucalyptus belongs to the family Myrtaceae, which is the main cultivated species in China. Eucalyptus urophylla GLU4 (GLU4) is widely grown in Guangxi. It is preferred for pulping because of its excellent cellulose content and fiber length. Based on GLU4 and CAD gene expression, a Eucalyptus variety low in lignin content should be obtained using transgenic technology, which could reduce the cost of pulp and improve the pulping rate, and have favorable prospects for application. However, the role and function of CAD in GLU4 is still unclear. In the present study, EuCAD was cloned from GLU4 and identified using bioinformatic tools. Subsequently, in order to evaluate its impact on lignin synthesis, a full-length EuCAD RNAi vector was constructed, and transgenic tobacco was obtained via Agrobacterium-mediated transformation. A significant decrease in CAD expression and lignin content in transgenic tobacco demonstrated a key role for EuCAD in lignin biosynthesis and established a regulatory role for RNAi. In our study, the direct molecular basis of EuCAD expression was determined, and the potential regulatory effects of this RNAi vector on lignin biosynthesis in E. urophylla GLU4 were demonstrated. Our results provide a theoretical basis for the study of lignin biosynthesis in Eucalyptus.
MeSH term(s)	Alcohol Oxidoreductases/genetics ; Alcohol Oxidoreductases/metabolism ; China ; Cloning, Molecular/methods ; Eucalyptus/enzymology ; Eucalyptus/genetics ; Gene Expression Regulation, Plant ; Lignin/biosynthesis ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified/growth & development ; Nicotiana/genetics ; Nicotiana/growth & development
Chemical Substances	Plant Proteins ; Lignin (9005-53-2) ; Alcohol Oxidoreductases (EC 1.1.-) ; cinnamyl alcohol dehydrogenase (EC 1.1.1.195)
Language	English
Publishing date	2016-12-02
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/gmr15049062
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: MODIS-based vegetation growth of temperate grassland and its correlation with meteorological factors in northern China

Jin, Y.X / Xu, B / Yang, X.C / Qin, Z.H / Wu, Q / Zhao, F / Chen, S / Li, J.Y / Ma, H.L

International journal of remote sensing. 2015 Oct. 18, v. 36, no. 19-20

2015

Abstract: Vegetation dynamics, particularly vegetation growth, are often used as indicators of potential grassland degradation. Grassland vegetation growth can be monitored using remotely sensed data, which has rapid and broad coverage. Grassland ecosystems are an ...

Abstract	Vegetation dynamics, particularly vegetation growth, are often used as indicators of potential grassland degradation. Grassland vegetation growth can be monitored using remotely sensed data, which has rapid and broad coverage. Grassland ecosystems are an important component of the regional landscape. In this study, we developed an applicable method for monitoring grassland growth. The dynamic variation in the grassland was analysed using Moderate Resolution Imaging Spectroradiometer (MODIS) data. The normalized difference vegetation index (NDVI) was calculated from 2001 to 2010 during the grassland growing season. To evaluate the grassland growth, the use of the growth index (GI) was proposed. According to the GI values, five growth grades were identified: worse, slightly worse, balanced, slightly better, and better. We explored the spatial-temporal variation of grassland growth and the relationship between grassland growth and meteorological factors (i.e. precipitation and temperature factors). Our results indicated that, compared with the multi-year average, the spatial-temporal variation of grassland growth was significantly different between 2001 and 2010. The vegetation growth was worse in 2009 compared with the multi-year average. A GI of ‘worse’ accounted for 66.73% of the area. The vegetation growth in 2003 was the best of the years between 2001 and 2010, and a better GI accounted for 58.08% of the area in 2003. The GI from 2004 to 2008 exhibited significant fluctuations. The correlation coefficient between the GI and precipitation or temperature indicated that meteorological factors likely affected the inter-annual variations in the grassland growth. The peak of the grassland growth season was positively correlated with the spatial patterns of precipitation and negatively correlated with those of temperature. Precipitation during the growing season was the main influence in the arid and semi-arid regions. Monitoring grassland growth using remote sensing can accurately reveal the grassland growth status at the macro-scale in a timely manner. This research proposes an effective method for monitoring grassland growth and provides a reference for the sustainable development of grassland ecosystems.
Keywords	correlation ; ecosystems ; grasslands ; growing season ; landscapes ; meteorological parameters ; moderate resolution imaging spectroradiometer ; monitoring ; normalized difference vegetation index ; remote sensing ; semiarid zones ; sustainable development ; temperature
Language	English
Dates of publication	2015-1018
Size	p. 5123-5136.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1497529-4
ISSN	1366-5901 ; 0143-1161
ISSN (online)	1366-5901
ISSN	0143-1161
DOI	10.1080/01431161.2015.1079346
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Article ; Online: Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease.

Wu, F / Xu, H-D / Guan, J-J / Hou, Y-S / Gu, J-H / Zhen, X-C / Qin, Z-H

Neuroscience

2014 Volume 284, Page(s) 900–911

Abstract: Background: Rotenone is an environmental neurotoxin that induces accumulation of α-synuclein and degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc), but the molecular mechanisms are not fully understood. We investigated ... ...

Abstract	Background: Rotenone is an environmental neurotoxin that induces accumulation of α-synuclein and degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc), but the molecular mechanisms are not fully understood. We investigated whether rotenone induced impairment of autophagic flux and lysosomal functions. Methods: Autophagy flux, accumulation of α-synuclein, lysosomal membrane integrity and neurodegeneration were assessed in the rotenone-treated rat model and PC12 cells, and the effects of the autophagy inducer trehalose on rotenone's cytotoxicity were also studied. Results: Rotenone administration significantly reduced motor activity and caused a loss of tyrosine hydroxylase in SNpc of Lewis rats. The degeneration of nigral dopaminergic neurons was accompanied by the deposition of α-synuclein aggregates, autophagosomes and redistribution of cathepsin D from lysosomes to the cytosol. In cultured PC12 cells, rotenone also induced increases in protein levels of α-synuclein, microtubule-associated protein 1 light chain 3-II, Beclin 1, and p62. Rotenone increased lysosomal membrane permeability as evidenced by leakage of N-acetyl-beta-d-glucosaminidase and cathepsin D, the effects were blocked by reactive oxygen species scavenger tiron. Autophagy inducer trehalose enhanced the nuclear translocation of transcription factor EB, accelerated the clearance of autophagosomes and α-synuclein and attenuated rotenone-induced cell death of PC12 cells. Meanwhile, administration of trehalose to rats in drinking water (2%) decreased rotenone-induced dopaminergic neurons loss in SNpc. Conclusions: These studies indicate that the lysosomal dysfunction contributes to rotenone's neurotoxicity and restoration of lysosomal function could be a new therapeutic strategy for Parkinson's disease.
MeSH term(s)	Animals ; Antiparkinson Agents/pharmacology ; Autophagy/drug effects ; Autophagy/physiology ; Lysosomes/drug effects ; Lysosomes/metabolism ; Male ; PC12 Cells ; Parkinsonian Disorders/drug therapy ; Parkinsonian Disorders/physiopathology ; Pars Compacta/drug effects ; Pars Compacta/physiopathology ; Random Allocation ; Rats ; Rats, Inbred Lew ; Rotenone/toxicity ; Trehalose/pharmacology ; Tyrosine 3-Monooxygenase/metabolism ; alpha-Synuclein/metabolism
Chemical Substances	Antiparkinson Agents ; Snca protein, rat ; alpha-Synuclein ; Rotenone (03L9OT429T) ; Trehalose (B8WCK70T7I) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2)
Language	English
Publishing date	2014-11-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2014.11.004
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