Result 1 - 10 of total 216
(Advances in experimental medicine and biology)
2020
| Author's details | Zheng-Hong Qin (ed.) |
|---|---|
| Series title | Advances in experimental medicine and biology |
| Language | English |
| Dates of publication | 2020-9999 |
| Size | Illustrationen |
| Publisher | Springer |
| Publishing place | Cham |
| Publishing country | China |
| Document type | Book ; Collection (display volumes) |
| HBZ-ID | HT020372344 |
| Database | Catalogue ZB MED Medicine, Health |
(Advances in experimental medicine and biology ; 1206)
2020
| Author's details | Zheng-Hong Qin (ed.) |
|---|---|
| Series title | Advances in experimental medicine and biology ; 1206 Autophagy ; Biology and diseases |
| Collection | Autophagy ; Biology and diseases |
| Language | English |
| Size | xv, 727 Seiten, Illustrationen |
| Publishing country | China |
| Document type | Book |
| HBZ-ID | HT020372356 |
| ISBN | 978-981-15-0601-7 ; 9789811506024 ; 981-15-0601-9 ; 9811506027 |
| Database | Catalogue ZB MED Medicine, Health |
| Shelf mark | Loan status | Location |
|---|---|---|
| Zs A 3192 -1206- | not available for loan | Zeitschriften-Lesesaal |
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2023 Volume 40, Issue 3, Page(s) 363–382
Abstract: Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic components are engulfed, autophagy can be divided into ... ...
| Abstract | Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes, where proteins, lipids, and organelles are degraded and recycled. According to the way the cytoplasmic components are engulfed, autophagy can be divided into macroautophagy, microautophagy, and chaperone-mediated autophagy. Recently, many studies have found that autophagy plays an important role in neurological diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, neuronal excitotoxicity, and cerebral ischemia. Autophagy maintains cell homeostasis in the nervous system via degradation of misfolded proteins, elimination of damaged organelles, and regulation of apoptosis and inflammation. AMPK-mTOR, Beclin 1, TP53, endoplasmic reticulum stress, and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological diseases. Here, we discuss the role, functions, and signal pathways of autophagy in neurological diseases, which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies. |
|---|---|
| MeSH term(s) | Humans ; Autophagy/physiology ; Nervous System Diseases ; Parkinson Disease/metabolism ; Alzheimer Disease ; Huntington Disease |
| Language | English |
| Publishing date | 2023-10-19 |
| Publishing country | Singapore |
| Document type | Journal Article ; Review |
| ZDB-ID | 2419741-5 |
| ISSN | 1995-8218 ; 1673-7067 |
| ISSN (online) | 1995-8218 |
| ISSN | 1673-7067 |
| DOI | 10.1007/s12264-023-01120-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6734: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 43, Issue 8, Page(s) 1889–1904
Abstract: The nicotinamide adenine dinucleotide ( ... ...
| Abstract | The nicotinamide adenine dinucleotide (NAD |
|---|---|
| MeSH term(s) | Energy Metabolism ; Humans ; NAD/metabolism ; NADP ; Oxidation-Reduction ; Phosphates |
| Chemical Substances | Phosphates ; NAD (0U46U6E8UK) ; NADP (53-59-8) |
| Language | English |
| Publishing date | 2022-01-11 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 1360774-1 |
| ISSN | 1745-7254 ; 0253-9756 ; 1671-4083 |
| ISSN (online) | 1745-7254 |
| ISSN | 0253-9756 ; 1671-4083 |
| DOI | 10.1038/s41401-021-00838-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1904: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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Aging and disease
2021 Volume 12, Issue 8, Page(s) 1879–1897
Abstract: Coenzyme I (nicotinamide adenine dinucleotide, ... ...
| Abstract | Coenzyme I (nicotinamide adenine dinucleotide, NAD |
|---|---|
| Language | English |
| Publishing date | 2021-12-01 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2152-5250 |
| ISSN | 2152-5250 |
| DOI | 10.14336/AD.2021.0523 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Frontiers in cell and developmental biology
2022 Volume 10, Page(s) 1058861
| Language | English |
|---|---|
| Publishing date | 2022-10-24 |
| Publishing country | Switzerland |
| Document type | Editorial |
| ZDB-ID | 2737824-X |
| ISSN | 2296-634X |
| ISSN | 2296-634X |
| DOI | 10.3389/fcell.2022.1058861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advances in experimental medicine and biology
2019 Volume 1206, Page(s) 509–525
Abstract: Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. ... ...
| Abstract | Autophagy is a conserved process that degrades intracellular components through lysosomes, thereby maintaining energy homeostasis and renewal of organelles. Mounting evidence indicates that autophagy plays a key role in aging and aging-related diseases. Enhanced autophagy can delay aging and prolong life span. The absence of autophagy leads to the accumulation of mutant and misfolded proteins in the cell, which is the basis for the emergence and development of neurodegenerative diseases and other aging-related diseases. It will be of importance to develop approaches to extend the lifespan and improve the health of elderly individuals through the modulation of autophagy. |
|---|---|
| MeSH term(s) | Aging ; Autophagy ; Homeostasis ; Humans ; Longevity ; Lysosomes ; Neurodegenerative Diseases/physiopathology |
| Language | English |
| Publishing date | 2019-11-27 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-15-0602-4_24 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advances in experimental medicine and biology
2019 Volume 1206, Page(s) 3–37
Abstract: Autophagy is an evolutionarily conserved process in which eukaryotic bilayer membrane vesicles enclose intracellular contents and transport them to lysosomes for degradation. In the 1990s, Ohsumi et al. identified multiple autophagy-related genes in a ... ...
| Abstract | Autophagy is an evolutionarily conserved process in which eukaryotic bilayer membrane vesicles enclose intracellular contents and transport them to lysosomes for degradation. In the 1990s, Ohsumi et al. identified multiple autophagy-related genes in a yeast model. Functional homologues of almost all yeast autophagy-related genes were found in higher eukaryotes. In 2003, Klionsky et al. named these genes the Atg genes and studied the interactions between the proteins they encoded and their functions in autophagy. In April 2005, a new journal, Autophagy, was published that was edited by Klionsky. The number of autophagy research papers indexed by PubMed has increased each year. In 2016, Yoshinori Ohsumi won the Nobel Prize in Medicine or Physiology for his discovery of the autophagy mechanism. Autophagy has thus become a hot research area, which involves biology, medicine, botany and microbiology. Many researchers are actively exploring the relationship between non-selective and selective autophagy and various pathophysiological states in humans, and are studying the molecular mechanisms underlying autophagy regulation in various biological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, immune responses, development and ageing. This chapter focuses on the history and current status of autophagy research and highlights the milestones that contributed to the development of the field. |
|---|---|
| MeSH term(s) | Autophagy ; History, 20th Century ; History, 21st Century ; Humans ; Lysosomes ; Neoplasms ; Nobel Prize ; Research/history ; Research/trends ; Saccharomyces cerevisiae |
| Language | English |
| Publishing date | 2019-11-27 |
| Publishing country | United States |
| Document type | Historical Article ; Journal Article |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-15-0602-4_1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Advances in experimental medicine and biology
2021 Volume 1208, Page(s) 265–287
Abstract: Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to ... ...
| Abstract | Biomarkers (short for biological markers) are biological measures of a biological state. Autophagy biomarkers play an important role as an indicator of autophagy during normal physiological processes, pathogenic processes or pharmacological responses to drugs. In this chapter, some biomarkers of different types of autophagy, including macroautophagy, selective autophagy, chaperone-mediated autophagy, and microautophagy, as well as the lysosomal biomarkers are introduced. The described biomarkers may be used to detect the level of autophagy in cells or tissues in a dynamic, real-time, and quantitative manner. However, each biomarker has its specific significance and limitation. Therefore, the analysis of the autophagy level in cells or tissues through the detection of autophagy biomarkers should be carried out carefully. |
|---|---|
| MeSH term(s) | Autophagy ; Biomarkers ; Lysosomes ; Microautophagy |
| Chemical Substances | Biomarkers |
| Language | English |
| Publishing date | 2021-07-14 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-16-2830-6_12 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Advances in experimental medicine and biology
2019 Volume 1206, Page(s) 109–126
Abstract: Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, ... ...
| Abstract | Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting protein. Subsequent studies have demonstrated that this landmark protein is essential for autophagy. By investigating the interaction between Bcl-2 and Beclin 1, key molecular mechanisms of mammalian autophagy regulation have been discovered. In this chapter, we will first review the discovery of Beclin 1 and then focus on the mechanisms of Bcl-2 and Beclin 1 regulation and their effect on autophagy regulation. Finally, we summarize the evidence related to the interaction of Bcl-2 and Beclin 1 and the involvement of these proteins in human diseases such as cancers, neurodegenerative diseases and infectious diseases. |
|---|---|
| MeSH term(s) | Animals ; Apoptosis Regulatory Proteins/metabolism ; Autophagy/genetics ; Beclin-1/metabolism ; Gene Expression Regulation ; Humans ; Proto-Oncogene Proteins c-bcl-2/metabolism |
| Chemical Substances | Apoptosis Regulatory Proteins ; Beclin-1 ; Proto-Oncogene Proteins c-bcl-2 |
| Language | English |
| Publishing date | 2019-11-27 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ISSN | 2214-8019 ; 0065-2598 |
| ISSN (online) | 2214-8019 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-981-15-0602-4_5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.