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Article ; Online: Tumor neoantigens and tumor immunotherapies.

Jiani, Wang / Qin, Tan / Jie, Ma

Aging medicine (Milton (N.S.W))

2024 Volume 7, Issue 2, Page(s) 224–230

Abstract: As a high-risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with ... ...

Abstract	As a high-risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer. Neoantigens, a unique class of tumor-specific antigens generated by non-synonymous mutations, are garnering increasing attention as targets for immunotherapy in clinical applications. Newly developed technologies, such as second-generation gene sequencing and mass spectrometry, have provided powerful technical support for the identification and prediction of neoantigens. At present, neoantigen-based immunotherapy has been extensively applied in clinical trials and has demonstrated both safety and efficacy, marking the beginning of a new era for cancer immunotherapy. This article reviews the conception, classification, inducers, and screening process of tumor neoantigens, as well as the application prospects and combination therapy strategies of neoantigen-based cancer immunotherapy.
Language	English
Publishing date	2024-04-12
Publishing country	Australia
Document type	Journal Article ; Review
ISSN	2475-0360
ISSN (online)	2475-0360
DOI	10.1002/agm2.12295
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus

Shan Huang / Ya-Qin Tan / Gang Zhou

Biomedicines, Vol 11, Iss 955, p

2023 Volume 955

Abstract: Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory disease. Interferon (IFN)-γ has been suggested to be vital for the OLP immune responses. A prominent innate-like lymphocyte subset, γδ T cells, span the innate–adaptive continuum and ... ...

Abstract	Oral lichen planus (OLP) is a chronic T cell-mediated inflammatory disease. Interferon (IFN)-γ has been suggested to be vital for the OLP immune responses. A prominent innate-like lymphocyte subset, γδ T cells, span the innate–adaptive continuum and exert immune effector functions by producing a wide spectrum of cytokines, including IFN-γ. The involvement and mechanisms of γδ T cells in the pathogenesis of OLP remain obscure. The expression of γδ T cells in lesion tissues and in the peripheral blood of OLP patients was determined via flow cytometry and immunohistochemistry, respectively. Human leukocyte antigen-DR (HLA-DR), cluster of differentiation (CD) 69, Toll-like receptors (TLRs), natural killer group 2, member D (NKG2D) and IFN-γ were detected in γδ T cells of OLP patients using flow cytometry. Additionally, the involvement of stimulator of the interferon genes (STING)-TANK-binding kinase 1 (TBK1) pathway in γδ T cells was evaluated by multi-color immunofluorescence. Western blotting was employed to investigate the regulatory mechanisms of γδ T cells in OLP. γδ T cells were significantly upregulated in the lesion tissues, whereas their peripheral counterparts were downregulated in OLP patients. Meanwhile, increased frequencies of local CD69 + and NKG2D + γδ T cells and peripheral HLA-DR + and TLR4 + γδ T cells were detected in OLP. Furthermore, significant co-localization of STING and TBK1 was observed in the γδ T cells of OLP lesions. In addition, enhanced IFN-γ and interleukin (IL)-17A were positively associated with the activated STING-TBK1 pathway and γδ T cells in OLP. Taken together, the upregulated STING-TBK1 pathway in activated γδ T cells might participate in the regulation of immune responses in OLP.
Keywords	oral lichen planus ; γδ T cells ; STING-TBK1 pathway ; interferon-γ ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: BEST1 Positive Monocytes in Circulation

Luyao Zhang / Yiran Wang / Wei Yuan / Changming An / Qin Tan / Jie Ma

Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)

Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes

2023

Abstract: Abstract Head and neck squamous cell carcinomas (HNSCCs) are characterized by an abundance of monocytes and macrophages recruited from the peripheral blood. However, it has not been determined whether these infiltrated cells can be released back into ... ...

Abstract	Abstract Head and neck squamous cell carcinomas (HNSCCs) are characterized by an abundance of monocytes and macrophages recruited from the peripheral blood. However, it has not been determined whether these infiltrated cells can be released back into circulation with a tumor‐associated neobiosignature. This study reports that Bestrophin1 (BEST1), a component protein of Ca2+‐activated Cl− channels (CaCCs), is highly expressed on classical monocytes in the peripheral blood of HNSCC patients. This is due to monocyte education by tumor cells, in which tumoral VEGF‐A upregulates BEST1 expression on monocytes through the MEK‐ERK‐ELK1 pathway. This leads to improved secretion of IL‐6 and IL‐8, which promotes tumor cell proliferation. This work also finds that BEST1 facilitates the motility of monocytes, contributing to the migration of these cells back into circulation. These results suggest that the expression of BEST1 on peripheral monocytes may be a potential tool for monitoring tumor progression, and opens up the possibility of searching for cancer biomarkers on monocytes rather than on the tumor or its products.
Keywords	bestrophin1 ; head and neck squamous cell carcinoma ; monocytes ; tumor microenvironment ; VEGF‐A ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surface charge regulation of imidazolium salts/starch/carboxymethyl cellulose ternary polymer blend films for controlling antimicrobial performance and hydrophobicity

Chen, Jing / Qin, Tan / Cheng, Youliang / Fang, Changqing / Zhang, Xiaolan / Chen, Meiju

International Journal of Biological Macromolecules. 2023 Aug., v. 245 p.125519-

2023

Abstract: Starch (SR)/carboxymethyl cellulose (CMC) based antimicrobial films have been widely applied in packaging field. As a high-effect antimicrobial agent, the surface charge of imidazolium salt plays an important effect on antimicrobial performances of ... ...

Abstract	Starch (SR)/carboxymethyl cellulose (CMC) based antimicrobial films have been widely applied in packaging field. As a high-effect antimicrobial agent, the surface charge of imidazolium salt plays an important effect on antimicrobial performances of starch/carboxymethyl cellulose. Here in, the surface charge of dodecyl imidazolium bromide salt was regulated via thiol-ene reaction. Furthermore, antibacterial films were prepared by mixing imidazolium salts with SR/CMC via solution casting method. Under the optimized ratio of CMC to SR, the antibacterial activity for as-prepared ternary polymer blend films was enhanced with the increasing of surface charge of imidazolium salt. The sample of ADSC-01 film with highest surface charge showed best antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.20 cm and 3.00 cm, respectively. In addition, hydrophobic property exhibited similar positive correlation with the surface charge. Therefore, this work provides a new route to regulate the antibacterial activity of bio-based ternary polymer blend films in the packaging.
Keywords	Escherichia coli ; anti-infective agents ; antibacterial properties ; carboxymethylcellulose ; hydrophobicity ; imidazoles ; polymers ; starch ; Imidazolium salts ; Surface charge ; Ternary polymer blend films
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125519
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Article ; Online: Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell.

Qin, Tan / Wang, Yu / Nie, Jing / Yu, Lushan / Zeng, Su

Biochimica et biophysica acta. General subjects

2022 Volume 1866, Issue 11, Page(s) 130224

Abstract: Background: Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction ... ...

Abstract	Background: Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction with HBV preS1 peptide. Methods: Recombinant NTCPs were expressed in Sf9 host cell using baculoviruses. Function of recombinant NTCP was verified by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method. A quantitative fluorescence resonance energy transfer (FRET) method was established to analyze the interaction between NTCP wild type (WT) and mutants. Co-immunoprecipitation (Co-IP) was used to test the interaction between NTCP variants. Results: Sub-cellular location of recombinant NTCPs varies with the modification of NTCP. Bands of monomer, dimer and oligomers were shown in gel analysis of NTCP. Significant FRET was observed between cyan florescence protein (CFP) tagged NTCP and yellow florescence protein (YFP) tagged NTCP. FRET efficiency between CFP- and YFP-NTCP S267F mutants was lower than WT. Co-IP results showed that S267F interacts with WT NTCP when co-expressed in cell. Conclusion: Dimer is the predominant form of NTCP expressed in Sf9 when solubilized with detergent. FRET and Co-IP analysis support that NTCP forms oligomers in Sf9 cell. General significance: Our results showed that NTCP formed oligomers in Sf9 cell. Meanwhile the FRET analysis of NTCP variants further elucidated the molecular mechanism of NTCP oligomerization.
MeSH term(s)	Animals ; Chromatography, Liquid ; Hepatitis B virus ; Insecta ; Organic Anion Transporters, Sodium-Dependent ; Sf9 Cells ; Symporters ; Tandem Mass Spectrometry
Chemical Substances	Organic Anion Transporters, Sodium-Dependent ; Symporters
Language	English
Publishing date	2022-08-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2022.130224
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Article ; Online: Surface charge regulation of imidazolium salts/starch/carboxymethyl cellulose ternary polymer blend films for controlling antimicrobial performance and hydrophobicity.

Chen, Jing / Qin, Tan / Cheng, Youliang / Fang, Changqing / Zhang, Xiaolan / Chen, Meiju

International journal of biological macromolecules

2023 Volume 245, Page(s) 125519

Abstract	Starch (SR)/carboxymethyl cellulose (CMC) based antimicrobial films have been widely applied in packaging field. As a high-effect antimicrobial agent, the surface charge of imidazolium salt plays an important effect on antimicrobial performances of starch/carboxymethyl cellulose. Here in, the surface charge of dodecyl imidazolium bromide salt was regulated via thiol-ene reaction. Furthermore, antibacterial films were prepared by mixing imidazolium salts with SR/CMC via solution casting method. Under the optimized ratio of CMC to SR, the antibacterial activity for as-prepared ternary polymer blend films was enhanced with the increasing of surface charge of imidazolium salt. The sample of ADSC-01 film with highest surface charge showed best antibacterial properties for E. coli and S. aureus with the inhibition zone of 3.20 cm and 3.00 cm, respectively. In addition, hydrophobic property exhibited similar positive correlation with the surface charge. Therefore, this work provides a new route to regulate the antibacterial activity of bio-based ternary polymer blend films in the packaging.
MeSH term(s)	Carboxymethylcellulose Sodium/chemistry ; Salts/pharmacology ; Polymers/pharmacology ; Escherichia coli ; Starch/pharmacology ; Staphylococcus aureus ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Carboxymethylcellulose Sodium (K679OBS311) ; Salts ; Polymers ; Starch (9005-25-8) ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125519
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Article ; Online: Bone morphogenetic proteins 2, 6, and 9 differentially regulate the osteogenic differentiation of immortalized preodontoblasts

Yuying Cao / Qin Tan / Jing Li / Jinhua Wang

Brazilian Journal of Medical and Biological Research, Vol 53, Iss

2020 Volume 9

Abstract: Our study attempted to compare the efficacies of bone morphogenetic protein (BMP) 2, 6, and 9 in inducing osteogenic differentiation of preodontoblasts (PDBs). We immortalized PDBs by introducing a reversible SV40 T antigen-based immortalization system. ... ...

Abstract	Our study attempted to compare the efficacies of bone morphogenetic protein (BMP) 2, 6, and 9 in inducing osteogenic differentiation of preodontoblasts (PDBs). We immortalized PDBs by introducing a reversible SV40 T antigen-based immortalization system. Cell proliferation capability was examined by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay. The effects of BMP2, 6, and 9 on the osteogenic differentiation of immortalized preodontoblasts (iPDBs) were measured by alkaline phosphatase (ALP) activity assays and alizarin red S staining. The expression of osteogenic markers was evaluated by semiquantitative real-time polymerase chain reaction analysis. To assess ectopic bone formation, rat-derived iPDBs were transfected in culture with adenoviral vectors designated Ad-BMP2, 6, and 9 and subcutaneously or intramuscularly injected into mice. Several BMPs retained endogenous expression in PDBs and regulated the mRNA expression of mineralized tissue-associated proteins. ALP activity and mineralized nodule formation were significantly increased in the Ad-BMP9-transfected group relative to the control group. In addition, the most significant hard tissue formation was in this group. The results indicated that BMP signaling was involved in the osteogenic differentiation of iPDBs. BMP9 could be an efficacious accelerant of the osteogenic differentiation of iPDBs.
Keywords	Preodontoblast ; Immortalized preodontoblast ; Bone morphogenetic proteins ; BMP2/6/9 ; Osteogenic differentiation ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CXC Chemokine Signaling in Progression of Epithelial Ovarian Cancer

Xinxin Huang / Juncheng Hao / Yan Qin Tan / Tao Zhu / Vijay Pandey / Peter E. Lobie

International Journal of Molecular Sciences, Vol 23, Iss 2642, p

Theranostic Perspectives

2022 Volume 2642

Abstract: Patients with epithelial ovarian cancer (EOC) are often diagnosed at an advanced stage due to nonspecific symptoms and ineffective screening approaches. Although chemotherapy has been available and widely used for the treatment of advanced EOC, the ... ...

Abstract	Patients with epithelial ovarian cancer (EOC) are often diagnosed at an advanced stage due to nonspecific symptoms and ineffective screening approaches. Although chemotherapy has been available and widely used for the treatment of advanced EOC, the overall prognosis remains dismal. As part of the intrinsic defense mechanisms against cancer development and progression, immune cells are recruited into the tumor microenvironment (TME), and this process is directed by the interactions between different chemokines and their receptors. In this review, the functional significance of CXC chemokine ligands/chemokine receptors (CXCL/CXCR) and their roles in modulating EOC progression are summarized. The status and prospects of CXCR/CXCL-based theranostic strategies in EOC management are also discussed.
Keywords	ovarian cancer ; CXC chemokine ligand (CXCL) ; CXC chemokine receptor (CXCR) ; tumor microenvironment (TME) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Examining spousal and family support as predictors of long-term weight loss and remission of type 2 diabetes following bariatric surgery in Singapore

Jean C J Liu / Kwang Wei Tham / Edina Yi-Qin Tan / Phong Ching Lee / Sonali Ganguly / Chin Hong Lim

BMJ Open, Vol 13, Iss

a retrospective cohort study

2023 Volume 5

Abstract: Objectives Postoperative outcomes vary considerably across bariatric patients and may be related to psychosocial factors. In this study, we examined whether a patient’s family support predicts postsurgical weight loss and the remission of type 2 diabetes ...

Abstract	Objectives Postoperative outcomes vary considerably across bariatric patients and may be related to psychosocial factors. In this study, we examined whether a patient’s family support predicts postsurgical weight loss and the remission of type 2 diabetes mellitus (T2DM).Design Retrospective cohort study in Singapore.Setting Participants were recruited from a public hospital in Singapore.Participants Between 2008 and 2018, 359 patients completed a presurgical questionnaire before undergoing gastric bypass or sleeve gastrectomy.Outcome measures As part of the questionnaire, patients described their family support in terms of structure (marital status, number of family members in the household) and function (marriage satisfaction, family emotional support, family practical support). Linear mixed-effects and Cox proportional-hazard models were used to examine whether these family support variables predicted percent total weight loss or T2DM remission up to 5 years postsurgery. T2DM remission was defined as glycated haemoglobin (HbA1c) <6.0% without medications.Results Participants had a mean preoperative body mass index of 42.6±7.7 kg/m2 and HbA1c (%) of 6.82±1.67. Marital satisfaction was found to be a significant predictor of postsurgical weight trajectories. Namely, patients who reported higher marital satisfaction were more likely to sustain weight loss than patients who reported lower marital satisfaction (β=0.92, SE=0.37, p=0.02). Family support did not significantly predict T2DM remission.Conclusions Given the link between marital support and long-term weight outcomes, providers could consider asking patients about their spousal relationships during presurgical counselling.Trial registration number NCT04303611.
Keywords	Medicine ; R
Subject code	616
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Oligomerization of the HBV/HDV functional receptor NTCP expressed in Sf9 insect cell

Qin, Tan / Wang, Yu / Nie, Jing / Yu, Lushan / Zeng, Su

Biochimica et biophysica acta. 2022 Nov., v. 1866, no. 11

2022

Abstract: Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction with HBV preS1 ...

Abstract	Sodium taurocholate co-transportering polypeptide (NTCP, SLC10A1) is a vital bile acid transporter and the functional receptor of hepatitis B and D virus. The oligomerization of NTCP is important for the structural study of its interaction with HBV preS1 peptide. Recombinant NTCPs were expressed in Sf9 host cell using baculoviruses. Function of recombinant NTCP was verified by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) method. A quantitative fluorescence resonance energy transfer (FRET) method was established to analyze the interaction between NTCP wild type (WT) and mutants. Co-immunoprecipitation (Co-IP) was used to test the interaction between NTCP variants. Sub-cellular location of recombinant NTCPs varies with the modification of NTCP. Bands of monomer, dimer and oligomers were shown in gel analysis of NTCP. Significant FRET was observed between cyan florescence protein (CFP) tagged NTCP and yellow florescence protein (YFP) tagged NTCP. FRET efficiency between CFP- and YFP-NTCP S267F mutants was lower than WT. Co-IP results showed that S267F interacts with WT NTCP when co-expressed in cell. Dimer is the predominant form of NTCP expressed in Sf9 when solubilized with detergent. FRET and Co-IP analysis support that NTCP forms oligomers in Sf9 cell. Our results showed that NTCP formed oligomers in Sf9 cell. Meanwhile the FRET analysis of NTCP variants further elucidated the molecular mechanism of NTCP oligomerization.
Keywords	Baculoviridae ; detergents ; energy transfer ; fluorescence ; gels ; hepatitis B ; insects ; liquid chromatography ; oligomerization ; polypeptides ; precipitin tests ; solubilization ; taurocholic acid ; viruses
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	840755-1
ISSN	0304-4165
ISSN	0304-4165
DOI	10.1016/j.bbagen.2022.130224
Database	NAL-Catalogue (AGRICOLA)

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