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Article ; Online: Evaluation of retinal microvasculature in exotropia with abnormal binocular vision by optical coherence tomography angiography.

Chen, Chun-Wen / Qin-Zhu / Ma, Chun-Hui / Yao, Jing-Yan

2023 Volume 23, Issue 1, Page(s) 152

Abstract: Background: To explore the retinal microvasculature in large-angle concomitant exotropia patients with abnormal binocular vision using optical coherence tomography angiography (OCTA) analysis.: Methods: OCTA images of 52 healthy and 100 strabismic ... ...

Abstract	Background: To explore the retinal microvasculature in large-angle concomitant exotropia patients with abnormal binocular vision using optical coherence tomography angiography (OCTA) analysis. Methods: OCTA images of 52 healthy and 100 strabismic eyes were analyzed to quantify the retinal thickness (RT), superficial capillary plexus (SCP), deep capillary plexus (DCP), and foveal avascular zone (FAZ). Paired t-tests were performed to compare differences between the two groups, the dominant eye and the deviated eye in the exotropia group, respectively. A p-value < 0.01 was considered significant. Results: The mean angle of deviation was 79.38 [± 25.64] (prism diopters, PD). There were significant differences in the DCP in deviated eyes between the exotropia group and the control group (fovea: p = 0.007; temporal: p = 0.014; nasal: p = 0.028; inferior: p = 0.013). The temporal SCP in the exotropia group was significantly higher than in the control group in deviated eyes (p = 0.020). No significant difference was found between dominant eyes and strabismic eyes (p > 0.01). Conclusions: The study showed that OCTA revealed subnormal DCP in patients with large-angle exotropia and abnormal binocularity which may be related to retinal suppression. Changes in the macular microvasculature may provide valuable insights into the development of strabismus. Further studies are needed to determine the clinical relevance of this finding. Trial registration: This trial is registered as ChiCTR2100052577 at www.Chictr.org.cn .
MeSH term(s)	Humans ; Exotropia ; Fluorescein Angiography/methods ; Microvessels ; Retinal Vessels ; Tomography, Optical Coherence/methods ; Vision Disorders ; Vision, Binocular
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-02900-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New Insights into Mechanisms Traditional Chinese Medicine for Allergic Rhinitis by Regulating Inflammatory and Oxidative Stress Pathways.

Qin, Zhu / Xie, Liangzhen / Li, Wentao / Wang, Chao / Li, Yan

Journal of asthma and allergy

2024 Volume 17, Page(s) 97–112

Abstract: Allergy rhinitis (AR) is becoming more common and has serious medical and societal consequences. Sneezing, paroxysmal nasal blockage, nasal itching, mucosal edema, coughing, and rhinorrhea are symptoms of this type I allergic immunological illness. ... ...

Abstract	Allergy rhinitis (AR) is becoming more common and has serious medical and societal consequences. Sneezing, paroxysmal nasal blockage, nasal itching, mucosal edema, coughing, and rhinorrhea are symptoms of this type I allergic immunological illness. Immunoglobulin E-mediated inflammation is the cause of it. Because AR is prone to recurrent attacks, extended medication therapy may impair its effectiveness. In addition to negatively affecting the patients' physical health, this can also negatively impact their mental health. During AR development, there are inflammatory and oxidative stress responses that are linked to problems in a number of signal transduction pathways. By using the terms "allergic rhinitis", "traditional Chinese medicine", "inflammation", and "oxidative stress", we screened for pertinent research published over the previous five years in databases like PubMed. We saw that NF-KB, TLR, IL-33/ST2, PI3K/AKT, MAPK, and Nrf2 are some of the most important inflammatory and oxidative stress pathways in AR. Studies have revealed that antioxidant and anti-inflammatory therapy reduced the risk of AR and was therapeutic; however, the impact of the therapy varies widely. The Chinese medical system places a high value on traditional Chinese medicine (TCM), which has been there for virtually all of China's 5000-year history. By influencing signaling pathways related to inflammation and oxidative stress, Chinese herbal medicine and its constituent compounds have been shown to prevent allergic rhinitis. This review will focus on this evidence and provide references for clinical treatment and scientific research applications.
Language	English
Publishing date	2024-02-19
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S444923
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Article ; Online: The benefits of being smaller

Aichun Xu / Ji Zhang / Qian Li / Zhongqiu Li / Qin Zhu

Avian Research, Vol 14, Iss , Pp 100079- (2023)

Consistent pattern for climate-induced range shift and morphological difference of three falconiforme species

2023

Abstract: Climate exerts a dominant control over the distribution of species. Generally, species migrate to higher elevations to track thermal niches, but variations in morphological traits can result in trait-specific responses to climate change. Here we ... ...

Abstract	Climate exerts a dominant control over the distribution of species. Generally, species migrate to higher elevations to track thermal niches, but variations in morphological traits can result in trait-specific responses to climate change. Here we attempted to explore how three sympatrically distributed raptor species (the Upland Buzzard Buteo hemilasius, UB; the Common Kestrel, also called Eurasian Kestrel Falco tinnunculus, EK; and the Saker Falcon Falco cherrug, SF) would respond to climate change over time, and whether their responses would bias by different morphology. We tested the alternative hypotheses for Allen's rule for UB, EK, and SF in Qinghai Province, China, by modeling their current and future habitat suitability and confirming whether a consistent pattern exists between climate-induced range shifts and morphological differences among species. The extent of the projected distribution range within protected areas was also calculated for each species. We identified the future downward elevation shift for all the species, but with the notable northeastward shifting of the suitable climate space for UB and SF. Climate change would induce range contraction in the future, and the most acute influence is always the result of the pessimistic SSP585 scenario. No obvious pattern in climate-induced range shift was found for EK, for whom the morphological traits were significantly smaller all the time. More seriously, the ratios of highly suitable habitats being protected for our three raptor species were almost at a deficient level (below 1%). This study firstly tested the alternative hypothesis of Allen's rule among raptors in Qinghai Province unprecedently, confirmed the morphological basis for different responses to changing climate across species, and demonstrated the protection deficiency under the current protected area design. We advocate more related studies in the future to verify our findings across more taxa.
Keywords	Allen's rule ; Climate change ; Morphology ; Qinghai Province ; Raptors ; Range contraction ; Zoology ; QL1-991
Subject code	333
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial timing of circulating seasonal influenza A and B viruses in China from 2014 to 2018

Ai-qin Zhu / Zhong-jie Li / Hang-jie Zhang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Major outbreaks of influenza virus occurred in China in 2017–2018. To describe the pattern of influenza circulation and timing of seasonal epidemics, we analyzed data from influenza-like illness (ILI) specimens on surveillance wards of sentinel ... ...

Abstract	Abstract Major outbreaks of influenza virus occurred in China in 2017–2018. To describe the pattern of influenza circulation and timing of seasonal epidemics, we analyzed data from influenza-like illness (ILI) specimens on surveillance wards of sentinel hospitals during 2014–2018. Among 1,890,084 ILI cases, 324,211 (17.2%) tested positive for influenza. Influenza A virus (particularly A/H3N2), which circulates annually, was detected in 62% of cases, compared with influenza B virus in 38% of cases. The detection rate of A/H1N1, A/H3N2, B/Victoria, and B/Yamagata viruses were 3.56%, 7.07%, 2.08%, and 3.45%, respectively. Influenza prevalence was generally stable over the four years analyzed, but obvious outbreaks occurred in 2015–2016 (17.28%) and 2017–2018 (22.67%), with B/Victoria and B/Yamagata contributing to these outbreaks, respectively. In the south, a characteristic peak in infections was detected in the summer (week 23–38), which was not detected in the north. Influenza B was found high frequency in school-age children (5–14 years) with 4.78% of B/Victoria and 6.76% of B/Yamagata. Therefore, the epidemiological characteristics of seasonal influenza were complex in China during 2014–2018, presenting distinctions in region, season, and susceptible population. These findings underline the importance of enhancing year-round influenza surveillance and provide a reference for the timing and variety of influenza vaccination.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Multi-Model Prediction Method for Coal Mine Gas Concentration with Hierarchical Structure

ZhaoZhao Zhang / Qiang Dai / YingQin Zhu

Applied Artificial Intelligence, Vol 36, Iss

2022 Volume 1

Abstract: The low concentration of gas in the gas blending process is influenced by a number of factors and is characterized by some time variation and non-linearity. Therefore, the gas concentration needs to be predicted. This paper proposes a multi-model ... ...

Abstract	The low concentration of gas in the gas blending process is influenced by a number of factors and is characterized by some time variation and non-linearity. Therefore, the gas concentration needs to be predicted. This paper proposes a multi-model forecasting method with a hierarchical structure. First, because the measured gas concentration time-series data contain a lot of noise, the time-series data are decomposed into several independent eigenmode functions by using empirical mode decomposition, adaptively denoising by low-pass filtering, and then using phase space reconstruction technology to obtain a new time-series sample. Then, the training samples are grouped by conditional fuzzy clustering to determine the number of sub-modules. Finally, the maximum membership method is used to select sub-models and sub-sub-models, and then a multi-model time-series prediction model is established. The model can not only select different sub-models to process data in different regions but also can process each data jointly by multiple sub-models in different sub-models. Experiments were carried out on low-concentration measured data extracted from mines. The experimental results show that the proposed prediction model can capture the nonlinear characteristics of gas concentration time series and is superior to other existing prediction models in accuracy.
Keywords	Electronic computers. Computer science ; QA75.5-76.95 ; Cybernetics ; Q300-390
Subject code	006
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sensitivity of sheltered mudflats to wind events

Qin Zhu / Wei Nie / Zhenchang Zhu / Yanpeng Cai / Zhifeng Yang

Frontiers in Earth Science, Vol

2022 Volume 10

Abstract: The impact of waves on the morphological changes of sheltered mudflats is less well studied compared to that on open flats. To investigate the sensitivity of low-energy sheltered mudflats to hydrodynamics such as waves, we carried out in situ ... ...

Abstract	The impact of waves on the morphological changes of sheltered mudflats is less well studied compared to that on open flats. To investigate the sensitivity of low-energy sheltered mudflats to hydrodynamics such as waves, we carried out in situ measurements of bed level, currents, and waves on the middle flat of a sheltered mudflat in a bay in southern China. Two 1-month measurements, March 26–26 April 2021, and July 8–8 August 2021, were performed for repetition. We found that the sheltered system was not as stable as it appeared. The maximum intratidal bed-level variation, ΔZ, was <5 mm in calm conditions. However, wind speeds slightly highly than 3.0 m/s, under which significant wave height was approximately 0.1 m, triggered significant bed-level variation patterns, with ΔZ reaching up to 2 cm. Intratidal bed-level change patterns depend on the relative dominance of waves and currents: low τc (current-induced bed shear stress) and high τw (wave-induced bed shear stress) promote the generation and migration of bed ripples; comparable τc and τw, with medium-to-high values, lead to non-cyclic bed-level change patterns; high τc and high τw result in bed accumulation/degradation superimposed by bed ripple migration. From a long-term perspective, i.e. in the time scale of month to year, sheltered mudflats are stable systems, and their high sensitivity causes short-term significant bed-level variation. The sensitivity and stability of sheltered mudflats must be further investigated to explore the effects of human intervention and global climate change.
Keywords	sheltered mudflat ; bed level change ; bed sensitivity ; wind event ; intratidal highresolution measurements ; Science ; Q
Subject code	551
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities

Pingting Li / Lingling Li / Qin Zhu / Mingfeng Xu

Molecules, Vol 26, Iss 4870, p

2021 Volume 4870

Abstract: Two new abietane diterpenoids ( 1,2 ), along with five known diterpenoids ( 3 – 7 ), were first isolated and purified from the stems of Clerodendrum bracteatum . The structures of the new compounds were established by extensive analysis of mass ... ...

Abstract	Two new abietane diterpenoids ( 1,2 ), along with five known diterpenoids ( 3 – 7 ), were first isolated and purified from the stems of Clerodendrum bracteatum . The structures of the new compounds were established by extensive analysis of mass spectrometric and 1-D, 2-D NMR spectroscopic data. Their antioxidant activities were determined on DPPH radical scavenging and ABTS. The in vitro cytotoxic activities of the compounds were evaluated against the HL-60 and A549 cell lines by the MTT method.
Keywords	Clerodendrum bracteatum ; abietane diterpene ; antioxidant activity ; cytotoxic activity ; Organic chemistry ; QD241-441
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Can Health Disparity Be Eliminated? The Role of Family Doctor Played in Shanghai, China

Jiaoling Huang / Qin Zhu / Jing Guo

International Journal of Environmental Research and Public Health, Vol 17, Iss 5548, p

2020 Volume 5548

Abstract: Background : Globally, the elimination of health disparity is a significant policy target. Primary health care has been implemented as a strategy to achieve this target in China for almost 10 years. This study examined whether family doctor (FD) policy ... ...

Abstract	Background : Globally, the elimination of health disparity is a significant policy target. Primary health care has been implemented as a strategy to achieve this target in China for almost 10 years. This study examined whether family doctor (FD) policy in Shanghai contributed to eliminating health disparity as expected. Methods: System dynamics modeling was performed to construct and simulate a system of health disparity formation (business-as-usual (BAU) scenario, without any interventions), a system with FD intervention (FD scenario), and three other systems with supporting policies (Policy 1/Policy 2/Policy hybrid scenario) from 2013 to 2050. Health disparities were simulated in different scenarios, making it possible to compare the BAU results with those of FD intervention and with other policy interventions. Findings: System dynamics models showed that the FD policy would play a positive role in reducing health disparities in the initial stage, and medical price control—rather than health management—was the dominant mechanism. However, in this model, the health gap was projected to expand again around 2039. The model examined the introduction of two intervention policies, with findings showing that the policy focused on socioeconomic status improvement would be more effective in reducing health disparities, suggesting that socioeconomic status is the fundamental cause of these disparities. Conclusions: The results indicate that health disparities could be optimized, but not eliminated, as long as differences in socioeconomic status persists.
Keywords	health disparity ; family doctor ; system dynamics modeling ; socioeconomic status ; China ; Medicine ; R
Subject code	360
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A cross-sectional study on interference control

Yanfang Peng / Qin Zhu / Biye Wang / Jie Ren

PeerJ, Vol 8, p e

age affects reactive control but not proactive control

2020 Volume 8365

Abstract: Background Working memory updating (WMU), a controlled process to continuously adapt to the changing task demand and environment, is crucial for cognitive executive function. Although previous studies have shown that the elderly were more susceptible to ... ...

Abstract	Background Working memory updating (WMU), a controlled process to continuously adapt to the changing task demand and environment, is crucial for cognitive executive function. Although previous studies have shown that the elderly were more susceptible to cognitive interference than the youngsters, the picture of age-related deterioration of WMU is incomplete due to lack of study on people at their middle ages. Thus, the present study investigated the impact of age on the WMU among adults by a cross-sectional design to verify whether inefficiency interference control accounts for the aging of WMU. Methods In total, 112 healthy adults were recruited for this study; 28 old adults (21 female) ranging from 60 to 78 years of age; 28 middle-age adults (25 female) ranging from 45 to 59 years of age; 28 adults (11 female) ranging from 26 to 44 years of age; and 28 young adults (26 female) ranging from 18 to 25 years of age. Each participant completed a 1-back task. The inverse efficiency score was calculated in various sequences of three trials in a row to quantify the performance of WMU for adults of various ages. Results Inverse efficiency score of both young groups (young adult and adult) were significantly shorter than the old group in both Repeat-Alternate (RA, including □□○ and ○○□) and Alternate-Alternate (AA, including ○□○ and □○□) sequential patterns and they were additionally better than the middle-age group in AA sequential pattern. Conclusion With the increase of difficulty in the task, the difference in reactive interference control between young and middle age was gradually revealed, while the difference between young and old remained to apparent. The degradation of WMU aging may begin from middle-age and presents selective impairment in that only reactive interference control, but not proactive interference control, shows pronounced age-related decline. The preliminary results can inform future studies to further explore the whole lifespan trajectories of cognitive functions.
Keywords	Interference control ; Aging ; Reactive control ; Proactive control ; 1-Back ; Middle age ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	150
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of photosynthetic fluorescence characteristics of several submerged plants in Honghu Lake, China

Yuan-Qin ZHU / Bo-Han JING / Long-Yi YUAN

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, Vol 49, Iss

2021 Volume 2

Abstract: Submerged plants are the pioneer species of eutrophic water remediation, and they are important for maintaining the health of aquatic ecosystem, while light is the main limiting factor for the growth of submerged plants. In this study, we measured the ... ...

Abstract	Submerged plants are the pioneer species of eutrophic water remediation, and they are important for maintaining the health of aquatic ecosystem, while light is the main limiting factor for the growth of submerged plants. In this study, we measured the maximal quantum yields of photosystemⅡ(Fv/Fm) and rapid light curves (RLCs) of five dominant submerged macrophytes in situ by using pulse-amplitude modulated fluorometer (Diving-PAM). Results revealed that P. crispus L. and M. verticillatum L. had the highest Fv/Fm value, all species’ Fv/Fm are less than 0.8. In addition, the variation trends of Fv'/Fm' and Fv/Fm were same. All species showed statistically significant differences in α, while P. crispus L. and M. verticillatum L. showed the highest α value in the five species. And the variation trends of rETRm and Ek were basically the same. It indicated that P. crispus L. and M. verticillatum L., both of which had high photosynthetic efficiency, had excellent ability to withstand hard light. Compared five species, P. crispus L. and M. verticillatum L. had resistance capacity to hard light as well as faster photosynthetic rate, and V. natans (Lour.) Hara had higher resistance capacity to low light. Thus, when submerged plants are used for water restoration, V. natans (Lour.) Hara could be regarded as a pioneer species in eutrophication water restoration. P. crispus L. and M. verticillatum L. will have better effects when used in shallow water areas.
Keywords	Honghu Lake ; submerged macrophytes ; rapid light curve ; quantum yield ; Forestry ; SD1-669.5 ; Agriculture (General) ; S1-972
Subject code	580
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	AcademicPres
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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