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  1. Article ; Online: Hydrophilic interaction liquid chromatography promotes the development of bio-separation and bio-analytical chemistry

    Sheng, Qianying / Liu, Meiyan / Lan, Minbo / Qing, Guangyan

    Trends in Analytical Chemistry. 2023 Aug., v. 165 p.117148-

    2023  

    Abstract: Hydrophilic interaction liquid chromatography (HILIC) has inherent advantages in the separation of hydrophilic or strongly polar substances (e.g., saccharides, glycopeptides, metabolites, etc.) due to strong hydrophilic interactions, which represents an ... ...

    Abstract Hydrophilic interaction liquid chromatography (HILIC) has inherent advantages in the separation of hydrophilic or strongly polar substances (e.g., saccharides, glycopeptides, metabolites, etc.) due to strong hydrophilic interactions, which represents an attractive complementary approach to the mainstreamed reversed phase LC. Significant improvement in sensitivity, analyte coverage, throughput, analysis speed, and resolution of HILIC largely promote the development of bio-separation and bio-analytical chemistry. Based on the theoretical guidance, a lot of functional hydrophilic materials have emerged, what follows is that people are more concerned about their innovations and breakthroughs. Meanwhile, the combination of HILIC with various separation and characterization techniques (such as HILIC MS, multidimensional LC) present high separation efficiency towards complex samples in the fields of proteomics, metabolomics, food, and medicine industry. In this review the latest progress in HILIC in the past five years are summarized in order to provide a reliable and perfect guidance for future research in bio-separation.
    Keywords analytical chemistry ; glycopeptides ; hydrophilic interaction chromatography ; hydrophilicity ; industry ; medicine ; metabolites ; metabolomics ; people ; proteomics ; Hydrophilic interaction ; HILIC materials ; Bio-separation ; Analysis ; Glycoproteomics ; Chromatography
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2023.117148
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  2. Article ; Online: Innovative Chemical Tools to Address Analytical Challenges of Protein Phosphorylation and Glycosylation.

    Li, Minmin / Xiong, Yuting / Qing, Guangyan

    Accounts of chemical research

    2023  Volume 56, Issue 18, Page(s) 2514–2525

    MeSH term(s) Humans ; Glycosylation ; Ligands ; Lipopolysaccharides ; Phosphorylation ; Stimuli Responsive Polymers
    Chemical Substances Ligands ; Lipopolysaccharides ; Stimuli Responsive Polymers
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.3c00397
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  3. Article ; Online: Sensitive and specific detection of saccharide species based on fluorescence: update from 2016.

    Huang, Xiaohuan / Han, Ying / Li, Junrong / Tang, Mingliang / Qing, Guangyan

    Analytical and bioanalytical chemistry

    2023  Volume 415, Issue 18, Page(s) 4061–4077

    Abstract: Increasing evidence supports the critical role of saccharides in various pathophysiological steps of tumor progression, where they regulate tumor proliferation, invasion, hematogenic metastasis, and angiogenesis. The identification and recognition of ... ...

    Abstract Increasing evidence supports the critical role of saccharides in various pathophysiological steps of tumor progression, where they regulate tumor proliferation, invasion, hematogenic metastasis, and angiogenesis. The identification and recognition of these saccharides provide a solid foundation for the development of targeted drug preparations, which are however not fully understood due to their complex and similar structures. In order to achieve fluorescence sensing of saccharides, extensive research has been conducted to design molecular probes and nanoparticles made of different materials. This paper aims to provide in-depth discussion of three main topics that cover the current status of the carbohydrate sensing based on the fluorescence sensing mechanism, including a phenylboronic acid-based sensing platform, non-boronic acid entities, as well as an enzyme-based sensing platform. It also highlights efforts made to understand the recognition mechanisms and improve the sensing properties of these systems. Finally, we present the challenge of achieving high selectivity and sensitivity recognition of saccharides, and suggest possible future avenues for exploration.
    MeSH term(s) Fluorescence ; Carbohydrates/chemistry ; Nanoparticles ; Molecular Probes
    Chemical Substances Carbohydrates ; Molecular Probes
    Language English
    Publishing date 2023-04-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-04703-w
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    In stock of ZB MED Bonn / Germany

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  4. Article ; Online: Phage display derived peptides for Alzheimer's disease therapy and diagnosis.

    Zhang, Xiancheng / Zhang, Xiaoyu / Gao, Huiling / Qing, Guangyan

    Theranostics

    2022  Volume 12, Issue 5, Page(s) 2041–2062

    Abstract: Alzheimer's disease (AD) is an incurable and fatal progressive neurodegenerative disorder associated with memory and cognition impairment. AD is one of the top medical care concerns across the world with a projected economic burden of $2 trillion by 2030. ...

    Abstract Alzheimer's disease (AD) is an incurable and fatal progressive neurodegenerative disorder associated with memory and cognition impairment. AD is one of the top medical care concerns across the world with a projected economic burden of $2 trillion by 2030. To date, however, there remains no effective disease-modifying therapy available. It is more important than ever to reveal novel therapeutic approaches. Peptide-based biotherapeutics has been a great potential strategy attributed to their distinct and superior biochemical characteristics, such as reproducible chemical synthesis and modification, rapid cell and tissue permeability, and fast blood clearance. Phage display, one of today's most powerful platforms, allows selection and identification of suitable peptide drug candidates with high affinities and specificity toward target, demonstrating the potential to overcome challenges and limitations in AD diagnosis/treatment. We aim to provide the first comprehensive review to summarize the status in this research direction. The biological overview of phage display is described, including basic biology of the phage vectors and construction principle of phage library, biopanning procedure, mirror image phage display, and various binding affinity evaluation approaches. Further, the applications of phage display in AD therapy, targeted drug delivery, and early detection are presented. Finally, we discuss the current challenges and offer a future outlook for further advancing the potential application of phage display on AD and other neurodegenerative diseases.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Bacteriophages ; Cell Surface Display Techniques/methods ; Humans ; Peptide Library ; Peptides/metabolism
    Chemical Substances Peptide Library ; Peptides
    Language English
    Publishing date 2022-01-31
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.68636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent Advances in the Modification and Characterization of Solid-State Nanopores.

    Lu, Wenqi / Cao, Yuchen / Qing, Guangyan

    Chemistry, an Asian journal

    2022  Volume 17, Issue 19, Page(s) e202200675

    Abstract: Nanopores, due to their advantages of being modifiable, controllability and sensitivity, have made a splash in recent years in the fields of biomolecular sequencing, small molecule detection, salt differential power generation, and biomimetic ion ... ...

    Abstract Nanopores, due to their advantages of being modifiable, controllability and sensitivity, have made a splash in recent years in the fields of biomolecular sequencing, small molecule detection, salt differential power generation, and biomimetic ion channels. In these applications, the role of chemical or biological modification is indispensable. Compared with small molecules, the modification of polymers is more difficult and the methods are more diverse. Choosing an appropriate modification method directly determines the success or failure of a research project; therefore, it is necessary to summarize polymer modification methods toward nanopores. In addition, it is also important to provide clear and convincing evidence that the nanopore modification is successful, the corresponding characterization methods are also indispensable. Therefore, this review will summarize the methods of polymer modification of nanopores and efficient characterization methods. We hope that this review will provide some reference value for like-minded researchers.
    MeSH term(s) Ion Channels ; Nanopores ; Nanotechnology/methods ; Polymers
    Chemical Substances Ion Channels ; Polymers
    Language English
    Publishing date 2022-09-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202200675
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  6. Article ; Online: Nanofluidic Device for Detection of Lysine Methylpeptides and Sensing of Lysine Methylation

    Xiong, Yuting / Li, Minmin / Cao, Yuchen / Li, Zan / Chang, Yongxin / Zhao, Xinjia / Qing, Guangyan

    Analytical Chemistry. 2023 May 04, v. 95, no. 19 p.7761-7769

    2023  

    Abstract: Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the ... ...

    Abstract Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the sake of recognition and detection. Herein, we present a nanofluidic electric sensing device based on a functionalized nanochannel that was constructed by introducing monotriazole-containing p-sulfonatocalix­[4]­arene (TSC) into a single asymmetric polymeric nanochannel via click chemistry. The device can selectively detect lysine methylpeptides with subpicomole sensitivity, distinguish between different lysine methylation states, and monitor the lysine methylation process by methyltransferase at the peptide level in real time. The introduced TSC molecule, with its confined asymmetric configuration, presents the remarkable ability to selectively bind to lysine methylpeptides, which, coupled with the release of the complexed Cu ions, allows the device to transform the molecular-level recognition to the discernible change in ionic current of the nanofluidic electric device, thus enabling detection. This work could serve as a stepping stone to the development of a new methyltransferase assay and the chemical that specifically targets lysine methylation in PTM proteomics.
    Keywords analytical chemistry ; lysine ; methylation ; methyltransferases ; peptides ; polymers ; post-translational modification ; proteomics
    Language English
    Dates of publication 2023-0504
    Size p. 7761-7769.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01074
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    In stock of ZB MED Bonn / Germany

    Z 4' 52/94: Show issues
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  7. Article ; Online: [Advances in materials for circulating tumor cells capture].

    Sun, Wenjing / Shi, Zhenqiang / Qing, Guangyan

    Se pu = Chinese journal of chromatography

    2021  Volume 39, Issue 10, Page(s) 1041–1044

    MeSH term(s) Cell Line, Tumor ; Cell Separation ; Humans ; Neoplastic Cells, Circulating
    Language Chinese
    Publishing date 2021-09-08
    Publishing country China
    Document type Journal Article
    ISSN 1872-2059
    ISSN (online) 1872-2059
    DOI 10.3724/SP.J.1123.2021.05020
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  8. Article ; Online: Comment on Preparation of Vortex Porous Graphene Chiral Membrane for Enantioselective Separation.

    Li, Minmin / Xiong, Yuting / Qing, Guangyan

    Analytical chemistry

    2021  Volume 93, Issue 10, Page(s) 4682–4684

    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.0c05448
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Nanofluidic Device for Detection of Lysine Methylpeptides and Sensing of Lysine Methylation.

    Xiong, Yuting / Li, Minmin / Cao, Yuchen / Li, Zan / Chang, Yongxin / Zhao, Xinjia / Qing, Guangyan

    Analytical chemistry

    2023  Volume 95, Issue 19, Page(s) 7761–7769

    Abstract: Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the ... ...

    Abstract Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the sake of recognition and detection. Herein, we present a nanofluidic electric sensing device based on a functionalized nanochannel that was constructed by introducing monotriazole-containing
    MeSH term(s) Methylation ; Lysine/metabolism ; Proteins/metabolism ; Protein Processing, Post-Translational ; Methyltransferases/metabolism
    Chemical Substances Lysine (K3Z4F929H6) ; Proteins ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c01074
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Robust Cellulose Nanocrystal-Based Self-Assembled Composite Membranes Doped with Polyvinyl Alcohol and Graphene Oxide for Osmotic Energy Harvesting.

    Zhang, Xin / Li, Minmin / Zhang, Fusheng / Li, Qiongya / Xiao, Jie / Lin, Qiwen / Qing, Guangyan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 50, Page(s) e2304603

    Abstract: Osmotic energy from the salinity gradients represents a promising energy resource with stable and sustainable characteristics. Nanofluidic membranes can be considered as powerful alternatives to the traditional low-performance ion exchange membrane to ... ...

    Abstract Osmotic energy from the salinity gradients represents a promising energy resource with stable and sustainable characteristics. Nanofluidic membranes can be considered as powerful alternatives to the traditional low-performance ion exchange membrane to achieve high-efficiency osmotic energy harvesting. However, the development of a highly efficient and easily scalable core membrane component from low-cost raw materials remains challenging. Here, a composite membrane based on the self-assembly of cellulose nanocrystals (CNCs) with polyvinyl alcohol (PVA) and graphene oxide (GO) nanoflakes as additives is developed to provide a solution. The introduction of soft PVA polymer significantly improves the mechanical strength and water stability of the composite membrane by forming a nacre-like structure. Benefiting from the abundant negative charges of CNC nanorods and GO nanoflakes and the generated network nanochannels, the composite membrane demonstrates a good cation-selective transport capacity, thus contributing to an optimal osmotic energy conversion of 6.5 W m
    Language English
    Publishing date 2023-08-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202304603
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