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  1. Article ; Online: A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants

    Xiaomin Duan / Rui Shi / Pulan Liu / Qingrui Huang / Fengze Wang / Xinyu Chen / Hui Feng / Weijin Huang / Junyu Xiao / Jinghua Yan

    Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-

    2022  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A combination vaccine against SARS-CoV-2 and H1N1 influenza based on receptor binding domain trimerized by six-helix bundle fusion core

    Rui Shi / Jiawei Zeng / Ling Xu / Fengze Wang / Xiaomin Duan / Yue Wang / Zheng Wu / Dandan Yu / Qingrui Huang / Yong-Gang Yao / Jinghua Yan

    EBioMedicine, Vol 85, Iss , Pp 104297- (2022)

    2022  

    Abstract: Summary: Background: Increasing severe morbidity and mortality by simultaneous or sequential infections with SARS-CoV-2 and influenza A viruses (IAV), especially in the elderly and obese patients, highlight the urgency of developing a combination vaccine ...

    Abstract Summary: Background: Increasing severe morbidity and mortality by simultaneous or sequential infections with SARS-CoV-2 and influenza A viruses (IAV), especially in the elderly and obese patients, highlight the urgency of developing a combination vaccine against COVID-19 and influenza. Methods: Self-assembling SARS-CoV-2 RBD-trimer and Influenza H1N1 HA1-trimer antigens were constructed, upon the stable fusion core in post-fusion conformation. Immunogenicity of SARS-CoV-2 RBD-trimer vaccine and H1N1 HA1-trimer antigens candidates were evaluated in mice. Protection efficacy of a combination vaccine candidate against SARS-CoV-2 and IAV challenge was identified using the K18-hACE2 mouse model. Findings: Both the resultant RBD-trimer for SARS-CoV-2 and HA1-trimer for H1N1 influenza fully exposed receptor-binding motifs (RBM) or receptor-binding site (RBS). Two-dose RBD-trimer induced significantly higher binding and neutralizing antibody titers, and also a strong Th1/Th2 balanced cellular immune response in mice. Similarly, the HA1-trimer vaccine was confirmed to exhibit potent immunogenicity in mice. A combination vaccine candidate, composed of RBD-trimer and HA1-trimer, afforded high protection efficacy in mouse models against stringent lethal SARS-CoV-2 and homogenous H1N1 influenza co-infection, characterized by 100% survival rate. Interpretation: Our results represent a proof of concept for a combined vaccine candidate based on trimerized receptor binding domain against co-epidemics of COVID-19 and influenza. Funding: This project was funded by the Strategic Priority Research Program of CAS (XDB29040201), the National Natural Science Foundation of China (81830050, 81901680, and 32070569) and China Postdoctoral Science Foundation (2021M703450).
    Keywords SARS-CoV-2 ; Influenza A viruses ; Co-infection ; Combined subunit vaccines ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

    Qingrui Huang / Kai Ji / Siyu Tian / Fengze Wang / Baoying Huang / Zhou Tong / Shuguang Tan / Junfeng Hao / Qihui Wang / Wenjie Tan / George F. Gao / Jinghua Yan

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 ... ...

    Abstract Several mRNA-based vaccines for SARS-CoV-2 are in late phase clinical development. Here, the authors show that a single immunization with a mRNA vaccine expressing SARS-CoV-2 spike RBD induces neutralizing antibodies that are maintained for at least 6.5 months and confer protection in a sera transfer study in mice.
    Keywords Science ; Q
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Publisher Correction

    Qingrui Huang / Kai Ji / Siyu Tian / Fengze Wang / Baoying Huang / Zhou Tong / Shuguang Tan / Junfeng Hao / Qihui Wang / Wenjie Tan / George F. Gao / Jinghua Yan

    Nature Communications, Vol 12, Iss 1, Pp 1-

    A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

    2021  Volume 1

    Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22820- ... ...

    Abstract A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22820-x
    Keywords Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The identification of a CD47-blocking “hotspot” and design of a CD47/PD-L1 dual-specific antibody with limited hemagglutination

    Rui Shi / Yan Chai / Xiaomin Duan / Xiaoshan Bi / Qingrui Huang / Qihui Wang / Shuguang Tan / George F. Gao / Jianhua Zhu / Jinghua Yan

    Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-

    2020  Volume 3

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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