LIVIVO - Search results -

Search results

Result 1 - 10 of total 80

Search options

Article ; Online: Persistent HPV infection after conization of cervical intraepithelial neoplasia—— a systematic review and meta-analysis

Yueyang Zhang / Zhiwen Ni / Ting Wei / Qingsong Liu

BMC Women's Health, Vol 23, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Objective To systematically evaluate several factors of persistent human papillomavirus (HPV) infection following conization in patients with cervical intraepithelial neoplasia (CIN). Methods PubMed, EMBASE and the Cochrane Library were searched ...

Abstract	Abstract Objective To systematically evaluate several factors of persistent human papillomavirus (HPV) infection following conization in patients with cervical intraepithelial neoplasia (CIN). Methods PubMed, EMBASE and the Cochrane Library were searched from January 1, 1998 to September 10, 2021. Random-effects models for meta-analyses were used and pooled relative risks with 95% confidence intervals were reported. Literature screening, data extraction, and assessment of the risk of bias in the included studies were conducted independently by two researchers. Data analysis was performed with Stata software, version 12.0. Results A total of 28 studies were included in this study. Meta-analysis revealed that surgical margin and residual disease were positively correlated with persistent HPV infection after conization. Compared with patients infected with other types of HPV, CIN patients with HPV 16 had a higher persistent infection rate (OR = 1.967, 95% CI (1.232–3.140), P < 0.05). Conclusions CIN patients who are postmenopausal, have positive surgical margins and residual lesions, and are positive for HPV 16 are prone to persistent HPV infection after conization.
Keywords	HPV ; Persistent infection ; CIN ; Conization ; Human papillomavirus ; Gynecology and obstetrics ; RG1-991 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Tympanoplasty with an Intact Stapes Superstructure in Chronic Otitis Media.

Schlemmer, Kurt / Qingsong, Liu / Linder, Thomas

The journal of international advanced otology

2021 Volume 17, Issue 4, Page(s) 282–287

Abstract: Background: The objective of our study was to ascertain the functional results in terms of air bone gap (ABG) closure over 4 frequencies (0.5, 1, 2, 3 kHz) in patients with chronic otitis media (COM) that underwent tympanoplasty in the presence of a ... ...

Abstract	Background: The objective of our study was to ascertain the functional results in terms of air bone gap (ABG) closure over 4 frequencies (0.5, 1, 2, 3 kHz) in patients with chronic otitis media (COM) that underwent tympanoplasty in the presence of a mobile stapes superstructure, and in particular excluding those cases in which the malleus was used in the reconstruction. Methods: A retrospective review of our database between January 1, 2006 and June 1, 2018 identified all cases that underwent one of 3 reconstructive options: the classic Type III tympanoplasty in an open-cavity setting; the "stapes augmentation" (SA) type reconstruction where the stapes superstructure is augmented to the drum by an interposing partial ossiculoplasty of either autologous bone, cartilage, or prosthetic material; and the use of a total articular replacement prosthesis (TORP) from the stapes footplate to the drum in the presence of an intact superstructure. Results: A total of 116 procedures in 112 patients were identified with a mean ABG reduction from 27 dB to 21 dB (P < .05). There was no significant difference in the mean post-operative ABG result between Type III (19.21 dB), TORP+ (24.90 dB), or SA (20.94 dB) reconstructions (P = .368). Overall, an ABG ≤ 20 dB or "surgical success" was achieved in 56% (n = 65) of cases. Only 20% (n = 23) of cases had "failure" or a post-operative ABG >30 dB. Conclusion: Tympanoplasty with an intact stapes superstructure in COM is expected to provide acceptable levels of surgical success. We did not identify any particular risk factors associated with improved outcome.
MeSH term(s)	Humans ; Ossicular Prosthesis ; Ossicular Replacement ; Otitis Media/surgery ; Retrospective Studies ; Stapes ; Treatment Outcome ; Tympanoplasty
Language	English
Publishing date	2021-07-19
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2561231-1
ISSN	2148-3817 ; 1308-7649 ; 2148-3817
ISSN (online)	2148-3817
ISSN	1308-7649 ; 2148-3817
DOI	10.5152/iao.2021.9267
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Novel aromatic carboxamides from dehydroabietylamine as potential fungicides

Zihui Yang / Qingsong Liu / Yue Sun / Xuebao Sun / Lu Sun / Linlin Chen / Wen Gu

Arabian Journal of Chemistry, Vol 15, Iss 12, Pp 104330- (2022)

Design, synthesis and antifungal evaluation

2022

Abstract: The present study was carried out to design and synthesize a number of novel aromatic carboxamide derivatives of dehydroabietylamine. The preliminary antifungal assay indicated that most of title compounds displayed moderate to good antifungal activity ... ...

Abstract	The present study was carried out to design and synthesize a number of novel aromatic carboxamide derivatives of dehydroabietylamine. The preliminary antifungal assay indicated that most of title compounds displayed moderate to good antifungal activity toward the six fungal strains in vitro. Compounds 3i, 3q, 4b and 4d showed significant antifungal activity against Sclerotinia sclerotiorum, with EC50 values ranging from 0.067 ∼ 0.393 mg/L. Compounds 3i, 4b and 4d also showed pronounced mycelial growth inhibition activities against B. cinerea and A. solani. Furthermore, in the in vivo assay, compound 4b exhibited brilliant protective activity against S. sclerotiorum-infected rape leaves. Meanwhile, the in vivo bioassay on tomato plants infected by B. cinerea showed that compound 3i and 4d displayed excellent protective activity at 200 mg/L, which were near to boscalid. Primary mechanistic study revealed that 4b could inhibit sclerotia formation as well as reduce the exopolysaccharide level. SEM and TEM analysis indicated that 4b possessed a strong ability to destroy the surface morphology of mycelia, cell structure and seriously interfere with the growth of the fungal pathogen. In addition, 4b exhibited good inhibitory activity (IC50 = 23.3 ± 1.6 μM) toward succinate dehydrogenase (SDH). Molecular modeling study confirmed the binding modes between compound 4b and SDH. The above antifungal results and fungicidal mechanism study revealed that this class of dehydroabietylamine derivatives could be potential SDH inhibitors and lead compounds for novel fungicides development.
Keywords	Dehydroabietylamine ; Aromatic derivatives ; Carboxamide ; Antifungal activity ; Succinate dehydrogenase inhibitor ; Molecular modeling ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Dynamic Changes and Characterization of the Metal Ions in the Silk Glands and Silk Fibers of Silkworm

Qingsong Liu / Xin Wang / Yifan Zhou / Xiaoyin Tan / Xiaoqian Xie / Yi Li / Haonan Dong / Zhangchen Tang / Ping Zhao / Qingyou Xia

International Journal of Molecular Sciences, Vol 24, Iss 6556, p

2023 Volume 6556

Abstract: Metal ions are involved in the conformational transition of silk fibroin and influence the structure and mechanical properties of silk fibers. However, the dynamic characteristics of metal ions during the formation of silk fibers remain unclear. In this ... ...

Abstract	Metal ions are involved in the conformational transition of silk fibroin and influence the structure and mechanical properties of silk fibers. However, the dynamic characteristics of metal ions during the formation of silk fibers remain unclear. In this study, we found that the silk glands of silkworms contain various metal elements, with varying levels of the metal elements in different zones of the glands and higher levels in the anterior silk glands. Additionally, the content of various metallic elements in the silk glands varied greatly before and after spinning, similar to their content in different cocoon layers, thus, indicating that the anterior silk glands maintain a certain metal ion environment for the transport and conformational transformation of the silk proteins. Most of the metallic elements located in fibroin were confirmed using degumming experiments. For the first time, a scanning electron microscope energy spectrometry system was used to characterize the metal elements in the cross-section of silk and cocoons. These findings have deepened our understanding of the relationship between the overall metal ion environment and silk fiber formation and help us further conceptualize the utilization of metal ions as targets to improve the mechanical properties of the silk fibers.
Keywords	silk gland ; silk fiber ; metal elements ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Repurposing clinically available drugs and therapies for pathogenic targets to combat SARS‐CoV‐2

Yiying Xue / Husheng Mei / Yisa Chen / James D. Griffin / Qingsong Liu / Ellen Weisberg / Jing Yang

MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)

2023

Abstract: Abstract The coronavirus disease 2019 (COVID‐19) pandemic has affected a large portion of the global population, both physically and mentally. Current evidence suggests that the rapidly evolving coronavirus subvariants risk rendering vaccines and ... ...

Abstract	Abstract The coronavirus disease 2019 (COVID‐19) pandemic has affected a large portion of the global population, both physically and mentally. Current evidence suggests that the rapidly evolving coronavirus subvariants risk rendering vaccines and antibodies ineffective due to their potential to evade existing immunity, with enhanced transmission activity and higher reinfection rates that could lead to new outbreaks across the globe. The goal of viral management is to disrupt the viral life cycle as well as to relieve severe symptoms such as lung damage, cytokine storm, and organ failure. In the fight against viruses, the combination of viral genome sequencing, elucidation of the structure of viral proteins, and identifying proteins that are highly conserved across multiple coronaviruses has revealed many potential molecular targets. In addition, the time‐ and cost‐effective repurposing of preexisting antiviral drugs or approved/clinical drugs for these targets offers considerable clinical advantages for COVID‐19 patients. This review provides a comprehensive overview of various identified pathogenic targets and pathways as well as corresponding repurposed approved/clinical drugs and their potential against COVID‐19. These findings provide new insight into the discovery of novel therapeutic strategies that could be applied to the control of disease symptoms emanating from evolving SARS‐CoV‐2 variants.
Keywords	combination therapy ; drug resistance ; pathogenic targets ; repurposing therapies ; SARS‐CoV‐2 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1

Xia Hu / Maoyuan Zhao / Shuangyuan Hu / Qingsong Liu / Wenhao Liao / Lina Wan / Feng Wei / Fangting Su / Yu Guo / Jinhao Zeng

Biological Procedures Online, Vol 25, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Background The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and development of GC, in which long non-coding RNAs (lncRNAs) are deeply involved. The purpose of this ... ...

Abstract	Abstract Background The incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and development of GC, in which long non-coding RNAs (lncRNAs) are deeply involved. The purpose of this study was to investigate the influences and mechanisms of LINC00853 in the progression and stemness of GC. Methods The level of LINC00853 was assessed based on The Cancer Genome Atlas (TCGA) database and GC cell lines by RT-PCR and in situ hybridization. An evaluation of biological functions of LINC00853 including cell proliferation, migration, and tumor stemness was conducted via gain-and loss-of-function experiments. Furthermore, RNA pull-down and RNA immunoprecipitation (RIP) assay were utilized to validate the connection between LINC00853 and the transcription factor Forkhead Box P3 (FOXP3). Nude mouse xenograft model was used to identify the impacts of LINC00853 on tumor development. Results We identified the up-regulated levels of lncRNA-LINC00853 in GC, and its overexpression correlates with poor prognosis in GC patients. Further study indicated that LINC00853 promoted cell proliferation, migration and cancer stemness while suppressed cell apoptosis. Mechanistically, LINC00853 directly bind to FOXP3 and promoted FOXP3-mediated transcription of PDZK1 interacting protein 1(PDZK1IP1). Alterations of FOXP3 or PDZK1IP1 reversed the LINC00853-induced biological effects on cell proliferation, migration and stemness. Moreover, xenograft tumor assay was used to investigate the function of LINC00853 in vivo. Conclusions Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.
Keywords	LINC00853 ; FOXP3 ; PDZK1IP1 ; Tumor stemness ; Gastric cancer ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: An overview of kinase downregulators and recent advances in discovery approaches

Beilei Wang / Hong Wu / Chen Hu / Haizhen Wang / Jing Liu / Wenchao Wang / Qingsong Liu

Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

2021 Volume 19

Abstract: Abstract Since the clinical approval of imatinib, the discovery of protein kinase downregulators entered a prosperous age. However, challenges still exist in the discovery of kinase downregulator drugs, such as the high failure rate during development, ... ...

Abstract	Abstract Since the clinical approval of imatinib, the discovery of protein kinase downregulators entered a prosperous age. However, challenges still exist in the discovery of kinase downregulator drugs, such as the high failure rate during development, side effects, and drug-resistance problems. With the progress made through multidisciplinary efforts, an increasing number of new approaches have been applied to solve the above problems during the discovery process of kinase downregulators. In terms of in vitro and in vivo drug evaluation, progress was also made in cellular and animal model platforms for better and more clinically relevant drug assessment. Here, we review the advances in drug design strategies, drug property evaluation technologies, and efficacy evaluation models and technologies. Finally, we discuss the challenges and perspectives in the development of kinase downregulator drugs.
Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: The impact of quick-freezing methods on the quality, moisture distribution and microstructure of prepared ground pork during storage duration

Zeyu Wu / Wanru Ma / Zhaojun Xian / Qingsong Liu / Ailing Hui / Wencheng Zhang

Ultrasonics Sonochemistry, Vol 78, Iss , Pp 105707- (2021)

2021

Abstract: The aim of present study was to investigate the influences of ultrasound-assisted immersion freezing (UIF), immersion freezing (IF) and air freezing (AF) on the quality, moisture distribution and microstructure properties of the prepared ground pork (PGP) ...

Abstract	The aim of present study was to investigate the influences of ultrasound-assisted immersion freezing (UIF), immersion freezing (IF) and air freezing (AF) on the quality, moisture distribution and microstructure properties of the prepared ground pork (PGP) during storage duration (0, 15, 30, 45, 60, 75 and 90 days). UIF treatment significantly reduced the freezing time by 60.32% and 39.02%, respectively, compared to IF and AF (P < 0.05). The experimental results of quality evaluation revealed that the L* and b* values, juice loss, cooking loss, TBARS values and carbonyl contents were decreased in the UIF treated samples, while the a* value, peak temperatures (Tm), enthalpy (ΔH) and sulfhydryl contents were significantly higher than those of IF and AF treated samples (P < 0.05). In addition, low-field nuclear magnetic resonance (LF-NMR) and differential scanning calorimetry (DSC) analysis demonstrated that UIF inhibited the mobility of immobilized water and reduced the loss of immobilized and free water, and then a high water holding capacity (WHC) was achieved. Compared to the IF and AF treatments, the UIF treated PGP samples possessed better microstructure. Therefore, UIF could induce the formation of ice crystals with smaller size and more even distribution during freezing process, which contributed to less damage to the muscle tissue and more satisfied product quality.
Keywords	Ultrasound-assisted immersion freezing ; Freezing rate ; Quality deterioration ; Ice crystals ; Myofibrillar protein ; Freezable water ; Chemistry ; QD1-999 ; Acoustics. Sound ; QC221-246
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: New criteria for selecting reliable Thellier-type paleointensity results from the 1960 Kilauea lava flows, Hawaii

Doohee Jeong / Qingsong Liu / Yuhji Yamamoto / Yongjae Yu / Xiang Zhao / Huafeng Qin

Earth, Planets and Space, Vol 73, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Thellier-type paleointensity experiments associated with partial thermal remanent magnetization checks have been widely used to determine paleointensity values from volcanic and archaeological media. However, previous studies have revealed that ... ...

Abstract	Abstract Thellier-type paleointensity experiments associated with partial thermal remanent magnetization checks have been widely used to determine paleointensity values from volcanic and archaeological media. However, previous studies have revealed that a substantial portion of paleointensity results with positive checks for historical lava samples largely fails to predict known Earth magnetic field intensity values. To determine the fidelity of paleointensity values, conventional Thellier-type paleointensity experiments were performed on Kilauea lava flows that erupted in 1960. The positive partial thermal remanent magnetization checks for our results range from 30.28 ± 1.38 µT to 52.94 ± 1.89 µT. This strongly indicates that conventional paleointensity checks cannot guarantee the fidelity of paleointensity results, especially when the unblocking temperatures for the newly formed magnetic particles are higher than the treatment temperature. Therefore, in this study, to check for thermal alteration during heating, the temperature dependence of the hysteresis parameter measured at room temperature for the thermally treated samples was also measured. Our new results show that nearly all biased paleointensity values correspond to a ratio of the coercivity of remanence to the magnetic coercivity of > 3 and a chemical alteration index > ~ 10%, which indicates the strong effect of the domain state and thermal alteration on the fidelity of the paleointensity results. Our study provides feasible criteria to further improve the fidelity of paleointensity estimations.
Keywords	Thellier-type experiment ; Paleointensity ; Domain state ; Thermal alteration ; Geography. Anthropology. Recreation ; G ; Geodesy ; QB275-343 ; Geology ; QE1-996.5
Subject code	530
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: π‐Conjugation Induced Anchoring of Ferrocene on Graphdiyne Enable Shuttle‐Free Redox Mediation in Lithium‐Oxygen Batteries

Xudong Li / Guokang Han / Zhengyi Qian / Qingsong Liu / Zhuomin Qiang / Yajie Song / Hua Huo / Chunyu Du / Shuaifeng Lou / Geping Yin

Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)

2022

Abstract: Abstract Soluble redox mediators (RMs), an alternative to conventional solid catalysts, have been considered an effective countermeasure to ameliorate sluggish kinetics in the cathode of a lithium–oxygen battery recently. Nevertheless, the high mobility ... ...

Abstract	Abstract Soluble redox mediators (RMs), an alternative to conventional solid catalysts, have been considered an effective countermeasure to ameliorate sluggish kinetics in the cathode of a lithium–oxygen battery recently. Nevertheless, the high mobility of RMs leads to serious redox shuttling, which induces an undesired lithium‐metal degeneration and RM decomposition during trade‐off catalysis against the sustainable operation of batteries. Here, a novel carbon family of graphdiyne matrix is first proposed to decouple the charge‐carrying redox property of ferrocene and the shuttle effects. It is demonstrated that a ferrocene‐anchored graphdiyne framework can function as stationary RM, not only preserving the redox‐mediating capability of ferrocene, but also promoting the local orientated three‐dimensional (3D) growth of Li2O2. As a result, the RM‐assisted catalysis in lithium–oxygen battery remains of remarkable efficiency and stability without the depletion of oxidized RMs or lithium degradation, resulting in a significantly enhanced electrochemical performance.
Keywords	electron interactions ; graphdiyne ; lithium‐oxygen batteries ; redox mediators ; shuttle phenomena ; Science ; Q
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED