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  1. Article ; Online: Authentication mechanism of network communication nodes based on information safety of the Internet of Vehicles

    Qiong Wu

    Proceedings of the Estonian Academy of Sciences, Vol 70, Iss 1, Pp 91-

    2021  Volume 97

    Abstract: The Internet of Vehicles (IoV) is an important part of intelligent traffic, and the problem of information safety is an essential task that has to be solved urgently. In this study, the main focus is on the authentication mechanism of communication nodes ...

    Abstract The Internet of Vehicles (IoV) is an important part of intelligent traffic, and the problem of information safety is an essential task that has to be solved urgently. In this study, the main focus is on the authentication mechanism of communication nodes in the IoV. Based on elliptic curve cryptography, an authentication method was designed; the processes of system establishment, pseudonym generation and message authentication were introduced; and the safety of the system was analysed. The results indicate that the proposed method has passed the correctness verification and has significant advantages compared to SPECS and b-SPECS in terms of time cost and authentication delay. The experimental results verify the reliability of the method, which makes some contributions to the authentication of communication nodes in the IoV and is beneficial to the further improvement of information security of the IoV.
    Keywords internet of vehicles ; information security ; elliptic curve cryptography ; communication nodes ; identity authentication ; Science ; Q
    Subject code 000
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Estonian Academy Publishers
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: EMT transcription factors activated circuits

    Tianying Chen / Wangyue Jia / Bo Zhang / Hanqi Xie / Qiong Wu

    Synthetic and Systems Biotechnology, Vol 9, Iss 1, Pp 1-

    A novel tool to study EMT dynamics and its therapeutic implications

    2024  Volume 10

    Abstract: The epithelial mesenchymal transition (EMT) plays significant roles in the progression of cancer and fibrotic disease. Moreover, this process is reversible, resulting in mesenchymal epithelial transition (MET), which plays an important role in cancer ... ...

    Abstract The epithelial mesenchymal transition (EMT) plays significant roles in the progression of cancer and fibrotic disease. Moreover, this process is reversible, resulting in mesenchymal epithelial transition (MET), which plays an important role in cancer metastasis. There is a lack of methods to trace and target EMT cells using synthetic biology circuits, which makes it difficult to study the cell fate or develop targeted treatments. In this study, we introduced responsive EMT sensing circuits, which sense the EMT using specific promoters that respond to transcription factors typical of EMT activation (EMT-TFs). The transcriptional strength of EMT-sensing promoters decreased more than 13-fold in response to the overexpression of the EMT-TF. Then, the NOT gate circuits were built by placing the tetR transcription repressor under the control of EMT sensing promoters and expressed an output signal using the constitutive CMV promoter modified with tetO sites This circuit is named EMT sensing and responding circuits .When the EMT transcription factors was present, we observed a 5.8-fold signal increase in the system. Then, we successfully distinguished mesenchymal breast cancer cells from epithelial cancer cells and repressed the proliferation of EMT tumor cells using our circuits. The EMT sensing and responding circuits are promising tools for the identification of EMT cells, which is crucial for EMT-related disease therapy and investigating the mechanisms underlying the reversible EMT process.
    Keywords Epithelial mesenchymal transition ; Synthetic biology ; Tumor killing ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-03-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Change in extreme precipitation events

    Mingjin Zhan / Qiong Wu / Longfei Zhan / Jiajie Xin

    Frontiers in Earth Science, Vol

    Exposure and vulnerability in the Poyang Lake Basin, China

    2023  Volume 11

    Abstract: On the basis of daily observations data from 1984 to 2020, the spatiotemporal characteristics of extreme precipitation events in the Poyang Lake Basin (China) were analyzed using the intensity–area–duration method. With consideration of spatially ... ...

    Abstract On the basis of daily observations data from 1984 to 2020, the spatiotemporal characteristics of extreme precipitation events in the Poyang Lake Basin (China) were analyzed using the intensity–area–duration method. With consideration of spatially distributed data on gross domestic product (GDP), population, and disaster losses related to historical extreme precipitation events, the exposure and vulnerability of the population and GDP of the study area to extreme precipitation events were systematically assessed. The results revealed the following. 1) The intensity and frequency of extreme precipitation, as well as the area affected, showed trends of increase, especially in the northeast of the basin. 2) Population exposure in the basin showed a trend of increase of 2.43 million/a. Change in population exposure was greatest in the most recent 10 years, with an average increase of 6.64 million/a. Change in extreme precipitation was the primary driver of the rapid increase in population exposure. 3) The average annual GDP exposure of the basin was ¥5.43 billion, and economic exposure has increased substantially at an average rate of ¥0.56 billion/a. Unlike population exposure, the increase in economic exposure was driven mainly by rapid economic growth. 4) By constructing vulnerability curves of economic losses in different decades, the trend of economic vulnerability was found to have clearly declined, i.e., economic vulnerability in 2010 was 13.3 (4.1) times lower than that in the 1990s (2000s). Effective disaster prevention and reduction measures should urgently be adopted in the study area to mitigate the effects of increase in extreme precipitation events.
    Keywords extreme precipitation events ; exposure ; vulnerability ; contribution rate ; intensity-loss rate curve ; IAD method ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Corrigendum

    Lingge Bai / Qiong Wu / Xinyue Zhang / Yuting Zhao

    Frontiers in Cell and Developmental Biology, Vol

    Autosis as a selective type of cell death

    2023  Volume 11

    Keywords autosis ; autophagy ; autophagic cell death ; Na+/K+-ATPase ; Beclin 1 ; cardiac glycosides ; Tat-BECN1 peptide ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Relationship between Chlorophyll Concentration and ENSO Events and Possible Mechanisms off the Changjiang River Estuary

    Qiong Wu / Xiaochun Wang / Yijun He / Jingjing Zheng

    Remote Sensing, Vol 15, Iss 2384, p

    2023  Volume 2384

    Abstract: More and more attention has been paid to the study of the impact of extreme climatic events on the ecological environment off the Changjiang River Estuary. In this study, the relationship between the chlorophyll concentration and ENSO (El Niño Southern ... ...

    Abstract More and more attention has been paid to the study of the impact of extreme climatic events on the ecological environment off the Changjiang River Estuary. In this study, the relationship between the chlorophyll concentration and ENSO (El Niño Southern Oscillation) events was studied. Several potential physical mechanisms between the ENSO and chlorophyll concentration were analyzed using observation and sensitivity experiments from a high-resolution ROMS-CoSiNE coupled model (Regional Ocean Modeling System-Carbon, Oxygen, Silicon, Nitrogen and Ecosystem) off the Changjiang River Estuary. Our results indicated that the April to August averaged chlorophyll concentration off the Changjiang River Estuary was significantly correlated with the December to February averaged ENSO indices in the previous winter. The 10 m wind speed and SST (Sea Surface Temperature) affected by an ENSO event had little effect on the chlorophyll concentration, while the discharge had a significant effect on the chlorophyll concentration off the Changjiang River Estuary, and the discharge was significantly and positively correlated with the ENSO indices. We tested the effect of interannual variations of the discharge and nutrients carried by discharge on the interannual variation in the chlorophyll concentration in the ENSO events. Two sensitivity experiments showed that when the nutrients in the freshwater discharge were kept as a constant seasonal cycle, the composite differences in the chlorophyll concentration between the positive and negative ENSO phases off the Changjiang River Estuary were reduced. When there were no nutrients in the freshwater discharge, the composite differences in the chlorophyll concentration between the positive and negative ENSO phases off the Changjiang River Estuary were reduced by one order of magnitude. The discharge can modify the stratification off the Changjiang River Estuary, and the nutrients carried by the discharge play a dominant role in determining the interannual variation of the chlorophyll ...
    Keywords Changjiang River Estuary ; discharge ; chlorophyll concentration ; El Niño Southern Oscillation ; ROMS-CoSiNE model ; Science ; Q
    Subject code 551
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Autosis as a selective type of cell death

    Lingge Bai / Qiong Wu / Xinyue Zhang / Yuting Zhao

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Keywords autosis ; autophagy ; autophagic cell death ; Na+/K+-ATPase ; Beclin 1 ; cardiac glycosides ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Acidity Quantification and Structure Analysis of Amide-AlCl 3 Liquid Coordination Complexes for C 4 Alkylation Catalysis

    Hao Li / Qiong Wu / Ying Liu / Jinrong Bao

    Molecules, Vol 28, Iss 23, p

    2023  Volume 7857

    Abstract: Liquid coordination complexes (LCCs), which are formed between metal halides and donor molecules, represent promising catalysts. Six amide-AlCl 3 LCCs were successfully synthesized, followed by their characterization through NMR, Raman, and UV-visible ... ...

    Abstract Liquid coordination complexes (LCCs), which are formed between metal halides and donor molecules, represent promising catalysts. Six amide-AlCl 3 LCCs were successfully synthesized, followed by their characterization through NMR, Raman, and UV-visible spectroscopy. The acidity of these LCCs was quantified by performing computational modelling of fluoride ion affinities (FIA) and experimental Gutmann–Beckett measurements. Spectroscopic analysis indicated bidentate coordination between amide ligands and Al, which induced asymmetric splitting of Al 2 Cl 6 into diverse ions such as [AlCl 2 L 2 ] + , [AlCl 4 ] − , [AlCl 3 L], and [Al 2 Cl 6 L]. The computed FIA was found to align well with the experimental acidity trends, thereby confirming the proposed structure of the LCC. In the alkylation tests, the LCC with a high acidity demonstrated an increase in the yields of C 5 -C 7 alkylates. These results provide an in-depth understanding of the tuneable structures of amide-AlCl 3 LCCs. The acidity of LCCs can be controlled by tuning the ratio of the organic ligand to AlCl 3 , which allows bidentate coordination to facilitate asymmetric splitting of Al 2 Cl 6 . The LCCs demonstrate a high degree of potential as versatile and sustainable acid catalysts in alkylation reactions. These findings may advance the foundational knowledge of LCCs for the purpose of targeted acid catalyst design.
    Keywords liquid coordination complexes ; Lewis acidity ; density functional theory ; NMR ; C 4 alkylation catalysts ; Organic chemistry ; QD241-441
    Subject code 290
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Airborne LiDAR Strip Adjustment Method Based on Point Clouds with Planar Neighborhoods

    Zhenxing Sun / Ruofei Zhong / Qiong Wu / Jiao Guo

    Remote Sensing, Vol 15, Iss 23, p

    2023  Volume 5447

    Abstract: Airborne light detection and ranging (LiDAR) data are increasingly used in various fields such as topographic mapping, urban planning, and emergency management. A necessary processing step in the application of airborne LiDAR data is the elimination of ... ...

    Abstract Airborne light detection and ranging (LiDAR) data are increasingly used in various fields such as topographic mapping, urban planning, and emergency management. A necessary processing step in the application of airborne LiDAR data is the elimination of mismatch errors. This paper proposes a new method for airborne LiDAR strip adjustment based on point clouds with planar neighborhoods; this method is intended to eliminate errors in airborne LiDAR point clouds. Initially, standard pre-processing tasks such as denoising, ground separation, and resampling are performed on the airborne LiDAR point clouds. Subsequently, this paper introduces a unique approach to extract point clouds with planar neighborhoods which is designed to enhance the registration accuracy of the iterative closest point (ICP) algorithm within the context of airborne LiDAR point clouds. Following the registration of the point clouds using the ICP algorithm, tie points are extracted via a point-to-plane projection method. Finally, a strip adjustment calculation is executed using the extracted tie points, in accordance with the strip adjustment equation for airborne LiDAR point clouds that was derived in this study. Three sets of airborne LiDAR point cloud data were utilized in the experiment outlined in this paper. The results indicate that the proposed strip adjustment method can effectively eliminate mismatch errors in airborne LiDAR point clouds, achieving a registration accuracy and absolute accuracy of 0.05 m. Furthermore, this method’s processing efficiency was more than five times higher than that of traditional methods such as ICP and LS3D.
    Keywords airborne LiDAR ; point clouds with planar neighborhoods ; point cloud registration ; strip adjustment ; Science ; Q
    Subject code 333
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Differential Expression Analysis Based on Ensemble Strategy on miRNA Profiles of Kidney Clear Cell Carcinoma

    Enyang Zhao / Ziqi Xi / Qiong Wu

    Frontiers in Bioscience-Landmark, Vol 28, Iss 11, p

    2023  Volume 283

    Abstract: Background: Kidney clear cell carcinoma (KIRC) is the most common type of kidney cancer, accounting for approximately 60–85% of all the kidney cancers. However, there are few options available for early treatment. Therefore, it is extremely important to ... ...

    Abstract Background: Kidney clear cell carcinoma (KIRC) is the most common type of kidney cancer, accounting for approximately 60–85% of all the kidney cancers. However, there are few options available for early treatment. Therefore, it is extremely important to identify biomarkers and study therapeutic targets for KIRC. Methods: Since there are few studies on KIRC, we used a data-driven approach to identify differential genes. Here, we used miRNA gene expression profile data from the TCGA database species of KIRC and proposed a machine learning-based approach to quantify the importance score of each gene. Then, an ensemble method was utilized to find the optimal subset of genes used to predict KIRC by clustering. The most genetic subset was then used to classify and predict KIRC. Results: Differential genes were screened by several traditional differential analysis methods, and the selected gene subset showed a better performance. Independent testing sets from the GEO database were used to verify the effectiveness of the optimal subset of genes. Besides, cross-validation was made to verify the effectiveness of the approach. Conclusions: Finally, important genes, such as miR-140 and miR-210, were found to be involved in the biochemical processes of KIRC, which also proved the effectiveness of our approach.
    Keywords kidney cancer ; mirna ; differential gene ; machine learning ; ensemble ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher IMR Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Impact of subintimal plaque modification (SPM) technique on failed intervention of coronary artery chronic total occlusion

    Na-Qiong Wu / Jie Qian

    Chronic Diseases and Translational Medicine, Vol 7, Iss 2, Pp 135-

    2021  Volume 138

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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