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  1. Article ; Online: Co‐Targeting Plk1 and DNMT3a in Advanced Prostate Cancer

    Zhuangzhuang Zhang / Lijun Cheng / Qiongsi Zhang / Yifan Kong / Daheng He / Kunyu Li / Matthew Rea / Jianling Wang / Ruixin Wang / Jinghui Liu / Zhiguo Li / Chongli Yuan / Enze Liu / Yvonne N. Fondufe‐Mittendorf / Lang Li / Tao Han / Chi Wang / Xiaoqi Liu

    Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract Because there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently needed. A new network‐based systems biology approach, XDeath, is developed to detect ... ...

    Abstract Abstract Because there is no effective treatment for late‐stage prostate cancer (PCa) at this moment, identifying novel targets for therapy of advanced PCa is urgently needed. A new network‐based systems biology approach, XDeath, is developed to detect crosstalk of signaling pathways associated with PCa progression. This unique integrated network merges gene causal regulation networks and protein‐protein interactions to identify novel co‐targets for PCa treatment. The results show that polo‐like kinase 1 (Plk1) and DNA methyltransferase 3A (DNMT3a)‐related signaling pathways are robustly enhanced during PCa progression and together they regulate autophagy as a common death mode. Mechanistically, it is shown that Plk1 phosphorylation of DNMT3a leads to its degradation in mitosis and that DNMT3a represses Plk1 transcription to inhibit autophagy in interphase, suggesting a negative feedback loop between these two proteins. Finally, a combination of the DNMT inhibitor 5‐Aza‐2’‐deoxycytidine (5‐Aza) with inhibition of Plk1 suppresses PCa synergistically.
    Keywords autophagy ; cell death ; crosstalk ; DNMT3a ; PCa ; phosphorylation ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Neurospora crassa tox-1 Gene Encodes a pH- and Temperature-Tolerant Mini-Cellulase

    Xiao, Yue / Qiongsi Zhang / Yiquan Luo / Ying Zhang / Xi Luo / Yuchuan Wang / Weiguo Cao / Vito De Pinto / Qiuyun Liu / Gang Li

    Journal of agricultural and food chemistry. 2016 June 15, v. 64, no. 23

    2016  

    Abstract: Cellulases that endure extreme conditions are essential in various industrial sectors. This study reports a mini-cellulase gene tox-1 from Neurospora crassa. The gene tox-1 was cloned in Escherichia coli after chimerization with the YebF gene and ... ...

    Abstract Cellulases that endure extreme conditions are essential in various industrial sectors. This study reports a mini-cellulase gene tox-1 from Neurospora crassa. The gene tox-1 was cloned in Escherichia coli after chimerization with the YebF gene and substitutions of certain isoleucine and valine with leucine residues. The yeast transformants could grow on rice straw–agar medium. The 44-amino acid peptide and its two mutant variants displayed potent cellulase activities in Congo Red assay and enzymatic assays. Conservative replacements with leucine have substantially increased the stabilities and half-lives of the peptides at alkaline pH and low and high temperatures and also the tolerance to organic solvents and surfactants, on the basis of activities toward cellose. The small size of the mini-cellulase would allow for commercially viable automatic chemical peptide synthesis. This work suggests that conservative leucine replacements may serve as a general strategy in the engineering of more robust enzymes with special features with little loss of activities.
    Keywords Escherichia coli ; Neurospora crassa ; endo-1,4-beta-glucanase ; genes ; half life ; isoleucine ; leucine ; mutants ; pH ; peptides ; rice ; solvents ; surfactants ; temperature ; valine ; yeasts
    Language English
    Dates of publication 2016-0615
    Size p. 4751-4757.
    Publishing place American Chemical Society, Books and Journals Division
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.6b00043
    Database NAL-Catalogue (AGRICOLA)

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