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  1. Article ; Online: Safety and efficacy of tislelizumab plus chemotherapy for first-line treatment of advanced esophageal squamous cell carcinoma and gastric/gastroesophageal junction adenocarcinoma.

    Qiu, Hai-Bo

    Thoracic cancer

    2020  Volume 11, Issue 12, Page(s) 3419–3421

    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Squamous Cell Carcinoma/pathology ; Esophagogastric Junction/pathology ; Female ; Humans ; Male ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/pathology
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; tislelizumab (0KVO411B3N)
    Language English
    Publishing date 2020-10-12
    Publishing country Singapore
    Document type Editorial
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.13690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Disease-specific analgesia and sedation in critically ill patients].

    Qiu, Hai-Bo

    Zhonghua nei ke za zhi

    2013  Volume 52, Issue 4, Page(s) 279–281

    MeSH term(s) Analgesia/methods ; Conscious Sedation ; Critical Illness/therapy ; Humans
    Language Chinese
    Publishing date 2013-04
    Publishing country China
    Document type Editorial
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
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  3. Article: [Zero tolerance to ventilator-associated pneumonia: starting from guideline].

    Qiu, Hai-bo

    Zhonghua nei ke za zhi

    2013  Volume 52, Issue 6, Page(s) 450–451

    MeSH term(s) Cross Infection/prevention & control ; Humans ; Pneumonia, Ventilator-Associated/prevention & control ; Practice Guidelines as Topic
    Language Chinese
    Publishing date 2013-06
    Publishing country China
    Document type Editorial
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
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  4. Article: [Critical care ensures better patients' safety].

    Qiu, Hai-bo

    Zhonghua nei ke za zhi

    2012  Volume 51, Issue 8, Page(s) 585–587

    MeSH term(s) Critical Care ; Humans ; Patient Safety
    Language Chinese
    Publishing date 2012-08
    Publishing country China
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
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  5. Article ; Online: Neural control of pressure support ventilation improved patient-ventilator synchrony in patients with different respiratory system mechanical properties: a prospective, crossover trial.

    Liu, Ling / Xu, Xiao-Ting / Yu, Yue / Sun, Qin / Yang, Yi / Qiu, Hai-Bo

    Chinese medical journal

    2021  Volume 134, Issue 3, Page(s) 281–291

    Abstract: Background: Conventional pressure support ventilation (PSP) is triggered and cycled off by pneumatic signals such as flow. Patient-ventilator asynchrony is common during pressure support ventilation, thereby contributing to an increased inspiratory ... ...

    Abstract Background: Conventional pressure support ventilation (PSP) is triggered and cycled off by pneumatic signals such as flow. Patient-ventilator asynchrony is common during pressure support ventilation, thereby contributing to an increased inspiratory effort. Using diaphragm electrical activity, neurally controlled pressure support (PSN) could hypothetically eliminate the asynchrony and reduce inspiratory effort. The purpose of this study was to compare the differences between PSN and PSP in terms of patient-ventilator synchrony, inspiratory effort, and breathing pattern.
    Methods: Eight post-operative patients without respiratory system comorbidity, eight patients with acute respiratory distress syndrome (ARDS) and obvious restrictive acute respiratory failure (ARF), and eight patients with chronic obstructive pulmonary disease (COPD) and mixed restrictive and obstructive ARF were enrolled. Patient-ventilator interactions were analyzed with macro asynchronies (ineffective, double, and auto triggering), micro asynchronies (inspiratory trigger delay, premature, and late cycling), and the total asynchrony index (AI). Inspiratory efforts for triggering and total inspiration were analyzed.
    Results: Total AI of PSN was consistently lower than that of PSP in COPD (3% vs. 93%, P = 0.012 for 100% support level; 8% vs. 104%, P = 0.012 for 150% support level), ARDS (8% vs. 29%, P = 0.012 for 100% support level; 16% vs. 41%, P = 0.017 for 150% support level), and post-operative patients (21% vs. 35%, P = 0.012 for 100% support level; 15% vs. 50%, P = 0.017 for 150% support level). Improved support levels from 100% to 150% statistically increased total AI during PSP but not during PSN in patients with COPD or ARDS. Patients' inspiratory efforts for triggering and total inspiration were significantly lower during PSN than during PSP in patients with COPD or ARDS under both support levels (P < 0.05). There was no difference in breathing patterns between PSN and PSP.
    Conclusions: PSN improves patient-ventilator synchrony and generates a respiratory pattern similar to PSP independently of any level of support in patients with different respiratory system mechanical properties. PSN, which reduces the trigger and total patient's inspiratory effort in patients with COPD or ARDS, might be an alternative mode for PSP.
    Trial registration: ClinicalTrials.gov, NCT01979627; https://clinicaltrials.gov/ct2/show/record/NCT01979627.
    MeSH term(s) Cross-Over Studies ; Humans ; Prospective Studies ; Respiration ; Respiration, Artificial ; Respiratory System ; Ventilators, Mechanical
    Language English
    Publishing date 2021-01-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The effect of obstructive jaundice on the sensitivity of intravenous anesthetic of remimazolam: study protocol for a controlled multicenter trial.

    Liu, Wen / Yang, Bin / Ji, Jun-Wei / Yang, Hua / Song, Hong-Hao / Qiu, Hai-Bo / Song, Jin-Chao

    Trials

    2022  Volume 23, Issue 1, Page(s) 23

    Abstract: Background: It is well known that obstructive jaundice could affect the pharmacodynamics of some anesthetics, and the sensitivity of some anesthetics would increase among icteric patients. Remimazolam is a new ultra-short-acting intravenous ... ...

    Abstract Background: It is well known that obstructive jaundice could affect the pharmacodynamics of some anesthetics, and the sensitivity of some anesthetics would increase among icteric patients. Remimazolam is a new ultra-short-acting intravenous benzodiazepine sedative/anesthetic, which is a high-selective and affinity ligand for the benzodiazepine site on the GABAA receptor. However, no study has reported the pharmacodynamics of remimazolam in patients with obstructive jaundice. We hypothesize that obstructive jaundice affects the pharmacodynamics of remimazolam, and the sensitivity of remimazolam increases among icteric patients.
    Methods/design: The study will be performed as a prospective, controlled, multicenter trial. The study design is a comparison of remimazolam requirements to reach a bispectral index of 50 in patients with obstructive jaundice versus non-jaundiced patients with chronic cholecystitisor intrahepatic bile duct stones. Remimazolam was infused at 6 mg/kg/h until this endpoint was reached.
    Discussion: Remimazolam could be suitable for anesthesia of patients with obstructive jaundice, because remimazolam is not biotransformed in the liver. Hyperbilirubinemia has been well-described to have toxic effects on the brain, which causes the increasing of sensitivity to some anesthetics, such as desflurane, isoflurane, and etomidate. Furthermore, remimazolam and etomidate have the same mechanism of action when exerting an anesthetic effect. We aim to demonstrate that obstructive jaundice affects the pharmacodynamics of remimazolam, and the dose of remimazolam when administered to patients with obstructive jaundice should be modified.
    Trial registration: Chinese Clinical Trial Registry ChiCTR2100043585 . Registered on 23 February 2021.
    MeSH term(s) Anesthetics, Intravenous ; Benzodiazepines ; Humans ; Hypnotics and Sedatives/adverse effects ; Jaundice, Obstructive/chemically induced ; Jaundice, Obstructive/diagnosis ; Jaundice, Obstructive/drug therapy ; Multicenter Studies as Topic ; Prospective Studies
    Chemical Substances Anesthetics, Intravenous ; Hypnotics and Sedatives ; Benzodiazepines (12794-10-4) ; remimazolam (7V4A8U16MB)
    Language English
    Publishing date 2022-01-08
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-021-05987-y
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  7. Article: T-cell Co-inhibitory Molecules in Sepsis-induced Immunosuppression: From Bench to Bedside.

    Xie, Jian-Feng / Qiu, Hai-Bo / Yang, Yi

    Chinese medical journal

    2017  Volume 130, Issue 10, Page(s) 1249–1252

    MeSH term(s) Adaptive Immunity/immunology ; Animals ; CTLA-4 Antigen/metabolism ; Humans ; Immunosuppression ; Intensive Care Units ; Programmed Cell Death 1 Receptor/metabolism ; Sepsis/immunology ; Sepsis/metabolism
    Chemical Substances CTLA-4 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2017-05-08
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    DOI 10.4103/0366-6999.205867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Challenge in clinical therapy for acute respiratory distress syndrome].

    Qiu, Hai-bo

    Zhonghua nei ke za zhi

    2008  Volume 47, Issue 8, Page(s) 617–619

    MeSH term(s) Humans ; Respiratory Distress Syndrome, Adult/therapy
    Language Chinese
    Publishing date 2008-08
    Publishing country China
    Document type Editorial
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
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  9. Article: [Titration of the optimal positive end-expiratory pressure and its prognostic value in acute respiratory distress syndrome].

    Qiu, Hai-bo

    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases

    2007  Volume 30, Issue 10, Page(s) 733–737

    MeSH term(s) Adult ; Humans ; Hypoxia/etiology ; Hypoxia/physiopathology ; Hypoxia/therapy ; Lung Volume Measurements ; Positive-Pressure Respiration/methods ; Prognosis ; Pulmonary Alveoli/pathology ; Pulmonary Alveoli/physiopathology ; Respiratory Distress Syndrome, Adult/complications ; Respiratory Distress Syndrome, Adult/physiopathology ; Respiratory Distress Syndrome, Adult/therapy ; Tidal Volume
    Language Chinese
    Publishing date 2007-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 1027965-9
    ISSN 1001-0939
    ISSN 1001-0939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Challenges in clinical diagnosis of acute respiratory distress syndrome].

    Qiu, Hai-Bo

    Zhonghua nei ke za zhi

    2007  Volume 46, Issue 10, Page(s) 793–795

    MeSH term(s) Humans ; Respiratory Distress Syndrome, Adult/diagnosis ; Respiratory Distress Syndrome, Adult/physiopathology
    Language Chinese
    Publishing date 2007-10
    Publishing country China
    Document type Editorial
    ZDB-ID 754223-9
    ISSN 0578-1426
    ISSN 0578-1426
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