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  1. Article: Trend in Antimicrobial Resistance of

    Liang, Yingjian / Qiu, Lidi / Zheng, Xiaobin / Liu, Jing

    publication RETRACTED

    Infection and drug resistance

    2021  Volume 14, Page(s) 2179–2181

    Abstract: In this report, we analyze the trends in antimicrobial resistance ... ...

    Abstract In this report, we analyze the trends in antimicrobial resistance of
    Language English
    Publishing date 2021-06-10
    Publishing country New Zealand
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S318005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical characteristics of hospitalized patients with Nocardia genus detection by metagenomic next generation sequencing in a tertiary hospital from southern China.

    Liang, Yingjian / Lin, Minmin / Qiu, Lidi / Chen, Meizhu / Tan, Cuiyan / Tu, Changli / Zheng, Xiaobin / Liu, Jing

    BMC infectious diseases

    2023  Volume 23, Issue 1, Page(s) 772

    Abstract: Objective: As an opportunistic pathogen, Nocardia often occurring in the immunocompromised hosts. As the unspecifc clinical presentation and low identification rate of the culture dependent methods, Nocardia infection may be under-diagnosis. Recent ... ...

    Abstract Objective: As an opportunistic pathogen, Nocardia often occurring in the immunocompromised hosts. As the unspecifc clinical presentation and low identification rate of the culture dependent methods, Nocardia infection may be under-diagnosis. Recent study have reported physicians could benefit from metagenomic next-generation sequencing (mNGS) in Nocardia diagnosis. Herein, we present patients with a positive detection of nocardiosis in mNGS, aiming to provide useful information for an differential diagnosis and patients management.
    Methods: A total of 3756 samples detected for mNGS from March 2019 to April 2022 at the Fifth Affifiliated Hospital of Sun Yat-sen University, were screened. Clinical records, laboratory finding, CT images and mNGS results were reviewed for 19 patients who were positive for Nocardia genus.
    Results: Samples from low respiratory tract obtained by bronchoscope took the major part of the positive (15/19). 12 of 19 cases were diagnosis as Nocardiosis Disease (ND) and over half of the ND individuals (7/12) were geriatric. Nearly all of them (10/12) were immunocompetent and 2 patients in ND group were impressively asymptomatic. Cough was the most common symptom. Nocardia cyriacigeorgica (4/12) was more frequently occurring in ND, followed by Nocardia abscessus (3/12). There are 3 individuals detected more than one kind of Nocardia species (Supplementary table 1). Except one with renal failure and one allergic to sulfamethoxazole, all of them received co-sulfonamide treatment and relieved eventually.
    Conclusion: Our study deciphered the clinical features of patients with positive nocardiosis detected by mNGS. Greater attention should be paid to the ND that occurred in the immunocompetent host and the geriatric. Due to the difficulties in establishing diagnosis of Nocardiosis disease, mNGS should play a much more essential role for a better assessment in those intractable cases. Co-sulfonamide treatment should still be the first choice of Nocardiosis disease.
    MeSH term(s) Humans ; Aged ; Tertiary Care Centers ; High-Throughput Nucleotide Sequencing ; Nocardia/genetics ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Sulfamethoxazole/therapeutic use ; Sulfanilamide ; China
    Chemical Substances Sulfamethoxazole (JE42381TNV) ; Sulfanilamide (21240MF57M)
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-023-08615-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tropheryma whipplei

    Lin, Minmin / Wang, Kongqiu / Qiu, Lidi / Liang, Yingjian / Tu, Changli / Chen, Meizhu / Wang, Zhenguo / Wu, Jian / Huang, Yiying / Tan, Cuiyan / Chen, Qijiu / Zheng, Xiaobin / Liu, Jing

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 961297

    Abstract: Tropheryma ... ...

    Abstract Tropheryma whipplei
    MeSH term(s) Bronchoalveolar Lavage Fluid/microbiology ; Cross-Sectional Studies ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tropheryma/genetics
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.961297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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