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  1. Article ; Online: Comment on 'Prediabetes is an independent risk factor for sarcopenia in older men, but not in older women: the Bunkyo Health Study' by Kaga et al.

    Qiu, Shanhu / Cai, Xue / Sun, Zilin / Wu, Tongzhi

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 14, Issue 5, Page(s) 2452–2453

    Language English
    Publishing date 2023-07-12
    Publishing country Germany
    Document type Letter
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13293
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  2. Article: Combined use of Anlotinib with chemotherapy in patients with advanced ovarian cancer: a real-world cohort study and meta-analysis.

    Hong, XinYi / Qiu, ShanHu / Ding, Bo / Xu, Hao / Shen, Yang

    Therapeutic advances in medical oncology

    2024  Volume 16, Page(s) 17588359231221336

    Abstract: Background: Anlotinib is a novel oral small-molecule receptor tyrosine kinase inhibitor. However, the efficacy and safety of its combined use with chemotherapy remain unclear in patients with advanced ovarian cancer.: Objectives: To assess the ... ...

    Abstract Background: Anlotinib is a novel oral small-molecule receptor tyrosine kinase inhibitor. However, the efficacy and safety of its combined use with chemotherapy remain unclear in patients with advanced ovarian cancer.
    Objectives: To assess the efficacy and safety of the combined use of Anlotinib with chemotherapy in patients with advanced ovarian cancer.
    Design: A multi-center retrospective real-world analysis and a meta-analysis.
    Data sources and methods: We enrolled patients with advanced ovarian cancer who received a combination therapy of Anlotinib and chemotherapy from 15 medical centers. We also searched electronic databases for studies assessing the efficacy and safety of the combined use of Anlotinib with chemotherapy in patients with ovarian cancer. The outcomes of interest included objective response rate (ORR), disease control rate (DCR), and median progression-free survival (mPFS).
    Results: A total of 71 patients, who were predominantly recurrent cases, were included in the real-world study. The ORR and DCR of the included patients were 40.8% and 76.1%, respectively; and their mPFS was 4.6 months. The log-rank test showed that previous antiangiogenic therapy was related to a longer mPFS (p < 0.05). Five studies in total were eligible for meta-analysis. The random-effects meta-analysis model showed that the ORR, DCR, and mPFS were 33.8% [95% confidence interval (CI) 22.7-44.8% from four studies], 90.6% (95% CI 73.6-99.9% from five studies), and 6.6 months (95% CI 4.9-8.4 months from five studies). The most common adverse events were hand-foot syndrome and hypertension.
    Conclusion: The combined use of Anlotinib with chemotherapy showed potential in treating patients with advanced ovarian cancer, with a tolerable safety profile.
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231221336
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  3. Article ; Online: Performance of different machine learning algorithms in identifying undiagnosed diabetes based on nonlaboratory parameters and the influence of muscle strength: A cross-sectional study.

    Xu, Ying / Qiu, Shanhu / Ye, Jinli / Chen, Dan / Wang, Donglei / Zhou, Xiaoying / Sun, Zilin

    Journal of diabetes investigation

    2024  

    Abstract: Aims/introduction: Machine learning algorithms based on the artificial neural network (ANN), support vector machine, naive Bayesian or logistic regression model are commonly used to identify diabetes. This study investigated which approach performed the ...

    Abstract Aims/introduction: Machine learning algorithms based on the artificial neural network (ANN), support vector machine, naive Bayesian or logistic regression model are commonly used to identify diabetes. This study investigated which approach performed the best and whether muscle strength provided any incremental benefit in identifying undiagnosed diabetes in Chinese adults.
    Methods: This cross-sectional study enrolled 4,482 eligible participants from eight provinces in China, who were randomly divided into the training dataset (n = 3,586) and the testing dataset (n = 896). Muscle strength was assessed by handgrip strength and the number of chair stands in the 30-s chair stand test. An oral glucose tolerance test was used to ascertain undiagnosed diabetes. The areas under the curve (AUCs) were calculated accordingly and compared with each other.
    Results: Of the included participants, 233 had newly diagnosed diabetes. All the four machine learning algorithms, which were developed based on nonlaboratory parameters, showed acceptable discriminative ability in identifying undiagnosed diabetes (all AUCs >0.70), with the ANN approach performing the best (AUC 0.806). Adding handgrip strength or the 30-s chair stand test to this approach did not increase the AUC further (P = 0.39 and 0.26, respectively). Furthermore, compared with the New Chinese Diabetes Risk Score, the ANN approach showed a larger AUC in identifying undiagnosed diabetes (P
    Conclusions: The ANN approach performed the best in identifying undiagnosed diabetes in Chinese adults; however, the addition of muscle strength might not improve its efficacy.
    Language English
    Publishing date 2024-03-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2625840-7
    ISSN 2040-1124 ; 2040-1116
    ISSN (online) 2040-1124
    ISSN 2040-1116
    DOI 10.1111/jdi.14166
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    Zs.A 6920: Show issues Location:
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  4. Article ; Online: High Vasohibin-2 expression correlated with autophagy in proliferative diabetic retinopathy.

    Ding, Yuzhi / Su, Na / Luan, Jie / Xu, Jian / Qiu, Shanhu / Sun, Zilin

    Experimental eye research

    2024  Volume 240, Page(s) 109808

    Abstract: Vasohibin-2 (VASH2) is confirmed to be associated with angiogenesis. To investigate the vitreous levels of VASH2 and how VASH2 induces angiogenesis in proliferative diabetic retinopathy (PDR), a total of 120 eyes were enrolled in this prospective and ... ...

    Abstract Vasohibin-2 (VASH2) is confirmed to be associated with angiogenesis. To investigate the vitreous levels of VASH2 and how VASH2 induces angiogenesis in proliferative diabetic retinopathy (PDR), a total of 120 eyes were enrolled in this prospective and randomized controlled study and the vitreous level of VASH2 was quantified by Luminex liquid suspension chip. Vector systems were applied in human retinal microvascular endothelial cells (HRMECs) for VASH2 gene overexpression, along with interfering lentiviral vectors (VASH2-shRNA) for VASH2 gene silencing. Cell migration, autophagic flux, as well as the expression of α-tubulin, detyrosinated ⍺-tubulin, LC3 II/LC3 I, P62 were detected under normal, VASH2 overexpression, or interference conditions. The level of VASH2 in PDR patients was significantly higher (218.61 ± 30.14 pg/ml) than that in ERM/MH patients (80.78 ± 2.05 pg/ml) (P = 0.001). The migration ability of HRMECs was significantly increased in VASH2 overexpression group, while in the interfering group, the migration ability decreased. VASH2 increased the detyrosination of ⍺-tubulin. The high fluorescence intensity of autophagic flux showed an activation of autophagy in VASH2 overexpression group, which was also confirmed by the increase of LC3 II/LC3 I ratio and the decrease of P62. Collectively, the present study shows in PDR, vitreous level of VASH2 is higher. VASH2 promotes neovascularization by inducing autophagy, suggesting VASH2 could be a new anti-angiogenic drug target for PDR.
    MeSH term(s) Humans ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/metabolism ; Endothelial Cells/metabolism ; Tubulin/metabolism ; Prospective Studies ; Neovascularization, Pathologic/metabolism ; Diabetes Mellitus/metabolism ; Angiogenic Proteins/genetics
    Chemical Substances Tubulin ; VASH2 protein, human ; Angiogenic Proteins
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2024.109808
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    Zs.A 163: Show issues Location:
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  5. Article: Editorial: Management of Diabetes and its Complications: A Focus on Endothelial Dysfunction.

    Qiu, Shanhu / Ma, Jianhua / Wu, Tongzhi

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 857983

    Language English
    Publishing date 2022-03-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.857983
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  6. Article ; Online: The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease.

    Liu, Dan / Guan, Xiaoyang / Chen, Ruoxin / Song, Ci / Qiu, Shanhu / Xu, Shengchun / Cao, Jingyuan / Liu, Hong

    Renal failure

    2024  Volume 46, Issue 1, Page(s) 2320261

    Abstract: Introduction: Insulin resistance (IR) plays an important role in the occurrence and development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). The triglyceride-glucose (TyG) index is a simple and effective tool to ... ...

    Abstract Introduction: Insulin resistance (IR) plays an important role in the occurrence and development of cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). The triglyceride-glucose (TyG) index is a simple and effective tool to evaluate IR. This study aimed to evaluate the association of the TyG index with coronary artery disease (CAD) and the severity of coronary artery stenosis (CAS) in nondialysis patients with stages 3-5 CKD.
    Methods: Nondialysis patients with stages 3-5 CKD who underwent the first coronary angiography at Zhongda Hospital affiliated with Southeast University from August 2015 to January 2017 were retrospectively analyzed. CAS was measured by coronary angiography, and the CAS score was calculated as the Gensini score. Logistic regression analysis was used to determine the related factors of CAD and severe CAS.
    Results: A total of 943 patients were enrolled in this cross-sectional study and 720 (76.4%) of these patients were diagnosed with CAD. The TyG index in the CAD group (7.29 ± 0.63) was significantly higher than that in the non-CAD group (7.11 ± 0.61) (
    Conclusions: The TyG index is associated with CAD and the severity of CAS in patients with nondialysis stages 3-5 CKD. A higher TyG index is an independent factor for CAD and severe CAS.
    MeSH term(s) Humans ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/etiology ; Glucose ; Retrospective Studies ; Triglycerides ; Cross-Sectional Studies ; Blood Glucose/analysis ; Biomarkers ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/etiology ; Risk Factors ; Renal Insufficiency, Chronic/complications
    Chemical Substances Glucose (IY9XDZ35W2) ; Triglycerides ; Blood Glucose ; Biomarkers
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2024.2320261
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    Zs.A 1331: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Circulating irisin in nonalcoholic fatty liver disease: an updated meta-analysis.

    Qiu, Shanhu / Wang, Qianqian / Cai, Xue / Sun, Zilin / Wu, Tongzhi

    Endokrynologia Polska

    2022  Volume 74, Issue 1, Page(s) 47–54

    Abstract: Introduction: Exogenous administration of recombinant irisin may reverse hepatic steatosis and steatohepatitis. However, it remains controversial as to whether nonalcoholic fatty liver disease (NAFLD) shows reduced circulating (serum/plasma) irisin ... ...

    Abstract Introduction: Exogenous administration of recombinant irisin may reverse hepatic steatosis and steatohepatitis. However, it remains controversial as to whether nonalcoholic fatty liver disease (NAFLD) shows reduced circulating (serum/plasma) irisin levels. A meta-analysis was conducted to address this issue.
    Material and methods: A literature search of databases was performed up to June 2021. Observational studies that reported circulating irisin in NAFLD ascertained by any methods (e.g. ultrasonography or magnetic resonance) and compared with any controls were eligible for inclusion. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were obtained using a random-effects meta-analysis model.
    Results: Eleven studies enrolling 1277 NAFLD cases and 944 non-NAFLD controls were included. The approaches used for NAFLD ascertainment included ultrasonography (4 studies), magnetic resonance (3 studies), and liver biopsy (5 studies). Meta-analysis showed that circulating irisin in NAFLD was comparable to any non-NAFLD controls (10 studies with 11 datasets; SMD -0.09, 95% CI: -0.48 to 0.29), including the body mass index (BMI)-matched and lean controls (both p ≥ 0.80). Restricting studies to NAFLD ascertained by magnetic resonance or liver biopsy rather than ultrasonography showed that serum irisin was reduced in NAFLD (5 studies, SMD -0.63, 95% CI: -1.14 to -0.13). Meta-analysis also suggested that circulating irisin did not differ between mild and moderate-to-severe NAFLD (7 studies; SMD 0.02, 95% CI: -0.25 to 0.30), and this association was not significantly moderated by study location (Europe versus Asia).
    Conclusions: Circulating irisin in NAFLD did not differ from any non-NAFLD controls and was unlikely to be affected by disease severity or racial-ethnic difference.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/pathology ; Fibronectins ; Magnetic Resonance Imaging ; Body Mass Index ; Severity of Illness Index ; Liver
    Chemical Substances Fibronectins
    Language English
    Publishing date 2022-09-12
    Publishing country Poland
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 419270-9
    ISSN 2299-8306 ; 0423-104X
    ISSN (online) 2299-8306
    ISSN 0423-104X
    DOI 10.5603/EP.a2022.0067
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    Zs.A 204: Show issues Location:
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  8. Article ; Online: Muscle Quality in Relation to Prediabetes Phenotypes: A Population-Based Study With Mediation Analysis.

    Qiu, Shanhu / Cai, Xue / Zhou, Xiaoying / Xu, Jinshui / Sun, Zilin / Guo, Haijian / Wu, Tongzhi

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 3, Page(s) e1151–e1158

    Abstract: Context: Prediabetes is associated with an increased risk of physical disability, yet no studies have assessed the extent to which muscle quality, a measure reflecting muscle functionality, was altered in prediabetes and its specific phenotype.: ... ...

    Abstract Context: Prediabetes is associated with an increased risk of physical disability, yet no studies have assessed the extent to which muscle quality, a measure reflecting muscle functionality, was altered in prediabetes and its specific phenotype.
    Objective: We evaluated their associations in a general US population with mediation analysis.
    Methods: This was a cross-sectional study based on the National Health and Nutrition Examination Survey 2011-2014. Participants with prediabetes were stratified as having an isolated defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or impaired hemoglobin A1c [IA1c]), 2 defects (IFG + IGT, IFG + IA1c, or IGT + IA1c), or all defects (IFG + IGT + IA1c). Muscle quality was calculated as dominant grip strength divided by dominant arm muscle mass measured by dual-energy X-ray absorptiometry.
    Results: We included 2351 participants (938 with prediabetes and 1413 with normoglycemia). Despite higher grip strength and larger arm muscle mass, arm muscle quality was lower in prediabetes and all prediabetes phenotypes (except for IGT) than normoglycemia (all P < .04), and was unrelated to prediabetes awareness. Arm muscle quality was decreased and the odds of low arm muscle quality was increased in prediabetes with increasing numbers of glucometabolic defects (both P < .001), with insulin resistance being the predominant mediator. HbA1c-defined prediabetes (IA1c) had lower arm muscle quality and higher odds of low arm muscle quality than blood glucose-defined prediabetes (IFG, IGT, or IFG + IGT).
    Conclusion: Muscle quality was impaired in prediabetes and its specific phenotype. Relative to blood glucose, elevated HbA1c might be a better predictor of reduced muscle quality.
    MeSH term(s) Humans ; Prediabetic State ; Blood Glucose ; Glycated Hemoglobin ; Cross-Sectional Studies ; Mediation Analysis ; Nutrition Surveys ; Glucose Intolerance ; Muscles ; Phenotype ; Fasting
    Chemical Substances Blood Glucose ; Glycated Hemoglobin
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad630
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  9. Book ; Online ; Thesis: Irisin response to exercise training in adults and its effect on the regulation of C2C12 cell proliferation and differentiation

    Qiu, Shanhu

    2015  

    Author's details Shanhu Qiu
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Ulm, 2015
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Is estimated cardiorespiratory fitness an effective predictor for cardiovascular and all-cause mortality? A meta-analysis.

    Qiu, Shanhu / Cai, Xue / Sun, Zilin / Wu, Tongzhi / Schumann, Uwe

    Atherosclerosis

    2021  Volume 330, Page(s) 22–28

    Abstract: Background and aims: Estimated cardiorespiratory fitness (eCRF) derived from algorithm correlates well with exercise testing-measured CRF, yet its clinical use for mortality risk stratification has not been systematically evaluated. This meta-analysis ... ...

    Abstract Background and aims: Estimated cardiorespiratory fitness (eCRF) derived from algorithm correlates well with exercise testing-measured CRF, yet its clinical use for mortality risk stratification has not been systematically evaluated. This meta-analysis with dose-response analysis was conducted to quantify its association with risk of cardiovascular and all-cause mortality.
    Methods: Electronic databases were searched for prospective cohort studies that investigated the association of eCRF with risk of cardiovascular and all-cause mortality. Study-specific multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per 1-metabolic equivalent (MET) higher of eCRF were pooled using a random-effects model.
    Results: Twenty-five datasets from 8 cohort studies that enrolled more than 170,000 participants were included. The summary HR per 1-MET higher of eCRF was 0.83 (95% CI 0.80 to 0.86) for cardiovascular mortality (11 datasets) and 0.83 (95% CI 0.78 to 0.88) for all-cause mortality (14 datasets) in the general population. These associations showed no sex-difference and were all linearly shaped (all p
    Conclusions: Higher eCRF was independently associated with lower risk of cardiovascular and all-cause mortality in the general population, indicating that eCRF might hold the potential as an effective and practical risk prediction tool in epidemiological or population research.
    MeSH term(s) Body Mass Index ; Cardiorespiratory Fitness ; Cardiovascular Diseases/diagnosis ; Exercise ; Exercise Test ; Humans ; Mortality ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2021-06-25
    Publishing country Ireland
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 80061-2
    ISSN 1879-1484 ; 0021-9150
    ISSN (online) 1879-1484
    ISSN 0021-9150
    DOI 10.1016/j.atherosclerosis.2021.06.904
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