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Article ; Online: 3D sponge loaded with cisplatin-CS-calcium alginate MPs utilized as a void-filling prosthesis for the efficient postoperative prevention of tumor recurrence and metastasis.

Yang, Yihong / Ye, Genlan / Qiu, Xiaozhong

RSC advances

2024 Volume 14, Issue 11, Page(s) 7517–7527

Abstract: Intraoperative bleeding is a pivotal factor in the initiation of early recurrence and tumor metastasis following breast cancer excision. Distinct advantages are conferred upon postoperative breast cancer treatment through the utilization of locally ... ...

Abstract	Intraoperative bleeding is a pivotal factor in the initiation of early recurrence and tumor metastasis following breast cancer excision. Distinct advantages are conferred upon postoperative breast cancer treatment through the utilization of locally administered implant therapies. This study devised a novel 3D sponge implant containing cisplatin-loaded chitosan-calcium alginate MPs capable of exerting combined chemotherapy and hemostasis effects. This innovative local drug-delivery implant absorbed blood and residual tumor cells post-tumor resection. Furthermore, the cisplatin-loaded chitosan-calcium alginate MPs sustainably targeted and eliminated cancer cells, thereby diminishing the risk of local recurrence and distant metastasis. This hydrogel material can also contribute to breast reconstruction, indicating the potential application of the 3D sponge in drug delivery for breast cancer treatment.
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07516h
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Article ; Online: Bioelectricity-coupling patches for repairing impaired myocardium.

Li, Yuedan / Qiu, Xiaozhong

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2022 Volume 14, Issue 4, Page(s) e1787

Abstract: Cardiac abnormalities, which account for extensive burdens on public health and economy, drive necessary attempts to revolutionize the traditional therapeutic system. Advances in cardiac tissue engineering have expanded a highly efficacious platform to ... ...

Abstract	Cardiac abnormalities, which account for extensive burdens on public health and economy, drive necessary attempts to revolutionize the traditional therapeutic system. Advances in cardiac tissue engineering have expanded a highly efficacious platform to address cardiovascular events, especially cardiac infarction. Current efforts to overcome biocompatible limitations highlight the constructs of a conductive cardiac patch to accelerate the industrial and clinical landscape that is amenable for patient-accurate therapy, regenerative medicine, disease modeling, and drug delivery. With the notion that cardiac tissue synchronically contracts triggered by electrical pulses, the cardiac patches based on conductive materials are developed and treated on the dysfunctional heart. In this review, we systematically summarize distinct conductive materials serving as the most promising alternatives (conductive nanomaterials, conductive polymers, piezoelectric polymers, and ionic electrolytes) to achieve electric signal transmission and engineered cardiac tissues. Existing applications are discussed considering how these patches containing conductive candidates are fabricated into diverse forms with major strategies. Ultimately, we try to define a new concept as a bioelectricity-coupling patch that provides a favorable cardiac micro-environment for cardiac functional activities. Underlying challenges and prospects are presented regarding industrial processing and cardiovascular treatment of conductive patch progress. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease.
MeSH term(s)	Biocompatible Materials ; Electric Conductivity ; Humans ; Myocardium ; Polymers ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Biocompatible Materials ; Polymers
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1787
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Zs.A 6781: Show issues

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Article ; Online: A rapid interactive chitosan-based medium with antioxidant and pro-vascularization properties for infected burn wound healing.

Li, Zhentao / Xing, Xianglong / Zhao, Chaoran / Wu, Qi / Liu, Junjie / Qiu, Xiaozhong / Wang, Leyu

Carbohydrate polymers

2024 Volume 333, Page(s) 121991

Abstract: Large-pore hydrogels are better suited to meet the management needs of nutrient transportation and gas exchange between infected burn wounds and normal tissues. However, better construction strategies are required to balance the pore size and mechanical ... ...

Abstract	Large-pore hydrogels are better suited to meet the management needs of nutrient transportation and gas exchange between infected burn wounds and normal tissues. However, better construction strategies are required to balance the pore size and mechanical strength of hydrogels to construct a faster substance/gas interaction medium between tissues. Herein, we developed spongy large pore size hydrogel (CS-TA@Lys) with good mechanical properties using a simple ice crystal-assisted method based on chitosan (CS), incorporating tannic acid (TA) and ε-polylysine (Lys). A large-pore and mechanically robust hydrogel medium was constructed based on hydrogen bonding between CS molecules. On this basis, a pro-restorative functional platform with antioxidation and pro-vascularization was constructed using TA and Lys. In vitro experiments displayed that the CS-TA@Lys hydrogel possessed favorable mechanical properties and fast interaction performances. In addition, the CS-TA@Lys hydrogel possessed the capacity to remove intra/extracellular reactive oxygen species (ROS) and possessed antimicrobial and pro-angiogenic properties. In vivo experiments displayed that the CS-TA@Lys hydrogel inhibited wound inflammation and promoted wound vascularization. In addition, the CS-TA@Lys hydrogel showed the potential for rapid hemostasis. This study provides a potential functional wound dressing with rapid interaction properties for skin wound repair.
MeSH term(s)	Humans ; Chitosan ; Antioxidants/pharmacology ; Burns/drug therapy ; Biocompatible Materials ; Hydrogels/pharmacology ; Neovascularization, Pathologic ; Wound Healing ; Anti-Bacterial Agents ; Polyphenols
Chemical Substances	Chitosan (9012-76-4) ; Antioxidants ; Tannic Acid ; Biocompatible Materials ; Hydrogels ; Anti-Bacterial Agents ; Polyphenols
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2024.121991
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Article ; Online: A cigarette filter-derived biomimetic cardiac niche for myocardial infarction repair.

Tang, Guofeng / Li, Zhentao / Ding, Chengbin / Zhao, Jiang / Xing, Xianglong / Sun, Yan / Qiu, Xiaozhong / Wang, Leyu

Bioactive materials

2024 Volume 35, Page(s) 362–381

Abstract: Cell implantation offers an appealing avenue for heart repair after myocardial infarction (MI). Nevertheless, the implanted cells are subjected to the aberrant myocardial niche, which inhibits cell survival and maturation, posing significant challenges ... ...

Abstract	Cell implantation offers an appealing avenue for heart repair after myocardial infarction (MI). Nevertheless, the implanted cells are subjected to the aberrant myocardial niche, which inhibits cell survival and maturation, posing significant challenges to the ultimate therapeutic outcome. The functional cardiac patches (CPs) have been proved to construct an elastic conductive, antioxidative, and angiogenic microenvironment for rectifying the aberrant microenvironment of the infarcted myocardium. More importantly, inducing implanted cardiomyocytes (CMs) adapted to the anisotropic arrangement of myocardial tissue by bioengineered structural cues within CPs are more conducive to MI repair. Herein, a functional Cig/(TA-Cu) CP served as biomimetic cardiac niche was fabricated based on structural anisotropic cigarette filter by modifying with tannic acid (TA)-chelated Cu
Language	English
Publishing date	2024-02-14
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2024.02.012
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Article ; Online: Molecularly Imprinted Macroporous Hydrogel Promotes Bone Regeneration via Osteogenic Induction and Osteoclastic Inhibition.

Chen, Jingxiao / Jing, Yihan / Liu, Yanhong / Luo, Yongxi / He, Yutong / Qiu, Xiaozhong / Zhang, Qingbin / Xu, Huiyong

Advanced healthcare materials

2024 , Page(s) e2400897

Abstract: Macroporous hydrogels offer physical supportive spaces and bio-instructive environment for the seeded cells, where cell-scaffold interactions directly influence cell fates and subsequently affect tissue regeneration post-implantation. Effectively ... ...

Abstract	Macroporous hydrogels offer physical supportive spaces and bio-instructive environment for the seeded cells, where cell-scaffold interactions directly influence cell fates and subsequently affect tissue regeneration post-implantation. Effectively modifying bioactive motifs at the inner pore surface provides appropriate niches for cell-scaffold interactions. A molecular imprinting method and sacrificial templates are introduced to prepare inner pore surface modification in the macroporous hydrogels. In detail, acrylated bisphosphonates (Ac-BPs) chelating to templates (CaCO
Language	English
Publishing date	2024-04-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202400897
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Zs.A 6966: Show issues

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Article ; Online: Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair.

Yin, Wenming / Yang, Chang / Liu, Dan / Cha, Shuhan / Cai, Liu / Ye, Genlan / Song, Xiaoping / Zhang, Jifeng / Qiu, Xiaozhong

Biomedical materials (Bristol, England)

2024 Volume 19, Issue 3

Abstract: It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease ... ...

Abstract	It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease of production, multi-scale porous structure, high flexibility, and excellent biocompatibility. By utilizing the reducing properties of polydopamine, non-conductive graphene oxide (GO) was converted into conductive reduced graphene oxide (rGO) and crosslinked
MeSH term(s)	Animals ; Spinal Cord Injuries/therapy ; Tissue Scaffolds/chemistry ; Porosity ; Graphite/chemistry ; Bivalvia ; Nerve Regeneration ; Polymers/chemistry ; Biocompatible Materials/chemistry ; Indoles/chemistry ; Animal Shells/chemistry ; Cell Differentiation ; Electric Conductivity ; Neurons ; Rats ; Rats, Sprague-Dawley ; Cell Adhesion ; Neurogenesis ; Tissue Engineering/methods ; Nerve Growth Factor/metabolism ; Nerve Growth Factor/chemistry ; Hippocampus
Chemical Substances	Graphite (7782-42-5) ; graphene oxide ; Polymers ; Biocompatible Materials ; polydopamine ; Indoles ; Nerve Growth Factor (9061-61-4)
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ad3f63
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Zs.A 6626: Show issues

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Article: [T

Zhou, Huimin / Qiu, Xiaozhong / Shen, Zheyu

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2020 Volume 40, Issue 3, Page(s) 427–444

Abstract: Magnetic resonance imaging (MRI) is an important imaging modality for clinical disease diagnosis, and nearly 50% of clinical MRI examinations require contrast agents to enhance the diagnostic sensitivity. This review provides a summary of the major MRI ... ...

Abstract	Magnetic resonance imaging (MRI) is an important imaging modality for clinical disease diagnosis, and nearly 50% of clinical MRI examinations require contrast agents to enhance the diagnostic sensitivity. This review provides a summary of the major MRI contrast agents and their classification, and the advantages and limits of the commercially available MRI contrast agents, and elaborates on the exceedingly small magnetic iron oxide nanoparticles (ES-MIONs), dotted core-shell iron and gadolinium hybrid nanoparticles (FeGd-HN) and exceedingly small gadolinium oxide nanoparticles (ES-GON). These nanoparticles can greatly improve the efficiency of T
MeSH term(s)	Contrast Media ; Humans ; Magnetic Resonance Imaging ; Nanoparticles ; Neoplasms ; Theranostic Nanomedicine
Chemical Substances	Contrast Media
Language	Chinese
Publishing date	2020-05-06
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2020.03.24
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Zs.A 6344: Show issues

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Article ; Online: Improved cancer immunotherapy strategies by nanomedicine.

Guo, Shuai / Feng, Jie / Li, Zongheng / Yang, Sugeun / Qiu, Xiaozhong / Xu, Yikai / Shen, Zheyu

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2022 Volume 15, Issue 3, Page(s) e1873

Abstract: Cancer immunotherapy agents fight cancer via immune system stimulation and have made significant advances in minimizing side effects and prolonging the survival of patients with solid tumors. However, major limitations still exist in cancer immunotherapy, ...

Abstract	Cancer immunotherapy agents fight cancer via immune system stimulation and have made significant advances in minimizing side effects and prolonging the survival of patients with solid tumors. However, major limitations still exist in cancer immunotherapy, including the inefficiency of immune response stimulation in specific cancer types, therapy resistance caused by the tumor microenvironment (TME), toxicities by the immune imbalance, and short lifetime of stimulator of interferon genes (STING) agonist. Recent advances in nanomedicine have shown significant potential in overcoming the obstacles of cancer immunotherapy. Several nanoscale agents have been reported for cancer immunotherapy, including nanoscale cancer vaccines impacting the STING pathway, nanomaterials reprogramming TME, nano-agents triggering immune response with immune checkpoint inhibitor synergy, ferroptosis-mediated and indoleamine-2,3-dioxygenase immunosuppression-mediated cancer immunotherapy, and nanomedicine-meditated chimeric antigen receptor-T-cell therapy. Herein, we summarize the major advances and innovations in nanomedicine-based cancer immunotherapy, and outline the opportunities and challenges to integrate more advanced nanomaterials into cancer immunotherapy. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.
MeSH term(s)	Humans ; Nanomedicine ; Immunotherapy ; Neoplasms/therapy ; Immunity ; Tumor Microenvironment
Language	English
Publishing date	2022-12-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1873
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Zs.A 6781: Show issues

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Article ; Online: Tumor-specific cyclic amplification of oxidative stress by disulfide-loaded fluoropolymer nanogels.

Xie, Ruihong / Zhang, Peng / Cai, Liu / Guo, Ranran / Wang, Leyu / Qiu, Xiaozhong / Tian, Ye

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2022 Volume 180, Page(s) 212–223

Abstract: Amplification of intracellular oxidative stress has been found to be an effective strategy to induce cancer cell death. Herein, the effect of a disulfide, 2,2'-dithiobis(5-aminopyridine) (BAPS), is revealed on depleting glutathione (GSH) circularly and ... ...

Abstract	Amplification of intracellular oxidative stress has been found to be an effective strategy to induce cancer cell death. Herein, the effect of a disulfide, 2,2'-dithiobis(5-aminopyridine) (BAPS), is revealed on depleting glutathione (GSH) circularly and generating superoxide anion (O
MeSH term(s)	Humans ; Nanogels ; Disulfides ; Glutathione/metabolism ; Oxidative Stress ; Neoplasms/drug therapy ; Cell Line, Tumor
Chemical Substances	Nanogels ; Disulfides ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2022-10-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2022.10.010
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Zs.B 1651: Show issues

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Article ; Online: Zwitterionic Conductive Hydrogel-Based Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration in Rats.

Xu, Yizhou / Liu, Jianing / Zhang, Peng / Ao, Xiang / Li, Yunlun / Tian, Ye / Qiu, Xiaozhong / Guo, Jiasong / Hu, Xiaofang

ACS biomaterials science & engineering

2023 Volume 9, Issue 12, Page(s) 6821–6834

Abstract: In recent years, conductive biomaterials have been widely used to enhance peripheral nerve regeneration. However, most biomaterials use electronic conductors to increase the conductivity of materials. As information carriers, electronic conductors always ...

Abstract	In recent years, conductive biomaterials have been widely used to enhance peripheral nerve regeneration. However, most biomaterials use electronic conductors to increase the conductivity of materials. As information carriers, electronic conductors always transmit discontinuous electrical signals, while biological systems essentially transmit continuous signals through ions. Herein, an ion-based conductive hydrogel was fabricated by simple copolymerization of the zwitterionic monomer sulfobetin methacrylate and hydroxyethyl methacrylate. Benefiting from the excellent mechanical stability, suitable electrical conductivity, and good cytocompatibility of the zwitterionic hydrogel, the Schwann cells cultured on the hydrogel could grow and proliferate better, and dorsal root ganglian had an increased neurite length. The zwitterionic hydrogel-based nerve guidance conduits were then implanted into a 10 mm sciatic nerve defect model in rats. Morphological analysis and electrophysiological data showed that the grafts achieved a regeneration effect close to that of the autologous nerve. Overall, our developed zwitterionic hydrogel facilitates efficient and efficacious peripheral nerve regeneration by mimicking the electrical and mechanical properties of the extracellular matrix and creating a suitable regeneration microenvironment, providing a new material reserve for the repair of peripheral nerve injury.
MeSH term(s)	Rats ; Animals ; Hydrogels/pharmacology ; Biocompatible Materials/pharmacology ; Sciatic Nerve/physiology ; Tissue Scaffolds ; Nerve Regeneration/physiology
Chemical Substances	Hydrogels ; Biocompatible Materials
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00761
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