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Article ; Online: Cytoskeleton Rearrangement in Podocytopathies: An Update.

Ma, Sijia / Qiu, Yang / Zhang, Chun

International journal of molecular sciences

2024 Volume 25, Issue 1

Abstract: Podocyte injury can disrupt the glomerular filtration barrier (GFB), leading to podocytopathies that emphasize podocytes as the glomerulus's key organizer. The coordinated cytoskeleton is essential for supporting the elegant structure and complete ... ...

Abstract	Podocyte injury can disrupt the glomerular filtration barrier (GFB), leading to podocytopathies that emphasize podocytes as the glomerulus's key organizer. The coordinated cytoskeleton is essential for supporting the elegant structure and complete functions of podocytes. Therefore, cytoskeleton rearrangement is closely related to the pathogenesis of podocytopathies. In podocytopathies, the rearrangement of the cytoskeleton refers to significant alterations in a string of slit diaphragm (SD) and focal adhesion proteins such as the signaling node nephrin, calcium influx via transient receptor potential channel 6 (TRPC6), and regulation of the Rho family, eventually leading to the disorganization of the original cytoskeletal architecture. Thus, it is imperative to focus on these proteins and signaling pathways to probe the cytoskeleton rearrangement in podocytopathies. In this review, we describe podocytopathies and the podocyte cytoskeleton, then discuss the molecular mechanisms involved in cytoskeleton rearrangement in podocytopathies and summarize the effects of currently existing drugs on regulating the podocyte cytoskeleton.
MeSH term(s)	Cytoskeleton ; Microtubules ; Calcium, Dietary ; Focal Adhesions ; Glomerular Filtration Barrier
Chemical Substances	Calcium, Dietary
Language	English
Publishing date	2024-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010647
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel Zn

Chen, Panpan / Xu, Chenyang / Qiu, Yang / Wang, Yi

Ecotoxicology and environmental safety

2024 Volume 273, Page(s) 116144

Abstract: Mesotrione, topramezone, tembotrione, and sulcotrione are four types of 4-hydroxyphenylpyruvate dioxidase (HPPD) inhibitor herbicides that are extensively employed in agricultural practices, but their usage also leads to environmental pollution and poses ...

Abstract	Mesotrione, topramezone, tembotrione, and sulcotrione are four types of 4-hydroxyphenylpyruvate dioxidase (HPPD) inhibitor herbicides that are extensively employed in agricultural practices, but their usage also leads to environmental pollution and poses risks to human health. A probe (E)-1-((2-(pyridin-2-yl) hydrazineylidene) methyl) naphthalen-2-ol (CHMN) based on chelation enhancement (CHEF) effect synthesized. CHMN was first chelated with Zn
MeSH term(s)	Humans ; Fluorescence ; 4-Hydroxyphenylpyruvate Dioxygenase ; Herbicides/pharmacology ; Zinc ; Enzyme Inhibitors/pharmacology ; Cyclohexanones ; Mesylates ; Sulfones
Chemical Substances	tembotrione (WA5UZ202KS) ; sulcotrione (5UEH9SXW7V) ; mesotrione (48TR68G21T) ; 4-Hydroxyphenylpyruvate Dioxygenase (EC 1.13.11.27) ; Herbicides ; Zinc (J41CSQ7QDS) ; Enzyme Inhibitors ; Cyclohexanones ; Mesylates ; Sulfones
Language	English
Publishing date	2024-02-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2024.116144
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Article ; Online: Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis.

Qiu, Yang / Bai, Lu / Zhao, Haosen / Mei, Xifan

BMC cancer

2024 Volume 24, Issue 1, Page(s) 520

Abstract: Acute myeloid leukaemia (AML) is a fatal haematopoietic malignancy and is treated with the conventional combination of cytarabine (Ara-C) and daunorubicin (Dau). The survival rate of AML patients is lower due to the cardiotoxicity of daunorubicin. ... ...

Abstract	Acute myeloid leukaemia (AML) is a fatal haematopoietic malignancy and is treated with the conventional combination of cytarabine (Ara-C) and daunorubicin (Dau). The survival rate of AML patients is lower due to the cardiotoxicity of daunorubicin. Clinically, homoharringtonine (HHT) plus Ara-C has been reported to be equally effective as Dau plus Ara-C in some types of AML patients with less toxic effects. We utilized the clinical use of homoharringtonine in combination with Ara-C to test its combination mechanism. We found that the insensitivity of AML cells to cytarabine-induced apoptosis is associated with increased Mcl-1 stability and p38 inactivation. HHT downregulates Mcl-1, phosphorylates H2AX and induces apoptosis by activating p38 MAPK. Inactivation of p38 through inhibitors and siRNA blocks apoptosis, H2AX phosphorylation and Mcl-1 reduction. HHT enhances Ara-C activation of the p38 MAPK signalling pathway, overcoming Ara-C tolerance to cell apoptosis by regulating the p38/H2AX/Mcl-1 axis. The optimal ratio of HHT to Ara-C for synergistic lethality in AML cells is 1:4 (M/M). HHT synergistically induces apoptosis in combination with Ara-C in vitro and prolongs the survival of xenografts. We provide a new mechanism for AML treatment by regulating the p38 MAPK/H2AX/Mcl-1 axis to improve cytarabine therapy.
MeSH term(s)	Humans ; Homoharringtonine/pharmacology ; Cytarabine/pharmacology ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/genetics ; Apoptosis/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism ; Animals ; Mice ; Xenograft Model Antitumor Assays ; Histones/metabolism ; Cell Line, Tumor ; Drug Synergism ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Phosphorylation/drug effects ; Female
Chemical Substances	Homoharringtonine (6FG8041S5B) ; Cytarabine (04079A1RDZ) ; Myeloid Cell Leukemia Sequence 1 Protein ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MCL1 protein, human ; Histones ; H2AX protein, human
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12286-7
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Book ; Online: Low-Rate, Low-Distortion Compression with Wasserstein Distortion

Qiu, Yang / Wagner, Aaron B.

2024

Abstract: Wasserstein distortion is a one-parameter family of distortion measures that was recently proposed to unify fidelity and realism constraints. After establishing continuity results for Wasserstein in the extreme cases of pure fidelity and pure realism, we ...

Abstract	Wasserstein distortion is a one-parameter family of distortion measures that was recently proposed to unify fidelity and realism constraints. After establishing continuity results for Wasserstein in the extreme cases of pure fidelity and pure realism, we prove the first coding theorems for compression under Wasserstein distortion focusing on the regime in which both the rate and the distortion are small. Comment: arXiv admin note: text overlap with arXiv:2310.03629
Keywords	Computer Science - Information Theory ; 94A34 ; E.4
Publishing date	2024-01-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A method for evaluating the toxicity interaction of binary mixtures.

Wei, Qiu-Yang

MethodsX

2020 Volume 7, Page(s) 101029

Abstract: Improving the formulation of biological insecticides for greater efficiency and competitiveness is of particular importance with respect to the successful application of these agents in the field. In this regard, mixing different agents is known to be an ...

Abstract	Improving the formulation of biological insecticides for greater efficiency and competitiveness is of particular importance with respect to the successful application of these agents in the field. In this regard, mixing different agents is known to be an effective strategy for enhancing practical pest control. However, traditional chemical-based control strategies have significant limitations that compromise control effectiveness, as effects tend to become increasingly dose-dependent over time. To overcome such limitations, and thereby ensure the continuous effective control of insect pests, we herein assessed the efficacy of binary mixtures of biological agents, with the aim of establishing an optimal ratio. The optimized mixture showed a significantly higher insecticidal effect, whereby biological pest control was considerably enhanced.•We combined
Language	English
Publishing date	2020-08-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2020.101029
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Article ; Online: A method for evaluating the toxicity interaction of binary mixtures

Qiu-yang Wei

MethodsX, Vol 7, Iss , Pp 101029- (2020)

2020

Abstract	Improving the formulation of biological insecticides for greater efficiency and competitiveness is of particular importance with respect to the successful application of these agents in the field. In this regard, mixing different agents is known to be an effective strategy for enhancing practical pest control. However, traditional chemical-based control strategies have significant limitations that compromise control effectiveness, as effects tend to become increasingly dose-dependent over time. To overcome such limitations, and thereby ensure the continuous effective control of insect pests, we herein assessed the efficacy of binary mixtures of biological agents, with the aim of establishing an optimal ratio. The optimized mixture showed a significantly higher insecticidal effect, whereby biological pest control was considerably enhanced. • We combined Beauveria bassiana spores with azadirachtin, a chemical pesticide of botanical origin, and by assessing the efficacy of these two elements combined in different ratios, obtained an optimal formula. Additionally, we evaluated the compatibility between the two elements, and then assessed potential synergistic effects, as determined by the co-toxicity coefficient. • This protocol is dependent on the results of bioassays. It is not only suitable for combining fungal and chemical agents for the purposes of biocontrol but is also applicable to a variety of biological pesticides. • The evaluated binary mixture showed enhanced effective insect control. This approach will contribute to reducing applied dosages, thereby promoting efficient pest control and reducing application costs.
Keywords	Bioassay ; Co-toxicity coefficient (CTC) ; Synergism ; Science ; Q
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trends of mental health care utilization among US adults from 1999 to 2018.

Wang, Junzhe / Qiu, Yang / Zhu, Xiaozhou

BMC psychiatry

2023 Volume 23, Issue 1, Page(s) 665

Abstract: Background: Mental health disorders affect millions of US adults, however, the trends and related factors for mental health care utilization in the US remain unknown.: Aims: Our study aimed to assess the trend of mental health utilization and related ...

Abstract	Background: Mental health disorders affect millions of US adults, however, the trends and related factors for mental health care utilization in the US remain unknown. Aims: Our study aimed to assess the trend of mental health utilization and related socio-demographic factors in the US. Methods: The study included 55,052 individuals from the National Health and Nutrition Examination Survey (NHANES) in 1999-2018. Temporal trends in the percentages of mental health care utilizers were estimated across survey cycles. Trends and linked factors of mental health care utilization were assessed by a logistic regression model, while the non-linearity was estimated by restricted cubic splines. Results: From 1999 to 2018, the percentage of mental health care utilizers in the US adult population increased from 7.0 to 11.3% (P < 0.001); meanwhile, the trends in males and females were consistent. The percentage increased positively with age in individuals aged 20-39 (P < 0.001) or aged 60 and over (P = 0.003). The trends were consistent in three race/ethnicity groups (P < 0.05). The logistic regression analysis revealed that several disparities existed in the subpopulations. Older age, female, lower family poverty-income ratio (PIR), chronic diseases, higher educational level, and smoking were estimated to be associated with a higher percentage of mental health care. Conclusions: The percentage of mental health care utilizers took on an increasing trend in the US adult population from 1999 to 2018. These trends were also observed in the subpopulations, but with disparities. Future research for exploring factors associated with mental health care utilizations is necessary.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Middle Aged ; Aged ; Nutrition Surveys ; Patient Acceptance of Health Care ; Mental Health ; Ethnicity ; Income
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-023-05156-2
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Article ; Online: Optimal placement criteria of hybrid mounting system for chassis in future mobility based on beam-type continuous smart structures.

Qiu, Yang / Hong, Dongwoo / Kim, Byeongil

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2317

Abstract: Recently, research into the development of hybrid and electric vehicles has been vigorously undertaken, indicating a trend toward the replacement of internal combustion engine vehicles. However, while high efficiency and light weight are crucial in the ... ...

Abstract	Recently, research into the development of hybrid and electric vehicles has been vigorously undertaken, indicating a trend toward the replacement of internal combustion engine vehicles. However, while high efficiency and light weight are crucial in the development of vehicles, they increase the excitation force of the engine. In addition, sensor placement in future mobility is very important since it causes malfunctioning of autonomous driving systems when the location and orientation of sensors are changed due to excessive vehicle vibration. To reduce the structure-borne noise and vibration caused by engine excitation, an active engine mounting system must be installed in an optimal location. Thus, in this study, to determine the optimal location for an active engine mounting system applied to a beam structure, a series of simulations with two different methodologies are performed. The overall beam structure with two active mounting systems is modeled based on the lumped parameter model. To determine the optimal position of the active mounting system, it is moved to equal intervals, and the force and phase of the active mounts at each location combination are calculated based on static and dynamic methods. The optimal position is suggested such that the vibration reduction is maximized, while the applied force is minimized. Additionally, a feasibility experiment is conducted to validate the proposed criteria and confirm the simulation results. The results demonstrate that the optimal location of the active engine mounting system with a minimized force requirement and maximized vibration reduction can be identified.
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29379-1
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Article ; Online: Optimal placement criteria of actuators for hybrid mounting system on a non-aligned plate structure.

Qiu, Yang / Hong, Dongwoo / Kim, Byeongil

Scientific reports

2023 Volume 13, Issue 1, Page(s) 17732

Abstract: Electric motors in electric and hybrid vehicles generate mid-frequency noise and vibration. These factors cause drivers to experience discomfort while traveling. Active mounting techniques have been extensively researched and developed to effectively ... ...

Abstract	Electric motors in electric and hybrid vehicles generate mid-frequency noise and vibration. These factors cause drivers to experience discomfort while traveling. Active mounting techniques have been extensively researched and developed to effectively address this issue. The optimal placement of an active mounting system is essential for enhancing NVH performance when an active mounting system is utilized. In order to propose optimal location criteria for active paths, this paper concentrates on developing an analytical model based on both dynamic and static analysis. The secondary forces along active trajectories are mathematically determined when a structure is subjected to an excitation force. These locations are considered optimal for the active mounting system if the secondary forces are comparatively minimal. Simulations and feasibility experiments are also conducted in order to validate the proposed method. In addition, the results are compared with the case of beam structure. It has been determined through this procedure that the active path's control performance will be enhanced if it is positioned in the optimal location and less control force is required than in the case of beam.
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-44980-0
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Article ; Online: Vibration characteristics of an active mounting system for motion control of a plate-like structure in future mobilities.

Hong, Dongwoo / Qiu, Yang / Kim, Byeongil

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16278

Abstract: The vibration and noise caused by electric motors in hybrid and electric vehicles (EVs) generate complex signals with a mid-frequency band, which causes uncomfortable vibration and noise. In order to isolate the vibration and noise, active engine ... ...

Abstract	The vibration and noise caused by electric motors in hybrid and electric vehicles (EVs) generate complex signals with a mid-frequency band, which causes uncomfortable vibration and noise. In order to isolate the vibration and noise, active engine mounting systems based on smart structures have attracted attention. Thus, in this study, the vibration attenuation performance was validated through simulation and feasibility experiments by applying an active mounting system using a piezoelectric stack actuator. A plate structure with three paths, consisting of two passive paths and one active path, was modeled using the lumped parameter method. The source part was excited by a sinusoidal and modulated signal with a mid-frequency band to validate the vibration attenuation performance. Furthermore, (1) mathematical modeling with a source-path-receiver structure was proposed based on lumped parameter modeling, (2) normalized least mean square (NLMS) and multi-NLMS algorithms were applied to implement motion control, and (3) a principal experimental setup was designed to validate the simulation results. Through this process, the vibration attenuation performance of the proposed active mount structure was validated.
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43419-w
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