LIVIVO - Search results -

Search results

Result 1 - 10 of total 29

Search options

Article ; Online: The Cost-Effectiveness of an Advanced Hybrid Closed-Loop System Compared to Standard Management of Type 1 Diabetes in a Singapore Setting.

Gardner, Daphne / Lakkad, Mrinmayee / Qiu, Zhiyu / Inoue, Yuta / Rama Chandran, Suresh / Wherry, Kael

2024 Volume 26, Issue 5, Page(s) 324–334

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/economics ; Diabetes Mellitus, Type 1/blood ; Cost-Benefit Analysis ; Singapore ; Hypoglycemic Agents/economics ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/therapeutic use ; Insulin Infusion Systems/economics ; Quality-Adjusted Life Years ; Male ; Female ; Blood Glucose Self-Monitoring/economics ; Insulin/administration & dosage ; Insulin/economics ; Insulin/therapeutic use ; Adult ; Blood Glucose/analysis ; Glycated Hemoglobin/analysis ; Middle Aged
Chemical Substances	Hypoglycemic Agents ; Insulin ; Blood Glucose ; Glycated Hemoglobin
Language	English
Publishing date	2024-03-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comparative Study
ZDB-ID	1452816-2
ISSN	1557-8593 ; 1520-9156
ISSN (online)	1557-8593
ISSN	1520-9156
DOI	10.1089/dia.2023.0455
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5269: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: YdfD, a Lysis Protein of the Qin Prophage, Is a Specific Inhibitor of the IspG-Catalyzed Step in the MEP Pathway of

Lu, Zhifang / Wang, Biying / Qiu, Zhiyu / Zhang, Ruiling / Zheng, Jimin / Jia, Zongchao

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Bacterial cryptic prophage (defective prophage) genes are known to drastically influence host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages encode lytic proteins to destroy the cell envelope. As natural antibiotics, ...

Abstract	Bacterial cryptic prophage (defective prophage) genes are known to drastically influence host physiology, such as causing cell growth arrest or lysis, upon expression. Many phages encode lytic proteins to destroy the cell envelope. As natural antibiotics, only a few lysis target proteins were identified.
MeSH term(s)	Biocatalysis ; Conserved Sequence ; Cysteine/chemistry ; Erythritol/analogs & derivatives ; Erythritol/metabolism ; Escherichia coli/metabolism ; Escherichia coli/ultrastructure ; Escherichia coli Proteins/metabolism ; Models, Biological ; Prophages/metabolism ; Protein Binding ; Protein Structure, Secondary ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Solutions ; Stress, Physiological ; Sugar Phosphates/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Chemical Substances	2-C-methylerythritol 4-phosphate ; Escherichia coli Proteins ; RNA, Messenger ; Solutions ; Sugar Phosphates ; Viral Proteins ; Cysteine (K848JZ4886) ; Erythritol (RA96B954X6)
Language	English
Publishing date	2022-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031560
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Preparation and SERS performance of silver nanowires arrays on paper by automatic writing method.

Wang, Kun / Qiu, Zhiyu / Qin, Yufei / Feng, Longxiu / Huang, Lei / Xiao, Guina

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2022 Volume 281, Page(s) 121580

Abstract: Silver nanowire ink was written on the surface of drawing paper by automatic writing method. Scanning electron microscopy was used to characterize the surface morphologies of the drawing paper before and after writing silver nanowires. The effects of ... ...

Abstract	Silver nanowire ink was written on the surface of drawing paper by automatic writing method. Scanning electron microscopy was used to characterize the surface morphologies of the drawing paper before and after writing silver nanowires. The effects of fabrication parameters and measurement parameters on silver nanowires arrays were investigated. Crystal violet was selected as the probe molecule to study the SERS performance of silver nanowires arrays. The detection limit of crystal violet was as low as 10
MeSH term(s)	Gentian Violet ; Nanowires/chemistry ; Silver/chemistry ; Spectrum Analysis, Raman/methods ; Writing
Chemical Substances	Silver (3M4G523W1G) ; Gentian Violet (J4Z741D6O5)
Language	English
Publishing date	2022-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2022.121580
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 51/98: Show issues
Z 1611 a: Show issues
924/340: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: PLK1-mediated phosphorylation of PPIL2 regulates HR

Qiu, Zhiyu / Hao, Shuailin / Song, Shikai / Zhang, Ruiling / Yan, Tingyu / Lu, Zhifang / Wang, Hailong / Jia, Zongchao / Zheng, Jimin

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 902403

Abstract: Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator of the pathway ... ...

Abstract	Homologous recombination (HR) is an error-free DNA double-strand break (DSB) repair pathway, which safeguards genome integrity and cell viability. Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator of the pathway which initiates the DNA end resection in HR. Ubiquitination modification of CtIP is known in some cases to control DNA resection and promote HR. However, it remains unclear how cells restrain CtIP activity in unstressed cells. We show that the ubiquitin E3 ligase PPIL2 is recruited to DNA damage sites through interactions with an HR-related protein ZNF830, implying PPIL2's involvement in DNA repair. We found that PPIL2 interacts with and ubiquitinates CtIP at the K426 site, representing a hereunto unknown ubiquitination site. Ubiquitination of CtIP by PPIL2 suppresses HR and DNA resection. This inhibition of PPIL2 is also modulated by phosphorylation at multiple sites by PLK1, which reduces PPIL2 ubiquitination of CtIP. Our findings reveal new regulatory complexity in CtIP ubiquitination in DSB repair. We propose that the PPIL2-dependent CtIP ubiquitination prevents CtIP from interacting with DNA, thereby inhibiting HR.
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.902403
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transarterial chemoembolization combined with microwave ablation and apatinib in patients with Barcelona clinic liver cancer Stage C hepatocellular carcinoma: A propensity score matching analysis.

Shuanggang, Chen / Shen, Lujun / Qiu, Zhiyu / Qi, Han / Cao, Fei / Xie, Lin / Fan, Weijun

Journal of cancer research and therapeutics

2020 Volume 16, Issue 2, Page(s) 250–257

Abstract: Context and aims: Apatinib combined with transarterial chemoembolization (TACE) has shown promising results in cases of Barcelona clinic liver cancer Stage C (BCLC C) hepatocellular carcinoma (HCC). This study aimed to investigate the efficacy and ... ...

Abstract	Context and aims: Apatinib combined with transarterial chemoembolization (TACE) has shown promising results in cases of Barcelona clinic liver cancer Stage C (BCLC C) hepatocellular carcinoma (HCC). This study aimed to investigate the efficacy and safety of TACE in combination with microwave ablation (MWA) and apatinib. Materials and methods: A retrospective, single.center study was undertaken using a one.to.one propensity score matching (PSM) analysis design and involved BCLC C HCC patients who underwent treatment with TACE.MWA.apatinib or TACE alone between January 2013 and June 2018. The patients were recommended to administer 500mg apatinib per day, combined with MWA and TACE. The adverse effects of apatinib, MWA. and TACE.related complications, progression.free survival (PFS), and overall survival (OS) were assessed. Results: Of the 149 patients with BCLC C HCC who underwent TACE.MWA.apatinib or TACE alone, 131 were included in our study. Among them, 21 (16.0%) received TACE.MWA.apatinib and 110 (84.0%) underwent TACE alone. After PSM, twenty pairs were enrolled into different treatment groups. Patients in the TACE.MWA.apatinib group had a significantly longer median PFS than patients in the TACE.alone group on both before (median, 8.9 vs. 1.7 months, P = 0.0002) and after PSM (median, 5.4 vs. 2.1 months, P = 0.001). They also had a significantly longer median OS than patients in the TACE.alone group on before (median, 24.4 vs. 5.8 months, P = 0.000007) and after PSM (median, 24.4 vs. 5.4 months, P = 0.00005). Conclusions: The combination of apatinib, TACE, and MWA in BCLC C HCC patients is safe and effective. Toxicity is manageable by adjusting the apatinib dosage.
MeSH term(s)	Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/mortality ; Combined Modality Therapy ; Disease Progression ; Female ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Male ; Microwaves/therapeutic use ; Middle Aged ; Neoplasm Staging ; Propensity Score ; Protein Kinase Inhibitors/administration & dosage ; Pyridines/administration & dosage ; Radiofrequency Ablation/mortality ; Retrospective Studies ; Survival Rate
Chemical Substances	Protein Kinase Inhibitors ; Pyridines ; apatinib (5S371K6132)
Language	English
Publishing date	2020-05-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2187633-2
ISSN	1998-4138 ; 0973-1482
ISSN (online)	1998-4138
ISSN	0973-1482
DOI	10.4103/jcrt.JCRT_345_19
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.

Wu, Wenping / Shen, Qingya / Zhang, Ruiling / Qiu, Zhiyu / Wang, Youjun / Zheng, Jimin / Jia, Zongchao

The EMBO journal

2020 Volume 39, Issue 19, Page(s) e104285

Abstract: The MICU1-MICU2 heterodimer regulates the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake. Herein, we present two crystal structures of the MICU1-MICU2 heterodimer, in which ... ...

Abstract	The MICU1-MICU2 heterodimer regulates the mitochondrial calcium uniporter (MCU) and mitochondrial calcium uptake. Herein, we present two crystal structures of the MICU1-MICU2 heterodimer, in which Ca
MeSH term(s)	Calcium/chemistry ; Calcium/metabolism ; Calcium Channels/chemistry ; Calcium Channels/genetics ; Calcium Channels/metabolism ; Calcium-Binding Proteins/chemistry ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cation Transport Proteins/chemistry ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Crystallography, X-Ray ; Humans ; Ion Transport ; Mitochondrial Membrane Transport Proteins/chemistry ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Membrane Transport Proteins/metabolism ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism
Chemical Substances	Calcium Channels ; Calcium-Binding Proteins ; Cation Transport Proteins ; MICU1 protein, human ; MICU2 protein, human ; Mitochondrial Membrane Transport Proteins ; Multiprotein Complexes ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.2019104285
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾

Article ; Online: Inkjet printed silver nanoparticles on hydrophobic papers for efficient detection of thiram.

Duan, Junli / Qiu, Zhiyu / Li, Ling / Feng, Longxiu / Huang, Lei / Xiao, Guina

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2020 Volume 243, Page(s) 118811

Abstract: Silver nanoparticles coated paper (AgNPs-paper) substrates were prepared by inkjet printing Ag ink on four different wettability papers. Scanning electron microscope and contact angle analyzer were used to characterize their surface morphology and ... ...

Abstract	Silver nanoparticles coated paper (AgNPs-paper) substrates were prepared by inkjet printing Ag ink on four different wettability papers. Scanning electron microscope and contact angle analyzer were used to characterize their surface morphology and wettability. AgNPs-paper substrates were used to detect the surface-enhanced Raman scattering (SERS) spectra of thiram aqueous solution. Relationships between the surface wettability, surface morphology and SERS activities of the substrates were systematically studied. The silver nanoparticles deposited on the hydrophobic papers (photographic paper, graph paper, and weighing paper) were evenly and densely arranged. While in-homogeneous distribution was observed on the hydrophilic printing paper. It can be found that the AgNPs-photographic paper with the maximum contact angle exhibited the highest SERS enhancement. The detection limit for thiram adsorbed on the AgNPs-photographic paper was 10
Language	English
Publishing date	2020-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2020.118811
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 51/98: Show issues
Z 1611 a: Show issues
924/340: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Dysregulation of PLOD2 Promotes Tumor Metastasis and Invasion in Hepatocellular Carcinoma.

Li, Keren / Niu, Yi / Li, Kai / Zhong, Chengrui / Qiu, Zhiyu / Yuan, Yichuan / Shi, Yunxing / Lin, Zhu / Huang, Zhenkun / Zuo, Dinglan / Yuan, Yunfei / Li, Binkui

Journal of clinical and translational hepatology

2023 Volume 11, Issue 5, Page(s) 1094–1105

Abstract: Background and aims: Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma (HCC) patients while the underlying mechanism of metastasis remains elusive. In our study, procollagen-lysine, 2-oxoglutarate 5- ... ...

Abstract	Background and aims: Metastasis is a major factor associated with high recurrence and mortality in hepatocellular carcinoma (HCC) patients while the underlying mechanism of metastasis remains elusive. In our study, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) was shown to be involved in the process of metastasis in HCC. Methods: The Cancer Genome Atlas (TCGA) database and HCC tissue microarrays were used to evaluate the expression of genes. Results: The expression of PLOD2 in HCC tissues was higher than that in adjacent tissues, and increased PLOD2 expression was often found in advanced tumors and was correlated with poor prognosis in HCC patients. Conclusions: High expression of PLOD2 was regulated by IRF5, which was correlated with the poor survival of HCC patients. PLOD2 enhanced HCC metastasis via BIRC3, suggesting that PLOD2 might be a valuable prognostic biomarker for HCC treatment.
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2022.00401
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: RFX6 facilitates aerobic glycolysis-mediated growth and metastasis of hepatocellular carcinoma through targeting PGAM1.

Qiu, Zhiyu / Wang, Chenwei / Huang, Pinzhu / Yuan, Yichuan / Shi, Yunxing / Lin, Zhu / Huang, Zhenkun / Zuo, Dinglan / Qiu, Jiliang / He, Wei / Shen, Jingxian / Niu, Yi / Yuan, Yunfei / Li, Binkui

Clinical and translational medicine

2023 Volume 13, Issue 12, Page(s) e1511

Abstract: Background: Hepatocellular carcinoma (HCC) cells undergo reprogramming of glucose metabolism to support uncontrolled proliferation, of which the intrinsic mechanism still merits further investigation. Although regulatory factor X6 (RFX6) is aberrantly ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) cells undergo reprogramming of glucose metabolism to support uncontrolled proliferation, of which the intrinsic mechanism still merits further investigation. Although regulatory factor X6 (RFX6) is aberrantly expressed in different cancers, its precise role in cancer development remains ambiguous. Methods: Microarrays of HCC tissues were employed to investigate the expression of RFX6 in tumour and adjacent non-neoplastic tissues. Functional assays were employed to explore the role of RFX6 in HCC development. Chromatin immunoprecipitation, untargeted metabolome profiling and sequencing were performed to identify potential downstream genes and pathways regulated by RFX6. Metabolic assays were employed to investigate the effect of RFX6 on glycolysis in HCC cells. Bioinformatics databases were used to validate the above findings. Results: HCC tissues exhibited elevated expression of RFX6. High RFX6 expression represented as an independent hazard factor correlated to poor prognosis in patients with HCC. RFX6 deficiency inhibited HCC development in vitro and in vivo, while its overexpression exerted opposite functions. Mechanistically, RFX6 bound to the promoter area of phosphoglycerate mutase 1 (PGAM1) and upregulated its expression. The increased PGAM1 protein levels enhanced glycolysis and further promoted the development of HCC. Conclusions: RFX6 acted as a novel driver for HCC development by promoting aerobic glycolysis, disclosing the potential of the RFX6-PGAM1 axis for therapeutic targeting.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/metabolism ; Cell Proliferation/genetics ; Glycolysis/genetics ; Liver Neoplasms/metabolism ; Phosphoglycerate Mutase/genetics ; Phosphoglycerate Mutase/metabolism
Chemical Substances	Phosphoglycerate Mutase (EC 5.4.2.11) ; Rfx6 protein, human ; phosphoglycerate mutase 1, human (EC 5.4.2.11)
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1511
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Design of bifunctional ultrathin MnO

Wu, Sheng-Tao / Su, Hui-Qi / Xiao, Qian-Xiang / Qiu, Zhi-Yu / Huang, Gang-Qiang / He, Man-Ni / Ge, Yi / Wang, Cong-Hui / Lin, Ying-Wu

Journal of hazardous materials

2023 Volume 461, Page(s) 132493

Abstract: Laccase-catalyzed oxidative reactions are increasingly examined as a reliable approach to environmental analysis and remediation, and it is urgent to widen metal category to compensate huge gap in the number of studies on copper- and non-copper laccase ... ...

Abstract	Laccase-catalyzed oxidative reactions are increasingly examined as a reliable approach to environmental analysis and remediation, and it is urgent to widen metal category to compensate huge gap in the number of studies on copper- and non-copper laccase mimics. Herein, two-dimensional ultrathin MnO
Language	English
Publishing date	2023-09-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132493
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito