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  1. Article ; Online: Causal associations between liver enzymes and diabetic microvascular complications

    Yang Li / Qiu Zhang

    PLoS ONE, Vol 19, Iss

    A univariable and multivariable Mendelian randomization

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Causal associations between liver enzymes and diabetic microvascular complications

    Yang Li / Qiu Zhang

    PLoS ONE, Vol 19, Iss 1, p e

    A univariable and multivariable Mendelian randomization.

    2024  Volume 0296894

    Abstract: Background Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The ... ...

    Abstract Background Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The purpose of this research is to examine the independent causal effects of liver enzymes on diabetic microvascular complications. Methods Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) were utilized to disentangle the causal effects. The genome-wide association study (GWAS) summary-level statistics were collected from the UK biobank and the FinnGen consortium. Single nucleotide polymorphisms (SNPs) were selected as genetic instruments with genome-wide significance (p < 5 ×10-8). Five UVMR approaches, including inverse variance weighted (IVW), Bayesian weighted Mendelian randomization, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), weighted median, and MR-Egger, and three MVMR approaches, including the extended versions of IVW, MR-Egger, and the Q-minimization methods, were performed to evaluate the causal effects. The robustness of the MR results was further confirmed using several sensitivity analyses. Results UVMR revealed that a genetically predisposed per standard deviation increase in serum alanine aminotransferase (ALT) level increased the risk of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) (IVW OR = 1.489, 95% CI = 1.206-1.772, p = 0.006). Likewise, serum aspartate aminotransferase (AST) levels showed similar results (IVW OR = 1.376, 95% CI = 1.115-1.638, p = 0.017). Furthermore, these effects were consistent after controlling for glycemia and blood pressure using MVMR analysis. Additionally, sensitivity analyses further strengthened the causality. However, no significant associations were found between alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and diabetic microvascular complications. Conclusions Robust evidence was demonstrated for an independent causal effect of serum ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Rupture of a previously undiagnosed intracranial aneurysm during endoscopic dacryocystorhinostomy

    Meng‐Qiu Zhang / Xin Wang

    Clinical Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)

    A case report

    2023  

    Abstract: Abstract Endoscopic endonasal dacryocystorhinostomy (EE‐DCR) is an effective treatment for dacryocystitis. Aneurysmal rupture is generally not considered a complication of EE‐DCR under general anesthesia. Here, we present a patient with intracerebral and ...

    Abstract Abstract Endoscopic endonasal dacryocystorhinostomy (EE‐DCR) is an effective treatment for dacryocystitis. Aneurysmal rupture is generally not considered a complication of EE‐DCR under general anesthesia. Here, we present a patient with intracerebral and subarachnoid hemorrhage secondary to the rupture of an undiagnosed intracranial aneurysm during EE‐DCR. Clinicians should be aware of such fatal complications when using any vasoconstrictor intraoperatively.
    Keywords case report ; endoscopic endonasal dacryocystorhinostomy ; intracerebral hemorrhage ; intracranial aneurysm ; subarachnoid hemorrhage ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A 14-Bit, 12 V-to-100 V Voltage Compliance Electrical Stimulator with Redundant Digital Calibration.

    Su, Kangyu / Qiu, Zhang / Xu, Jian

    Micromachines

    2023  Volume 14, Issue 11

    Abstract: Electrical stimulation is an important technique for modulating the functions of the nervous system through electrical stimulus. To implement a more competitive prototype that can tackle the domain-specific difficulties of existing electrical stimulators, ...

    Abstract Electrical stimulation is an important technique for modulating the functions of the nervous system through electrical stimulus. To implement a more competitive prototype that can tackle the domain-specific difficulties of existing electrical stimulators, three key techniques are proposed in this work. Firstly, a load-adaptive power saving technique called over-voltage detection is implemented to automatically adjust the supply voltage. Secondly, redundant digital calibration (RDC) is proposed to improve current accuracy and ensure safety during long-term electrical stimulation without costing too much circuit area and power. Thirdly, a flexible waveform generator is designed to provide arbitrary stimulus waveforms for particular applications. Measurement results show the stimulator can adjust the supply voltage from 12 V to 100 V automatically, and the measured effective resolution of the stimulation current reaches 14 bits in a full range of 6.5 mA. Without applying charge balancing techniques, the average mismatch between the cathodic and anodic current pulses in biphasic stimulus is 0.0427%. The proposed electrical stimulator can generate arbitrary stimulus waveforms, including sine, triangle, rectangle, etc., and it is supposed to be competitive for implantable and wearable devices.
    Language English
    Publishing date 2023-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14112001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acute air embolism caused by autotransfusion during percutaneous atrial septal defect closure

    Yu‐Qi Liao / Meng‐Qiu Zhang

    Clinical Case Reports, Vol 10, Iss 3, Pp n/a-n/a (2022)

    A case report

    2022  

    Abstract: Abstract Atrial septal defect is a common congenital heart disease in adults and it is often asymptomatic. Percutaneous device closure is gaining popularity, but percutaneous repair of atrial septal defect leading to left atrial rupture and subsequent ... ...

    Abstract Abstract Atrial septal defect is a common congenital heart disease in adults and it is often asymptomatic. Percutaneous device closure is gaining popularity, but percutaneous repair of atrial septal defect leading to left atrial rupture and subsequent autotransfusion under high pressure leading to air embolism has not been reported yet.
    Keywords air embolism ; atrial septal defect ; autologous blood transfusion ; case report ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association between vitamin D and insulin resistance in adults with latent tuberculosis infection

    Yong Chen / Yi-qing Chen / Qiu Zhang

    Journal of Infection and Public Health, Vol 15, Iss 8, Pp 930-

    Results from the National Health and Nutrition Examination Survey (NHANES) 2011–2012

    2022  Volume 935

    Abstract: Background: Evidence demonstrated that vitamin D insufficiency was involved in insulin resistance (IR) pathogenesis and associated with tuberculosis. However, the association of vitamin D and IR in patients with latent tuberculosis infection (LTBI) ... ...

    Abstract Background: Evidence demonstrated that vitamin D insufficiency was involved in insulin resistance (IR) pathogenesis and associated with tuberculosis. However, the association of vitamin D and IR in patients with latent tuberculosis infection (LTBI) remains unclear. This study aims to evaluate the association between vitamin D and insulin resistance in US adults with LTBI. Method: National Health and Nutrition Examination Survey (NHANES) participants ≥ 20 years during the years 2011–2012 with positive QuantiFERON®-TB Gold-In-Tube (QFT) or tuberculin skin testing (TST) were enrolled in present study. Participants with LTBI were divided into 2 groups: (1) vitamin D insufficiency group (n = 267), and (2) vitamin D sufficiency group (n = 437). Results: Weighted analysis of all the population in the study showed that serum 25(OH)D inversely correlated with HOMA-IR (r = −0.14, P = 0.008). The vitamin D insufficiency group had higher fasting insulin (17.5 (1.38) vs. 15.29 (3.1), respectively, P = 0.0013) and HOMA-IR (5.0 (0.4) vs. 4.5 (1), respectively, P = 0.013) than the vitamin D sufficiency group. In adjusted analysis, vitamin D levels was independently associated with insulin resistance (adjusted OR [aOR] 2.74; 95% CI, 1.01–7.48, p = 0.0489). Conclusions: Taken together, our study suggested that serum 25(OH) D concentrations were inversely and independently associated with HOMA-IR in LTBI.
    Keywords Vitamin D ; Insulin resistance ; Latent tuberculosis infection ; NHANES ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A High Precision, Wide Dynamic Range Closed-Loop Neuromodulation IC With Rapid Stimulation Artifact Recovery.

    Qiu, Zhang / Nguyen, Anh Tuan / Su, Kangyu / Yang, Zhi / Xu, Jian

    IEEE transactions on biomedical circuits and systems

    2024  Volume 18, Issue 2, Page(s) 274–287

    Abstract: This article presents a high precision, wide dynamic range (DR) closed-loop neuromodulation (CLNM) system that can completely reject stimulation artifacts (SA) and achieve rapid SA recovery. In the recorder, a novel SA quick-blanking scheme is proposed ... ...

    Abstract This article presents a high precision, wide dynamic range (DR) closed-loop neuromodulation (CLNM) system that can completely reject stimulation artifacts (SA) and achieve rapid SA recovery. In the recorder, a novel SA quick-blanking scheme is proposed for rail-to-rail SA rejection while minimizing SA recovery time. Besides, a new analog front-end (AFE) architecture based on a frequency-shaping (FS) technique is developed to extend DR intrinsically. In the stimulator, a stimulation driver implemented with a proposed redundant crossfire (RXF) technique is incorporated to improve the effective resolution of the stimulation current. The designed CLNM system is implemented in a 180 nm Bipolar-CMOS-DMOS (BCD) process. Measurement results show that the system is capable of tolerating rail-to-rail (5 V) SA and reducing the SA recovery time from 12 ms to 0.15 ms. The FS recorder extends the DR at low frequencies (LF) to 17.5 bits to enhance tolerance to LF interferences. The proposed stimulator adopting the 4-way RXF topology improves the effective resolution to 12.75 bits without consuming much extra area and power. Animal experiments demonstrate that the designed system can acquire high-fidelity neural signals immediately after stimulation onsets, thus supporting concurrent recording and stimulation.
    MeSH term(s) Animals ; Artifacts
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-9990
    ISSN (online) 1940-9990
    DOI 10.1109/TBCAS.2023.3321295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Gastroprotective effects of Chinese Rana chensinensis skin collagen against ethanol-induced gastric ulcer in mice.

    Li-Qiu Zhang, - / Ling-Ling Lv, - / Xiao-Tian Jiang, - / Yu Chen, - / Min-Yan Piao, - / Su-Yun Shi, -

    Pakistan journal of pharmaceutical sciences

    2023  Volume 36, Issue 3, Page(s) 819–827

    Abstract: Gastric ulcer is a common gastrointestinal disease caused by excessive gastric acid secretion, which has been recognized as one of the most common causes of morbidity and mortality in the world. The skin of Rana chensinensis is rich in collagen and many ... ...

    Abstract Gastric ulcer is a common gastrointestinal disease caused by excessive gastric acid secretion, which has been recognized as one of the most common causes of morbidity and mortality in the world. The skin of Rana chensinensis is rich in collagen and many previous studies have shown that it has certain bioactivity. Therefore, we extracted and purified collagen with a molecular weight less than 10000 Da from the skin of Rana chensinensis, and studied its gastric protective mechanism through the model of ethanol-induced gastric ulcer in Balb/c mice. The results showed that through macroscopic observation and significantly reduced ulcer index, it was proved that PCRCS could protect gastric mucosa and alleviate the damage of ethanol to gastric mucosa. PCRCS reduced ethanol-induced oxidative stress by boosting depleted SOD levels and dramatically lowering MDA levels, as well as significantly reducing lipid peroxidation. Additionally PCRCS (Protein Chinese Rana chesinensis Skin) additionally decreased the launch of inflammatory mediators TNF-α and IL-6 and more desirable the content material of protective elements NO and PGE2 in gastric mucosa. Based on these findings, we believe that PCRCS has potential stomach protective effects on ethanol-induced gastric ulcer, which may be achieved by inhibiting oxidative stress and stomach inflammation.
    MeSH term(s) Animals ; Mice ; Anti-Ulcer Agents/adverse effects ; Anti-Ulcer Agents/pharmacology ; Anti-Ulcer Agents/therapeutic use ; Collagen/pharmacology ; Ethanol/toxicity ; Gastric Mucosa/drug effects ; Mice, Inbred BALB C ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Protective Agents/adverse effects ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; China ; Disease Models, Animal ; Ranidae ; Skin
    Chemical Substances Anti-Ulcer Agents ; Collagen (9007-34-5) ; Ethanol (3K9958V90M) ; Protective Agents
    Language English
    Publishing date 2023-08-14
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cognition and Social Behaviors Related to COVID-19 Among Students in Medical Colleges

    Qiu Zhang / Xiaoya Lu / Mengxin Liao / Xinyue Zhang / Liqing Yao

    Frontiers in Public Health, Vol

    A Cross-Sectional Study in Guangdong Province of China

    2022  Volume 10

    Abstract: BackgroundThe COVID-19 pandemic is a public health emergency of international concern. This study aimed to describe the cognition and social behaviors related to COVID-19 among medical college students in China and to explore the relevant factors that ... ...

    Abstract BackgroundThe COVID-19 pandemic is a public health emergency of international concern. This study aimed to describe the cognition and social behaviors related to COVID-19 among medical college students in China and to explore the relevant factors that have affected individual social behaviors. The study could enrich practical research on the social behaviors of college students during the COVID-19 pandemic.MethodsFrom February to April 2020, online questionnaire survey was conducted meticulously. Based on their majors, the students were divided into a medical student group (249 cases) and a near-peer medical student group (397 cases). Descriptive statistics was used to elaborate the cognition related to the pandemic and the status quo of social behaviors among these students. A multiple linear regression model was established to analyze the relevant factors affecting individual social behaviors from various perspectives during the pandemic.ResultsRegarding the cognition situation: 76.32% of those surveyed had good pandemic awareness, and the average general cognition score was 30.55 ± 3.17 points. In terms of social behaviors, the average scores for purposive rational actions and affective actions during the outbreak were relatively high, scoring 8.85 ± 1.72 points (>10 points) and 4.32 ± 1.41 points (>6 points), respectively, while the average value rational actions score was relatively low at 5.95 ± 1.90 points (>10 points). The results of the multiple linear regression model showed that urban college students had higher scores for purposive rational actions; college students with the CCP membership had higher value rational actions scores; school and major were also significant factors affecting affective actions scoring. The COVID-19 cognition score had a significant effect on the social behavior score in all dimensions (P < 0.001).ConclusionsThe cognition of COVID-19 among students in Chinese medical colleges was good, and pandemic cognition was an important factor that affected individual social behaviors. Universities and colleges should strengthen the publicity and education of knowledge related to COVID-19, guide students to internalize their knowledge of the pandemic into positive behaviors, and help to win the battle of pandemic prevention and control.
    Keywords COVID-19 pandemic ; cognition ; social behavior ; medical college students ; China ; Public aspects of medicine ; RA1-1270
    Subject code 120
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A Sparse Model of Guided Wave Tomography for Corrosion Mapping in Structure Health Monitoring Applications

    Yu Gao / Jian Qiu Zhang

    Applied Sciences, Vol 9, Iss 15, p

    2019  Volume 3126

    Abstract: To improve the reconstruction image spatial resolutions of ultrasonic guided wave ray tomography, a sparse model, based on the differences between the inspected and original slowness of the ultrasonic guided waves propagating in the plate-like or pipe- ... ...

    Abstract To improve the reconstruction image spatial resolutions of ultrasonic guided wave ray tomography, a sparse model, based on the differences between the inspected and original slowness of the ultrasonic guided waves propagating in the plate-like or pipe-like materials, is first proposed in this paper. Unlike the conventional ultrasonic guided wave tomography whose reconstruction image resolutions are limited by an underdetermined linear model, analyses show that our new model, although it is also underdetermined, can give the optimal solution of the reconstruction image when the constraints on the sparsity of the slowness difference distribution are valid. The reason for the validation of the sparse constraints on the corrosions of the materials is explained. Based on our new model, a least absolute shrinkage and selection operator (LASSO) approach to do the thickness change mapping of a structure health monitoring (SHM) application is then formulated. Analyses also show that the visible artifacts can be avoided using our method, and the spatial resolutions of reconstruction image by our approach can further be improved by increasing the number of grids in the calculation. The approach is validated by experimental work on an aluminum plate. It is also shown that compared to the conventional ray tomography, the presented method can achieve a relatively high spatial resolution, with good suppression of artifacts.
    Keywords ultrasonic guided wave ; LASSO ; thickness mapping ; material corrosions ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 535
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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