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  1. Article ; Online: The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers

    Chang-Zhou Feng / Ning-Zhe Li / Xi-Bo Hu / Yin-Yin Xie / Qiu-Hua Huang / Jianming Zhang / Zhu Chen / Sai-Juan Chen / Fudi Wang / Xiao-Jian Sun

    Genes and Diseases, Vol 10, Iss 3, Pp 735-

    2023  Volume 738

    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation

    Yi-Fan Zhang / Xiao-Lin Wang / Chun-Hui Xu / Na Liu / Ling Zhang / Yu-Ming Zhang / Yin-Yin Xie / Yuan-Liang Zhang / Qiu-Hua Huang / Lan Wang / Zhu Chen / Sai-Juan Chen / Robert G. Roeder / Shuhong Shen / Kai Xue / Xiao-Jian Sun

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: The ETO-family transcriptional corepressors, including ETO, ETO2, and MTGR1, are all involved in leukemia-causing chromosomal translocations. In every case, an ETO-family corepressor acquires a DNA-binding domain (DBD) to form a typical transcription ... ...

    Abstract The ETO-family transcriptional corepressors, including ETO, ETO2, and MTGR1, are all involved in leukemia-causing chromosomal translocations. In every case, an ETO-family corepressor acquires a DNA-binding domain (DBD) to form a typical transcription factor—the DBD binds to DNA, while the ETO moiety manifests transcriptional activity. A directly comparative study of these “homologous” fusion transcription factors may clarify their similarities and differences in regulating transcription and leukemogenesis. Here, we performed a side-by-side comparison between AML1-ETO and ETO2-GLIS2, the most common fusion proteins in M2-and M7-subtypes of acute myeloid leukemia, respectively, by inducible expression of them in U937 leukemia cells. We found that, although AML1-ETO and ETO2-GLIS2 can use their own DBDs to bind DNA, they share a large proportion of genome-wide binding regions dependent on other cooperative transcription factors, including the ETS-, bZIP- and bHLH-family proteins. AML1-ETO acts as either transcriptional repressor or activator, whereas ETO2-GLIS2 mainly acts as activator. The repressor-versus-activator functions of AML1-ETO might be determined by the abundance of cooperative transcription factors/cofactors on the target genes. Importantly, AML1-ETO and ETO2-GLIS2 differentially regulate key transcription factors in myeloid differentiation including PU.1 and C/EBPβ. Consequently, AML1-ETO inhibits, but ETO2-GLIS2 facilitates, myeloid differentiation of U937 cells. This function of ETO2-GLIS2 is reminiscent of a similar effect of MLL-AF9 as previously reported. Taken together, this directly comparative study between AML1-ETO and ETO2-GLIS2 in the same cellular context provides insights into context-dependent transcription regulatory mechanisms that may underlie how these seemingly “homologous” fusion transcription factors exert distinct functions to drive different subtypes of leukemia.
    Keywords AML1-ETO ; ETO2-GLIS2 ; leukemia ; transcription factor ; transcriptional context ; cell differentiation ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Fumigation treatment of Four Yellow Qing Ling Water with artificial tears for dry eyes

    Yan-Yan Chen / Chong Huang / Yun-Hong Feng / Yuan-Fang Luo / Qiu-Hua Huang / Xin-Hui Yao / Shou-Mei Jin / Jing Xie / Yuan-Hong Lin / Ren-Feng Deng

    Guoji Yanke Zazhi, Vol 18, Iss 4, Pp 762-

    2018  Volume 764

    Abstract: AIM: To observe the clinical efficacy of fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)for dry eye, and to provide the reference for clinical treatment of dry eye. METHODS: Totally 82 patients(164 eyes)were randomly ... ...

    Abstract AIM: To observe the clinical efficacy of fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)for dry eye, and to provide the reference for clinical treatment of dry eye. METHODS: Totally 82 patients(164 eyes)were randomly divided into two groups from June 2016 to December 2016 in Ophthalmology Department of our hospital. The patients in control group were given artificial tears; the patients in the observation group were given artificial tears and fumigation treatment of traditional Chinese(Four Yellow Qing Ling Water)once a day. After treatment for 14d, the Schirmer Ⅰ test(SⅠt), break-up time(BUT), cornea fluorescein staining(FL)and clinical efficacy of two groups were compared. RESULTS: The efficiency rate of observation group was significantly better than the control group(87.8% vs 70.7%, P <0.5). The SⅠt and BUT in the observation group were significantly higher than those in the control group(8.43±2.51mm/5min vs 6.38±2.52mm/5min, P <0.05; 8.60±2.47s vs 6.35±2.29s, P <0.05); the FL in the observation group(0.84±0.75 vs 1.26±0.84, P <0.05)significantly lower than those in the control group. CONCLUSION: The fumigation treatment of traditional Chinese medicine(Four Yellow Qing Ling Water)combined with artificial tears for dry eyes can improve the clinical symptoms of dry eye syndrome.
    Keywords traditional Chinese medicine ; herbal fumigation ; artificial tears ; dry eye ; Ophthalmology ; RE1-994
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Press of International Journal of Ophthalmology (IJO PRESS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1

    Du, Ting-Ting / Hong-Bo Fan / Mei Dong / Min Deng / Peng-Fei Xu / Qiu-Hua Huang / Rui-Bao Ren / Ting-Xi Liu / Wei-Jun Pan / Yi Chen / Yi Jin / Zhi-Wei Dong

    Developmental biology. 2014 Aug. 15, v. 392, no. 2

    2014  

    Abstract: As the primary driving forces of gastrulation, convergence and extension (C&E) movements lead to a medio-lateral narrowing and an anterior–posterior elongation of the embryonic body axis. Histone methylation as a post-translational modification plays a ... ...

    Abstract As the primary driving forces of gastrulation, convergence and extension (C&E) movements lead to a medio-lateral narrowing and an anterior–posterior elongation of the embryonic body axis. Histone methylation as a post-translational modification plays a critical role in early embryonic development, but its functions in C&E movements remain largely unknown. Here, we show that the setdb2-dvr1 transcriptional cascade plays a critical role in C&E movements during zebrafish gastrulation. Knockdown of Setdb2, a SET domain-containing protein possessing a potential histone H3K9 methyltransferase activity, induced abnormal C&E movements, resulting in anterior–posterior shortening and medio-lateral expansion of the embryonic axis, as well as abnormal notochord cell polarity. Furthermore, we found that Setdb2 functions through fine-tuning the expression of dvr1, a ligand of the TGF-β superfamily, to an appropriate level to ensure proper C&E movements in a non-cell-autonomous manner. In addition, both overexpression and knockdown of Dvr1 at the one-cell stage resulted in defects at epiboly and C&E. These data demonstrate that Setdb2 is a novel regulator for C&E movements and acts by modulating the expression level of dvr1, suggesting that Dvr1 acts as a direct and essential mediator for C&E cell movements.
    Keywords cell polarity ; Danio rerio ; enzyme activity ; gastrulation ; histones ; ligands ; methylation ; methyltransferases ; post-translational modification ; transcription (genetics) ; transforming growth factor beta
    Language English
    Dates of publication 2014-0815
    Size p. 233-244.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2014.05.022
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.

    Xiao-Jian Sun / Peng-Fei Xu / Ting Zhou / Ming Hu / Chun-Tang Fu / Yong Zhang / Yi Jin / Yi Chen / Sai-Juan Chen / Qiu-Hua Huang / Ting Xi Liu / Zhu Chen

    PLoS ONE, Vol 3, Iss 1, p e

    2008  Volume 1499

    Abstract: SET domain-containing proteins represent an evolutionarily conserved family of epigenetic regulators, which are responsible for most histone lysine methylation. Since some of these genes have been revealed to be essential for embryonic development, we ... ...

    Abstract SET domain-containing proteins represent an evolutionarily conserved family of epigenetic regulators, which are responsible for most histone lysine methylation. Since some of these genes have been revealed to be essential for embryonic development, we propose that the zebrafish, a vertebrate model organism possessing many advantages for developmental studies, can be utilized to study the biological functions of these genes and the related epigenetic mechanisms during early development. To this end, we have performed a genome-wide survey of zebrafish SET domain genes. 58 genes total have been identified. Although gene duplication events give rise to several lineage-specific paralogs, clear reciprocal orthologous relationship reveals high conservation between zebrafish and human SET domain genes. These data were further subject to an evolutionary analysis ranging from yeast to human, leading to the identification of putative clusters of orthologous groups (COGs) of this gene family. By means of whole-mount mRNA in situ hybridization strategy, we have also carried out a developmental expression mapping of these genes. A group of maternal SET domain genes, which are implicated in the programming of histone modification states in early development, have been identified and predicted to be responsible for all known sites of SET domain-mediated histone methylation. Furthermore, some genes show specific expression patterns in certain tissues at certain stages, suggesting the involvement of epigenetic mechanisms in the development of these systems. These results provide a global view of zebrafish SET domain histone methyltransferases in evolutionary and developmental dimensions and pave the way for using zebrafish to systematically study the roles of these genes during development.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2008-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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