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  1. Article ; Online: The Impacts of Medical Resources on Emerging Self-Limiting Infectious Diseases

    Dayong Zhou / Liyan Gao / Qiuhui Pan / Mingfeng He

    Applied Sciences, Vol 12, Iss 4255, p

    2022  Volume 4255

    Abstract: The spread of emerging self-limiting infectious diseases is closely related to medical resources. This paper introduces the concept of safe medical resources, i.e., the minimum medical resources that are needed to prevent the overburden of medical ... ...

    Abstract The spread of emerging self-limiting infectious diseases is closely related to medical resources. This paper introduces the concept of safe medical resources, i.e., the minimum medical resources that are needed to prevent the overburden of medical resources, and explores the impacts of medical resources on the spread of emerging self-limiting infectious diseases. The results showed that when the isolation rate of hospitalized patients who have mild infections is low, increasing the isolation rate of patients with severe infections requires safe more medical resources. On the contrary, when the isolation rate of hospitalized patients with mild infections is at a high level, increasing the isolation rate of patients with severe infections results in a decrease in safe medical resources. Furthermore, when the isolation rates of patients with mild and severe infections increase simultaneously, safe medical resources decrease gradually. That is to say, when the medical resources are at a low level, it is more necessary to improve the isolation rates of infected individuals so as to avoid the phenomenon of overburdened medical resources and control the spread of emerging infectious diseases. In addition, overwhelmed medical resources increase the number of deaths. Meanwhile, for different emerging self-limiting infectious diseases, as long as the recovery periods are the same, safe medical resources also remain the same.
    Keywords self-limiting ; emerging infectious diseases ; SEIHR model ; overwhelmed medical resources ; isolation rate ; numerical simulation ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 302
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Injurious information propagation and its global stability considering activity and normalized recovering rate.

    Chaoqian Wang / Ziwei Wang / Qiuhui Pan

    PLoS ONE, Vol 16, Iss 10, p e

    2021  Volume 0258859

    Abstract: This paper establishes a compartment model describing the propagation of injurious information among a well-mixed population. We define the information's injuriousness as the people practicing the information being injured and leaving the system. Some ... ...

    Abstract This paper establishes a compartment model describing the propagation of injurious information among a well-mixed population. We define the information's injuriousness as the people practicing the information being injured and leaving the system. Some informed people practice the information and are active, while others do not practice and are inactive. With the recovery resources fixed, the two groups of informed people's recovering rates are normalized considering the information features. The stability of the nonlinear system is thoroughly studied. Analyzing the reproduction number of the injurious information, we find that in general parameter space, when there are people in an informed compartment, it is not always necessary to consider their recovery resource allocation. Instead, only when their proportion reaches a critical point should it be allocated. Unless the people in an informed compartment form a certain proportion, we can take a laissez-faire attitude towards them. In a more realistic parameter space, once inactive informed people exist, they should be allocated recovery resources. On the one hand, when the recovering rate rises, the focus on both groups of informed people is necessary for more situations. On the other hand, when the rate of active informed people leaving the system rises, ignoring active informed people benefits removing the injurious information in more cases. The model provides qualitative ways in the scenarios of removing injurious information.
    Keywords Medicine ; R ; Science ; Q
    Subject code 306
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Injurious information propagation and its global stability considering activity and normalized recovering rate

    Chaoqian Wang / Ziwei Wang / Qiuhui Pan

    PLoS ONE, Vol 16, Iss

    2021  Volume 10

    Abstract: This paper establishes a compartment model describing the propagation of injurious information among a well-mixed population. We define the information’s injuriousness as the people practicing the information being injured and leaving the system. Some ... ...

    Abstract This paper establishes a compartment model describing the propagation of injurious information among a well-mixed population. We define the information’s injuriousness as the people practicing the information being injured and leaving the system. Some informed people practice the information and are active, while others do not practice and are inactive. With the recovery resources fixed, the two groups of informed people’s recovering rates are normalized considering the information features. The stability of the nonlinear system is thoroughly studied. Analyzing the reproduction number of the injurious information, we find that in general parameter space, when there are people in an informed compartment, it is not always necessary to consider their recovery resource allocation. Instead, only when their proportion reaches a critical point should it be allocated. Unless the people in an informed compartment form a certain proportion, we can take a laissez-faire attitude towards them. In a more realistic parameter space, once inactive informed people exist, they should be allocated recovery resources. On the one hand, when the recovering rate rises, the focus on both groups of informed people is necessary for more situations. On the other hand, when the rate of active informed people leaving the system rises, ignoring active informed people benefits removing the injurious information in more cases. The model provides qualitative ways in the scenarios of removing injurious information.
    Keywords Medicine ; R ; Science ; Q
    Subject code 306
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Modeling the Parasitic Filariasis Spread by Mosquito in Periodic Environment

    Yan Cheng / Xiaoyun Wang / Qiuhui Pan / Mingfeng He

    Computational and Mathematical Methods in Medicine, Vol

    2017  Volume 2017

    Abstract: In this paper a mosquito-borne parasitic infection model in periodic environment is considered. Threshold parameter R0 is given by linear next infection operator, which determined the dynamic behaviors of system. We obtain that when R0<1, the disease- ... ...

    Abstract In this paper a mosquito-borne parasitic infection model in periodic environment is considered. Threshold parameter R0 is given by linear next infection operator, which determined the dynamic behaviors of system. We obtain that when R0<1, the disease-free periodic solution is globally asymptotically stable and when R0>1 by Poincaré map we obtain that disease is uniformly persistent. Numerical simulations support the results and sensitivity analysis shows effects of parameters on R0, which provided references to seek optimal measures to control the transmission of lymphatic filariasis.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Throwing and manipulating and cheating with a DNA nano-dice

    Xiaochen Tang / Tianshu Chen / Wenxing Li / Dongsheng Mao / Chenbin Liu / Qi Wu / Nan Huang / Song Hu / Fenyong Sun / Qiuhui Pan / Xiaoli Zhu

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 13

    Abstract: Abstract Artificial molecular machines have captured the imagination of researchers, given their clear potential to mimic and influence human life. Key to behavior simulation is to reproduce the specific properties of physical or abstract systems. Dice ... ...

    Abstract Abstract Artificial molecular machines have captured the imagination of researchers, given their clear potential to mimic and influence human life. Key to behavior simulation is to reproduce the specific properties of physical or abstract systems. Dice throwing, as a stochastic model, is commonly used for result judgment or plan decision in real life. In this perspective we utilize DNA cube framework for the design of a dice device at the nanoscale to reproduce probabilistic events in different situations: equal probability, high probability, and low probability. We first discuss the randomness of DNA cube, or dice, adsorbing on graphene oxide, or table, and then explore a series of events that change the probability through the way in which the energy released from entropy-driven strand displacement reactions or changes in intermolecular forces. As such, the DNA nano-dice system provides guideline and possibilities for the design, engineering, and quantification of behavioral probability simulation, a currently emerging area of molecular simulation research.
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Five-Species Jungle Game.

    Yibin Kang / Qiuhui Pan / Xueting Wang / Mingfeng He

    PLoS ONE, Vol 11, Iss 6, p e

    2016  Volume 0157938

    Abstract: In this paper, we investigate the five-species Jungle game in the framework of evolutionary game theory. We address the coexistence and biodiversity of the system using mean-field theory and Monte Carlo simulations. Then, we find that the inhibition from ...

    Abstract In this paper, we investigate the five-species Jungle game in the framework of evolutionary game theory. We address the coexistence and biodiversity of the system using mean-field theory and Monte Carlo simulations. Then, we find that the inhibition from the bottom-level species to the top-level species can be critical factors that affect biodiversity, no matter how it is distributed, whether homogeneously well mixed or structured. We also find that predators' different preferences for food affect species' coexistence.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Population Dynamics of Patients with Bacterial Resistance in Hospital Environment

    Leilei Qu / Qiuhui Pan / Xubin Gao / Mingfeng He

    Computational and Mathematical Methods in Medicine, Vol

    2016  Volume 2016

    Abstract: During the past decades, the increase of antibiotic resistance has become a major concern worldwide. The researchers found that superbugs with new type of resistance genes (NDM-1) have two aspects of transmission characteristics; the first is that the ... ...

    Abstract During the past decades, the increase of antibiotic resistance has become a major concern worldwide. The researchers found that superbugs with new type of resistance genes (NDM-1) have two aspects of transmission characteristics; the first is that the antibiotic resistance genes can horizontally transfer among bacteria, and the other is that the superbugs can spread between humans through direct contact. Based on these two transmission mechanisms, we study the dynamics of population in hospital environment where superbugs exist. In this paper, we build three mathematic models to illustrate the dynamics of patients with bacterial resistance in hospital environment. The models are analyzed using stability theory of differential equations. Positive equilibrium points of the system are investigated and their stability analysis is carried out. Moreover, the numerical simulation of the proposed model is also performed which supports the theoretical findings.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A Five Species Cyclically Dominant Evolutionary Game with Fixed Direction

    Yibin Kang / Qiuhui Pan / Xueting Wang / Mingfeng He

    Entropy, Vol 18, Iss 8, p

    A New Way to Produce Self-Organized Spatial Patterns

    2016  Volume 284

    Abstract: Cyclically dominant systems are hot issues in academia, and they play an important role in explaining biodiversity in Nature. In this paper, we construct a five-strategy cyclically dominant system. Each individual in our system changes its strategy along ...

    Abstract Cyclically dominant systems are hot issues in academia, and they play an important role in explaining biodiversity in Nature. In this paper, we construct a five-strategy cyclically dominant system. Each individual in our system changes its strategy along a fixed direction. The dominant strategy can promote a change in the dominated strategy, and the dominated strategy can block a change in the dominant strategy. We use mean-field theory and cellular automaton simulation to discuss the evolving characters of the system. In the cellular automaton simulation, we find the emergence of spiral waves on spatial patterns without a migration rate, which suggests a new way to produce self-organized spatial patterns.
    Keywords ordinary differential equation ; cellular-automata ; evolutionary games ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Transmission Dynamics of Resistant Bacteria in a Predator-Prey System

    Xubin Gao / Qiuhui Pan / Mingfeng He

    Computational and Mathematical Methods in Medicine, Vol

    2015  Volume 2015

    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Medicine (General) ; R5-920 ; Medicine ; R
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Transmission Dynamics of Resistant Bacteria in a Predator-Prey System

    Xubin Gao / Qiuhui Pan / Mingfeng He

    Computational and Mathematical Methods in Medicine, Vol

    2015  Volume 2015

    Abstract: This paper discusses the impact on human health caused by the addition of antibiotics in the feed of food animals. We use the established transmission rule of resistant bacteria and combine it with a predator-prey system to determine a differential ... ...

    Abstract This paper discusses the impact on human health caused by the addition of antibiotics in the feed of food animals. We use the established transmission rule of resistant bacteria and combine it with a predator-prey system to determine a differential equations model. The equations have three steady equilibrium points corresponding to three population dynamics states under the influence of resistant bacteria. In order to quantitatively analyze the stability of the equilibrium points, we focused on the basic reproduction numbers. Then, both the local and global stability of the equilibrium points were quantitatively analyzed by using essential mathematical methods. Numerical results are provided to relate our model properties to some interesting biological cases. Finally, we discuss the effect of the two main parameters of the model, the proportion of antibiotics added to feed and the predation rate, and estimate the human health impacts related to the amount of feed antibiotics used. We further propose an approach for the prevention of the large-scale spread of resistant bacteria and illustrate the necessity of controlling the amount of in-feed antibiotics used.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 629
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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