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Article: Five years of safety profile of bevacizumab: an analysis of real-world pharmacovigilance and randomized clinical trials.

Wang, Li / Fei, Yibo / Qu, Han / Zhang, Haiyang / Wang, Yuanyuan / Wu, Zhenghua / Fan, Guorong

Journal of pharmaceutical health care and sciences

2024 Volume 10, Issue 1, Page(s) 1

Abstract: Objective: Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. It has a wide range of clinical applications in various cancers and retinal diseases. The drugs entered the Chinese market by a large margin in 2017, and the ... ...

Abstract	Objective: Bevacizumab is a monoclonal antibody against vascular endothelial growth factor. It has a wide range of clinical applications in various cancers and retinal diseases. The drugs entered the Chinese market by a large margin in 2017, and the user population changed to some extent. This study reevaluated the safety of bevacizumab through an analysis of the World Pharmacovigilance database (Food and Drug Administration Open Vigil 2.1) in conjunction with a comprehensive meta-analysis of RCTs. Methods: Real-world pharmacovigilance data originating from case reports were mined using Open Vigil and coded at the preferred term (PT) level using the Standardized MedDRA Query. Proportional reporting ratios (PRR) and reporting odds ratios (ROR) were used to detect safety signals. Eligible items were screened by searching PubMed, Wanfang, and Web of Science, and data were extracted for systematic review and meta-analysis using RevMan 5.4 software. Results: Analysis of the drug pharmacovigilance database revealed that the most significant PRRs were limb decortication syndrome (PRR = 2926), stomal varices (PRR = 549), anastomotic (PRR = 457) and ureteral fistula (PRR = 406). Most safety signals at the PT level emerged as various types of injuries, toxicities, operational complications, systemic diseases, various reactions at the administration site, hematological and lymphatic disorders, and gastrointestinal disorders. Adverse reactions such as nasal septal perforation (PRR = 47.502), necrotizing fasciitis (PRR = 20.261), and hypertensive encephalopathy (PRR = 18.288) listed as rare in drug specifications should not be ignored with a high signal in the real world. A total of 8 randomized controlled trials (RCTs) were included in the meta-analysis, and the overall risk of adverse reactions following bevacizumab administration was relatively low, indicating a good safety profile (HR = 1.19, 95% CI:0.85 ~ 1.65, p = 0.32). Conclusion: The frequent adverse reactions of bevacizumab occurring in the real world are consistent with the data provided in RCTs and drug specifications. However, adverse reactions such as nasal septum perforation, necrotizing fasciitis, hypertensive encephalopathy and so on, listed as rare in drug specifications, may have a high signal of correlation in the real world, which all requires active monitoring and timely adjustment of bevacizumab posology during its clinical use.
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2809913-8
ISSN	2055-0294
ISSN	2055-0294
DOI	10.1186/s40780-023-00314-w
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Article ; Online: Acid-washed zero-valent aluminum as a highly efficient persulfate activator for degradation of phenacetin

Wu, Junxue / Wang, Bin / Qu, Han / Wang, Fang / Duan, Lei / Yu, Gang

Environ Sci Pollut Res. 2023 Feb., v. 30, no. 7 p.19439-19449

2023

Abstract: Phenacetin (PNT) is one of the most frequently detected nonsteroidal anti-inflammatory drugs in the water ecosystems, which poses a potential risk to environmental aquatic organisms. Acid-washed zero-valent aluminum (ZVAl) as a highly efficient activator ...

Abstract	Phenacetin (PNT) is one of the most frequently detected nonsteroidal anti-inflammatory drugs in the water ecosystems, which poses a potential risk to environmental aquatic organisms. Acid-washed zero-valent aluminum (ZVAl) as a highly efficient activator for persulfate (PS) process was investigated to degrade PNT from the aqueous solution. The results indicated that acid-washed pretreatment for ZVAl could efficiently increase the degradation efficiency of PNT in the PS treatment. The degradation efficiency of PNT (50 μM) was up to 90% in 4 hours with the addition of 0.2 g/L acid-washed ZVAl and 8 mM PS at pH 6.8 and 25 °C. The PNT degradation followed pseudo-first order kinetics in the present system. High activator dosage, PS concentration, and reaction temperature could enhance the PNT degradation. The presence of inorganic anions (i.e., NO₃⁻, HCO₃⁻) and humic acid (HA) showed inhibitory effects on the PNT degradation. The reuse results illustrated the acid-washed ZVAl material would have continuous and efficient activation performance for PS to degrade the PNT. Radical scavenger experiments and electron paramagnetic resonance indicated that both SO₄•⁻ and •OH were major reactive species during the PNT degradation. The possible degradation pathways of PNT mainly included the break of C–N and C–O bonds and further oxidation.
Keywords	aluminum ; aqueous solutions ; electron paramagnetic resonance spectroscopy ; humic acids ; oxidation ; pH ; risk ; temperature
Language	English
Dates of publication	2023-02
Size	p. 19439-19449.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-23473-z
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Article ; Online: Understanding and addressing the environmental risk of microplastics

Qu, Han / Diao, Hongting / Han, Jiajun / Wang, Bin / Yu, Gang

Front. Environ. Sci. Eng.. 2023 Jan., v. 17, no. 1 p.12-12

2023

Abstract: Over the past decades, the plastic production has been dramatically increased. Indeed, a category of small plastic particles mainly with the shapes of fragments, fibers, or spheres, called microplastics (particles smaller than 5 mm) and nanoplastics ( ... ...

Abstract	Over the past decades, the plastic production has been dramatically increased. Indeed, a category of small plastic particles mainly with the shapes of fragments, fibers, or spheres, called microplastics (particles smaller than 5 mm) and nanoplastics (particles smaller than 1 µm) have attracted particular attention. Because of its wide distribution in the environment and potential adverse effects to animal and human, microplastic pollution has been reported as a serious environment problem receiving increased attention in recent years. As one of the commonly detected emerging contaminants in the environment, recent evidence indicates that the concentration of microplastics show an increasing trend, for the reason that up to 12.7 million metric tons of plastic litter is released into aquatic environment from land-based sources each year. Furthermore, microplastic exposure levels of model organisms in laboratory studies are usually several orders of magnitude higher than those found in environment, and the microplastics exposure conditions are also different with those observed in the environment. Additionally, the detection of microplastics in feces indicates that they can be excreted out of the bodies of animal and human. Hence, great uncertainties might exist in microplastics exposure and health risk assessment based on current studies, which might be exaggerated. Policies reduce microplastic emission sources and hence minimize their environmental risks are determined. To promote the above policies, we must first overcome the technical obstacles of detecting microplastics in various samples.
Keywords	aquatic environment ; feces ; health effects assessments ; humans ; nanoplastics ; pollution ; risk
Language	English
Dates of publication	2023-01
Size	p. 12.
Publishing place	Higher Education Press
Document type	Article ; Online
ZDB-ID	2662203-8
ISSN	2095-221X ; 2095-2201
ISSN (online)	2095-221X
ISSN	2095-2201
DOI	10.1007/s11783-023-1612-5
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Article ; Online: Synthesis of an Environmentally Friendly Modified Mulberry Branch-Derived Biochar Composite: High Degradation Efficiency of BPA and Mitigation of Toxicity in Silkworm Larvae.

Qu, Han / Chen, Lin / Yang, Fujian / Zhu, Jiangwei / Qi, Chengdu / Peng, Guilong

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: In the present study, mulberry branch-derived biochar CuO (MBC/CuO) composite was successfully synthesized and used as a catalyst to activate persulfate (PS) for the degradation of bisphenol A (BPA). The MBC/CuO/PS system exhibited a high degradation ... ...

Abstract	In the present study, mulberry branch-derived biochar CuO (MBC/CuO) composite was successfully synthesized and used as a catalyst to activate persulfate (PS) for the degradation of bisphenol A (BPA). The MBC/CuO/PS system exhibited a high degradation efficiency (93%) of BPA, under the conditions of 0.1 g/L MBC/CuO, 1.0 mM PS, 10 mg/L BPA. Free radical quenching and electron spin-resonance spectroscopy (ESR) experiments confirmed that both free radicals
MeSH term(s)	Animals ; Bombyx ; Morus ; Free Radicals/chemistry ; Water Pollutants, Chemical/chemistry
Chemical Substances	bisphenol A (MLT3645I99) ; cupric oxide (V1XJQ704R4) ; biochar ; Free Radicals ; Water Pollutants, Chemical
Language	English
Publishing date	2023-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043609
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Article ; Online: Does the aging behavior of microplastics affect the process of denitrification by the difference of copper ion adsorption?

Li, Lanxi / Chen, Mengli / Liu, Shushan / Bao, Huanyu / Yang, Dongxu / Qu, Han / Chen, Yi

Journal of hazardous materials

2023 Volume 452, Page(s) 131276

Abstract: Riparian sediment is a hot zone for denitrification that can withhold copper and microplastics (MPs) from outside. It has been proven that MPs affect denitrification and the existing forms of copper in the environment. However, the impact of copper on ... ...

Abstract	Riparian sediment is a hot zone for denitrification that can withhold copper and microplastics (MPs) from outside. It has been proven that MPs affect denitrification and the existing forms of copper in the environment. However, the impact of copper on sediment denitrification under exposure to MPs remains unclear. This study revealed the response of sediment denitrification to copper availability under the adsorption of MPs and the complexation of MP-derived dissolved organic matter (DOM). These results showed that MP accumulation inhibited denitrification. However, aged MPs increased the activity of nitrite reductase (12.64%), nitrogen dioxide reductase (37.68%), and electron transport (28.93%) compared with pristine MPs. The aging behavior of MPs alleviated 28.18% nitrite accumulation and 16.41-118.35% nitrous oxide emissions. Thus, the aging behavior of MPs alleviated the inhibition of denitrification. Notably, we resolved the copper ion adsorption and complexation by MPs, MP-derived DOM contributed to the denitrification process, and we found that the key nitrogen removal factors were affected by K
MeSH term(s)	Microplastics/pharmacology ; Plastics ; Denitrification ; Copper/pharmacology ; Adsorption
Chemical Substances	Microplastics ; Plastics ; Copper (789U1901C5)
Language	English
Publishing date	2023-03-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131276
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Article: Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model.

Zhou, Wen / Qu, Han / Fu, Xiao-Xiao / Xu, Miao-Miao / Li, Qiang / Jiang, Yuan / Han, Shu

Frontiers in pharmacology

2024 Volume 15, Page(s) 1290128

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1290128
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Article: Additive manufacturing of continuous BF-reinforced PES composite material and mechanical and wear properties evaluation

Wu, Wenzheng / Li, Zihan / Lin, Guoqiang / Ma, Jinrong / Gao, Zhiwei / Qu, Han / Zhang, Fu

Journal of materials science. 2022 July, v. 57, no. 27

2022

Abstract: Fiber-reinforced thermoplastic polymer composites are widely applied in engineering. The use of continuous fibers in these composites provides superior mechanical properties and material performance compared with those achieved when short fibers are used. ...

Abstract	Fiber-reinforced thermoplastic polymer composites are widely applied in engineering. The use of continuous fibers in these composites provides superior mechanical properties and material performance compared with those achieved when short fibers are used. In this study, pure poly(ethersulfone) (PES) and its continuous fiber-reinforced composites were manufactured using fused deposition modeling 3D printing technology. PES composite filaments reinforced with continuous basalt fiber (BF) were prepared. The method and temperature for printing the BF-reinforced PES, the strength of the interfacial bonding between the BF and the PES matrix, and the abrasiveness of the composite were all studied in detail. The results revealed that PES printed at 360 °C exhibits the highest tensile strength. Furthermore, the tensile and bending strengths of the PES/BF composite were found to be increased by 217.06% and 87.96%, respectively, compared with those of pure PES. To improve the interfacial bonding properties between the fiber and resin matrix, the fiber was modified using a silane coupling agent. This decreased the mass wear and the wear scar width by 80% and 45%, respectively, compared with those for pure PES.
Keywords	basalt ; composite materials ; silane ; temperature ; tensile strength ; thermoplastics
Language	English
Dates of publication	2022-07
Size	p. 12903-12915.
Publishing place	Springer US
Document type	Article
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-022-07425-z
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Article: Occurrence and distribution of micro- and mesoplastics in the high-latitude nature reserve, northern China

Gong, Wenwen / Xing, Yu / Han, Lihua / Lu, Anxiang / Qu, Han / Xu, Li

Frontiers of environmental science & engineering. 2022 Sept., v. 16, no. 9

2022

Abstract: Microplastics pollution has received growing attention worldwide in recent years. However, data on microplastics in the freshwater environment are still limited, especially in high-latitude nature reserves in Northern China. The first study on ... ...

Abstract	Microplastics pollution has received growing attention worldwide in recent years. However, data on microplastics in the freshwater environment are still limited, especially in high-latitude nature reserves in Northern China. The first study on microplastic pollution in the Liaohe River Reserve in Northern China is reported here, and mesoplastics were also incorporated. Surface water and sediment samples were collected from 32 sites along the nature reserve. The abundance, type, shape, color, and size of micro- and mesoplastics were measured using density extraction, optical microscopy, and FTIR spectroscopy. The data showed that diverse micro- and mesoplastics were found widespread in the 32 sites, and the average abundance of these plastics was 0.11±0.04 10⁻² items/L in surface water and 62.29±54.30 items/kg in sediment. Moreover, 70% and 66% were smaller than 2000 µm in surface water and sediment, respectively. Fiber accounted for 91.86% in surface water and 43.48% in sediment, indicating that the major source of micro- and mesoplastics in the Liaohe River Reserve may be domestic sewage and aquaculture. A total of 16 and 27 polymers were identified in surface water and sediment, respectively, and mostly consisted of rayon, polyester, polystyrene, and poly(ethylene terephthalate). Moreover, both the risk index and the pollution load index demonstrated a low risk of micro- and mesoplastics in surface water and sediment in the Liaohe River Reserve.
Keywords	Fourier transform infrared spectroscopy ; aquaculture ; color ; conservation areas ; freshwater ; latitude ; light microscopy ; microplastics ; pollution load ; polystyrenes ; rayon ; risk ; rivers ; sediments ; sewage ; surface water ; China
Language	English
Dates of publication	2022-09
Size	p. 113.
Publishing place	Higher Education Press
Document type	Article
ZDB-ID	2662203-8
ISSN	2095-221X ; 2095-2201
ISSN (online)	2095-221X
ISSN	2095-2201
DOI	10.1007/s11783-022-1534-7
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Book ; Online: Generalized Constraints as A New Mathematical Problem in Artificial Intelligence

Hu, Bao-Gang / Qu, Han-Bing

A Review and Perspective

2020

Abstract: In this comprehensive review, we describe a new mathematical problem in artificial intelligence (AI) from a mathematical modeling perspective, following the philosophy stated by Rudolf E. Kalman that "Once you get the physics right, the rest is ... ...

Abstract	In this comprehensive review, we describe a new mathematical problem in artificial intelligence (AI) from a mathematical modeling perspective, following the philosophy stated by Rudolf E. Kalman that "Once you get the physics right, the rest is mathematics". The new problem is called "Generalized Constraints (GCs)", and we adopt GCs as a general term to describe any type of prior information in modelings. To understand better about GCs to be a general problem, we compare them with the conventional constraints (CCs) and list their extra challenges over CCs. In the construction of AI machines, we basically encounter more often GCs for modeling, rather than CCs with well-defined forms. Furthermore, we discuss the ultimate goals of AI and redefine transparent, interpretable, and explainable AI in terms of comprehension levels about machines. We review the studies in relation to the GC problems although most of them do not take the notion of GCs. We demonstrate that if AI machines are simplified by a coupling with both knowledge-driven submodel and data-driven submodel, GCs will play a critical role in a knowledge-driven submodel as well as in the coupling form between the two submodels. Examples are given to show that the studies in view of a generalized constraint problem will help us perceive and explore novel subjects in AI, or even in mathematics, such as generalized constraint learning (GCL). Comment: 20 pages, 16 figures, 3 tables
Keywords	Computer Science - Artificial Intelligence
Subject code	004
Publishing date	2020-11-11
Publishing country	us
Document type	Book ; Online
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Article ; Online: HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape.

Qu, Meng / Qu, Han / Jia, Zhenyu / Kay, Steve A

Nature communications

2021 Volume 12, Issue 1, Page(s) 6350

Abstract: Transcription modulated by the circadian clock is diverse across cell types, underlying circadian control of peripheral metabolism and its observed perturbation in human diseases. We report that knockout of the lineage-specifying Hnf4a gene in mouse ... ...

Abstract	Transcription modulated by the circadian clock is diverse across cell types, underlying circadian control of peripheral metabolism and its observed perturbation in human diseases. We report that knockout of the lineage-specifying Hnf4a gene in mouse liver causes associated reductions in the genome-wide distribution of core clock component BMAL1 and accessible chromatin marks (H3K4me1 and H3K27ac). Ectopically expressing HNF4A remodels chromatin landscape and nucleates distinct tissue-specific BMAL1 chromatin binding events, predominantly in enhancer regions. Circadian rhythms are disturbed in Hnf4a knockout liver and HNF4A-MODY diabetic model cells. Additionally, the epigenetic state and accessibility of the liver genome dynamically change throughout the day, synchronized with chromatin occupancy of HNF4A and clustered expression of circadian outputs. Lastly, Bmal1 knockout attenuates HNF4A genome-wide binding in the liver, likely due to downregulated Hnf4a transcription. Our results may provide a general mechanism for establishing circadian rhythm heterogeneity during development and disease progression, governed by chromatin structure.
MeSH term(s)	ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Animals ; CLOCK Proteins/genetics ; CLOCK Proteins/metabolism ; Chromatin/metabolism ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Circadian Rhythm/physiology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Epigenomics ; Gene Expression Regulation ; Genome ; Hepatocyte Nuclear Factor 4/genetics ; Hepatocyte Nuclear Factor 4/metabolism ; Histones ; Humans ; Liver/metabolism ; Male ; Mice ; Mice, Knockout ; Mutation
Chemical Substances	ARNTL Transcription Factors ; Bmal1 protein, mouse ; Chromatin ; DNA-Binding Proteins ; Hepatocyte Nuclear Factor 4 ; Histones ; Hnf4a protein, mouse ; CLOCK Proteins (EC 2.3.1.48)
Language	English
Publishing date	2021-11-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-26567-3
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