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Book ; Thesis: Die Wirkung der Dopamin-Agonisten Quinpirol und SKF auf Neurone des Corpus geniculatum laterale, pars dorsalis (Cgld) der Wistarratte

Quäschling, Ulf

2000

Author's details	von Ulf Quäschling
Language	German
Size	93 Bl., Ill., graph. Darst., 30 cm
Edition	[Mikrofiche-Ausg.]
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Berlin, Humboldt-Univ., Diss., 2000
HBZ-ID	HT013144589
Database	Catalogue ZB MED Medicine, Health

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Article: Treatment of Supraophthalmic Internal Carotid Artery Fenestration with an Associated Aneurysm via Flow Diversion: A Case Report.

Kasper, Johannes / Nestler, Ulf / Meixensberger, Jürgen / Quäschling, Ulf

International medical case reports journal

2021 Volume 14, Page(s) 487–491

Abstract: Cerebral artery fenestration with flow-associated aneurysm is rare among cerebrovascular pathologies. Treatment includes open neurosurgery and/or endovascular treatment. We report a case of a 53-year-old woman with an incidentally detected aneurysm ... ...

Abstract	Cerebral artery fenestration with flow-associated aneurysm is rare among cerebrovascular pathologies. Treatment includes open neurosurgery and/or endovascular treatment. We report a case of a 53-year-old woman with an incidentally detected aneurysm during magnetic resonance tomography. As the underlying cause, a digital subtraction angiography revealed a left internal carotid artery fenestration. Elective endovascular treatment via flow diversion was indicated and a pipeline embolization device was implanted. Follow-up examinations presented a completely occluded additional caudal limb and a decreasing aneurysm size. No clinically adverse events occurred within twenty-four-month post-treatment. Therefore, sole flow diversion was a feasible treatment option in this case.
Language	English
Publishing date	2021-07-20
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495077-4
ISSN	1179-142X
ISSN	1179-142X
DOI	10.2147/IMCRJ.S317709
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Article ; Online: Raumforderung der Nasennebenhöhlen mit Blutungskomplikation der A. carotis interna.

Stöhr, Matthäus / Fest, Sandra / von Braun, Amrei / Quaeschling, Ulf / Schob, Stefan / Dietz, Andreas

Laryngo- rhino- otologie

2022 Volume 101, Issue 9, Page(s) 741–744

Title translation	Paranasal sinus mucormycosis with internal carotid artery bleeding.
MeSH term(s)	Carotid Artery, Internal/diagnostic imaging ; Humans ; Mucormycosis/complications ; Mucormycosis/diagnosis ; Mucormycosis/surgery ; Paranasal Sinus Diseases/diagnostic imaging ; Paranasal Sinus Diseases/surgery ; Paranasal Sinuses
Language	German
Publishing date	2022-02-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	96005-6
ISSN	1438-8685 ; 0340-1588 ; 0935-8943
ISSN (online)	1438-8685
ISSN	0340-1588 ; 0935-8943
DOI	10.1055/a-1744-6437
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Article: Management of Cavernous Carotid Artery Aneurysms: A Retrospective Single-Center Experience.

Fehrenbach, Michael Karl / Dietel, Eric / Wende, Tim / Kasper, Johannes / Sander, Caroline / Wilhelmy, Florian / Quaeschling, Ulf / Meixensberger, Juergen / Nestler, Ulf

Brain sciences

2022 Volume 12, Issue 3

Abstract: Objective: While cavernous carotid aneurysms can cause neurological symptoms, their often-uneventful natural course and the increasing options of intravascular aneurysm closure call for educated decision-making. However, evidence-based guidelines are ... ...

Abstract	Objective: While cavernous carotid aneurysms can cause neurological symptoms, their often-uneventful natural course and the increasing options of intravascular aneurysm closure call for educated decision-making. However, evidence-based guidelines are missing. Here, we report 64 patients with cavernous carotid aneurysms, their respective therapeutic strategies, and follow-up. Methods: We included all patients with cavernous carotid aneurysms who presented to our clinic between 2014 and 2020 and recorded comorbidities (elevated blood pressure, diabetes mellitus, and nicotine consumption), PHASES score, aneurysm site, size and shape, therapeutic strategy, neurological deficits, and clinical follow-up. Results: The mean age of the 64 patients (86% female) was 53 years, the mean follow-up time was 3.8 years. A total of 22 patients suffered from cranial nerve deficit. Of these patients, 50% showed a relief of symptoms regardless of the therapy regime. We found no significant correlations between aneurysm size or PHASES score and the occurrence of neurological symptoms. Conclusion: If aneurysm specific symptoms persist over a longer period of time, relief is difficult to achieve despite aneurysm treatment. Patients should be advised by experts in neurovascular centers, weighing the possibility of an uneventful course against the risks of treatment. In this regard, more detailed prospective data is needed to improve individual patient counseling.
Language	English
Publishing date	2022-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci12030330
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Article ; Online: Comparison of the unruptured intracranial aneurysm treatment score recommendations with clinical treatment results - A series of 322 aneurysms.

Wende, Tim / Kasper, Johannes / Wilhelmy, Florian / Prasse, Gordian / Quäschling, Ulf / Haase, Amelie / Meixensberger, Jürgen / Nestler, Ulf

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2022 Volume 98, Page(s) 104–108

Abstract: Intracranial aneurysms occur with a prevalence of 3-5 %. Subarachnoid hemorrhage (SAH) due to aneurysm rupture is a rare but possibly fatal complication, so that occlusion of unruptured intracranial aneurysms (UIA) must be considered. The Unruptured ... ...

Abstract	Intracranial aneurysms occur with a prevalence of 3-5 %. Subarachnoid hemorrhage (SAH) due to aneurysm rupture is a rare but possibly fatal complication, so that occlusion of unruptured intracranial aneurysms (UIA) must be considered. The Unruptured Intracranial Aneurysm Treatment Score (UIATS) offers support for clinical decision making and has been shown to correlate with real life decisions in clinical practice. However, there is no data concerning the correlation of patient outcome and UIATS. Patients presenting to our outpatient clinic between January 1st, 2014 and December 31st, 2017 were retrospectively analyzed. We recorded the Extended Glasgow Outcome Scale (GOS-E) for longest possible follow-up, the choice of treatment, complications and UIATS recommendation. We included 221 patients with 322 UIA. 124 (38.5 %) UIA were observed and 198 (61.5 %) were occluded, of which 62 (31.3 %) underwent open surgery and 136 (68.7 %) were treated endovascularly. Spearman's rank correlation between our treatment choice and conclusive UIATS recommendation was 0.362 (p < 0.001). If UIATS was inconclusive, there were significantly more treatment-associated deteriorations (10/66 versus 7/132, p = 0.020). Otherwise, UIATS was not significantly associated with outcome. Therefore, treatment choice for UIA remains an individual decision. However, inconclusive UIATS must trigger vigilance and may be a negative prognostic marker for complications.
MeSH term(s)	Aneurysm, Ruptured/epidemiology ; Aneurysm, Ruptured/surgery ; Humans ; Intracranial Aneurysm/surgery ; Neurosurgical Procedures ; Retrospective Studies ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery ; Treatment Outcome
Language	English
Publishing date	2022-02-10
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2022.01.038
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Article: Raumforderung der Nasennebenhöhlen mit Blutungskomplikation der A. carotis interna

Stöhr, Matthäus / Fest, Sandra / von Braun, Amrei / Quaeschling, Ulf / Schob, Stefan / Dietz, Andreas

Laryngo-Rhino-Otologie

2022 Volume 101, Issue 09, Page(s) 741–744

Keywords	Mukormykose ; Nasennebenhöhlenchirugie ; Carotis-interna-Blutung ; Nasennebenhöhlentumor ; Schädelbasisdefekt ; fungi infection ; paranasal sinus tumor ; paranasal sinus surgery
Language	German
Publishing date	2022-02-08
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/a-1744-6437
Database	Thieme publisher's database

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Article: Persistent hyperprolactinemia, transient hypopituitarism, and transient contralateral third nerve palsy after endovascular treatment of an internal carotid artery aneurysm: Case report and review of the literature.

Wende, Tim / Hamerla, Gordian / Quäschling, Ulf / Haase, Amelie / Meixensberger, Jürgen / Nestler, Ulf

SAGE open medical case reports

2020 Volume 8, Page(s) 2050313X20948714

Abstract: Intracranial aneurysms have an estimated prevalence of about 3%. A rare subgroup are aneurysms of the internal carotid artery that develop medially into the sellar region. Due to the risk of rupture with subsequent subarachnoid hemorrhage and of ... ...

Abstract	Intracranial aneurysms have an estimated prevalence of about 3%. A rare subgroup are aneurysms of the internal carotid artery that develop medially into the sellar region. Due to the risk of rupture with subsequent subarachnoid hemorrhage and of compression of surrounding structures, mechanical occlusion is advised. Hypopituitarism is not a rare disease and most often related to pituitary adenoma. Only 0.17% of cases with hypopituitarism are caused by unruptured intracranial aneurysms. Today, the predominant treatment of these aneurysms is endovascular coiling or application of flow diverting stents. We present the case of a 60-year-old female patient, who was treated with endovascular coiling for a right-sided, intracavernous, incidental internal carotid artery aneurysm. On postinterventional day 6, she was readmitted with contralateral third nerve palsy, mild hyponatremia und thyreotropic insufficiency. The symptoms recovered after anti-edematous treatment with corticosteroids; only an asymptomatic hyperprolactinemia persisted. To the best of our knowledge, this is the first case report of transient contralateral cranial nerve palsy combined with transient hypopituitarism after endovascular treatment of an internal carotid aneurysm. As treatment we propose corticosteroids, if necessary in combination with nonsteroidal anti-inflammatory drugs, in order to inhibit inflammatory reactions of the aneurysm wall compromising the nearby, partially compressed neural structures.
Language	English
Publishing date	2020-08-29
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X20948714
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Article ; Online: Epidemiologic and anatomic aspects comparing incidental and ruptured intracranial aneurysms: A single centre experience.

Haase, Amelie / Schob, Stefan / Quäschling, Ulf / Hoffmann, Karl-Titus / Meixensberger, Jürgen / Nestler, Ulf

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020 Volume 81, Page(s) 151–157

Abstract: The feasibility of multicentric international data such as integrated in the PHASES score for patient counseling in unruptured intracranial aneurysms has recently been challenged. To determine, whether this data is applicable to local populations in a ... ...

Abstract	The feasibility of multicentric international data such as integrated in the PHASES score for patient counseling in unruptured intracranial aneurysms has recently been challenged. To determine, whether this data is applicable to local populations in a restricted catchment area, we performed a retrospective mono-centric analysis comparing patients with ruptured aneurysms to patients with incidental aneurysms. 200 patients with unruptured aneurysms and 197 patients after aneurysmal subarachnoid hemorrhage were analyzed for risk factors differing between the groups and to the general German population. Subgroup analysis was performed for 25 patients harboring multiple aneurysms, in 19 patients with intracavernous aneurysms and in 77 women of childbearing potential. While the preponderance of female patients was confirmed, significantly more men figured in the patient group with subarachnoid hemorrhage (36.4%) than among unruptured aneurysms (25%). Patients with bleeding events were significantly younger (51.6 years) than patients with incidental aneurysms (57.8 years). The rupture risk prediction of the PHASES score concerning aneurysm size below 7 mm and patient age over 70 years could not be confirmed, instead score points correlated to the clinical outcome after rupture. In our population, pregnant women were not overrepresented. Intracavernous carotid aneurysms contributed to the low risk profile of giant aneurysms. Thus, recommendations from pooled international data have to be adapted cautiously to local circumstances. We retained seven items with predictive value for outpatient counseling: age, smoking, hypertonus and concurrent vascular aberrations as patient characteristics and irregular shape, (increasing) largest diameter and the harboring vessel for the aneurysm.
MeSH term(s)	Adult ; Aged ; Aneurysm, Ruptured/epidemiology ; Female ; Humans ; Intracranial Aneurysm/epidemiology ; Male ; Middle Aged ; Pregnancy ; Retrospective Studies ; Risk Factors ; Subarachnoid Hemorrhage/epidemiology
Language	English
Publishing date	2020-10-10
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.09.048
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.

Golombek, Thomas / Henker, Robert / Rehak, Matus / Quäschling, Ulf / Lordick, Florian / Knödler, Maren

Oncology research and treatment

2019 Volume 42, Issue 3, Page(s) 123–127

Abstract: Background: Mixed adenoneuroendocrine carcinomas (MANECs) are rare malignancies with both neuroendocrine and non-neuroendocrine components. To date, the prognosis of gastroenteropancreatic MANECs remains dismal, and treatment options are mainly based on ...

Abstract	Background: Mixed adenoneuroendocrine carcinomas (MANECs) are rare malignancies with both neuroendocrine and non-neuroendocrine components. To date, the prognosis of gastroenteropancreatic MANECs remains dismal, and treatment options are mainly based on guidelines for the treatment of pure neuroendocrine carcinomas or small cell lung cancer. Established first-line therapy in the metastatic situation is cisplatin and etoposide. Platinum derivatives are known to cause a variety of side effects also involving the visual system. Severe orbital and optic nerve toxicities have been described mainly after intracarotid infusion of cisplatin. Case report: Herein we report a rare case of a 60-year-old male patient suffering from MANEC of the gastroesophageal junction with HER2/neu overexpression who developed severe orbital and ocular neurotoxicity (grade 3 according to CTCAE v4.03) after intravenous cisplatin. Conclusion: We discuss diagnostic approaches and differential diagnoses in this clinical situation. Before starting treatment with intravenous and topical steroids, it is crucial to rule out meningeal and cerebral spread as well as paraneoplastic and endocrine syndromes.
MeSH term(s)	Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Administration, Intravenous/adverse effects ; Antineoplastic Agents/adverse effects ; Carcinoma, Neuroendocrine/drug therapy ; Carcinoma, Neuroendocrine/pathology ; Cisplatin/adverse effects ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/pathology ; Exophthalmos/chemically induced ; Exophthalmos/diagnostic imaging ; Exophthalmos/drug therapy ; Glucocorticoids/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Oculomotor Muscles/diagnostic imaging ; Oculomotor Muscles/drug effects ; Optic Nerve/diagnostic imaging ; Optic Nerve/drug effects ; Receptor, ErbB-2/metabolism
Chemical Substances	Antineoplastic Agents ; Glucocorticoids ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2019-02-23
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2760274-6
ISSN	2296-5262 ; 2296-5270
ISSN (online)	2296-5262
ISSN	2296-5270
DOI	10.1159/000495218
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Article: Nimodipine vs. Milrinone - Equal or Complementary Use? A Retrospective Analysis.

Jentzsch, Jennifer / Ziganshyna, Svitlana / Lindner, Dirk / Merkel, Helena / Mucha, Simone / Schob, Stefan / Quäschling, Ulf / Hoffmann, Karl-Titus / Werdehausen, Robert / Halama, Dirk / Gaber, Khaled / Richter, Cindy

Frontiers in neurology

2022 Volume 13, Page(s) 939015

Abstract: Background: Cerebral vasospasm (CVS) continues to account for high morbidity and mortality in patients surviving the initial aneurysmal subarachnoid hemorrhage (SAH). Nimodipine is the only drug known to reduce delayed cerebral ischemia (DCI), but it is ...

Abstract	Background: Cerebral vasospasm (CVS) continues to account for high morbidity and mortality in patients surviving the initial aneurysmal subarachnoid hemorrhage (SAH). Nimodipine is the only drug known to reduce delayed cerebral ischemia (DCI), but it is believed not to affect large vessel CVS. Milrinone has emerged as a promising option. Our retrospective study focused on the effectiveness of the intra-arterial application of both drugs in monotherapy and combined therapy. Methods: We searched for patients with aneurysmal SAH, angiographically confirmed CVS, and at least one intra-arterial pharmacological angioplasty. Ten defined vessel sections on angiograms were assessed before and after vasodilator infusion. The improvement in vessel diameters was compared to the frequency of DCI-related cerebral infarction before hospital discharge and functional outcome reported as the modified Rankin Scale (mRS) score after 6 months. Results: Between 2014 and 2021, 132 intra-arterial interventions (144 vascular territories, 12 bilaterally) in 30 patients were analyzed for this study. The vasodilating effect of nimodipine was superior to milrinone in all intradural segments. There was no significant intergroup difference concerning outcome in mRS ( Conclusions: The monotherapy with intra-arterial nimodipine was superior to milrinone. Nimodipine and milrinone may be used complementary in an escalation scheme with the administration of nimodipine first, complemented by milrinone in cases of severe CVS. Milrinone monotherapy is not recommended.
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.939015
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