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Article ; Online: MRD end point in myeloma: ready for prime time?

Quach, Hang

2022 Volume 139, Issue 6, Page(s) 799–802

MeSH term(s)	Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Neoplasm, Residual ; Prognosis
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021013363
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: How are economic evaluations carried out for primary caries prevention strategies?

Quach, Henry

Evidence-based dentistry

2021 Volume 22, Issue 3, Page(s) 90

Abstract: Aims To summarise evidence on economic evaluations (EEs) of primary caries prevention in preschool children aged 2-5 years and to evaluate the reporting quality of full EE studies using a quality assessment tool.Methods Systematic literature search from ... ...

Abstract	Aims To summarise evidence on economic evaluations (EEs) of primary caries prevention in preschool children aged 2-5 years and to evaluate the reporting quality of full EE studies using a quality assessment tool.Methods Systematic literature search from several databases. The reporting quality was assessed using the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist.Results In total, 808 studies were identified and 39 were included in review. Complex multi-component interventions were the most common followed by water fluoridation. Cost analysis and cost-effectiveness were the most common EEs. Parameters that were not reported well were: characterising uncertainty, study perspective, sensitivity analysis and discount rate.Conclusions The number of EEs has increased but there is inconsistency in how EEs are conducted and reported.
MeSH term(s)	Child, Preschool ; Cost-Benefit Analysis ; Dental Caries/prevention & control ; Dental Caries Susceptibility ; Fluoridation ; Humans ; Primary Prevention
Language	English
Publishing date	2021-09-24
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1457588-7
ISSN	1476-5446 ; 1462-0049
ISSN (online)	1476-5446
ISSN	1462-0049
DOI	10.1038/s41432-021-0200-4
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Zs.A 4972: Show issues

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Article ; Online: How can children be involved in developing oral health education interventions?

Quach, Henry

Evidence-based dentistry

2020 Volume 21, Issue 3, Page(s) 104–105

Abstract: This review examined the oral health interventions that have been developed for elementary school age children and the involvement of children in these intervention studies. Eight randomised controlled trials involving 3,232 children were analysed using ... ...

Abstract	This review examined the oral health interventions that have been developed for elementary school age children and the involvement of children in these intervention studies. Eight randomised controlled trials involving 3,232 children were analysed using deductive content analysis by two authors. Child involvement was categorised using the Typology of Youth Participation and Empowerment TYPE model. In all eight studies, the interventions were designed by the researchers and adult-led without involvement of children. Further studies with participatory research methodology are recommended to better understand the role of involvement of children in oral health education.Data sources The data search was carried out in April 2018 using PubMed, CINAHL, Embase and Scopus databases. The search focused on elementary age school children (6-12 years) who were involved in oral health education intervention studies. Exclusion criteria were studies involving children with mental or physical impairment, undergoing hospital or orthodontic treatment, preventative treatments or solely targeted towards parents/caregivers or teachers.Study selection A systematic review method of randomised controlled trials (RCTs) was selected. Titles and abstracts were included or excluded before full text analysis for eligibility was carried out. Studies were assessed by two authors with a third author to be consulted in cases of disagreement.Data extraction and synthesis Study sample, intervention duration and content, selection, use of educational methods including use of a theoretical framework and outcomes were extracted from the data. Child involvement was categorised using the Typology of Youth Participation and Empowerment (TYPE) pyramid (Wong et al., 2010).
MeSH term(s)	Adolescent ; Adult ; Child ; Health Education, Dental ; Humans ; Oral Health ; Oral Hygiene ; Quality of Life ; Schools
Language	English
Publishing date	2020-09-25
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1457588-7
ISSN	1476-5446 ; 1462-0049
ISSN (online)	1476-5446
ISSN	1462-0049
DOI	10.1038/s41432-020-0122-6
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Article ; Online: Need for tracheostomy in major head and neck ablative surgery: a paradigm shift during the COVID-19 pandemic.

Quach, H / McGuire, B / Wallace, C / Shekar, K

Annals of the Royal College of Surgeons of England

2022 Volume 104, Issue 9, Page(s) 700–702

Abstract: Introduction: Management of the airway in the perioperative period for patients requiring major head and neck ablative surgery has commonly included the performance of elective surgical tracheostomy. This has been standard practice in most maxillofacial ...

Abstract	Introduction: Management of the airway in the perioperative period for patients requiring major head and neck ablative surgery has commonly included the performance of elective surgical tracheostomy. This has been standard practice in most maxillofacial units across the UK, including ours. However, the COVID-19 pandemic and emerging guidelines on aerosol-generating procedures required us to revisit the need for a perioperative tracheostomy. Methods: We present our series of 29 consecutive cases, cared for during the first wave of the COVID-19 pandemic, that were managed either using surgical tracheostomy or overnight tracheal intubation. Results: Out of 29 patients 3 received a surgical tracheostomy. The average duration of tracheostomy use was 8 days. Twenty patients were managed using a period of overnight tracheal intubation. Average duration of tracheal intubation was 1.2 days, with an average intensive care unit stay of 1.7 days. The average duration of hospital stay was 15.8 days for patients managed with overnight tracheal intubation and 30.1 days for patients who received a surgical tracheostomy. The return to theatre rate was 13.8% for reasons including flap failure and neck space infection. There were no airway issues reported in this series of patients. Conclusions: Our findings suggest that overnight tracheal intubation can be a safe alternative to surgical tracheostomy in the majority of cases.
MeSH term(s)	Humans ; Tracheostomy/methods ; COVID-19/epidemiology ; Pandemics ; Retrospective Studies ; Intubation, Intratracheal/methods
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	80044-2
ISSN	1478-7083 ; 0035-8843
ISSN (online)	1478-7083
ISSN	0035-8843
DOI	10.1308/rcsann.2021.0327
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Article ; Online: Multiplex immunohistochemistry elucidates increased distance between cytotoxic T cells and plasma cells in relapsed myeloma, and identifies Lag-3 as the most common checkpoint receptor on cytotoxic T cells of myeloma patients.

Ninkovic, Slavisa / Purton, Louise E / Harrison, Simon J / Quach, Hang

Haematologica

2024 Volume 109, Issue 5, Page(s) 1487–1500

Abstract: A dysfunctional immune tumor microenvironment facilitates disease progression in multiple myeloma (MM). Using multiplex immunohistochemistry (mIHC), we describe the quantitative and qualitative changes in CD3+CD8+ cytotoxic T cells and assess their ... ...

Abstract	A dysfunctional immune tumor microenvironment facilitates disease progression in multiple myeloma (MM). Using multiplex immunohistochemistry (mIHC), we describe the quantitative and qualitative changes in CD3+CD8+ cytotoxic T cells and assess their proximity to malignant plasma cells (PC) in patients with monoclonal gammopathy of undetermined significance (MGUS), and newly diagnosed (ND) and relapsed and/or refractory (RR) MM. Formalin-fixed, paraffin-embedded trephine sections from patients with MGUS (N=32), NDMM (N=65), and RRMM (N=59) were sequentially stained for CD138, CD3, CD8, and checkpoint receptors (CPR) Tim-3, Lag-3, and PD-1. The Halo® image analysis platform was used for cell segmentation and phenotyping, facilitating enumeration of cytotoxic T cells and analysis of proximity to PC. The percentage of CD8+ cytotoxic T cells in proximity to PC is greater in patients with NDMM than patients with RRMM (at 50 μm distance, 90.8% vs. 81.5%; P=0.038). There is a trend for more CD3+ T cells in MGUS (P=0.08) but no difference was observed in the prevalence of CD8+ cytotoxic T cells (P=0.48). Lag-3 is the most common CPR expressed on cytotoxic T cells in myeloma (P<0.0001), while PD-1 is the most common CPR on CD8- T cells of patients with MGUS and RRMM. Our study is the first to report on the spatial relationship between T cells and PC using mIHC on FFPE bone marrow trephine sections from patients with PC dyscrasia. The proximity of T cells to PC during early stages of MM, and overexpression of Lag-3, validate the move of immune therapeutic strategies, including T-cell engagers and checkpoint inhibitors, to upfront treatment or in early-line treatment of MM.
MeSH term(s)	Humans ; Multiple Myeloma/immunology ; Multiple Myeloma/pathology ; Multiple Myeloma/metabolism ; Multiple Myeloma/diagnosis ; Lymphocyte Activation Gene 3 Protein ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; Male ; Female ; Middle Aged ; Plasma Cells/metabolism ; Plasma Cells/pathology ; Plasma Cells/immunology ; Aged ; Immunohistochemistry ; Antigens, CD/metabolism ; Antigens, CD/analysis ; Aged, 80 and over ; Adult ; Tumor Microenvironment/immunology ; Monoclonal Gammopathy of Undetermined Significance/pathology ; Monoclonal Gammopathy of Undetermined Significance/metabolism ; Monoclonal Gammopathy of Undetermined Significance/immunology
Chemical Substances	Lymphocyte Activation Gene 3 Protein ; Lag3 protein, human ; Antigens, CD
Language	English
Publishing date	2024-05-01
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2023.283344
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Article ; Online: Recent Developments in Convenience of Administration of the Anti-CD38 Antibody Isatuximab: Subcutaneous Delivery and Fast Intravenous Infusion in Patients With Multiple Myeloma.

Quach, Hang / Parmar, Gurdeep / Mateos, Maria-Victoria / Ailawadhi, Sikander / Leleu, Xavier

Clinical lymphoma, myeloma & leukemia

2024

Abstract: Isatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings ... ...

Abstract	Isatuximab-based combinations are among the accepted standard-of-care regimens for early-line treatment of patients with relapsed/refractory multiple myeloma (RRMM), based on the results of the Phase 3 ICARIA-MM and IKEMA trials. Further study findings have shown benefit with Isa-based combinations in patients with newly diagnosed MM, as reported from the randomized GMMG-HD7 and CONCEPT trials. Isa is currently approved in various countries for intravenous (IV) administration in patients with RRMM. A more convenient route of administration, such as subcutaneous (SC) injection, and faster IV infusion may substantially increase convenience of treatment. In this review, we outline evidence emerging from clinical trials that shows increasing clinical applicability of Isa across the MM therapeutic spectrum. We then review recent study results demonstrating that new treatment modalities, either SC Isa administration via an on-body delivery system (OBDS) or fast, 30-minute, fixed-volume IV infusion, are safe and effective, and enhance convenience of treatment with Isa for MM patients and healthcare providers. In the recently reported Phase 1b study, the safety profile and efficacy of Isa administered SC plus pomalidomide-dexamethasone were comparable to those observed with Isa administered IV plus pomalidomide-dexamethasone in the control arm and in the ICARIA-MM trial. Analysis of patient-reported outcomes indicated patient confidence in SC Isa administration and satisfaction with treatment delivery by OBDS. These findings point to SC administration as the preferred route for future treatment with Isa-based combinations, as well as to the use of fast, 30-minute IV infusions in settings where SC administration of Isa might not be available.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2024.02.004
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Article ; Online: Response adaptive salvage with KTd and ASCT for functional high-risk multiple myeloma-The Australasian Leukemia and Lymphoma Group (ALLG) MM17 Trial.

Turner, R / Quach, H / Horvath, N / Kerridge, I / Lee, E / Morris, E / Kalff, A / Khong, T / Reynolds, J / Spencer, A

British journal of haematology

2023 Volume 202, Issue 3, Page(s) 530–538

Abstract: We evaluated re-induction incorporating carfilzomib-thalidomide-dexamethasone (KTd) and autologous stem cell transplantation (ASCT) for newly diagnosed multiple myeloma (NDMM) refractory, or demonstrating a suboptimal response, to non-IMID bortezomib- ... ...

Abstract	We evaluated re-induction incorporating carfilzomib-thalidomide-dexamethasone (KTd) and autologous stem cell transplantation (ASCT) for newly diagnosed multiple myeloma (NDMM) refractory, or demonstrating a suboptimal response, to non-IMID bortezomib-based induction. KTd salvage consisted of thalidomide 100 mg daily and dexamethasone 20 mg orally combined with carfilzomib 56 mg/m
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation ; Thalidomide ; Dexamethasone ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Transplantation, Autologous ; Bortezomib/therapeutic use ; Leukemia/drug therapy ; Lymphoma/drug therapy
Chemical Substances	Thalidomide (4Z8R6ORS6L) ; Dexamethasone (7S5I7G3JQL) ; Bortezomib (69G8BD63PP)
Language	English
Publishing date	2023-06-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18914
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Article ; Online: Peripheral blood stem cell mobilisation following bortezomib, lenalidomide and dexamethasone induction for multiple myeloma: a real-world single-centre experience.

Sim, Shirlene / Quach, Hang / Pham, Tina / Smooker, Veronica / Filshie, Robin

Internal medicine journal

2023 Volume 54, Issue 1, Page(s) 108–114

Abstract: Background: Bortezomib, lenalidomide and dexamethasone (VRd) is now the standard-of-care induction therapy for newly diagnosed transplant-eligible multiple myeloma patients, replacing bortezomib, cyclophosphamide and dexamethasone (VCD) therapy. ... ...

Abstract	Background: Bortezomib, lenalidomide and dexamethasone (VRd) is now the standard-of-care induction therapy for newly diagnosed transplant-eligible multiple myeloma patients, replacing bortezomib, cyclophosphamide and dexamethasone (VCD) therapy. Lenalidomide can negatively impact stem cell yield because of its myelosuppressive effects, although studies have shown that the latter can be overcome with the use of cyclophosphamide for peripheral blood stem cell (PBSC) mobilisation. Aims and methods: To investigate whether lenalidomide impacts on PBSC mobilisation and to evaluate the optimal mobilisation strategy post VRd induction, we performed a retrospective review of 56 myeloma patients at a single centre who had PBSC mobilisation between January 2019 and March 2021 and compared three cohorts: (i) VCD induction; mobilisation with granulocyte colony-stimulating factor (G-CSF) alone (n = 23); (ii) four cycles VRd induction; mobilisation with G-CSF and cyclophosphamide (G-CSF + Cyclo) (n = 20); and (iii) three cycles VRd induction; mobilisation with G-CSF alone (n = 13). Results: There was no difference in the mean total CD34 count between VCD and VRd patients who had G-CSF mobilisation (6.27 × 10 Conclusion: We conclude that successful PBSC mobilisation for at least one ASCT is possible after three cycles of VRd induction using G-CSF alone. The upfront use of a cyclophosphamide-based mobilisation strategy has a role in patients who have had VRd induction, where the aim is to collect enough stem cells for two or more ASCTs.
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/diagnosis ; Bortezomib/therapeutic use ; Lenalidomide/therapeutic use ; Peripheral Blood Stem Cells ; Dexamethasone/therapeutic use ; Cyclophosphamide/therapeutic use ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Transplantation, Autologous ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Hematopoietic Stem Cell Mobilization
Chemical Substances	Bortezomib (69G8BD63PP) ; Lenalidomide (F0P408N6V4) ; Dexamethasone (7S5I7G3JQL) ; Cyclophosphamide (8N3DW7272P) ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	English
Publishing date	2023-07-23
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16170
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Digital filtering of ghost signal in phase measuring deflectometry.

Jeong, Byeongjoon / Ordones, Sotero / Quach, Henry / Kim, Daewook / Choi, Heejoo

Optics letters

2023 Volume 48, Issue 7, Page(s) 1642–1645

Abstract: We introduce a method of geometric screen modification to remove ghost reflections commonly observed in deflectometry optical testing. The proposed method modifies the optical layout and illumination source area to bypass the generation of reflected rays ...

Abstract	We introduce a method of geometric screen modification to remove ghost reflections commonly observed in deflectometry optical testing. The proposed method modifies the optical layout and illumination source area to bypass the generation of reflected rays from the undesired surface. The layout flexibility of deflectometry allows us to design specific system layouts that avoid the generation of interrupting secondary rays. The proposed method is supported by optical raytrace simulations, and experimental results are demonstrated with convex and concave lens case studies. Finally, the limitations of the digital masking method are discussed.
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.485459
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Article: Calcium channel blocker induced gingival enlargement following implant placement in a fibula free flap reconstruction of the mandible: a case report.

Quach, Henry / Ray-Chaudhuri, Arijit

International journal of implant dentistry

2020 Volume 6, Issue 1, Page(s) 47

Abstract: Background: Gingival tissue enlargement is a common side effect of antiepileptic medications (e.g. phenytoin and sodium valproate), immunosuppressing drugs (e.g. cyclosporine) and calcium channel blockers (e.g. nifedipine, verapamil, amlodipine) ( ... ...

Abstract	Background: Gingival tissue enlargement is a common side effect of antiepileptic medications (e.g. phenytoin and sodium valproate), immunosuppressing drugs (e.g. cyclosporine) and calcium channel blockers (e.g. nifedipine, verapamil, amlodipine) (Murakami et al. 2018, Clin Periodontol 45:S17-S27, 2018). The clinical and histological appearances of lesions caused by these drugs are indistinguishable from one another (Murakami et al. 2018, Clin Periodontol 45:S17-S27, 2018). Drug-induced gingival enlargement is rarely seen in edentulous patients. Case presentation: This case presents a 72-year-old female with a history of squamous cell carcinoma of the floor of the mouth treated with surgical excision and fibula-free flap reconstruction. Following the uncovering of osseointegrated implants placed in the fibular-free flap, the patient developed gingival enlargement of the floor of the mouth. Cessation of amlodipine and switching to an alternative medication lead to a resolution of the enlarged tissue. Conclusions: This case illustrates that gingival enlargement can occur around dental implants, most notably in rehabilitation cases in patients who have had head and neck cancer. Clinicians should be aware of the risk of gingival enlargement in hypertensive patients taking calcium channel blockers prior to implant placement.
Language	English
Publishing date	2020-08-18
Publishing country	Germany
Document type	Journal Article
ISSN	2198-4034
ISSN	2198-4034
DOI	10.1186/s40729-020-00242-6
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