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Article ; Online: Cytokines and exosomal miRNAs in skeletal muscle-adipose crosstalk.

Guo, Liu / Quan, Menchus / Pang, Weijun / Yin, Yulong / Li, Fengna

Trends in endocrinology and metabolism: TEM

2023 Volume 34, Issue 10, Page(s) 666–681

Abstract: Skeletal muscle and adipose tissues (ATs) are secretory organs that release secretory factors including cytokines and exosomes. These factors mediate muscle-adipose crosstalk to regulate systemic metabolism via paracrine and endocrine pathways. Myokines ... ...

Abstract	Skeletal muscle and adipose tissues (ATs) are secretory organs that release secretory factors including cytokines and exosomes. These factors mediate muscle-adipose crosstalk to regulate systemic metabolism via paracrine and endocrine pathways. Myokines and adipokines are cytokines secreted by skeletal muscle and ATs, respectively. Exosomes loaded with nucleic acids, proteins, lipid droplets, and organelles can fuse with the cytoplasm of target cells to perform regulatory functions. A major regulatory component of exosomes is miRNA. In addition, numerous novel myokines and adipokines have been identified through technological innovations. These discoveries have identified new biomarkers and sparked new insights into the molecular regulation of skeletal muscle growth and adipose deposition. The knowledge may contribute to potential diagnostic and therapeutic targets in metabolic disease.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Cytokines ; Obesity ; Muscle, Skeletal ; Adipokines
Chemical Substances	MicroRNAs ; Cytokines ; Adipokines
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2023.07.006
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Article ; Online: Exosomal Secretion of Adipose Tissue during Various Physiological States.

Quan, Menchus / Kuang, Shihuan

Pharmaceutical research

2020 Volume 37, Issue 11, Page(s) 221

Abstract: Exosomes are secreted extracellular vesicles containing a wide array of biologically active components. Recent studies have demonstrated that exosomes serve as an important vehicle for extracellular communication and exert systemic effects on the ... ...

Abstract	Exosomes are secreted extracellular vesicles containing a wide array of biologically active components. Recent studies have demonstrated that exosomes serve as an important vehicle for extracellular communication and exert systemic effects on the physiology of organisms. Adipose tissues (ATs) play a key role in balancing systemic energy homeostasis as a central hub for fatty acid metabolism. At the same time, proper endocrine function of ATs has also been shown to be crucial for regulating physiological and metabolic health. The endocrine function of ATs is partially mediated by AT-derived exosomes that regulate metabolic homeostasis, such as insulin signaling, lipolysis, and inflammation. During the pathogenesis of obesity, metabolic syndrome, and cancer, exosomes shed by the resident cells in ATs may also have a role in regulating the progression of these diseases along with associated pathologies. In this review, we summarize the contents of AT-derived exosomes and their effects on various cell populations along with possible underlying molecular mechanisms. We further discuss the potential applications of exosomes as a drug delivery tool and therapeutic target.
MeSH term(s)	Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; Exosomes/metabolism ; Exosomes/pathology ; Exosomes/transplantation ; Humans ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/pathology ; Metabolic Syndrome/therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Obesity/metabolism ; Obesity/pathology ; Obesity/therapy ; Secretory Pathway ; Signal Transduction
Language	English
Publishing date	2020-10-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	843063-9
ISSN	1573-904X ; 0724-8741 ; 0739-0742
ISSN (online)	1573-904X
ISSN	0724-8741 ; 0739-0742
DOI	10.1007/s11095-020-02941-6
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Article ; Online: Sustained activation of notch signaling maintains tumor-initiating cells in a murine model of liposarcoma.

Tien, Pei-Chieh / Quan, Menchus / Kuang, Shihuan

Cancer letters

2020 Volume 494, Page(s) 27–39

Abstract: Cells in a tumor are heterogeneous, often including a small number of tumor-initiating cells (TICs) and the majority of cancerous and non-cancerous cells. We have previously reported that constitutive activation of Notch signaling in adipocytes of mice ... ...

Abstract	Cells in a tumor are heterogeneous, often including a small number of tumor-initiating cells (TICs) and the majority of cancerous and non-cancerous cells. We have previously reported that constitutive activation of Notch signaling in adipocytes of mice leads to dedifferentiated liposarcoma (DDLPS), an aggressive liposarcoma (LPS) with no effective treatment. Here, we explored the role of Notch signaling in cellular heterogeneity of LPS. We performed serial transplantations to enrich for TICs, and derived cells exhibiting sustained Notch activation (mLPS1 cells) and cells with normal Notch activity (mLPS2 cells). Both mLPS1 and mLPS2 cells proliferated rapidly, and neither exhibited contact inhibition. However, only the mLPS1 cells exhibited tumorigenicity and gave rise to LPS upon engraftment into mice. The mLPS1 cells also highly expressed markers of cancer stem cells (Cd133), mesenchymal stem cells (Cd73, Cd90, Cd105, Dlk1) and the long non-coding RNA Rian. By contrast, the mLPS2 cells accumulated lipid droplets and expressed mature adipocyte markers when induced to differentiate. Most importantly, CRISPR-mediated disruption of Notch abrogated the tumorigenic properties of mLPS1 cells. These results reveal a key role of Notch signaling in maintaining TICs in LPS.
MeSH term(s)	Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Liposarcoma/genetics ; Liposarcoma/metabolism ; Liposarcoma/pathology ; Mice ; Neoplasm Transplantation/methods ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Receptors, Notch/metabolism ; Serial Passage ; Signal Transduction
Chemical Substances	Biomarkers, Tumor ; Receptors, Notch
Language	English
Publishing date	2020-08-28
Publishing country	Ireland
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2020.08.029
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Article: Structure and diversity of Fusarium communities inhabiting non-cultivated grass inflorescences in New York State

Fulcher, Michael R / Oladipo, Eniola D / Winans, James B / Quan, Menchus / Bergstrom, Gary C

Canadian journal of plant pathology. 2021 Jan. 02, v. 43, no. 1

2021

Abstract: The structure and diversity of wild grass spike-inhabiting Fusarium communities are not well understood. Fifteen common, non-cultivated grasses were surveyed across two years, regions, and land uses for spike-dwelling Fusarium spp. Eleven fungal species ... ...

Abstract	The structure and diversity of wild grass spike-inhabiting Fusarium communities are not well understood. Fifteen common, non-cultivated grasses were surveyed across two years, regions, and land uses for spike-dwelling Fusarium spp. Eleven fungal species were identified from 857 isolates, including two, F. camptoceras and F. lactis, not recorded previously in New York state or on grass hosts. Species diversity and community structure varied by year and region. Land use and host community did not influence Fusarium communities, and no species-specific grass-Fusarium associations were detected. Fusarium communities were divided into two categories, those dominated by F. graminearum and those dominated by F. sporotrichioides. The community formation process is relevant to disease prediction and toxin monitoring in cropping systems as well as to land management practices at the intersection of agricultural and natural spaces.
Keywords	community structure ; fungi ; grasses ; land use ; plant pathology ; prediction ; species diversity ; toxins ; New York
Language	English
Dates of publication	2021-0102
Size	p. 48-55.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	763044-x
ISSN	0706-0661 ; 1715-2992
ISSN	0706-0661 ; 1715-2992
DOI	10.1080/07060661.2020.1788166
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Article ; Online: Monitoring drug metabolic pathways through extracellular vesicles in mouse plasma.

Wu, Xiaofeng / Quan, Menchus / Hadisurya, Marco / Hu, Jianzhong / Liu, Yi-Kai / Zhuang, Yuxin / Li, Li / Iliuk, Anton B / Yang, Jun J / Kuang, Shihuan / Tao, W Andy

PNAS nexus

2024 Volume 3, Issue 2, Page(s) pgae023

Abstract: The ability to monitor the response of metabolic enzymes to drug exposure in individuals is highly appealing and critical to personalized medicine. Although pharmacogenomics assesses genotypic differences, it does not report changes in metabolic enzyme ... ...

Abstract	The ability to monitor the response of metabolic enzymes to drug exposure in individuals is highly appealing and critical to personalized medicine. Although pharmacogenomics assesses genotypic differences, it does not report changes in metabolic enzyme activities due to environmental factors such as drug interactions. Here, we report a quantitative proteomics strategy to monitor drug metabolic pathways by profiling metabolic enzymes in circulating extracellular vesicles (EVs) upon drug exposure. Mass spectrometry (MS)-based measurement revealed that changes in metabolic enzyme abundance in EVs paralleled those in hepatic cells isolated from liver tissue. Coupling with multiplexed isotopic labeling, we temporally quantified 34 proteins involved in drug absorption, distribution, metabolism, and excretion (ADME) pathways. Out of 44 known ADME proteins in plasma EVs, previously annotated mouse cytochrome P450 3A11 (Cyp3a11), homolog to human CYP3A4, and uridine 5'-diphospho (UDP) glucuronosyltransferase 2A3 (Ugt2a3), increased upon daily rifampicin dosage. Dasatinib, a tyrosine kinase inhibitor to treat leukemia, also elevated Cyp3a11 levels in plasma EVs, but to a lesser extent. Altogether, this study demonstrates that measuring drug enzymes in circulating EVs as an effective surrogate is highly feasible and may transform today's drug discovery and development for personalized medicine.
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ISSN	2752-6542
ISSN (online)	2752-6542
DOI	10.1093/pnasnexus/pgae023
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Article: The Incidence of

Fulcher, Michael R / Winans, James B / Quan, Menchus / Bergstrom, Gary C

Plant disease

2020 Volume 104, Issue 10, Page(s) 2681–2687

Abstract: The movement of plant pathogens between cultivated and natural host communities can result in lost agricultural production and altered microbial or plant biodiversity. ...

Abstract	The movement of plant pathogens between cultivated and natural host communities can result in lost agricultural production and altered microbial or plant biodiversity.
MeSH term(s)	Fusarium/genetics ; Incidence ; New York ; Plant Diseases ; Poaceae ; Triticum
Language	English
Publishing date	2020-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-20-0286-RE
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Article: The Incidence of Fusarium graminearum in Wild Grasses is Associated With Rainfall and Cumulative Host Density in New York

Fulcher, Michael R / Winans, James B / Quan, Menchus / Bergstrom, Gary C

Plant disease. 2020 Oct., v. 104, no. 10

2020

Abstract: The movement of plant pathogens between cultivated and natural host communities can result in lost agricultural production and altered microbial or plant biodiversity. Fusarium graminearum incidence was studied in wild grass hosts for 3 years to better ... ...

Abstract	The movement of plant pathogens between cultivated and natural host communities can result in lost agricultural production and altered microbial or plant biodiversity. Fusarium graminearum incidence was studied in wild grass hosts for 3 years to better understand the ecology of this plant pathogen at the interface of crop fields and nonagricultural environments. Research sites (n = 23) were spread between regions of high and low agricultural production and included both agricultural and nonagricultural fields. Pathogen incidence in living grass spikes and senesced, overwintered stems varied between regions of New York and was lowest in a region with sparser agricultural production (P = 0.001). However, pathogen incidence within regions was similar at both agricultural and nonagricultural sites. The groundcover of crop and wild hosts within 1 km of sample sites were equally effective predictors of pathogen incidence, indicating either host group may drive pathogen spread. Rainfall in the 8 weeks preceding sample collection was strongly correlated with F. graminearum incidence in grasses, as well as an increased prevalence of F. graminearum in Fusarium spp. communities (P = 0.001). Grass species diversity was not associated with a reduction in pathogen incidence, and F. graminearum incidence did not vary among the most well-sampled grasses. These results indicate the pathogen colonizes and spreads in noncultivated grasses in a manner consistent with existing concepts of pathogen epidemiology in cereal crops. Increasing host acreage, whether cultivated or not, could drive the colonization of grasses in remote or protected environments, potentially altering their microbial communities.
Keywords	Fusarium graminearum ; epidemiology ; grain crops ; grasses ; hosts ; microbial communities ; plant pathogenic fungi ; rain ; species diversity ; stems ; New York
Language	English
Dates of publication	2020-10
Size	p. 2681-2687.
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-02-20-0286-RE
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Article: Population Genetics of Fusarium graminearum at the Interface of Wheat and Wild Grass Communities in New York

Fulcher, Michael R / Bergstrom, Gary C / Oladipo, Eniola D / Quan, Menchus / Winans, James B

Phytopathology. 2019 Dec., v. 109, no. 12

2019

Abstract: Fusarium graminearum is primarily understood as an agricultural pathogen affecting cereal crops, but its host range also includes diverse, noncultivated grasses ubiquitous across agricultural and natural environments. Wild grasses may select for the ... ...

Abstract	Fusarium graminearum is primarily understood as an agricultural pathogen affecting cereal crops, but its host range also includes diverse, noncultivated grasses ubiquitous across agricultural and natural environments. Wild grasses may select for the production of diverse toxin variants (chemotypes) and serve as reservoirs of genetic diversity or sources of disease-inciting inoculum. Populations at the intersection of wheat and wild grass communities were described using 909 isolates collected from wheat spikes, wild grass spikes, and overwintered wild grass stems found at natural and agricultural sites in regions of high and low crop production. Trichothecene (TRI) genotypes correlated to pathogen chemotype were predicted from two loci, and multilocus genotypes (MLGs) were determined using eight microsatellite loci. The genetic diversity of wild grass and wheat-derived populations was comparable, and their differentiation was low. Duplicate MLGs were rare even in samples collected from a single square meter, although they could be found in multiple hosts, environments, regions, and years. TRI genotype frequencies differed between region and land use. Admixture between TRI genotype-defined populations, which correspond to three previously described sympatric North American populations, was detected and was highest in a region with remote host communities and little agricultural production. Nonagricultural environments may maintain different pathogen TRI genotypes than wheat fields and provide an opportunity for recombination between isolates from different F. graminearum populations. A lack of structural barriers suggests that pathogen gene flow is uninhibited between wheat and wild grass communities, and the recovery of putative clones from multiple hosts and environments provides initial evidence that noncultivated grasses are a source of local and regional inoculum.
Keywords	chemotypes ; clones ; crop production ; Fusarium graminearum ; gene flow ; genetic variation ; grain crops ; grasses ; host range ; hosts ; inoculum ; land use ; loci ; microsatellite repeats ; pathogens ; stems ; sympatry ; trichothecenes ; Triticum ; wheat ; New York
Language	English
Dates of publication	2019-12
Size	p. 2124-2131.
Publishing place	Phytopathology
Document type	Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-05-19-0169-R
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Article: Population Genetics of

Fulcher, Michael R / Winans, James B / Quan, Menchus / Oladipo, Eniola D / Bergstrom, Gary C

Phytopathology

2019 Volume 109, Issue 12, Page(s) 2124–2131

Abstract: ... Fusarium ... ...

Abstract	Fusarium graminearum
MeSH term(s)	Fusarium/genetics ; Gene Flow ; Genetic Variation ; Genetics, Population ; Genotype ; Mycotoxins/genetics ; New York ; Plant Diseases/microbiology ; Poaceae/microbiology ; Trichothecenes ; Triticum/microbiology
Chemical Substances	Mycotoxins ; Trichothecenes ; trichothecene (7OO57LYZ5I)
Language	English
Publishing date	2019-10-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	208889-7
ISSN	1943-7684 ; 0031-949X
ISSN (online)	1943-7684
ISSN	0031-949X
DOI	10.1094/PHYTO-05-19-0169-R
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Article: New insight into the species diversity and life cycles of rust fungi (Pucciniales) affecting bioenergy switchgrass (Panicum virgatum) in the Eastern and Central United States

Kenaley, Shawn C / Aime, M. Catherine / Bergstrom, Gary C / Quan, Menchus

Mycological progress. 2018 Nov., v. 17, no. 11

2018

Abstract: Research was undertaken to clarify the taxonomic identity of leaf rust (Pucciniales) fungi on bioenergy switchgrass in the Eastern and Central U.S. We integrated internal transcribed spacer 2 (ITS2) and partial 28S ribosomal RNA gene sequence data from ... ...

Abstract	Research was undertaken to clarify the taxonomic identity of leaf rust (Pucciniales) fungi on bioenergy switchgrass in the Eastern and Central U.S. We integrated internal transcribed spacer 2 (ITS2) and partial 28S ribosomal RNA gene sequence data from collections taken from cultivated switchgrass and herbarium specimens, including purported aecial and telial states of Puccinia graminicola and Puccinia pammelii. Maximum likelihood and Bayesian analyses revealed four monophyletic clades: Puccinia emaculata sensu stricto (s.s.), P. pammelii, P. graminicola, and Puccinia novopanici. Results also indicated that P. emaculata s.s. was not affecting cultivated, bioenergy switchgrass. Aecidium pammelii and P. pammelii were distinct phylogenetically from P. emaculata s.s. and grouped within a well-supported clade, demonstrating aecial-telial host alternation for P. pammelii between Euphorbia corollata and switchgrass. Aecidium stillingiae on queen’s delight (Stillingia sylvatica)—a purported aecial state host for P. graminicola—shared identical sequences with the recently described species Puccinia pascua. The latter fungus, however, was recovered within a subclade of P. graminicola. Hence, queen’s delight likely is not an aecial host to P. graminicola s.s. Additional molecular studies are warranted to determine species boundaries within the P. graminicola complex. The majority of contemporary collections from cultivated switchgrass were recognized as P. novopanici. Collectively, bioenergy switchgrass is host to at least three phylogenetically distinct species, presenting a significant challenge to the future selection and breeding of switchgrass with improved rust resistance.
Keywords	Aecidium ; bioenergy ; breeding ; Euphorbia corollata ; herbaria ; internal transcribed spacers ; leaf rust ; monophyly ; Panicum virgatum ; plant pathogenic fungi ; Puccinia ; ribosomal DNA ; ribosomal RNA ; species diversity ; statistical analysis ; Stillingia ; Midwestern United States
Language	English
Dates of publication	2018-11
Size	p. 1251-1267.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	2226747-5
ISSN	1861-8952 ; 1617-416X
ISSN (online)	1861-8952
ISSN	1617-416X
DOI	10.1007/s11557-018-1434-1
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