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Article: Application of Indocyanine Green Enhanced Fluorescence in Esophageal Surgery: A Mini Review.

Tamburini, Nicola / Chiozza, Matteo / Maniscalco, Pio / Resta, Giuseppe / Marino, Serafino / Quarantotto, Francesco / Anania, Gabriele / Cavallesco, Giorgio

Frontiers in surgery

2022 Volume 9, Page(s) 961856

Abstract: Despite recent technological innovations and the development of minimally invasive surgery, esophagectomy remains an operation burdened with severe postoperative complications. Fluorescence imaging, particularly using indocyanine green (ICG), offers the ... ...

Abstract	Despite recent technological innovations and the development of minimally invasive surgery, esophagectomy remains an operation burdened with severe postoperative complications. Fluorescence imaging, particularly using indocyanine green (ICG), offers the ability to address a number of issues faced during esophagectomy. The three main indications for the intraoperative use of ICG during esophagectomy are visualization of conduit vascular supply, allow identification of sentinel nodes and visualization of the thoracic duct. The purpose of this mini review is to present an overview of current practice in fluorescence imaging utilizing ICG during esophagectomy, as well as to demonstrate how this technology can guide lymphadenectomy and reduce surgical morbidity such as anastomotic leaking and chylothorax.
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.961856
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Article ; Online: Unilateral Thoracoscopic Thymectomy for Thymoma: Does Side Matter? A Single Institutional Experience.

Tamburini, Nicola / D'Urbano, Francesco / Bagolini, Francesco / Trapella, Giulia Salerno / Quarantotto, Francesco / Cavallesco, Giorgio / Maniscalco, Pio

The Thoracic and cardiovascular surgeon

2021 Volume 71, Issue 5, Page(s) 418–424

Abstract: Background: Thoracoscopic thymectomy is increasingly performed for the treatment of early stage thymoma. It is characterized by shorter postoperative hospital stay, decreased intraoperative blood loss, and fewer complications compared with transsternal ... ...

Abstract	Background: Thoracoscopic thymectomy is increasingly performed for the treatment of early stage thymoma. It is characterized by shorter postoperative hospital stay, decreased intraoperative blood loss, and fewer complications compared with transsternal thymectomy. Unilateral video-assisted thoracic surgery (VATS) thymectomy can be easily performed from either side of the thorax, because thymus is located in the middle of mediastinum. However, the side that provides better outcomes remains controversial. The purpose of this study was to compare the efficacy of right and left approaches in performing unilateral thoracoscopic thymectomy for thymoma. Methods: Consecutive patients affected by thymoma who underwent VATS thymectomy on either side between February 2001 and March 2020 were enrolled in the study. Clinicopathologic, surgical, and oncological outcomes were retrospectively analyzed and compared among the two surgical approaches. Results: Unilateral VATS approaches were performed on 29 patients: 12 (41%) on the left side and 17 (59%) on the right side. The mean age was 63.1 ± 11.3 years and the female/male ratio was 1.73:1. The mean operative time and the hospital stay for the left-side VATS and right-side VATS groups were, respectively, 168 ± 49.5 versus 171 ± 47.9 minutes ( Conclusion: Unilateral VATS thymectomy in patients with thymoma can be safely and effectively performed by experienced surgeons in either side of the thorax with equivalent oncological outcomes.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Aged ; Thymoma/diagnostic imaging ; Thymoma/surgery ; Thymectomy/adverse effects ; Retrospective Studies ; Treatment Outcome ; Thymus Neoplasms/diagnostic imaging ; Thymus Neoplasms/surgery ; Thoracic Surgery, Video-Assisted/adverse effects
Language	English
Publishing date	2021-09-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0041-1731778
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Article ; Online: Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System.

Tamburini, Nicola / Maniscalco, Pio / Migliorelli, Andrea / Nigim, Fares / Quarantotto, Francesco / Maietti, Elisa / Cavallesco, Giorgio

The Thoracic and cardiovascular surgeon

2019 Volume 68, Issue 5, Page(s) 433–439

Abstract: Background: This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a ... ...

Abstract	Background: This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease. Methods: Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed.The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Results: A significant correlation between the TNM stages and the histological classification was found ( Conclusions: There is a significant correlation between the new TNM staging and the histological grade WHO. The ability to implement a complete resection, the overall and disease-free survival is closely related to the thymoma stage. Furthermore, both histotype and stage correlate with disease-free survival. In fact, the least aggressive stages, both WHO and TNM, have a free time out of disease superior to advanced stages.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Databases, Factual ; Disease-Free Survival ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Neoplasms, Glandular and Epithelial/mortality ; Neoplasms, Glandular and Epithelial/secondary ; Neoplasms, Glandular and Epithelial/surgery ; Predictive Value of Tests ; Retrospective Studies ; Thymectomy ; Thymus Neoplasms/mortality ; Thymus Neoplasms/pathology ; Thymus Neoplasms/surgery ; Time Factors ; Young Adult
Language	English
Publishing date	2019-02-22
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0039-1678612
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Article: Factors Associated with Early Discharge after Thoracoscopic Lobectomy: Results from the Italian VATS Group Registry.

Maniscalco, Pio / Tamburini, Nicola / Fabbri, Nicolò / Quarantotto, Francesco / Rizzardi, Giovanna / Amore, Dario / Lopez, Camillo / Crisci, Roberto / Spaggiari, Lorenzo / Valpiani, Giorgia / Bertolaccini, Luca / Cavallesco, Giorgio / On Behalf Of The Vats Group

Journal of clinical medicine

2022 Volume 11, Issue 24

Abstract: Objective. There are limited data for estimating the risk of early discharge following thoracoscopic lobectomy. The objective was to identify the factors associated with a short length of stay and verify the influence of these variables in uncomplicated ... ...

Abstract	Objective. There are limited data for estimating the risk of early discharge following thoracoscopic lobectomy. The objective was to identify the factors associated with a short length of stay and verify the influence of these variables in uncomplicated patients. Methods. We reviewed all lobectomies reported to the Italian VATS Group between January 2014 and January 2020. Patients and perioperative characteristics were divided into two subgroups based on whether or not they met the target duration of stay (≤ or >4 days). The association between preoperative and intraoperative variables and postoperative length of stay (LOS) ≤4 days was assessed using a stepwise multivariable logistic regression analysis to identify factors independently associated with LOS and factors related to LOS in uncomplicated cases. Results. Among 10,240 cases who underwent thoracoscopic lobectomy, 37.6% had a hospital stay ≤4 days. Variables associated with LOS included age, hospital surgical volume, Diffusion Lung CO % (81 [69−94] vs. 85 [73−98]), Forced Expiratory Volume (FEV1) % (92 [79−106] vs. 96 [82−109]), operative time (180 [141−230] vs. 160 [125−195]), uniportal approach (571 [9%] vs. 713 [18.5%]), bioenergy sealer use, and pain control through intercostal block or opioids (p < 0.001). Except for FEV1 and blood loss, all other factors emerged significantly associated with LOS when the analysis was limited to uncomplicated patients. Conclusions. Demographic, clinical, and surgical variables are associated with early discharge after thoracoscopic lobectomy. This study indicates that these characteristics are associated with early discharge. This result can be used in association with clinical judgment to identify appropriate patients for fast-track protocols.
Language	English
Publishing date	2022-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11247356
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Article: Unilateral Thoracoscopic Thymectomy for Thymoma: Does Side Matter? A Single Institutional Experience

Tamburini, Nicola / D'Urbano, Francesco / Bagolini, Francesco / Trapella, Giulia Salerno / Quarantotto, Francesco / Cavallesco, Giorgio / Maniscalco, Pio

The Thoracic and Cardiovascular Surgeon

2021 Volume 71, Issue 05, Page(s) 418–424

Abstract	Background: Thoracoscopic thymectomy is increasingly performed for the treatment of early stage thymoma. It is characterized by shorter postoperative hospital stay, decreased intraoperative blood loss, and fewer complications compared with transsternal thymectomy. Unilateral video-assisted thoracic surgery (VATS) thymectomy can be easily performed from either side of the thorax, because thymus is located in the middle of mediastinum. However, the side that provides better outcomes remains controversial. The purpose of this study was to compare the efficacy of right and left approaches in performing unilateral thoracoscopic thymectomy for thymoma. Methods: Consecutive patients affected by thymoma who underwent VATS thymectomy on either side between February 2001 and March 2020 were enrolled in the study. Clinicopathologic, surgical, and oncological outcomes were retrospectively analyzed and compared among the two surgical approaches. Results: Unilateral VATS approaches were performed on 29 patients: 12 (41%) on the left side and 17 (59%) on the right side. The mean age was 63.1 ± 11.3 years and the female/male ratio was 1.73:1. The mean operative time and the hospital stay for the left-side VATS and right-side VATS groups were, respectively, 168 ± 49.5 versus 171 ± 47.9 minutes ( p = 0.9) and 3 ± 1.03 days versus 3.65 ± 1.93 days ( p = 0.7). Postoperative complications occurred in one patient (3%) for left-side VATS group and one patient (3%) for right-side VATS. The 5-year disease-free survival was comparable between two groups ( p = 0.74). Conclusion: Unilateral VATS thymectomy in patients with thymoma can be safely and effectively performed by experienced surgeons in either side of the thorax with equivalent oncological outcomes.
Keywords	myasthenia gravis ; VATS ; thymectomy ; outcomes ; thymoma
Language	English
Publishing date	2021-09-14
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0041-1731778
Database	Thieme publisher's database

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Article: Misdiagnosis of anomalous pulmonary venous connections in a patient with lung cancer and a review of the literature.

Tamburini, Nicola / Marchi, Irene / Bassi, Matteo / Anania, Gabriele / Quarantotto, Francesco / Cavallesco, Giorgio / Maniscalco, Pio

Journal of thoracic disease

2017 Volume 9, Issue 8, Page(s) E723–E726

Abstract: A partial anomalous pulmonary venous connection (PAPVC) is a rare congenital defect in which at least one pulmonary vein doesn't drain into the left atrium but into a systemic vein or even into the right atrium, causing a left-to right shunt. PAPVC with ... ...

Abstract	A partial anomalous pulmonary venous connection (PAPVC) is a rare congenital defect in which at least one pulmonary vein doesn't drain into the left atrium but into a systemic vein or even into the right atrium, causing a left-to right shunt. PAPVC with a small amount of shunt are usually asymptomatic, and can not be detected during lifetime. Nevertheless, if those patients undergo a major lung resection, the surgical procedure could precipitate right heart failure if this anomalous shunt remains uncorrected. Therefore, it is considered to be very important preoperative diagnosis. In case report, we present a case of a 54-year-old woman with a right upper lobe non-small cell lung cancer and previous history of left lung resection for tuberculosis. During surgery, an anomalous pulmonary vein branch draining into the superior vena cava was incidentally detected. The abnormality was diagnosed as a PAPVC. A right upper open lobectomy was performed. The anomaly was corrected and the surgery was successful without postoperative complications. Surgeons should be aware of this rare anomaly and carefully evaluate preoperative images CT scans of the pulmonary veins.
Language	English
Publishing date	2017-08-30
Publishing country	China
Document type	Case Reports
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd.2017.07.36
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Article ; Online: Synchronous pancreatic and pulmonary metastases from solitary fibrous tumor of the pleura: report of a case.

Tamburini, Nicola / Fabbri, Nicolò / Anania, Gabriele / Maniscalco, Pio / Quarantotto, Francesco / Rinaldi, Rosa / Cavallesco, Giorgio

Tumori

2017 Volume 103, Issue Suppl. 1, Page(s) e9–e11

Abstract: Introduction: Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been ...

Abstract	Introduction: Solitary fibrous tumor of the pleura is an uncommon tumor with an indolent course and a good prognosis after surgical resection. However, the tumor occasionally follows an unpredictable clinical course and malignant transformation has been reported to increase the rate of local recurrence. Solitary extrathoracic metastasis from solitary fibrous tumor of the pleura is an uncommon finding. Case presentation: In this case report we present the first case of a synchronous single pulmonary and pancreatic metastasis treated with minimally invasive surgery. Conclusions: Pancreatic recurrence should be considered in the postoperative follow-up in patients with solitary fibrous tumor of the pleura.
Language	English
Publishing date	2017-11-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.5301/tj.5000592
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Article ; Online: Surgical excision of a tufted angioma of the hand in an adult-a rare case report with a review of literature.

Fabbri, Nicolò / Quarantotto, Francesco / Caruso, Annalisa / Montinari, Elena / Rubino, Serena / Tamburini, Nicola / Maniscalco, Pio / Cavallesco, Giorgio

AME case reports

2019 Volume 3, Page(s) 7

Abstract: Tufted Angiomas, also known as angioblastomas/Angioblastoma of Nagakawa, are rare vascular neoplasms of both sexes localised to the skin and subcutaneous tissues with the upper trunk and neck being the most common sites. They are more common in children ... ...

Abstract	Tufted Angiomas, also known as angioblastomas/Angioblastoma of Nagakawa, are rare vascular neoplasms of both sexes localised to the skin and subcutaneous tissues with the upper trunk and neck being the most common sites. They are more common in children but a few cases in juveniles and adults have been reported. Typically, Tufted Angioma remains stable or can show rarely a spontaneous regression. This article wants to evaluate the efficacy of current treatment modalities for tufted angioma (TA). A review was performed using PubMed database (Medline) for clinical studies. We report our case, a 29-year-old female who presented with a second finger of the left hand, painful, slowly progressive, firm swelling diagnosed as Tufted Angioma on histopathology and immunohistochemistry after complete surgical excision.
Language	English
Publishing date	2019-03-14
Publishing country	China
Document type	Case Reports
ISSN	2523-1995
ISSN (online)	2523-1995
DOI	10.21037/acr.2019.02.02
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Article: Thymic Epithelial Tumors: Prognostic Significance and Relationship between Histology and the New TNM Staging System

Tamburini, Nicola / Maniscalco, Pio / Migliorelli, Andrea / Nigim, Fares / Quarantotto, Francesco / Maietti, Elisa / Cavallesco, Giorgio

The Thoracic and Cardiovascular Surgeon

2019 Volume 68, Issue 05, Page(s) 433–439

Abstract	Background: This study aims to describe the relationship between the new tumor nodes metastasis (TNM) staging and World Health Organization (WHO) classification and to identify how these two variables relate to each other and whether they possess a prognostic value in predicting survival and recurrence of disease. Methods: Medical records of 54 patients who underwent surgery for thymic epithelial tumors between 1996 and 2015 were reviewed. The histologic type of neoplasm was classified according to the criteria of WHO and staging was evaluated using the new TNM classification system. Results: A significant correlation between the TNM stages and the histological classification was found ( p < 0.001). Complete resection is related to both TNM stage and histological grading ( p < 0.001). Evaluation of the 5- and 10-year survival curves shows how these are significantly correlated only at the stage ( p = 0.03 and = 0.04, respectively). The risk of death at 5 and 10 years for stages III to IV is six and three times higher than in stages I to II, respectively. Regarding the disease-free survival, there is significant correlation with both staging and histology ( p = 0.001 and = 0.02, respectively). Conclusions: There is a significant correlation between the new TNM staging and the histological grade WHO. The ability to implement a complete resection, the overall and disease-free survival is closely related to the thymoma stage. Furthermore, both histotype and stage correlate with disease-free survival. In fact, the least aggressive stages, both WHO and TNM, have a free time out of disease superior to advanced stages.
Keywords	thymoma ; surgery ; pathology ; mediastinal tumor ; prognosis
Language	English
Publishing date	2019-02-22
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0039-1678612
Database	Thieme publisher's database

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Article ; Online: Endovascular and thoracoscopic treatment for post-lobectomy hemothorax.

Grossi, William / Maniscalco, Pio / Quarantotto, Francesco / Cavallesco, Giorgio

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2012 Volume 41, Issue 2, Page(s) 456

MeSH term(s)	Aneurysm, False/complications ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aortic Diseases/complications ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/surgery ; Aortography ; Carcinoma, Non-Small-Cell Lung/surgery ; Hemothorax/diagnostic imaging ; Hemothorax/etiology ; Hemothorax/surgery ; Humans ; Lung Neoplasms/surgery ; Male ; Pneumonectomy/adverse effects ; Thoracoscopy/methods ; Tomography, X-Ray Computed
Language	English
Publishing date	2012-02
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1016/j.ejcts.2011.05.062
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