Result 1 - 10 of total 25
Science & Technology Review
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #825586 |
| Database | COVID19 |
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Journal of Alzheimer's disease : JAD
2023 Volume 93, Issue 2, Page(s) 483–493
Abstract: Background: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable on caffeine consumption and brain amyloid positivity.: Objective: We aimed to determine the relationship ... ...
| Abstract | Background: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable on caffeine consumption and brain amyloid positivity. Objective: We aimed to determine the relationship between caffeine consumption and brain amyloid pathology in cognitively normal older adults. Methods: The dataset used for analysis in this cross-sectional study was selected from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study. Multivariable logistic regression analyses were performed to explore the association between caffeine consumption and amyloid positivity using odds ratios (ORs) and 95% confidence intervals (CIs). Results: In total, 4,394 participants were included in the final analysis. No significant association between caffeine consumption and amyloid positivity was observed in the whole participants (OR, 0.95; 95% CI, 0.78-1.14; p = 0.558). Subgroup analysis showed that caffeine intake was significantly associated with decreased amyloid positivity in males (OR, 0.72; 95% CI, 0.54-0.97; p = 0.032) but not in females (OR, 1.14; 95% CI, 0.90-1.46; p = 0.280), and the association between caffeine and amyloid positivity was not affected by age or APOE genotypes. In addition, different levels of caffeine were not associated with amyloid positivity. Conclusion: The findings suggest that caffeine consumption was not significantly associated with amyloid positivity in the whole sample. However, caffeine consumption may be inversely associated with amyloid positivity among males but not females. More studies are needed to explore the mechanisms underlying caffeine consumption and brain amyloid positivity. |
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| MeSH term(s) | Male ; Humans ; Aged ; Caffeine ; Amyloid beta-Peptides/metabolism ; Cross-Sectional Studies ; Brain/pathology ; Amyloidogenic Proteins ; Positron-Emission Tomography ; Alzheimer Disease/epidemiology ; Alzheimer Disease/pathology |
| Chemical Substances | Caffeine (3G6A5W338E) ; Amyloid beta-Peptides ; Amyloidogenic Proteins |
| Language | English |
| Publishing date | 2023-04-10 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1440127-7 |
| ISSN | 1875-8908 ; 1387-2877 |
| ISSN (online) | 1875-8908 |
| ISSN | 1387-2877 |
| DOI | 10.3233/JAD-220591 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6084: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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International journal of environmental research and public health
2022 Volume 19, Issue 6
Abstract: Digital mental health services (DMHSs) have great potential for mitigating the mental health burden related to COVID-19, but public accessibility (ease of acquiring services when needed) to DMHSs during the pandemic is largely unknown. Accessibility to ... ...
| Abstract | Digital mental health services (DMHSs) have great potential for mitigating the mental health burden related to COVID-19, but public accessibility (ease of acquiring services when needed) to DMHSs during the pandemic is largely unknown. Accessibility to DMHSs was tracked longitudinally among a nationwide sample of 18,804 adults in China from before to one year after COVID-19 outbreak. Unconditional and conditional latent growth curve models and latent growth mixture models were fitted to explore the overall growth trend, influencing factors, and latent trajectory classes of accessibility to DMHSs throughout COVID-19. Generalized estimating equation models and generalized linear mixed models were employed to explore the association between accessibility to DMHSs and long-term mental health symptoms. We found that people generally reported increased difficulty in accessing DMHSs from before to one year after COVID-19 outbreak. Males, youngsters, individuals with low socioeconomic status, and individuals greatly affected by COVID-19 reported greater difficulty in accessing DMHSs. Four DMHS accessibility trajectory classes were identified: "lowest-great increase" (6.3%), "moderate low-slight increase" (44.4%), "moderate high-slight decrease" (18.1%) and "highest-great decrease" (31.2%). Trajectory classes reporting greater difficulty in accessing DMHSs were at higher risk for long-term mental symptoms. In conclusion, an overall increase in difficulty in accessing DMHSs is observed throughout COVID-19, and heterogeneity exists in DMHS accessibility trajectories. Our results suggest that easy access to DMHSs should be consistently facilitated. Moreover, access gaps should be reduced across demographic groups, and target populations for service allocation should alter as the pandemic evolves. |
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| MeSH term(s) | Adult ; COVID-19/epidemiology ; Health Services Accessibility ; Humans ; Male ; Mental Disorders/epidemiology ; Mental Health ; Mental Health Services |
| Language | English |
| Publishing date | 2022-03-17 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2175195-X |
| ISSN | 1660-4601 ; 1661-7827 |
| ISSN (online) | 1660-4601 |
| ISSN | 1661-7827 |
| DOI | 10.3390/ijerph19063593 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Epidemiology and psychiatric sciences
2022 Volume 31, Page(s) e69
Abstract: Aims: COVID-19 has long-term impacts on public mental health, while few research studies incorporate multidimensional methods to thoroughly characterise the psychological profile of general population and little detailed guidance exists for mental ... ...
| Abstract | Aims: COVID-19 has long-term impacts on public mental health, while few research studies incorporate multidimensional methods to thoroughly characterise the psychological profile of general population and little detailed guidance exists for mental health management during the pandemic. This research aims to capture long-term psychological profile of general population following COVID-19 by integrating trajectory modelling approaches, latent trajectory pattern identification and network analyses. Methods: Longitudinal data were collected from a nationwide sample of 18 804 adults in 12 months after COVID-19 outbreak in China. Patient Health Questionnaire-9, Generalised Anxiety Disorder-7 and Insomnia Severity Index were used to measure depression, anxiety and insomnia, respectively. The unconditional and conditional latent growth curve models were fitted to investigate trajectories and long-term predictors for psychological symptoms. We employed latent growth mixture model to identify the major psychological symptom trajectory patterns, and ran sparse Gaussian graphical models with graphical lasso to explore the evolution of psychopathological network. Results: At 12 months after COVID-19 outbreak, psychological symptoms generally alleviated, and five psychological symptom trajectories with different demographics were identified: normal stable (63.4%), mild stable (15.3%), mild-increase to decrease (11.7%), mild-decrease to increase (4.0%) and moderate/severe stable (5.5%). The finding indicated that there were still about 5% individuals showing consistently severe distress and approximately 16% following fluctuating psychological trajectories, who should be continuously monitored. For individuals with persistently severe trajectories and those with fluctuating trajectories, central or bridge symptoms in the network were mainly 'motor abnormality' and 'sad mood', respectively. Compared with initial peak and late COVID-19 phase, aftermath of initial peak might be a psychologically vulnerable period with highest network connectivity. The central and bridge symptoms for aftermath of initial peak ('appetite change' and 'trouble of relaxing') were totally different from those at other pandemic phases ('sad mood'). Conclusions: This research identified the overall growing trend, long-term predictors, trajectory classes and evolutionary pattern of psychopathological network of psychological symptoms in 12 months after COVID-19 outbreak. It provides a multidimensional long-term psychological profile of the general population after COVID-19 outbreak, and accentuates the essentiality of continuous psychological monitoring, as well as population- and time-specific psychological management after COVID-19. We believe our findings can offer reference for long-term psychological management after pandemics. |
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| MeSH term(s) | Adult ; COVID-19 ; Depression/psychology ; Disease Outbreaks ; Humans ; SARS-CoV-2 ; Sleep Initiation and Maintenance Disorders/epidemiology |
| Language | English |
| Publishing date | 2022-09-27 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2607964-1 |
| ISSN | 2045-7979 ; 2045-7960 |
| ISSN (online) | 2045-7979 |
| ISSN | 2045-7960 |
| DOI | 10.1017/S2045796022000518 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5143: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 22, Issue 1, Page(s) 562
Abstract: Background: High-quality mental health services can improve outcomes for people with mental health problems and abate the burden of mental disorders. We sought to identify the challenges the country's mental health system currently faces and the human ... ...
| Abstract | Background: High-quality mental health services can improve outcomes for people with mental health problems and abate the burden of mental disorders. We sought to identify the challenges the country's mental health system currently faces and the human resource situation related to psychological services and to provide recommendations on how the mental health workforce situation could be addressed in China. Methods: This study used a cross-sectional survey design. A web-based questionnaire approach and a convenience sampling method were adopted. It was carried out from September 2020 to January 2021 in China, and we finally included 3824 participants in the analysis. Descriptive statistical analysis of the characteristics of the study sample was performed. The risk factors for competence in psychological counseling/psychotherapy were assessed using multiple linear regression analysis. Results: Workforce related to psychotherapy is scarce in China, especially in Western China and community mental health sectors. Psychiatrists (39.1%) and nurses (38.9%) were the main service providers of psychotherapy in psychiatric hospitals, and clinical psychologists (6.9%) and counsellors (5.0%) were seriously scarce in mental health care sectors. A total of 74.2% of respondents had no systematic psychological training, and 68.4 and 69.2% of them had no self-experience and professional supervision, respectively. Compared with clinical psychologists and counselors, psychiatrists and nurses had less training. Systematic psychological training (β = - 0.88), self-experience (β = - 0.59) and professional supervision (β = - 1.26) significantly influenced psychotherapy capacity (P<0.001). Conclusions: Sustained effort will be required to provide a high-quality, equitably distributed psychotherapy workforce in China, despite challenges for community mental health sectors and western China being likely to continue for some time. Because mental illness is implicated in so many burgeoning social ills, addressing this shortfall could have wide-ranging benefits. |
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| MeSH term(s) | China ; Cross-Sectional Studies ; Delivery of Health Care ; Humans ; Mental Health Services ; Workforce |
| Language | English |
| Publishing date | 2022-08-22 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2050438-X |
| ISSN | 1471-244X ; 1471-244X |
| ISSN (online) | 1471-244X |
| ISSN | 1471-244X |
| DOI | 10.1186/s12888-022-04204-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2022 Volume 12, Issue 1
Abstract: During the pandemic era, quarantines might potentially have negative effects and disproportionately exacerbate health condition problems. We conducted this cross-sectional, national study to ascertain the prevalence of constant pain symptoms and how ... ...
| Abstract | During the pandemic era, quarantines might potentially have negative effects and disproportionately exacerbate health condition problems. We conducted this cross-sectional, national study to ascertain the prevalence of constant pain symptoms and how quarantines impacted the pain symptoms and identify the factors associated with constant pain to further guide reducing the prevalence of chronic pain for vulnerable people under the pandemic. The sociodemographic data, quarantine conditions, mental health situations and pain symptoms of the general population were collected. After adjusting for potential confounders, long-term quarantine (≥15 days) exposures were associated with an increased risk of constant pain complaints compared to those not under a quarantine (Odds Ratio (OR): 1.26; 95% Confidence Interval (CI): 1.03, 1.54; |
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| Language | English |
| Publishing date | 2022-01-05 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2651993-8 |
| ISSN | 2076-3425 |
| ISSN | 2076-3425 |
| DOI | 10.3390/brainsci12010079 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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European psychiatry : the journal of the Association of European Psychiatrists
2021 Volume 64, Issue 1, Page(s) e18
Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic is a major threat to the public. However, the comprehensive profile of suicidal ideation among the general population has not been systematically investigated in a large sample in the age of ... ...
| Abstract | Background: The coronavirus disease 2019 (COVID-19) pandemic is a major threat to the public. However, the comprehensive profile of suicidal ideation among the general population has not been systematically investigated in a large sample in the age of COVID-19. Methods: A national online cross-sectional survey was conducted between February 28, 2020 and March 11, 2020 in a representative sample of Chinese adults aged 18 years and older. Suicidal ideation was assessed using item 9 of the Patient Health Questionnaire-9. The prevalence of suicidal ideation and its risk factors was evaluated. Results: A total of 56,679 participants (27,149 males and 29,530 females) were included. The overall prevalence of suicidal ideation was 16.4%, including 10.9% seldom, 4.1% often, and 1.4% always suicidal ideation. The prevalence of suicidal ideation was higher in males (19.1%) and individuals aged 18-24 years (24.7%) than in females (14.0%) and those aged 45 years and older (11.9%). Suicidal ideation was more prevalent in individuals with suspected or confirmed infection (63.0%), frontline workers (19.2%), and people with pre-existing mental disorders (41.6%). Experience of quarantine, unemployed, and increased psychological stress during the pandemic were associated with an increased risk of suicidal ideation and its severity. However, paying more attention to and gaining a better understanding of COVID-19-related knowledge, especially information about psychological interventions, could reduce the risk. Conclusions: The estimated prevalence of suicidal ideation among the general population in China during COVID-19 was significant. The findings will be important for improving suicide prevention strategies during COVID-19. |
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| MeSH term(s) | Adolescent ; Adult ; COVID-19/epidemiology ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Pandemics ; Prevalence ; Quarantine/psychology ; Quarantine/statistics & numerical data ; Risk Factors ; SARS-CoV-2 ; Stress, Psychological/epidemiology ; Suicidal Ideation ; Suicide/prevention & control ; Suicide/psychology ; Suicide/statistics & numerical data ; Unemployment/psychology ; Unemployment/statistics & numerical data ; Young Adult |
| Language | English |
| Publishing date | 2021-02-03 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1074337-6 |
| ISSN | 1778-3585 ; 0767-399X ; 0924-9338 |
| ISSN (online) | 1778-3585 |
| ISSN | 0767-399X ; 0924-9338 |
| DOI | 10.1192/j.eurpsy.2021.5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2369: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 558: Show issues |
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2023 Volume 69, Page(s) 101773
| MeSH term(s) | Humans ; Adult ; Sleep Initiation and Maintenance Disorders/drug therapy ; Network Meta-Analysis |
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| Language | English |
| Publishing date | 2023-03-15 |
| Publishing country | England |
| Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Comment |
| ZDB-ID | 1414211-9 |
| ISSN | 1532-2955 ; 1087-0792 |
| ISSN (online) | 1532-2955 |
| ISSN | 1087-0792 |
| DOI | 10.1016/j.smrv.2023.101773 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5901: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 68, Page(s) 101746
Abstract: Insomnia is one of the most common and burdensome disorders in adults. We compared and ranked insomnia medication on the basis of their efficacy and tolerability. We performed a systematic review and network meta-analysis of placebo-controlled or head-to- ...
| Abstract | Insomnia is one of the most common and burdensome disorders in adults. We compared and ranked insomnia medication on the basis of their efficacy and tolerability. We performed a systematic review and network meta-analysis of placebo-controlled or head-to-head randomized controlled trials for primary insomnia in adults comparing 20 drugs. We searched eight databases and seven trial registers from inception to March 1st, 2022. Primary outcomes included sleep latency (SL), awake time after sleep onset (WASO) and discontinuation for adverse events (AED), and secondary outcomes included total sleep time (TST), sleep efficiency (SE), sleep quality (SQ) and adverse events (ADE). Pooled standardized mean differences or odds ratios with 95% credible intervals were estimated using pairwise and network meta-analysis with random-effects. Differences among trial findings were explored in subgroup and sensitivity analyses. Confidence in evidence was assessed using GRADE. The PROSPERO registered number is CRD42020182144. We identified 22,538 records and included 69 studies (17,319 patients). Orexin receptor antagonists (ORAs) are more efficacious than benzodiazepine-like drugs (Z-drugs) and placebo for WASO and SE, and better than melatonin receptor agonists (MRAs) for SL, WASO and SE. ORAs ranked the best in SL (SUCRA value: 0.84), WASO (0.93), TST (0.86) and SE (0.96). Lemborexant and daridorexant (two ORAs) showed greater efficacy than placebo for SL, WASO, and TST, with good tolerability. Z-drugs were more efficacious than placebo for SL, WASO, TST and SE, but with higher risk to safety. Zaleplon and eszopiclone had better efficacy than placebo for TST and SQ respectively. MRAs may also be efficacious for sleep-onset insomnia with good safety. However, the long-term adverse effects of all medications are unclear. Insomnia medications differ in their efficacy and tolerability. ORAs have superior efficacy and tolerability. These findings should aid clinicians in matching risk/benefits of drugs available in their countries to insomnia symptoms. |
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| MeSH term(s) | Humans ; Adult ; Sleep Initiation and Maintenance Disorders/drug therapy ; Network Meta-Analysis ; Sleep ; Hypnotics and Sedatives/adverse effects ; Wakefulness ; Treatment Outcome |
| Chemical Substances | Hypnotics and Sedatives |
| Language | English |
| Publishing date | 2023-01-14 |
| Publishing country | England |
| Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1414211-9 |
| ISSN | 1532-2955 ; 1087-0792 |
| ISSN (online) | 1532-2955 |
| ISSN | 1087-0792 |
| DOI | 10.1016/j.smrv.2023.101746 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5901: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 71, Page(s) 101815
| Language | English |
|---|---|
| Publishing date | 2023-07-04 |
| Publishing country | England |
| Document type | Letter |
| ZDB-ID | 1414211-9 |
| ISSN | 1532-2955 ; 1087-0792 |
| ISSN (online) | 1532-2955 |
| ISSN | 1087-0792 |
| DOI | 10.1016/j.smrv.2023.101815 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5901: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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