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  1. Article: Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity.

    Garg, Diya / Que, Loretta G / Ingram, Jennifer L

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1315540

    Abstract: Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, ... ...

    Abstract Over 20 million adults and 6 million children in the United States (US) have asthma, a chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and mucus hypersecretion. Obesity, another highly prevalent disease in the US, is a major risk factor for asthma and a significant cause of diminished asthma control, increased submucosal eosinophilia, and reduced quality of life. A large subgroup of these patients experiences severe symptoms and recurrent exacerbations despite maximal dosage of standard asthma therapies. In the past two decades, the development of biological therapies has revolutionized the field and advanced our understanding of type 2 inflammatory biomarkers. However, patients with obesity and comorbid asthma are not principally considered in clinical trials of biologics. Large landmark cluster analyses of patients with asthma have consistently identified specific asthma phenotypes that associate with obesity but may be differentiated by age of asthma onset and inflammatory cell profiles in sputum. These patterns suggest that biologic processes driving asthma pathology are heterogenous among patients with obesity. The biological mechanisms driving pathology in patients with asthma and comorbid obesity are not well understood and likely multifactorial. Future research needs to be done to elicit the cellular and metabolic functions in the relationship of obesity and asthma to yield the best treatment options for this multiplex condition. In this review, we explore the key features of type 2 inflammation in asthma and discuss the effectiveness, safety profile, and research gaps regarding the currently approved biological therapies in asthma patients with obesity.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1315540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma.

    Dixon, Anne E / Que, Loretta G

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 4, Page(s) 388–389

    MeSH term(s) Child ; Humans ; Pediatric Obesity ; T-Lymphocytes ; Asthma/immunology ; Muscle, Smooth ; Myocytes, Smooth Muscle ; CD4-Positive T-Lymphocytes
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1870ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Obesity and Asthma.

    Dixon, Anne E / Que, Loretta G

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 5, Page(s) 662–674

    Abstract: Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma-recent studies in the United States suggest that 60% of ... ...

    Abstract Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma-recent studies in the United States suggest that 60% of adults with severe asthma are obese. Multiple mechanisms link obesity and asthma, which are discussed in this article, and these pathways contribute to different phenotypes of asthma among people with obesity. From a practical aspect, changes in physiology and immune markers affect diagnosis and monitoring of disease activity in people with asthma and obesity. Obesity also affects response to asthma medications and is associated with an increased risk of co-morbidities such as gastroesophageal reflux disease, depression, and obstructive sleep apnea, all of which may affect asthma control. Obese people may be at elevated risk of exacerbations related to increased risk of severe disease in response to viral infections. Interventions that target improved dietary quality, exercise, and weight loss are likely to be particularly helpful for this patient population.
    MeSH term(s) Asthma/drug therapy ; Asthma/epidemiology ; Asthma/etiology ; Humans ; Obesity/complications ; Obesity/epidemiology ; Prevalence ; Risk Factors ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1742384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.

    Kim, Haein R / Ingram, Jennifer L / Que, Loretta G

    Journal of asthma and allergy

    2023  Volume 16, Page(s) 481–499

    Abstract: 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly ... ...

    Abstract 20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. Obesity, another highly prevalent disease in the US, is a major risk factor for asthma and a significant cause of oxidative stress throughout the body. People with asthma and comorbid obesity are susceptible to developing severe asthma that cannot be sufficiently controlled with current treatments. More research is needed to understand how asthma pathobiology is affected when the patient has comorbid obesity. Because the airway epithelium directly interacts with the outside environment and interacts closely with the immune system, understanding how the airway epithelium of patients with asthma and comorbid obesity is altered compared to that of lean asthma patients will be crucial for developing more effective treatments. In this review, we discuss how oxidative stress plays a role in two chronic inflammatory diseases, obesity and asthma, and propose a mechanism for how these conditions may compromise the airway epithelium.
    Language English
    Publishing date 2023-05-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S402340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Advances in Asthma.

    Dixon, Anne E / Carr, Tara F / Que, Loretta G

    Seminars in respiratory and critical care medicine

    2022  Volume 43, Issue 5, Page(s) 593–594

    MeSH term(s) Asthma/therapy ; Humans
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1753473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Obesity and Asthma

    Dixon, Anne E. / Que, Loretta G.

    Seminars in Respiratory and Critical Care Medicine

    (Advances in Asthma)

    2022  Volume 43, Issue 05, Page(s) 662–674

    Abstract: Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma—recent studies in the United States suggest that 60% of ... ...

    Series title Advances in Asthma
    Abstract Obesity is a major risk factor for the development of asthma, and the prevalence of obesity is higher in people with asthma than in the general population. Obese people often have severe asthma—recent studies in the United States suggest that 60% of adults with severe asthma are obese. Multiple mechanisms link obesity and asthma, which are discussed in this article, and these pathways contribute to different phenotypes of asthma among people with obesity. From a practical aspect, changes in physiology and immune markers affect diagnosis and monitoring of disease activity in people with asthma and obesity. Obesity also affects response to asthma medications and is associated with an increased risk of co-morbidities such as gastroesophageal reflux disease, depression, and obstructive sleep apnea, all of which may affect asthma control. Obese people may be at elevated risk of exacerbations related to increased risk of severe disease in response to viral infections. Interventions that target improved dietary quality, exercise, and weight loss are likely to be particularly helpful for this patient population.
    Keywords airway reactivity ; oscillometry ; exacerbation ; weight loss ; diet ; co-morbidities ; viral infection ; gastroesophageal reflux disease ; obstructive sleep apnea ; depression ; type 2 inflammation
    Language English
    Publishing date 2022-02-17
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1742384
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.

    McCravy, Matthew / Ingram, Jennifer L / Que, Loretta G

    Journal of asthma and allergy

    2021  Volume 14, Page(s) 179–186

    Abstract: Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, ... ...

    Abstract Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, T
    Language English
    Publishing date 2021-03-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S282284
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  8. Article ; Online: Electronic Cigarettes: A Pro-Con Review of the Current Literature.

    Giovacchini, Coral X / Crotty Alexander, Laura E / Que, Loretta G

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 11, Page(s) 2843–2851

    Abstract: Electronic cigarettes (e-cigarettes, e-cigs, or electronic nicotine delivery systems) are battery-operated devices typically containing glycerol and/or propylene glycol-based solutions with varying nicotine content, known as e-liquids. Although e- ... ...

    Abstract Electronic cigarettes (e-cigarettes, e-cigs, or electronic nicotine delivery systems) are battery-operated devices typically containing glycerol and/or propylene glycol-based solutions with varying nicotine content, known as e-liquids. Although e-cigarettes were originally developed as a potentially less harmful alternative to traditional combustible tobacco cigarette smokers, several factors have driven their popularity among smokers and nonsmokers alike, including their sleek product designs, innumerable appealing flavors, lack of combustible smoke and odor, and high potential nicotine concentrations. Furthermore, many advocates have promoted the idea that e-cigarettes are safe to use, or at least safer than conventional tobacco, despite limited longitudinal data to support these claims. Here, we examine what is known about the impacts of e-cigarette use on traditional cigarette smoking cessation, lung health, and youth and young adult tobacco product exposure. Upon review of the currently available literature, the negative effects of e-cigarette use seem to outweigh any potential benefit, because the available evidence does not confirm the use of e-cigarettes as an effective strategy for supporting traditional combustible tobacco cigarette smoking cessation, particularly given the emerging adverse effects on lung health and the potential future public health effects of e-cigarette adoption among a burgeoning new generation of tobacco product users.
    MeSH term(s) Young Adult ; Adolescent ; Humans ; Electronic Nicotine Delivery Systems ; Nicotine/adverse effects ; Smoking Cessation ; Smokers ; Public Health
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.07.009
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  9. Article: Advances in Asthma

    Dixon, Anne E. / Carr, Tara F. / Que, Loretta G.

    Seminars in Respiratory and Critical Care Medicine

    (Advances in Asthma)

    2022  Volume 43, Issue 05, Page(s) 593–594

    Series title Advances in Asthma
    Language English
    Publishing date 2022-07-08
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1753473
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

    Chumakova-Orin, Maryna / Ingram, Jennifer L / Que, Loretta G / Pagidipati, Neha / Gordee, Alexander / Kuchibhatla, Maragatha / Seymour, Keri A

    Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

    2023  Volume 20, Issue 1, Page(s) 18–28

    Abstract: Background: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery.: Objectives: The incidence of short-term major adverse cardiovascular events (MACE) ...

    Abstract Background: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery.
    Objectives: The incidence of short-term major adverse cardiovascular events (MACE) in patients with MetS undergoing bariatric surgery is not well characterized.
    Setting: Accredited bariatric surgery centers in the United States and Canada.
    Methods: A total of 760,076 patients aged ≥18 years with body mass index ≥35 kg/m
    Results: Of the 577,882 patients included, 111,128 (19.2%) exhibited MetS. Patients with MetS more frequently experienced MACE compared with patients without MetS (.3% versus .1%; P < .001). The odds of MACE were greater for patients with MetS versus Non-MetS (odds ratio [OR] 2.87; 95% CI, 2.49-3.32) in the unadjusted analysis. MetS without HLD, MetS with HLD, and Non-MetS with HLD are significantly associated with MACE when compared with those with non-MetS without HLD.
    Conclusions: Patients with MetS have an increased frequency of cardiac events following bariatric surgery. Future studies should determine if optimization of 1 or more components of MetS or other related co-morbidities reduces the cardiovascular risk for patients.
    MeSH term(s) Humans ; United States ; Adolescent ; Adult ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Risk Factors ; Bariatric Surgery/methods ; Comorbidity ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/complications ; Myocardial Infarction/etiology ; Myocardial Infarction/complications ; Hyperlipidemias/complications ; Retrospective Studies
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274243-8
    ISSN 1878-7533 ; 1550-7289
    ISSN (online) 1878-7533
    ISSN 1550-7289
    DOI 10.1016/j.soard.2023.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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