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  1. Article ; Online: Melioidosis in a traveller from Africa.

    Igea, Pilar / Quereda, Carmen / Gomez G de la Pedrosa, Elia / Montaño, Lorena / Tato, Marta / Norman, Francesca F

    Journal of travel medicine

    2023  Volume 30, Issue 2

    MeSH term(s) Humans ; Melioidosis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Africa ; Burkholderia pseudomallei
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taad005
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    Zs.A 4120: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Non-perinatal listeriosis: Changes in frequency, clinical spectrum and prognostic factors.

    Corral, Luis / de Los Santos, Ignacio / Quereda, Carmen / Acebrón, Fernando / Ruíz-Garbajosa, Patricia / Muriel, Alfonso / Corral, Íñigo

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2023  Volume 42, Issue 1, Page(s) 24–29

    Abstract: Introduction: Listeria monocytogenes infection is a severe disease affecting mainly aged people and patients with immune depression. The incidence of listeriosis seems to be increasing. In the present study cases of listeriosis from two hospitals are ... ...

    Abstract Introduction: Listeria monocytogenes infection is a severe disease affecting mainly aged people and patients with immune depression. The incidence of listeriosis seems to be increasing. In the present study cases of listeriosis from two hospitals are analyzed with the aims of studying changes in its incidence, clinical forms of presentation and possible factors associated with mortality.
    Methods: Retrospective multicentric study of patients with culture-proven listeriosis in two university hospitals in Madrid between 1977 and 2021. Epidemiological and clinical variables, as well as factors for immune depression, complementary studies and treatments were registered. Factors associated with mortality were analyzed.
    Results: A total of 194 cases of listeriosis were analyzed. The incidence of listeriosis among in-patients increased through the study period, with a significant drop in the number of cases in 2020. The most common clinical presentations were isolated bacteriemia (37.1%) and central nervous system involvement (CNS) (36.6%). Symptoms of gastroenteritis occurred in 21% of cases. Other focal infections were present in 16.5% of patients, the most frequent were spontaneous bacterial peritonitis (8.2%), cholecystitis (2.1%), respiratory infection (1.5%) and vascular prothesis infection (1.5%). In-hospital mortality was 24.7%. Independent factors associated with mortality at admission were age (Odds Ratio [OR] 1.027, 95% confidence interval [IC95%] 1.003-1.056) and a diagnosis of a solid tumor (OR 3.525, IC95% 1.652-7.524).
    Conclusions: This study confirms an increasing incidence of listeriosis in our millieu. The most common clinical presentations were isolated bacteriemia and central nervous system involvement. In-hospital mortality was associated with age and the diagnosis of a solid tumor.
    MeSH term(s) Humans ; Aged ; Listeria monocytogenes ; Retrospective Studies ; Prognosis ; Listeriosis/diagnosis ; Listeriosis/epidemiology ; Bacteremia/complications ; Neoplasms/complications ; Neoplasms/epidemiology
    Language English
    Publishing date 2023-01-14
    Publishing country Spain
    Document type Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2023.01.002
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  3. Article ; Online: Post-Hypoxic Myoclonus after COVID-19 Infection Recovery.

    Ros-Castelló, Victoria / Quereda, Carmen / López-Sendón, José / Corral, Iñigo

    Movement disorders clinical practice

    2020  Volume 7, Issue 8, Page(s) 983–984

    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13025
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  4. Article ; Online: IFN-γ

    Vallejo, Alejandro / Vizcarra, Pilar / Quereda, Carmen / Moreno, Ana / Casado, José Luis

    European journal of clinical investigation

    2021  Volume 51, Issue 12, Page(s) e13636

    Abstract: Background: Healthcare workers (HCWs) are at increased risk since they are directly exposed to SARS-CoV-2-infected patients, and nevertheless, some remain without the development of anti-SARS-CoV-2 antibodies or related symptoms, suggesting less ... ...

    Abstract Background: Healthcare workers (HCWs) are at increased risk since they are directly exposed to SARS-CoV-2-infected patients, and nevertheless, some remain without the development of anti-SARS-CoV-2 antibodies or related symptoms, suggesting less susceptibility to the infection.
    Methods: This cross-sectional, case-control study aimed to compare SARS-CoV-2 T-cell response by two different technologies, the analysis of IFN-γ
    Results: A high proportion of uninfected HCWs (53.8%) had pre-existing IFN-γ
    Conclusions: The good concordance between the proportion of individuals with IFN-γ release after SARS-COV-2 stimulation with the proportion of individuals with specific IFN-γ
    MeSH term(s) Adult ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; COVID-19/immunology ; Case-Control Studies ; Coronavirus Nucleocapsid Proteins ; Cross-Sectional Studies ; Female ; Health Personnel ; Humans ; In Vitro Techniques ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interferon-gamma Release Tests ; Male ; Middle Aged ; Nurses ; Phosphoproteins ; Physicians ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus ; T-Lymphocyte Subsets ; T-Lymphocytes/immunology ; Viral Matrix Proteins
    Chemical Substances Coronavirus Nucleocapsid Proteins ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; Viral Matrix Proteins ; membrane protein, SARS-CoV-2 ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2 ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.13636
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    Zs.A 677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV/HCV-coinfected patients with advanced fibrosis/cirrhosis.

    Berenguer, Juan / Aldámiz-Echevarría, Teresa / Hontañón, Víctor / Fanciulli, Chiara / Quereda, Carmen / Busca, Carmen / Domínguez, Lourdes / Hernández, Cristina / Vergas, Jorge / Gaspar, Gabriel / García-Fraile, Lucio J / Díez, Cristina / De Miguel, Marta / Bellón, José M / Bañares, Rafael / González-García, Juan

    Hepatology (Baltimore, Md.)

    2024  

    Abstract: Background and aims: We assessed long-term clinical outcomes and prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected with HIV/HCV with advanced fibrosis or cirrhosis.: ... ...

    Abstract Background and aims: We assessed long-term clinical outcomes and prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected with HIV/HCV with advanced fibrosis or cirrhosis.
    Approach and results: A total of 1300 patients who achieved sustained viral response with direct-acting antivirals from 2014 to 2017 in Spain were included: 1145 with compensated advanced chronic liver disease (384 advanced fibrosis and 761 compensated cirrhosis) and 155 with decompensated cirrhosis. The median follow-up was 40.9 months. Overall, 85 deaths occurred, 61 due to non-liver non-AIDS-related causes that were the leading cause of death across all stages of liver disease. The incidence (95% CI) of decompensation per 100 person-years (py) was 0 in patients with advanced fibrosis, 1.01 (0.68-1.51) in patients with compensated cirrhosis, and 8.35 (6.05-11.53) in patients with decompensated cirrhosis. The incidence (95% CI) of HCC per 100 py was 0.34 (0.13-0.91) in patients with advanced fibrosis, 0.73 (0.45-1.18) in patients with compensated cirrhosis, and 1.92 (1.00-3.70) per 100 py in patients with decompensated cirrhosis. Prognostic factors for decompensation in patients with compensated advanced chronic liver disease included serum albumin, liver stiffness measurement (LSM), and fibrosis 4. In this population, LSM and LSM-based posttreatment risk stratification models showed their predictive ability for decompensation and HCC.
    Conclusions: Non-liver non-AIDS-related events were the leading causes of morbidity and mortality after direct-acting antiviral cure among coinfected patients with advanced fibrosis/cirrhosis. Among those with compensated advanced chronic liver disease, baseline LSM and posttreatment LSM-based models helped to assess decompensation and HCC risk.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000838
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    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Expansion of CD56

    Casado, José L / Moraga, Elisa / Vizcarra, Pilar / Velasco, Héctor / Martín-Hondarza, Adrián / Haemmerle, Johannes / Gómez, Sandra / Quereda, Carmen / Vallejo, Alejandro

    Viruses

    2021  Volume 14, Issue 1

    Abstract: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection induces elevated levels of inflammatory cytokines, which are mainly produced by the innate response to the virus. The role of NK cells, which are potent producers of IFN-γ and ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection induces elevated levels of inflammatory cytokines, which are mainly produced by the innate response to the virus. The role of NK cells, which are potent producers of IFN-γ and cytotoxicity, has not been sufficiently studied in the setting of SARS-CoV-2 infection. We confirmed a different distribution of NK cell subsets in hospitalized COVID-19 patients despite their NK cell deficiency. The impairment of this innate defense is mainly focused on the cytotoxic capacity of the CD56
    MeSH term(s) Aged ; CD56 Antigen/metabolism ; COVID-19/blood ; COVID-19/immunology ; Female ; GPI-Linked Proteins/metabolism ; Hospitalization ; Humans ; Inflammation ; Killer Cells, Natural/metabolism ; Lymphocyte Subsets/metabolism ; Male ; Middle Aged ; Receptors, IgG/metabolism ; Receptors, KIR/metabolism ; SARS-CoV-2
    Chemical Substances CD56 Antigen ; FCGR3B protein, human ; GPI-Linked Proteins ; NCAM1 protein, human ; Receptors, IgG ; Receptors, KIR
    Language English
    Publishing date 2021-12-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Post‐Hypoxic Myoclonus after COVID ‐19 Infection Recovery

    Ros‐Castelló, Victoria / Quereda, Carmen / López‐Sendón, José / Corral, Iñigo

    Movement Disorders Clinical Practice ; ISSN 2330-1619 2330-1619

    2020  

    Keywords covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/mdc3.13025
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Expansion of CD56dimCD16neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients

    Casado, José L. / Moraga, Elisa / Vizcarra, Pilar / Velasco, Héctor / Martín-Hondarza, Adrián / Haemmerle, Johannes / Gómez, Sandra / Quereda, Carmen / Vallejo, Alejandro

    Viruses. 2021 Dec. 28, v. 14, no. 1

    2021  

    Abstract: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection induces elevated levels of inflammatory cytokines, which are mainly produced by the innate response to the virus. The role of NK cells, which are potent producers of IFN-γ and ... ...

    Abstract Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection induces elevated levels of inflammatory cytokines, which are mainly produced by the innate response to the virus. The role of NK cells, which are potent producers of IFN-γ and cytotoxicity, has not been sufficiently studied in the setting of SARS-CoV-2 infection. We confirmed a different distribution of NK cell subsets in hospitalized COVID-19 patients despite their NK cell deficiency. The impairment of this innate defense is mainly focused on the cytotoxic capacity of the CD56ᵈⁱᵐ NK cells. On the one hand, we found an expansion of the CD56ᵈⁱᵐCD16ⁿᵉᵍ NK subset, lower cytotoxic capacities, and high frequencies of inhibitory 2DL1 and 2DL1/S1 KIR receptors in COVID-19 patients. On the other hand, the depletion of CD56ᵈⁱᵐCD16ᵈⁱᵐ/ᵇʳⁱᵍʰᵗ NK cell subsets, high cytotoxic capacities, and high frequencies of inhibitory 2DL1 KIR receptors were found in COVID-19 patients. In contrast, no differences in the distribution of CD56ᵇʳⁱᵍʰᵗ NK cell subsets were found in this study. These alterations in the distribution and phenotype of NK cells might enhance the impairment of this crucial innate line of defense during COVID-19 infection.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus ; Severe acute respiratory syndrome coronavirus 2 ; cytokines ; cytotoxicity ; phenotype ; viruses
    Language English
    Dates of publication 2021-1228
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010046
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: HTLV-2 Enhances CD8

    Abad-Fernández, María / Hernández-Walias, Francisco J / Ruiz de León, María J / Vivancos, María J / Pérez-Elías, María J / Moreno, Ana / Casado, José L / Quereda, Carmen / Dronda, Fernando / Moreno, Santiago / Vallejo, Alejandro

    Viruses

    2022  Volume 14, Issue 11

    Abstract: People living with HIV-1 and HTLV-2 concomitantly show slower ... ...

    Abstract People living with HIV-1 and HTLV-2 concomitantly show slower CD4
    MeSH term(s) Humans ; Human T-lymphotropic virus 2 ; HIV-1/physiology ; Proviruses ; CD8-Positive T-Lymphocytes/pathology ; Viral Load ; HTLV-II Infections ; HIV Infections ; Coinfection ; HIV Seropositivity ; Hepatitis C/complications
    Language English
    Publishing date 2022-11-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14112472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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