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  1. Article ; Online: Nanostructured poly(thiophene acetic acid)/Au/poly(methylene blue) interface for electrochemical immunosensing of p53 protein.

    Cruz-Pacheco, Andrés F / Quinchia, Jennifer / Orozco, Jahir

    Mikrochimica acta

    2023  Volume 190, Issue 4, Page(s) 136

    Abstract: A poly(thiophene acetic acid)/Au/poly(methylene blue) nanostructured interface was electrochemically assembled step-by-step on screen-printed carbon electrodes (SPCE) for label-free detection of p53 protein. The initial electrical conductive properties ... ...

    Abstract A poly(thiophene acetic acid)/Au/poly(methylene blue) nanostructured interface was electrochemically assembled step-by-step on screen-printed carbon electrodes (SPCE) for label-free detection of p53 protein. The initial electrical conductive properties of the polymeric interface were increased with an additional layer of poly(methylene blue) electropolymerized in the presence of gold nanoparticles. The nano-immunosensing architecture was prepared by covalent immobilization of anti-p53 antibodies as bioreceptors through the poly(thiophene acetic acid) moieties. The nano-immunosensor assembly was extensively characterized by ultraviolet-visible spectrophotometry, dynamic and electrophoretic light scattering, scanning electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, atomic force microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. Under optimal conditions, p53 was specifically and selectively detected by square wave voltammetry in a linear range between 1 and 100 ng mL
    MeSH term(s) Humans ; Acetic Acid ; Electrochemical Techniques/methods ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Methylene Blue ; Thiophenes
    Chemical Substances Acetic Acid (Q40Q9N063P) ; Gold (7440-57-5) ; Methylene Blue (T42P99266K) ; Thiophenes ; TP53 protein, human
    Language English
    Publishing date 2023-03-15
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-05683-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

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  2. Article ; Online: Cerium oxide-doped PEDOT nanocomposite for label-free electrochemical immunosensing of anti-p53 autoantibodies.

    Cruz-Pacheco, Andrés F / Quinchia, Jennifer / Orozco, Jahir

    Mikrochimica acta

    2022  Volume 189, Issue 6, Page(s) 228

    Abstract: A label-free nanoimmunosensor is reported based on p53/ ... ...

    Abstract A label-free nanoimmunosensor is reported based on p53/CeO
    MeSH term(s) Autoantibodies ; Biosensing Techniques/methods ; Bridged Bicyclo Compounds, Heterocyclic ; Cerium ; Metal Nanoparticles/chemistry ; Nanocomposites/chemistry ; Polymers
    Chemical Substances Autoantibodies ; Bridged Bicyclo Compounds, Heterocyclic ; Polymers ; poly(3,4-ethylene dioxythiophene) ; Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Language English
    Publishing date 2022-05-25
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-022-05322-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

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  3. Article: Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery.

    Hernández Becerra, Elisa / Quinchia, Jennifer / Castro, Cristina / Orozco, Jahir

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community's attention due to their biocompatibility, versatility, and ... ...

    Abstract Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community's attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the "on-demand" release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties' features and polymersomes' composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes' perspectives.
    Language English
    Publishing date 2022-03-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12050836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Selective heterogeneous hydrodeoxygenation of acetophenone over monometallic and bimetallic Pt-Co catalyst.

    Pino, Natalia / Quinchia, Jennifer / Gómez, Santiago / Espinal, Juan F / Montoya, Alejandro / López, Diana

    Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

    2021  Volume 379, Issue 2209, Page(s) 20200346

    Abstract: The hydrodeoxygenation (HDO) of acetophenone was evaluated in liquid phase and gas phase over monometallic Pt/ ... ...

    Abstract The hydrodeoxygenation (HDO) of acetophenone was evaluated in liquid phase and gas phase over monometallic Pt/SiO
    Language English
    Publishing date 2021-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 208381-4
    ISSN 1471-2962 ; 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    ISSN (online) 1471-2962
    ISSN 0080-4614 ; 0264-3820 ; 0264-3952 ; 1364-503X
    DOI 10.1098/rsta.2020.0346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  5. Article: Electrochemical Biosensors for Determination of Colorectal Tumor Biomarkers.

    Quinchia, Jennifer / Echeverri, Danilo / Cruz-Pacheco, Andrés Felipe / Maldonado, María Elena / Orozco, Jahir

    Micromachines

    2020  Volume 11, Issue 4

    Abstract: The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and ... ...

    Abstract The accurate determination of specific tumor markers associated with cancer with non-invasive or minimally invasive procedures is the most promising approach to improve the long-term survival of cancer patients and fight against the high incidence and mortality of this disease. Quantification of biomarkers at different stages of the disease can lead to an appropriate and instantaneous therapeutic action. In this context, the determination of biomarkers by electrochemical biosensors is at the forefront of cancer diagnosis research because of their unique features such as their versatility, fast response, accurate quantification, and amenability for multiplexing and miniaturization. In this review, after briefly discussing the relevant aspects and current challenges in the determination of colorectal tumor markers, it will critically summarize the development of electrochemical biosensors to date to this aim, highlighting the enormous potential of these devices to be incorporated into the clinical practice. Finally, it will focus on the remaining challenges and opportunities to bring electrochemical biosensors to the point-of-care testing.
    Language English
    Publishing date 2020-04-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11040411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Disposable electrochemical immunoplatform to shed light on the role of the multifunctional glycoprotein TIM-1 in cancer cells invasion.

    Quinchia, Jennifer / Blázquez-García, Marina / Torrente-Rodríguez, Rebeca M / Ruiz-Valdepeñas Montiel, Víctor / Serafín, Verónica / Rejas-González, Raquel / Montero-Calle, Ana / Orozco, Jahir / Pingarrón, José M / Barderas, Rodrigo / Campuzano, Susana

    Talanta

    2023  Volume 267, Page(s) 125155

    Abstract: Detecting overexpression of cancer biomarkers is an excellent tool for diagnostic/prognostic and follow-up of patients with cancer or their response to treatment. This work illustrates the relevance of interrogating the levels of T-cell immunoglobulin ... ...

    Abstract Detecting overexpression of cancer biomarkers is an excellent tool for diagnostic/prognostic and follow-up of patients with cancer or their response to treatment. This work illustrates the relevance of interrogating the levels of T-cell immunoglobulin and mucin domain 1 (TIM-1) protein as a diagnostic/prognostic biomarker of high-prevalence breast and lung cancers by using an amperometric disposable magnetic microparticles-assisted immunoplatform. The developed method integrates the inherent advantages of carboxylic acid-functionalized magnetic beads (HOOC-MBs) as pre-concentrator support and the amperometric transduction at screen-printed carbon electrodes (SPCEs). The immunoplatform involves a sandwich-type immunoassay assembled on HOOC-MBs through the specific capture/labeling of TIM-1 using capture antibodies and horseradish peroxidase (HRP)-conjugated biotinylated detection antibodies as biorecognition elements. The magnetic immunoconjugates were confined onto the working electrode (WE) surface of the SPCEs for amperometric detection using the hydroquinone/hydrogen peroxide/HRP (HQ/H
    MeSH term(s) Humans ; Hydrogen Peroxide/chemistry ; Antibodies/chemistry ; Immunoconjugates/chemistry ; Magnetics ; Horseradish Peroxidase ; Glycoproteins ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Electrodes ; Immunoassay/methods ; Limit of Detection ; Neoplasms
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Antibodies ; Immunoconjugates ; Horseradish Peroxidase (EC 1.11.1.-) ; Glycoproteins
    Language English
    Publishing date 2023-09-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.125155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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