LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article: Clotting Dysfunction in Sepsis: A Role for ROS and Potential for Therapeutic Intervention.

Lopes-Pires, Maria Elisa / Frade-Guanaes, Jéssica Oliveira / Quinlan, Gregory J

2021 Volume 11, Issue 1

Abstract: Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and ... ...

Abstract	Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and nitrogen species (RNS) production occurs, instigated by a variety of sources, including activated inflammatory cells, such as neutrophils, platelets, and cells from the vascular endothelium. Inflammation can become an inappropriate self-sustaining and expansive process, resulting in sepsis. Patients with sepsis often exhibit loss of aspects of normal vascular homeostatic control, resulting in abnormal coagulation events and the development of disseminated intravascular coagulation. Diagnosis and treatment of sepsis remain a significant challenge for healthcare providers globally. Targeting the drivers of excessive oxidative/nitrosative stress using antioxidant treatments might be a therapeutic option. This review focuses on the association between excessive oxidative/nitrosative stress, a common feature in sepsis, and loss of homeostatic control at the level of the vasculature. The literature relating to potential antioxidants is also described.
Language	English
Publishing date	2021-12-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010088
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Clotting Dysfunction in Sepsis: A Role for ROS and Potential for Therapeutic Intervention

Lopes-Pires, Maria Elisa / Frade-Guanaes, Jéssica Oliveira / Quinlan, Gregory J.

Antioxidants. 2021 Dec. 30, v. 11, no. 1

2021

Abstract	Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and nitrogen species (RNS) production occurs, instigated by a variety of sources, including activated inflammatory cells, such as neutrophils, platelets, and cells from the vascular endothelium. Inflammation can become an inappropriate self-sustaining and expansive process, resulting in sepsis. Patients with sepsis often exhibit loss of aspects of normal vascular homeostatic control, resulting in abnormal coagulation events and the development of disseminated intravascular coagulation. Diagnosis and treatment of sepsis remain a significant challenge for healthcare providers globally. Targeting the drivers of excessive oxidative/nitrosative stress using antioxidant treatments might be a therapeutic option. This review focuses on the association between excessive oxidative/nitrosative stress, a common feature in sepsis, and loss of homeostatic control at the level of the vasculature. The literature relating to potential antioxidants is also described.
Keywords	antioxidants ; coagulation ; death ; disseminated intravascular coagulation ; endothelium ; health services ; inflammation ; neutrophils ; nitrogen ; oxygen ; pathogens ; therapeutics
Language	English
Dates of publication	2021-1230
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010088
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Phagomimetic action of antibiotics: Revisited. How do antibiotics know where to go?

Gutteridge, John M C / Quinlan, Gregory J / Kovacic, Peter

Biochemical and biophysical research communications

2019 Volume 521, Issue 3, Page(s) 721–724

Abstract: Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen ... ...

Abstract	Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a 'respiratory burst' in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event. Antibiotics in their normal bacterial environment, and ROS, are both increasingly implicated in purposeful signalling functions, rather than their more widely known roles in bacterial killing and molecular damage. Here, we extend our comparison between antibiotics and phagocytic cells to propose that antibiotics actively accumulate at a site of pathogen infection or tumour growth. A common link being virulent cellular growth. When this occurs, new proteins are secreted, aberrant iron acquisition takes place, and lipocalins are released. Each provide a mechanism by which antibiotics can bind, and be retained, at an active site of pathogen infection or tumour growth.
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Antibiotics, Antineoplastic/pharmacokinetics ; Antibiotics, Antineoplastic/pharmacology ; Bacteria/drug effects ; Bacteria/metabolism ; Bacterial Infections/drug therapy ; Bacterial Infections/metabolism ; Humans ; Iron/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Phagocytes/drug effects ; Phagocytes/metabolism ; Phagocytosis/drug effects ; Reactive Oxygen Species/metabolism
Chemical Substances	Anti-Bacterial Agents ; Antibiotics, Antineoplastic ; Reactive Oxygen Species ; Iron (E1UOL152H7)
Language	English
Publishing date	2019-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.10.152
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Phagomimetic action of antibiotics: Revisited. How do antibiotics know where to go?

Gutteridge, John M.C / Quinlan, Gregory J / Kovacic, Peter

Biochemical and biophysical research communications. 2020 Jan. 15, v. 521, no. 3

2020

Abstract: Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a ‘respiratory burst’ in which superoxide radicals are released. We have previously compared the release of reactive oxygen ... ...

Abstract	Phagocytic cells know exactly where an infection is by following chemotactic signals. The phagocytosis of bacteria results in a ‘respiratory burst’ in which superoxide radicals are released. We have previously compared the release of reactive oxygen species (ROS) by antibiotics, during electron transfer reactions, to this event. Antibiotics in their normal bacterial environment, and ROS, are both increasingly implicated in purposeful signalling functions, rather than their more widely known roles in bacterial killing and molecular damage. Here, we extend our comparison between antibiotics and phagocytic cells to propose that antibiotics actively accumulate at a site of pathogen infection or tumour growth. A common link being virulent cellular growth. When this occurs, new proteins are secreted, aberrant iron acquisition takes place, and lipocalins are released. Each provide a mechanism by which antibiotics can bind, and be retained, at an active site of pathogen infection or tumour growth.
Keywords	active sites ; cell growth ; chemotaxis ; electron transfer ; neoplasms ; pathogens ; phagocytosis ; research ; virulence
Language	English
Dates of publication	2020-0115
Size	p. 721-724.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.10.152
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 71/706: Show issues
Z 3.8: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Pulmonary Arterial Hypertension: Iron Matters.

Ramakrishnan, Latha / Pedersen, Sofia L / Toe, Quezia K / Quinlan, Gregory J / Wort, Stephen J

Frontiers in physiology

2018 Volume 9, Page(s) 641

Abstract: The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost ... ...

Abstract	The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with disease. This review provides a background for iron regulation in humans, describes PAH classifications, and discusses emerging literature, which suggests a role for disrupted iron homeostatic control in various sub-types of PAH, including a role for decompartmentalization of hemoglobin. Finally, the potential for therapeutic options to restore iron homeostatic balance in PAH are discussed.
Language	English
Publishing date	2018-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2018.00641
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: potential implications for SARS-CoV-2 infection of vascular endothelial cells.

Toe, Quezia K / Issitt, Theo / Mahomed, Abdul / Panselinas, Ioannis / Almaghlouth, Fatma / Burke-Gaffney, Anne / Wort, Stephen John / Quinlan, Gregory J

bioRxiv

Abstract: Emerging studies from the ongoing covid-19 pandemic have implicated vascular dysfunction and endotheliitis in many patients presenting with severe disease. However, there is limited evidence for the expression of ACE2 (the principal co-receptor for Sars- ... ...

Abstract	Emerging studies from the ongoing covid-19 pandemic have implicated vascular dysfunction and endotheliitis in many patients presenting with severe disease. However, there is limited evidence for the expression of ACE2 (the principal co-receptor for Sars-Cov-2 cellular attachment) in vascular endothelial cells which has prompted the suggestion that the virus does not infect these cell types. However, the studies presented here demonstrate enhanced expression of ACE2 at the level of both mRNA and protein, in human pulmonary artery endothelial cells (PAECs) challenged with either IL-6 or hepcidin. Notably elevated levels both these iron-regulatory elements have been described in Covid-19 patients with severe disease and are further associated with morbidity and mortality. Additionally, levels of both IL-6 and hepcidin are often elevated in the elderly and in chronic disease settings, these populations being at greater risk of adverse outcomes from Sars-Cov-2 infection. A role for IL-6 and hepcidin as modulators of ACE2 expression seems plausible, additional, studies are required to determine if viral infection can be demonstrated in PAECs challenged with either of these iron-regulatory elements.
Keywords	covid19
Language	English
Publishing date	2021-04-08
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.04.08.437687
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Plasma S100A8/A9 heterodimer is an early prognostic marker of acute kidney injury associated with cardiac surgery.

Nikolakopoulou, Zacharoula / Hector, Lauren R / Creagh-Brown, Benedict C / Evans, Timothy W / Quinlan, Gregory J / Burke-Gaffney, Anne

Biomarkers in medicine

2019 Volume 13, Issue 3, Page(s) 205–218

Abstract: Aim: We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB).: Patients & methods: Plasma levels of ... ...

Abstract	Aim: We investigated whether plasma levels of the inflammation marker S100A8/A9, could predict acute kidney injury (AKI) onset in patients undergoing cardiac surgery necessitating cardiopulmonary bypass (CPB). Patients & methods: Plasma levels of S100A8/A9 and other neutrophil cytosolic proteins were measured in 39 patients pre- and immediately post-CPB. Results: All markers increased significantly post-CPB with S100A8/A9, S100A12 and myeloperoxidase levels significantly higher in patients who developed AKI within 7 days. S100A8/A9 had good prognostic utility for AKI, with an area under the receiver operating characteristic curve of 0.81 (95% CI: 0.676-0.949) and a cut-off value of 10.6 μg/ml (85.7% sensitivity and 75% specificity) irrespective of age. Conclusion: Plasma S100A8/A9 levels immediately after cardiac surgery, can predict onset of AKI, irrespective of age.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Aged ; Biomarkers/blood ; Calgranulin A/blood ; Calgranulin B/blood ; Cardiac Surgical Procedures/adverse effects ; Cardiopulmonary Bypass/adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Prognosis ; ROC Curve
Chemical Substances	Biomarkers ; Calgranulin A ; Calgranulin B ; S100A8 protein, human ; S100A9 protein, human
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2481014-9
ISSN	1752-0371 ; 1752-0363
ISSN (online)	1752-0371
ISSN	1752-0363
DOI	10.2217/bmm-2018-0238
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6985: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Decreased breath excretion of redox active iron in COPD: a protective failure?

Mumby, Sharon / Saito, Junpei / Adcock, Ian M / Chung, Kian Fan / Quinlan, Gregory J

The European respiratory journal

2015 Volume 47, Issue 4, Page(s) 1267–1270

MeSH term(s)	Bleomycin/chemistry ; Breath Tests ; Case-Control Studies ; Exhalation ; Hepcidins/blood ; Humans ; Interleukin-6/blood ; Iron/chemistry ; Oxidants/chemistry ; Oxidation-Reduction ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Signal Transduction ; Smoking
Chemical Substances	Hepcidins ; IL6 protein, human ; Interleukin-6 ; Oxidants ; Bleomycin (11056-06-7) ; Iron (E1UOL152H7)
Language	English
Publishing date	2015-12-23
Publishing country	England
Document type	Letter ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.01710-2015
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan, Suzanne M / Mumby, Sharon / Adcock, Ian M / Choi, Augustine M K / Chung, Kian Fan / Quinlan, Gregory J

American journal of respiratory and critical care medicine

2017 Volume 196, Issue 9, Page(s) 1103–1112

MeSH term(s)	Administration, Inhalation ; Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/metabolism ; Comorbidity ; Homeostasis ; Humans ; Iron/metabolism ; Iron/therapeutic use ; Iron Chelating Agents/therapeutic use ; Iron Deficiencies ; Iron Overload/drug therapy ; Iron Overload/epidemiology ; Iron Overload/metabolism ; Lung/metabolism ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/metabolism ; Smoking/metabolism
Chemical Substances	Iron Chelating Agents ; Iron (E1UOL152H7)
Language	English
Publishing date	2017-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.201702-0311PP
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.80: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Modified criteria for the systemic inflammatory response syndrome improves their utility following cardiac surgery.

MacCallum, Niall S / Finney, Simon J / Gordon, Sarah E / Quinlan, Gregory J / Evans, Timothy W

Chest

2014 Volume 145, Issue 6, Page(s) 1197–1203

Abstract: Background: Debate remains regarding whether the systemic inflammatory response syndrome (SIRS) identifies patients with clinically important inflammation. Defining criteria may be disproportionately sensitive and lack specificity. We investigated the ... ...

Abstract	Background: Debate remains regarding whether the systemic inflammatory response syndrome (SIRS) identifies patients with clinically important inflammation. Defining criteria may be disproportionately sensitive and lack specificity. We investigated the incidence and evolution of SIRS in a homogenous population (following cardiac surgery) over 7 days to establish the relationship between SIRS and outcome, modeling alternative permutations of the criteria to increase their discriminatory power for mortality, length of stay, and organ dysfunction. Methods: We conducted a retrospective analysis of prospectively collected data from a cardiothoracic ICU. Consecutive patients requiring ICU admission for the first time after cardiac surgery (N = 2,764) admitted over a 41-month period were studied. Results: Concurrently, 96.2% of patients met the standard two criterion definition for SIRS within 24 h of ICU admission. Their mortality was 2.78%. By contrast, three or four criteria were more discriminatory of patients with higher mortality (4.21% and 10.2%, respectively). A test dataset suggested that meeting two criteria for at least 6 consecutive h may be the best model. This had a positive and negative predictive value of 7% and 99.5%, respectively, in a validation dataset. It performed well at predicting organ dysfunction and prolonged ICU admission. Conclusions: The concept of SIRS remains valid following cardiac surgery. With suitable modification, its specificity can be improved significantly. We propose that meeting two or more defining criteria for 6 h could be used to define better populations with more difficult clinical courses following cardiac surgery. This group may merit a different clinical approach.
MeSH term(s)	Aged ; Cohort Studies ; Female ; Humans ; Incidence ; Intensive Care Units ; Male ; Middle Aged ; Patient Selection ; Predictive Value of Tests ; Prospective Studies ; Retrospective Studies ; Sensitivity and Specificity ; Survival Rate ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/mortality ; Thoracic Surgery ; Time Factors
Language	English
Publishing date	2014-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.13-1023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 349: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito