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  1. Article: ICU Admission Tool for Congenital Heart Catheterization (iCATCH): A Predictive Model for High Level Post-Catheterization Care and Patient Management.

    Quinn, Brian P / Shirley, Lauren C / Yeh, Mary J / Gauvreau, Kimberlee / Ibla, Juan C / Kotin, Sarah G / Porras, Diego / Bergersen, Lisa J

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2022  Volume 23, Issue 10, Page(s) 822–830

    Abstract: Objectives: Currently, there are no prediction tools available to identify patients at risk of needing high-complexity care following cardiac catheterization for congenital heart disease. We sought to develop a method to predict the likelihood a patient ...

    Abstract Objectives: Currently, there are no prediction tools available to identify patients at risk of needing high-complexity care following cardiac catheterization for congenital heart disease. We sought to develop a method to predict the likelihood a patient will require intensive care level resources following elective cardiac catheterization.
    Design: Prospective single-center study capturing important patient and procedural characteristics for predicting discharge to the ICU. Characteristics significant at the 0.10 level in the derivation dataset (July 1, 2017 to December 31, 2019) were considered for inclusion in the final multivariable logistic regression model. The model was validated in the testing dataset (January 1, 2020 to December 31, 2020). The novel pre-procedure cardiac status (PCS) feature, collection started in January 2019, was assessed separately in the final model using the 2019 through 2020 dataset.
    Setting: Tertiary pediatric heart center.
    Patients: All elective cases coming from home or non-ICU who underwent a cardiac catheterization from July 2017 to December 2020.
    Interventions: None.
    Measurements and main results: A total of 2,192 cases were recorded in the derivation dataset, of which 11% of patients ( n = 245) were admitted to the ICU, while 64% ( n = 1,413) were admitted to a medical unit and 24% ( n = 534) were discharged home. In multivariable analysis, the following predictors were identified: 1) weight less than 5 kg and 5-9.9 kg, 2) presence of systemic illness, 3) recent cardiac intervention less than 90 days, and 4) ICU Admission Tool for Congenital Heart Catheterization case type risk categories (1-5), with C -statistics of 0.79 and 0.76 in the derivation and testing cohorts, respectively. The addition of the PCS feature fit into the final model resulted in a C -statistic of 0.79.
    Conclusions: The creation of a validated pre-procedural risk prediction model for ICU admission following congenital cardiac catheterization using a large volume, single-center, academic institution will improve resource allocation and prediction of capacity needs for this complex patient population.
    MeSH term(s) Cardiac Catheterization/adverse effects ; Child ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/surgery ; Humans ; Intensive Care Units ; Logistic Models ; Patient Admission ; Prospective Studies ; Risk Factors
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Catheterization for Congenital Heart Disease Adjustment for Risk Method II.

    Quinn, Brian P / Gunnelson, Lauren C / Kotin, Sarah G / Gauvreau, Kimberlee / Yeh, Mary J / Hasan, Babar / Lozier, John / Barry, Oliver M / Shahanavaz, Shabana / Batlivala, Sarosh P / Salavitabar, Arash / Foerster, Susan / Goldstein, Bryan / Divekar, Abhay / Holzer, Ralf / Nicholson, George T / O'Byrne, Michael L / Whiteside, Wendy / Bergersen, Lisa

    Circulation. Cardiovascular interventions

    2024  Volume 17, Issue 3, Page(s) e012834

    Abstract: Background: Current metrics used to adjust for case mix complexity in congenital cardiac catheterization are becoming outdated due to the introduction of novel procedures, innovative technologies, and expanding patient subgroups. This study aims to ... ...

    Abstract Background: Current metrics used to adjust for case mix complexity in congenital cardiac catheterization are becoming outdated due to the introduction of novel procedures, innovative technologies, and expanding patient subgroups. This study aims to develop a risk adjustment methodology introducing a novel, clinically meaningful adverse event outcome and incorporating a modern understanding of risk.
    Methods: Data from diagnostic only and interventional cases with defined case types were collected for patients ≤18 years of age and ≥2.5 kg at all Congenital Cardiac Catheterization Project on Outcomes participating centers. The derivation data set consisted of cases performed from 2014 to 2017, and the validation data set consisted of cases performed from 2019 to 2020. Severity level 3 adverse events were stratified into 3 tiers by clinical impact (3a/b/c); the study outcome was clinically meaningful adverse events, severity level ≥3b (3bc/4/5).
    Results: The derivation data set contained 15 224 cases, and the validation data set included 9462 cases. Clinically meaningful adverse event rates were 4.5% and 4.2% in the derivation and validation cohorts, respectively. The final risk adjustment model included age <30 days, Procedural Risk in Congenital Cardiac Catheterization risk category, and hemodynamic vulnerability score (C statistic, 0.70; Hosmer-Lemeshow
    Conclusions: CHARM II (Congenital Heart Disease Adjustment for Risk Method II) risk adjustment methodology allows for equitable comparison of clinically meaningful adverse events among institutions and operators with varying patient populations and case mix complexity performing pediatric cardiac catheterization.
    MeSH term(s) Child ; Humans ; Infant ; Risk Factors ; Treatment Outcome ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/therapy ; Hemodynamics ; Risk Adjustment/methods
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.123.012834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Procedural Risk in Congenital Cardiac Catheterization (PREDIC

    Quinn, Brian P / Yeh, Mary / Gauvreau, Kimberlee / Ali, Fatima / Balzer, David / Barry, Oliver / Batlivala, Sarosh / Berman, Darren / Foerster, Susan / Goldstein, Bryan / Hainstock, Michael / Holzer, Ralf / Janssen, Dana / O'Byrne, Michael L / Shirley, Lauren / Trucco, Sara / Whiteside, Wendy / Bergersen, Lisa

    Journal of the American Heart Association

    2021  Volume 11, Issue 1, Page(s) e022832

    Abstract: Background Advancements in the field, including novel procedures and multiple interventions, require an updated approach to accurately assess patient risk. This study aims to modernize patient hemodynamic and procedural risk classification through the ... ...

    Abstract Background Advancements in the field, including novel procedures and multiple interventions, require an updated approach to accurately assess patient risk. This study aims to modernize patient hemodynamic and procedural risk classification through the creation of risk assessment tools to be used in congenital cardiac catheterization. Methods and Results Data were collected for all cases performed at sites participating in the C3PO (Congenital Cardiac Catheterization Project on Outcomes) multicenter registry. Between January 2014 and December 2017, 23 119 cases were recorded in 13 participating institutions, of which 88% of patients were <18 years of age and 25% <1 year of age; a high-severity adverse event occurred in 1193 (5.2%). Case types were defined by procedure(s) performed and grouped on the basis of association with the outcome, high-severity adverse event. Thirty-four unique case types were determined and stratified into 6 risk categories. Six hemodynamic indicator variables were empirically assessed, and a novel hemodynamic vulnerability score was determined by the frequency of high-severity adverse events. In a multivariable model, case-type risk category (odds ratios for category: 0=0.46, 1=1.00, 2=1.40, 3=2.68, 4=3.64, and 5=5.25; all
    MeSH term(s) Cardiac Catheterization/adverse effects ; Cardiac Catheterization/methods ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/etiology ; Heart Defects, Congenital/therapy ; Hemodynamics ; Humans ; Infant ; Odds Ratio ; Registries ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2021-12-22
    Publishing country England
    Document type Case Reports ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.121.022832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interpreting Quality Improvement When Introducing New Technology: A Collaborative Experience in ASD Device Closures.

    Yeh, Mary J / Shirley, Lauren / Balzer, David T / Boe, Brian A / El-Said, Howaida / Foerster, Susan / Gauvreau, Kimberlee / Gudausky, Todd M / Hainstock, Michael R / Maschietto, Nicola / Nicholson, George T / Quinn, Brian P / Shahanavaz, Shabana / Trucco, Sara / Whiteside, Wendy / Bergersen, Lisa

    Pediatric cardiology

    2021  Volume 43, Issue 3, Page(s) 596–604

    Abstract: The objective of this study was to evaluate the impact of the regular introduction of new technologies into interventional cardiac catheterization procedures, in this case new atrial septal defect (ASD) closure devices, while conducting a multi-center ... ...

    Abstract The objective of this study was to evaluate the impact of the regular introduction of new technologies into interventional cardiac catheterization procedures, in this case new atrial septal defect (ASD) closure devices, while conducting a multi-center collaborative initiative to reduce radiation usage during all procedures. Data were collected prospectively by 8 C3PO institutions between January 1, 2014 and December 31, 2017 for ASD device closure procedures in the cardiac catheterization lab during a quality improvement (QI) initiative aimed at reducing patient radiation exposure. Radiation exposure was measured in dose area product per body weight (µGy*m
    MeSH term(s) Cardiac Catheterization/methods ; Fluoroscopy/methods ; Heart Septal Defects, Atrial/surgery ; Humans ; Quality Improvement ; Radiation Dosage ; Radiation Exposure/prevention & control ; Retrospective Studies ; Septal Occluder Device ; Treatment Outcome
    Language English
    Publishing date 2021-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-021-02762-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Identification of compounds from Etonia rosemary (Conradina etonia).

    Quinn, Brian P / Bernier, Ulrich R / Booth, Matthew M

    Journal of chromatography. A

    2007  Volume 1160, Issue 1-2, Page(s) 306–310

    Abstract: Mosquitoes transmit pathogens that result in diseases harmful to human, livestock, and wildlife hosts. Numerous measures can be used to reduce insect-borne disease risk to humans, and one approach is the use of topical repellents to prevent host-seeking ... ...

    Abstract Mosquitoes transmit pathogens that result in diseases harmful to human, livestock, and wildlife hosts. Numerous measures can be used to reduce insect-borne disease risk to humans, and one approach is the use of topical repellents to prevent host-seeking arthropods from taking a blood meal. A current emphasis in the development of new repellents is that they be safe. Therefore, natural products sources are increasingly being explored. Compounds from plants of the mint family (Lamiaceae) have been demonstrated to be insect repellents. This study examines compounds from Etonia rosemary (Conradina etonia) to identify compounds for examination as insect repellents. Samples of Etonia rosemary were passively extracted with hexane, dichloromethane, and methanol and analyzed by GC/MS. This extraction method was chosen to eliminate thermal degradation of plant components that can occur during the distillation procedure. Additional headspace volatile compounds from this plant were identified using microscale purge-and-trap GC/MS. A variety of terpenes, terpenic alcohols, ketones, and aldehydes were identified in the extracts with terpenes and short-chained aldehydes detected in greatest abundance.
    MeSH term(s) Gas Chromatography-Mass Spectrometry ; Organic Chemicals/analysis ; Plant Extracts/chemistry ; Rosmarinus/chemistry ; Volatilization
    Chemical Substances Organic Chemicals ; Plant Extracts
    Language English
    Publishing date 2007-08-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2007.05.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Longitudinal Improvements in Radiation Exposure in Cardiac Catheterization for Congenital Heart Disease: A Prospective Multicenter C3PO-QI Study.

    Quinn, Brian P / Cevallos, Priscila / Armstrong, Aimee / Balzer, David / El-Said, Howaida / Foerster, Susan / Glatz, Andrew C / Goodman, Andrea / Goldstein, Bryan / Hainstock, Michael / Janssen, Dana / Kreutzer, Jacqueline / Latson, Larry / Leahy, Ryan / Petit, Christopher / Shahanavaz, Shabana / Trucco, Sara / Whiteside, Wendy / Zampi, Jeffrey D /
    Bergersen, Lisa

    Circulation. Cardiovascular interventions

    2020  Volume 13, Issue 5, Page(s) e008172

    Abstract: Background: The C3PO-QI (Congenital Cardiac Catheterization Project on Outcomes - Quality Improvement), a multicenter registry launched in 2015, instituted quality improvement (QI) initiatives to reduce patient radiation exposure. Through regular ... ...

    Abstract Background: The C3PO-QI (Congenital Cardiac Catheterization Project on Outcomes - Quality Improvement), a multicenter registry launched in 2015, instituted quality improvement (QI) initiatives to reduce patient radiation exposure. Through regular collaboration, this initiative would allow for harmony among active participants, maximizing efforts and efficiency at achieving radiation best practices. This study sought to report these efforts with a detailed methodology for which institutions can target initiatives, reducing radiation exposure, and increasing patient safety.
    Methods: Data were collected prospectively by 8 C3PO-QI institutions between January 1, 2015 and December 31, 2017. Radiation exposure was measured in dose area product per body weight (dose area product/kg; µGy*m
    Results: The study consisted of 15 257 unique cases. Median exposure (dose area product/kg) was decreased by 30% for all procedures. Dose area product/kg was reduced in all 3 REC, with the greatest improvement observed in REC I (REC I, -37%; REC II, -23%; REC III, -27%). Although the baseline radiation exposures and exact percent decrease varied across all C3PO-QI sites, each institution demonstrated improvements in radiation dose over time. These improvements occurred with the implementation of institution-specific QI interventions accelerated by participation in the C3PO-QI multicenter collaborative.
    Conclusions: Substantial radiation dose reductions can be achieved using targeted QI methodology and interventions. Participation in a multicenter QI collaborative may accelerate improvement across all centers due to enhanced engagement and shared learning between sites.
    MeSH term(s) Adolescent ; Adult ; Cardiac Catheterization/adverse effects ; Child ; Child, Preschool ; Coronary Angiography/adverse effects ; Databases, Factual ; Female ; Healthcare Disparities ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/therapy ; Humans ; Infant ; Male ; Patient Safety ; Prospective Studies ; Quality Improvement ; Quality Indicators, Health Care ; Radiation Dosage ; Radiation Exposure/adverse effects ; Radiation Exposure/prevention & control ; Radiation Injuries/etiology ; Radiation Injuries/prevention & control ; Radiation Protection ; Risk Assessment ; Risk Factors ; Time Factors ; Young Adult
    Language English
    Publishing date 2020-05-15
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.119.008172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Radiation Risk Categories in Cardiac Catheterization for Congenital Heart Disease: A Tool to Aid in the Evaluation of Radiation Outcomes.

    Quinn, Brian P / Armstrong, Aimee K / Bauser-Heaton, Holly D / Callahan, Ryan / El-Said, Howaida G / Foerster, Susan R / Goldstein, Bryan H / Goodman, Andrea S / Gudausky, Todd M / Kreutzer, Jacqueline N / Leahy, Ryan A / Petit, Christopher J / Rockefeller, Toby A / Shahanavaz, Shabana / Trucco, Sara M / Bergersen, Lisa

    Pediatric cardiology

    2018  Volume 40, Issue 2, Page(s) 445–453

    Abstract: To stratify diverse procedure types into categories with similar radiation exposure in cardiac catheterization for congenital heart disease. Radiation exposures for a comprehensive list of specific procedure types and stratification of outcomes based on ... ...

    Abstract To stratify diverse procedure types into categories with similar radiation exposure in cardiac catheterization for congenital heart disease. Radiation exposures for a comprehensive list of specific procedure types and stratification of outcomes based on radiation risk are not currently available. Data between January 2014 and December 2015 were collected on all cases performed at sites participating in C3PO-QI (Congenital Cardiac Catheterization Outcomes Project-Quality Improvement Initiative) and 9 centers were included. Using expert consensus, 40 unique procedure types were defined by diagnostic characteristics or the intervention(s) performed, and dose area product (DAP) per kilogram of body weight (µGy × m
    MeSH term(s) Adolescent ; Cardiac Catheterization/adverse effects ; Child ; Child, Preschool ; Consensus ; Fluoroscopy/adverse effects ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Prospective Studies ; Quality Improvement ; Radiation Dosage ; Radiation Exposure ; Radiography, Interventional/adverse effects ; Risk Assessment/methods ; Risk Factors ; Young Adult
    Language English
    Publishing date 2018-11-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-018-2024-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The potency-insolubility conundrum in pharmaceuticals: Mechanism and solution for hepatitis C protease inhibitors.

    Connelly, Patrick R / Snyder, Phillip W / Zhang, Yuegang / McClain, Brian / Quinn, Brian P / Johnston, Steve / Medek, Ales / Tanoury, Jerry / Griffith, James / Patrick Walters, W / Dokou, Eleni / Knezic, Dragutin / Bransford, Philip

    Biophysical chemistry

    2015  Volume 196, Page(s) 100–108

    Abstract: As compounds are optimized for greater potency during pharmaceutical discovery, their aqueous solubility often decreases, making them less viable as orally-administered drugs. To investigate whether potency and insolubility share a common origin, we ... ...

    Abstract As compounds are optimized for greater potency during pharmaceutical discovery, their aqueous solubility often decreases, making them less viable as orally-administered drugs. To investigate whether potency and insolubility share a common origin, we examined the structural and thermodynamic properties of telaprevir, a sparingly soluble inhibitor of hepatitis C virus protease. Comparison of the hydrogen bond motifs in crystalline telaprevir with those present in the protease-telaprevir complex revealed striking similarities. Additionally, the thermodynamics of telaprevir dissolution closely resembles those of protein-ligand dissociation. Together, these findings point to a common origin of potency and insolubility rooted in particular amide-amide hydrogen bond patterns. The insolubility of telaprevir is shown by computational analysis to be caused by interactions in the crystal, not unfavorable hydrophobic hydration. Accordingly, competing out the particular amide-amide hydrogen bond motifs in crystalline telaprevir with 4-hydroxybenzoic acid yielded a co-crystalline solid with excellent aqueous dissolution and oral absorption. The analysis suggests a generalizable approach for identifying drug candidate compounds that either can or cannot be rendered orally bioavailable by alteration of their crystalline solid phases, in an approach that provides a pragmatic way to attain substantial enhancements in the success rate of drug discovery and development.
    MeSH term(s) Amides/chemistry ; Hepacivirus/enzymology ; Hydrogen Bonding ; Oligopeptides/chemistry ; Oligopeptides/metabolism ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protein Binding ; Solubility ; Temperature ; Thermodynamics ; Viral Nonstructural Proteins/antagonists & inhibitors ; Viral Nonstructural Proteins/metabolism
    Chemical Substances Amides ; NS3 protein, hepatitis C virus ; Oligopeptides ; Protease Inhibitors ; Viral Nonstructural Proteins ; telaprevir (655M5O3W0U)
    Language English
    Publishing date 2015-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185052-0
    ISSN 1873-4200 ; 0301-4622
    ISSN (online) 1873-4200
    ISSN 0301-4622
    DOI 10.1016/j.bpc.2014.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Volatile compounds from the integument of White Leghorn Chickens (Gallus gallus domesticus L.): Candidate attractants of ornithophilic mosquito species

    Bernier, Ulrich R / Allan, Sandra A / Quinn, Brian P / Kline, Daniel L / Barnard, Donald R / Clark, Gary G

    Journal of separation science. 2008 Apr., v. 31, no. 6-7

    2008  

    Abstract: Candidate kairomones of ornithophilic mosquito species are reported from GC/MS analysis of compounds from the skin on the back, the feet, and feathers from the back of White Leghorn chickens (Gallus gallus domesticus). Hexane and ether extracts of ... ...

    Abstract Candidate kairomones of ornithophilic mosquito species are reported from GC/MS analysis of compounds from the skin on the back, the feet, and feathers from the back of White Leghorn chickens (Gallus gallus domesticus). Hexane and ether extracts of chicken feathers differ significantly in attractiveness of Culex spp. mosquitoes. The active (hexane) extracts contained an abundance of alcohols, ketones, and diones. The inactive (ether) extracts contained aldehydes, which also were in the hexane extracts. Analysis of hexane extracts from chicken feet, skin, and feathers demonstrated the qualitative similarity in the compounds collected with subtle differences observed in the quantitative amounts of these compounds. Aldehydes and carboxylic acids were detected in a concentrated ether extract of feathers in quantitatively similar ratios within each compound class for the corresponding series of C₆-C₉ aldehydes and acids.
    Keywords chickens ; White Leghorn ; integument ; skin ; feathers ; animal tissue extracts ; volatile compounds ; chemical composition ; kairomones ; insect attractants ; odors ; Culex ; host seeking
    Language English
    Dates of publication 2008-04
    Size p. 1092-1099.
    Publishing place Wiley-VCH Verlag
    Document type Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.200700434
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Analysis of extracted and volatile components in blackstrap molasses feed as candidate house fly attractants.

    Quinn, Brian P / Bernier, Ulrich R / Geden, Christopher J / Hogsette, Jerome A / Carlson, David A

    Journal of chromatography. A

    2007  Volume 1139, Issue 2, Page(s) 279–284

    Abstract: House flies are a ubiquitous insect that have the potential to spread many diseases to humans and livestock. Managing house fly populations is accomplished by having desirable baits, traps, and killing agents. Most house fly baits are designed for ... ...

    Abstract House flies are a ubiquitous insect that have the potential to spread many diseases to humans and livestock. Managing house fly populations is accomplished by having desirable baits, traps, and killing agents. Most house fly baits are designed for outdoor use or limited indoor use, and have a foul odor that is not conducive to food preparatory and dining areas. Blackstrap molasses has long been used as a house fly bait, but it is sticky and viscous, making it difficult to handle. This study sought to identify compounds present in blackstrap molasses that might be attractive to house flies, and therefore, provide the public with an indoor bait that does not have an offensive smell and is easy to handle. Indoor bioassays with house flies using 50% blackstrap molasses diluted in deionized water, a hexane extract of blackstrap molasses, and deionized water, elicited 86.2%, 70.6%, and 13.8% responses, respectively. Hexane and diethyl ether extracts of blackstrap molasses produced a large number of compounds with widely differing organic structures including substituted phenols, nitrogen and oxygen heterocycles, carboxylic acids, and many other organic compounds.
    MeSH term(s) Animals ; Houseflies/drug effects ; Insect Control ; Molasses/analysis ; Oils, Volatile/analysis ; Oils, Volatile/pharmacology ; Pest Control, Biological ; Pheromones/analysis ; Pheromones/pharmacology
    Chemical Substances Oils, Volatile ; Pheromones ; insect attractants
    Language English
    Publishing date 2007-01-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2006.11.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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