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  1. AU="Quinn, Patrick J"
  2. AU="Debnath Pal"
  3. AU="Kamali Kakhki, Reza"
  4. AU=Mortele Koenraad J
  5. AU="Skaarup, Søren H"
  6. AU="Lin, Li-Er"
  7. AU=Goulard Marie
  8. AU=Rosner Mitchell H
  9. AU="Murphy, Bríd"
  10. AU="Tsuneyoshi, Isao"
  11. AU="Tram, Le Thi Hong"
  12. AU="Veli-Pekka Jaakola"
  13. AU="Erduğan, Hüseyin"

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  1. Artikel ; Online: A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells.

    Tieu, Victor / Sotillo, Elena / Bjelajac, Jeremy R / Chen, Crystal / Malipatlolla, Meena / Guerrero, Justin A / Xu, Peng / Quinn, Patrick J / Fisher, Chris / Klysz, Dorota / Mackall, Crystal L / Qi, Lei S

    Cell

    2024  Band 187, Heft 5, Seite(n) 1278–1295.e20

    Abstract: CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To address these challenges, we developed multiplexed effector guide arrays (MEGA), ...

    Abstract CRISPR technologies have begun to revolutionize T cell therapies; however, conventional CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To address these challenges, we developed multiplexed effector guide arrays (MEGA), a platform for programmable and scalable regulation of the T cell transcriptome using the RNA-guided, RNA-targeting activity of CRISPR-Cas13d. MEGA enables quantitative, reversible, and massively multiplexed gene knockdown in primary human T cells without targeting or cutting genomic DNA. Applying MEGA to a model of CAR T cell exhaustion, we robustly suppressed inhibitory receptor upregulation and uncovered paired regulators of T cell function through combinatorial CRISPR screening. We additionally implemented druggable regulation of MEGA to control CAR activation in a receptor-independent manner. Lastly, MEGA enabled multiplexed disruption of immunoregulatory metabolic pathways to enhance CAR T cell fitness and anti-tumor activity in vitro and in vivo. MEGA offers a versatile synthetic toolkit for applications in cancer immunotherapy and beyond.
    Mesh-Begriff(e) Humans ; Gene Expression Profiling ; Metabolic Engineering/methods ; RNA ; T-Lymphocytes ; Transcriptome
    Chemische Substanzen RNA (63231-63-0)
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.035
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch: Veterinary microbiology and microbial disease

    Quinn, Patrick J

    2011  

    Abstract: Veterinary Microbiology is one of the core subjects for veterinary students. Fully revised and expanded, this new edition covers every aspect of veterinary microbiology for students in both paraclinical and clinical years. It provides concise ... ...

    Verfasserangabe P. J. Quinn
    Abstract "Veterinary Microbiology is one of the core subjects for veterinary students. Fully revised and expanded, this new edition covers every aspect of veterinary microbiology for students in both paraclinical and clinical years. It provides concise descriptions of the groups of micro-organisms, diseases they produce, immunological aspects and a summary of infectious diseases based on their main clinical signs. New to this edition:Diagrams throughout showing the transmission of infection New chapters on the application of molecular methods, food safety and public health, skin, the respiratory system, cardiology, and the urinary tract Revisions to existing text and many more illustrations"--Provided by publisher
    Mesh-Begriff(e) Communicable Diseases/microbiology ; Communicable Diseases/veterinary ; Microbiology ; Veterinary Medicine
    Schlagwörter Veterinary microbiology
    Sprache Englisch
    Umfang XII, 912 S., zahlr. Ill., graph. Darst.
    Ausgabenhinweis 2. ed.
    Dokumenttyp Buch
    Anmerkung *Hier auch später erschienene, unveränderte Nachdrucke* ; Literaturangaben
    ISBN 9781405158237 ; 1405158239
    Datenquelle Bibliothek der Tierärztlichen Hochschule Hannover

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  3. Buch: Veterinary microbiology and microbial disease

    Quinn, Patrick J

    2011  

    Abstract: Veterinary Microbiology is one of the core subjects for veterinary students. Fully revised and expanded, this new edition covers every aspect of veterinary microbiology for students in both paraclinical and clinical years. It provides concise ... ...

    Verfasserangabe P. J. Quinn
    Abstract "Veterinary Microbiology is one of the core subjects for veterinary students. Fully revised and expanded, this new edition covers every aspect of veterinary microbiology for students in both paraclinical and clinical years. It provides concise descriptions of the groups of micro-organisms, diseases they produce, immunological aspects and a summary of infectious diseases based on their main clinical signs. New to this edition:Diagrams throughout showing the transmission of infection New chapters on the application of molecular methods, food safety and public health, skin, the respiratory system, cardiology, and the urinary tract Revisions to existing text and many more illustrations"--Provided by publisher
    Mesh-Begriff(e) Communicable Diseases/microbiology ; Communicable Diseases/veterinary ; Microbiology ; Veterinary Medicine
    Schlagwörter Veterinary microbiology
    Sprache Englisch
    Umfang XII, 912 S., zahlr. Ill., graph. Darst.
    Ausgabenhinweis 2. ed.
    Verlag Wiley-Blackwell
    Erscheinungsort Chichester, West Sussex
    Dokumenttyp Buch
    Anmerkung Hier auch später erschienene, unveränderte Nachdrucke ; Literaturangaben
    ISBN 9781405158237 ; 1405158239
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  4. Artikel ; Online: Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow's Milk Protein Allergy.

    Gold, Michael S / Quinn, Patrick J / Campbell, Dianne E / Peake, Jane / Smart, Joanne / Robinson, Marnie / O'Sullivan, Michael / Vogt, Josef Korbinian / Pedersen, Helle Krogh / Liu, Xiaoqiu / Pazirandeh-Micol, Elham / Heine, Ralf G

    Nutrients

    2022  Band 14, Heft 11

    Abstract: This open-label, non-randomized, multicenter trial (Registration: NCT03661736) aimed to assess if an amino acid-based formula (AAF) supplemented with two human milk oligosaccharides (HMO) supports normal growth and is well tolerated in infants with a cow' ...

    Abstract This open-label, non-randomized, multicenter trial (Registration: NCT03661736) aimed to assess if an amino acid-based formula (AAF) supplemented with two human milk oligosaccharides (HMO) supports normal growth and is well tolerated in infants with a cow's milk protein allergy (CMPA). Term infants aged 1-8 months with moderate-to-severe CMPA were enrolled. The study formula was an AAF supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT). Infants were fed the study formula for 4 months and were offered to remain on the formula until 12 months of age. Tolerance and safety were assessed throughout the trial. Out of 32 infants (mean age 18.6 weeks; 20 (62.5%) male), 29 completed the trial. During the 4-month principal study period, the mean weight-for-age Z score (WAZ) increased from -0.31 at the baseline to +0.28 at the 4-months' follow-up. Linear and head growth also progressed along the WHO child growth reference, with a similar small upward trend. The formula was well tolerated and had an excellent safety profile. When comparing the microbiome at the baseline to the subsequent visits, there was a significant on-treatment enrichment in HMO-utilizing bifidobacteria, which was associated with a significant increase in fecal short-chain fatty acids. In addition, we observed a significant reduction in the abundance of fecal Proteobacteria, suggesting that the HMO-supplemented study formula partially corrected the gut microbial dysbiosis in infants with CMPA.
    Mesh-Begriff(e) Amino Acids ; Animals ; Cattle ; Female ; Gastrointestinal Microbiome ; Humans ; Infant ; Infant Formula ; Male ; Milk Hypersensitivity ; Milk, Human ; Oligosaccharides
    Chemische Substanzen Amino Acids ; Oligosaccharides
    Sprache Englisch
    Erscheinungsdatum 2022-05-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14112297
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: How does peer teaching compare to faculty teaching? A systematic review and meta-analysis (.).

    Rees, Eliot L / Quinn, Patrick J / Davies, Benjamin / Fotheringham, Victoria

    Medical teacher

    2016  Band 38, Heft 8, Seite(n) 829–837

    Abstract: Purpose: In undergraduate medical education, peer-teaching has become an established and common method to enhance student learning. Evidence suggests that peer-teaching provides learning benefits for both learners and tutors. We aimed to describe the ... ...

    Abstract Purpose: In undergraduate medical education, peer-teaching has become an established and common method to enhance student learning. Evidence suggests that peer-teaching provides learning benefits for both learners and tutors. We aimed to describe the outcomes for medical students taught by peers through systematic review and meta-analysis of existing literature.
    Methods: Seven databases were searched through 21 terms and their Boolean combinations. Studies reporting knowledge or skills outcomes of students taught by peers compared to those taught by faculty or qualified clinicians were included. Extracted data on students' knowledge and skills outcomes were synthesised through a random effects model meta-analysis.
    Results: The search yielded 2292 studies. Five hundred and fifty-three duplicates and 1611 irrelevant articles were removed during title-screening. The abstracts of 128 papers were screened against the inclusion and exclusion criteria. Ten studies have been included in the review. Meta-analyses showed no significant difference in peer-teaching compared to faculty teaching for knowledge or skills outcomes, standardised mean differences were 0.07 (95% CI: -0.07, 0.21) and 0.11 (95% CI: -0.07, 1.29), respectively.
    Conclusion: Students taught by peers do not have significantly different outcomes to those taught by faculty. As the process of teaching helps to develop both tutor knowledge and teaching skills, peer-teaching should be supported.
    Mesh-Begriff(e) Databases, Factual ; Education, Medical, Undergraduate ; Faculty, Medical ; Peer Group ; Students, Medical ; Teaching
    Sprache Englisch
    Erscheinungsdatum 2016-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Review
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.3109/0142159X.2015.1112888
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: FOXO1 is a master regulator of memory programming in CAR T cells.

    Doan, Alexander E / Mueller, Katherine P / Chen, Andy Y / Rouin, Geoffrey T / Chen, Yingshi / Daniel, Bence / Lattin, John / Markovska, Martina / Mozarsky, Brett / Arias-Umana, Jose / Hapke, Robert / Jung, In-Young / Wang, Alice / Xu, Peng / Klysz, Dorota / Zuern, Gabrielle / Bashti, Malek / Quinn, Patrick J / Miao, Zhuang /
    Sandor, Katalin / Zhang, Wenxi / Chen, Gregory M / Ryu, Faith / Logun, Meghan / Hall, Junior / Tan, Kai / Grupp, Stephan A / McClory, Susan E / Lareau, Caleb A / Fraietta, Joseph A / Sotillo, Elena / Satpathy, Ansuman T / Mackall, Crystal L / Weber, Evan W

    Nature

    2024  Band 629, Heft 8010, Seite(n) 211–218

    Abstract: A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in ... ...

    Abstract A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in vivo
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Cell Line, Tumor ; Chromatin/metabolism ; Chromatin/genetics ; Forkhead Box Protein O1/metabolism ; Gene Editing ; Immunologic Memory ; Immunotherapy, Adoptive ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/metabolism ; Receptors, Chimeric Antigen/genetics ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/cytology
    Chemische Substanzen Chromatin ; Forkhead Box Protein O1 ; FOXO1 protein, human ; Receptors, Chimeric Antigen ; TCF7 protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07300-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Publisher Correction: FOXO1 is a master regulator of memory programming in CAR T cells.

    Doan, Alexander E / Mueller, Katherine P / Chen, Andy Y / Rouin, Geoffrey T / Chen, Yingshi / Daniel, Bence / Lattin, John / Markovska, Martina / Mozarsky, Brett / Arias-Umana, Jose / Hapke, Robert / Jung, In-Young / Wang, Alice / Xu, Peng / Klysz, Dorota / Zuern, Gabrielle / Bashti, Malek / Quinn, Patrick J / Miao, Zhuang /
    Sandor, Katalin / Zhang, Wenxi / Chen, Gregory M / Ryu, Faith / Logun, Meghan / Hall, Junior / Tan, Kai / Grupp, Stephan A / McClory, Susan E / Lareau, Caleb A / Fraietta, Joseph A / Sotillo, Elena / Satpathy, Ansuman T / Mackall, Crystal L / Weber, Evan W

    Nature

    2024  Band 629, Heft 8011, Seite(n) E11

    Sprache Englisch
    Erscheinungsdatum 2024-04-09
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07450-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Enhanced T cell effector activity by targeting the Mediator kinase module.

    Freitas, Katherine A / Belk, Julia A / Sotillo, Elena / Quinn, Patrick J / Ramello, Maria C / Malipatlolla, Meena / Daniel, Bence / Sandor, Katalin / Klysz, Dorota / Bjelajac, Jeremy / Xu, Peng / Burdsall, Kylie A / Tieu, Victor / Duong, Vandon T / Donovan, Micah G / Weber, Evan W / Chang, Howard Y / Majzner, Robbie G / Espinosa, Joaquin M /
    Satpathy, Ansuman T / Mackall, Crystal L

    Science (New York, N.Y.)

    2022  Band 378, Heft 6620, Seite(n) eabn5647

    Abstract: T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR knockout screens in human chimeric antigen receptor (CAR) T cells. Top hits ... ...

    Abstract T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR knockout screens in human chimeric antigen receptor (CAR) T cells. Top hits were
    Mesh-Begriff(e) Humans ; Cyclin-Dependent Kinase 8/metabolism ; Cyclin-Dependent Kinases/metabolism ; Mediator Complex/genetics ; T-Lymphocytes/immunology ; Transcription Factors/genetics ; Receptors, Chimeric Antigen ; Genome-Wide Association Study ; Cyclin C/genetics ; Genetic Testing ; Immunotherapy, Adoptive ; Neoplasms/immunology ; Neoplasms/therapy
    Chemische Substanzen Cyclin-Dependent Kinase 8 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; Mediator Complex ; Transcription Factors ; Receptors, Chimeric Antigen ; MED12 protein, human ; CCNC protein, human ; Cyclin C
    Sprache Englisch
    Erscheinungsdatum 2022-11-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn5647
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: FOXO1 is a master regulator of CAR T memory programming.

    Doan, Alexander / Mueller, Katherine P / Chen, Andy / Rouin, Geoffrey T / Daniel, Bence / Lattin, John / Chen, Yingshi / Mozarsky, Brett / Markovska, Martina / Arias-Umana, Jose / Hapke, Robert / Jung, Inyoung / Xu, Peng / Klysz, Dorota / Bashti, Malek / Quinn, Patrick J / Sandor, Katalin / Zhang, Wenxi / Hall, Junior /
    Lareau, Caleb / Grupp, Stephan A / Fraietta, Joseph A / Sotillo, Elena / Satpathy, Ansuman T / Mackall, Crystal L / Weber, Evan W

    Research square

    2023  

    Abstract: Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid ... ...

    Abstract Poor CAR T persistence limits CAR T cell therapies for B cell malignancies and solid tumors
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.21203/rs.3.rs-2802998/v1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Buch: The conning of America

    Quinn, Patrick J

    the Great War and American popular literature

    (Costerus ; N.S., 136)

    2001  

    Verfasserangabe Patrick J. Quinn
    Serientitel Costerus ; N.S., 136
    Schlagwörter Weltkrieg ; Literatur ; USA
    Sprache Englisch
    Umfang X, 261 S
    Verlag Rodopi
    Erscheinungsort Amsterdam u.a.
    Dokumenttyp Buch
    ISBN 904201475X ; 9789042014756
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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