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  1. Article ; Online: Endometrial cancer: predictors and oncological safety of tumor tissue manipulation.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Lago, Víctor / Tauste, Carmen / Díaz-Feijoo, Berta / Cabrera, Silvia / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Marcos-Sanmartin, Josefa / Cazorla, Eduardo / Lorenzo, Cristina / Rodríguez-Hernández, José Ramón / Roldán-Rivas, Fernando / Gilabert-Estellés, Juan / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2023  Volume 26, Issue 5, Page(s) 1098–1105

    Abstract: Purpose: The main goal of this study is to assess the impact of tumor manipulation on the presence of lympho-vascular space invasion and its influence on oncological results.: Methods: We performed a retrospective multi-centric study amongst patients ...

    Abstract Purpose: The main goal of this study is to assess the impact of tumor manipulation on the presence of lympho-vascular space invasion and its influence on oncological results.
    Methods: We performed a retrospective multi-centric study amongst patients who had received primary surgical treatment for apparently early-stage endometrial cancer. A multivariate statistical analysis model was designed to assess the impact that tumor manipulation (with the use of uterine manipulator or preoperative hysteroscopy) has on lympho-vascular development (LVSI) in the final surgical specimen.
    Results: A total of 2852 women from 15 centers were included and divided into two groups based on the lympho-vascular status in the final surgical specimen: 2265 (79.4%) had no LVSI and 587 (20.6%) presented LVSI. The use of uterine manipulator was associated with higher chances of lympho-vascular involvement regardless of the type used: Balloon manipulator (HR: 95% CI 4.64 (2.99-7.33); p < 0.001) and No-Balloon manipulator ([HR]: 95% CI 2.54 (1.66-3.96); p < 0.001). There is no evidence of an association between the use of preoperative hysteroscopy and higher chances of lympho-vascular involvement (HR: 95% CI 0.90 (0.68-1.19); p = 0.479).
    Conclusion: Whilst performing common gynecological procedures, iatrogenic distention and manipulation of the uterine cavity are produced. Our study suggests that the use of uterine manipulator increases the rate of LVSI and, therefore, leads to poorer oncological results. Conversely, preoperative hysteroscopy does not show higher rates of LVSI involvement in the final surgical specimen and can be safely used.
    MeSH term(s) Female ; Humans ; Retrospective Studies ; Hysterectomy/methods ; Endometrial Neoplasms/surgery ; Endometrial Neoplasms/pathology ; Neoplasm Staging
    Language English
    Publishing date 2023-09-05
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-023-03310-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6644: Show issues Location:
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  2. Article ; Online: Oncological safety of hysteroscopy in endometrial cancer.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Gil-Moreno, Antonio / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Lorenzo, Cristina / Cazorla, Eduardo / Gilabert-Estellés, Juan / Sánchez, Lourdes / Roldán-Rivas, Fernando / Díaz-Feijoo, Berta / Rodríguez-Hernández, José Ramón / Marcos-Sanmartin, Josefina / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2022  

    Abstract: Objective: It has been suggested that the manipulation of neoplastic tissue during hysteroscopy may lead to dissemination of tumor cells into the peritoneal cavity and worsen prognosis and overall survival. The goal of this study was to assess the ... ...

    Abstract Objective: It has been suggested that the manipulation of neoplastic tissue during hysteroscopy may lead to dissemination of tumor cells into the peritoneal cavity and worsen prognosis and overall survival. The goal of this study was to assess the oncological safety comparing hysteroscopy to Pipelle blind biopsy in the presurgical diagnosis of patients with endometrial cancer.
    Methods: We performed a retrospective multicentric study among patients who had received primary surgical treatment for endometrial cancer. A multivariate statistical analysis model was used to compare relapse and survival rates in patients who had been evaluated preoperatively either by hysteroscopy or Pipelle biopsy. The relapse rate, disease-free survival, and overall survival were assessed as the main outcomes. The histological type, tumor size, myometrial invasion, International Federation of Gynecology and Obstetrics (FIGO) stage, surgical approach, use of a uterine manipulator, and adjuvant treatment were also included in the analysis.
    Results: A total of 1731 women from 15 centers were included: 1044 in the hysteroscopy group and 687 in the Pipelle sampling group. 225 patients relapsed during the 10 year follow-up period: 139 (13.3%) in the hysteroscopy group and 86 (12.4%) in the Pipelle sampling group. There is no evidence of an association between the use of hysteroscopy as a diagnostic method and relapse rate (HR 1.24, 95% CI 0.92 to 1.66; p=0.16), lower disease-free survival (HR 1.23, 95% CI 0.92 to 1.66; p=0.15), or overall survival (HR 0.95, 95% CI 0.70 to 1.29; p=0.76).
    Conclusion: Hysteroscopy is a safe diagnostic method for patients with endometrial cancer with no impact on oncological outcomes when compared with sampling by Pipelle.
    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-003586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen.

    Quintana-Bertó, Raquel / Padilla-Iserte, Pablo / Gil-Moreno, Antonio / Oliver-Pérez, Reyes / Coronado, Pluvio J / Martín-Salamanca, María Belén / Pantoja-Garrido, Manuel / Lorenzo, Cristina / Beric, Duska / Gilabert-Estellés, Juan / Sánchez, Lourdes / Roldán-Rivas, Fernando / Díaz-Feijoo, Berta / Rodríguez-Hernández, José Ramón / Marcos-Sanmartin, Josefina / Muruzábal, Juan Carlos / Cañada, Antonio / Domingo, Santiago

    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

    2022  Volume 24, Issue 12, Page(s) 2388–2394

    Abstract: Purpose: The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer.! ...

    Abstract Purpose: The main goal of this study is to assess the diagnostic agreement between preoperative biopsy and definitive histology of the surgical specimen to determine which sampling method is most suitable for diagnosis of early-stage endometrial cancer.
    Methods: We performed a retrospective multicentric study to assess the correlation between three endometrial sampling methods (hysteroscopy, pipelle and D&C) in patients who had undergone preoperative endometrial biopsy and received primary surgical treatment for endometrial cancer. The primary objective was the agreement rate between hysteroscopy (HSC), endometrial biopsy (pipelle) and dilatation and curettage (D&C).
    Results: A total of 1833 women who underwent preoperative sampling at 15 centers were included: 1042 biopsies were performed by HSC, 703 by pipelle and 88 by D&C. All three methods presented a moderate diagnostic concordance (κ = 0.40-0.61) with the definitive specimen's histology: HSC (κ = 0.47), pipelle sampling (κ = 0.48) and D&C (κ = 0.48). Likewise, a subgroup analysis was performed by histological subtype comparing HSC and endometrial biopsy, showing that neither is superior as a diagnostic method.
    Conclusions: According to this study, the use of pipelle sampling could become an adequate diagnostic method in endometrial cancer due to its similar agreement to HSC, ease of use and affordability.
    MeSH term(s) Biopsy/methods ; Dilatation and Curettage ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/surgery ; Endometrium/pathology ; Endometrium/surgery ; Female ; Humans ; Retrospective Studies
    Language English
    Publishing date 2022-08-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2397359-6
    ISSN 1699-3055 ; 1699-048X
    ISSN (online) 1699-3055
    ISSN 1699-048X
    DOI 10.1007/s12094-022-02893-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6644: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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