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Article ; Online: Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life.

Monedero Cobeta, Ignacio / Gomez Bris, Raquel / Rodríguez-Rodríguez, Pilar / Saez, Angela / Quintana-Villamandos, Begoña / González Granado, Jose Maria / Arribas, Silvia Magdalena

Pediatric research

2024

Abstract: Background: Adverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of diseases in adulthood. Fetal programming induced by factors like maternal undernutrition leads to low birth ...

Abstract	Background: Adverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of diseases in adulthood. Fetal programming induced by factors like maternal undernutrition leads to low birth weight and increases the risk of cardiometabolic diseases. Methods: We studied a rat model of maternal undernutrition during gestation (MUN) to investigate gene expression changes in cardiac tissue using RNA-sequencing of day 0-1 litters. Moreover, we analyzed the impact of lactation at day 21, in MUN model and cross-fostering experiments, on cardiac structure and function assessed by transthoracic echocardiography, and gene expression changes though qPCR. Results: Our analysis identified specific genes with altered expression in MUN rats at birth. Two of them, Agt and Pparg, stand out for being associated with cardiac hypertrophy and fibrosis. At the end of the lactation period, MUN males showed increased expression of Agt and decreased expression of Pparg, correlating with cardiac hypertrophy. Cross-fostering experiments revealed that lactation with control breastmilk mitigated these expression changes reducing cardiac hypertrophy in MUN males. Conclusions: Our findings highlight the interplay between fetal programming, gene expression, and cardiac hypertrophy suggesting that lactation period is a potential intervention window to mitigate the effects of fetal programming. Impact: Heart remodeling involves the alteration of several groups of genes and lactation period plays a key role in establishing gene expression modification caused by fetal programming. We could identify expression changes of relevant genes in cardiac tissue induced by undernutrition during fetal life. We expose the contribution of the lactation period in modulating the expression of Agt and Pparg, relevant genes associated with cardiac hypertrophy. This evidence reveal lactation as a crucial intervention window for preventing or countering fetal programming.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-024-03042-5
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article: Cardiac output monitoring with pulmonary versus trans-cardiopulmonary thermodilution in left ventricular assist devices: Interchangeable methods?

Quintana-Villamandos, Begoña / Barranco, Mónica / Fernández, Ignacio / Ruiz, Manuel / Del Cañizo, Juan Francisco

Frontiers in physiology

2022 Volume 13, Page(s) 889190

Abstract: Cardiac output (CO) measurement is mandatory in patients with left ventricular assist devices (LVADs). Thermodilution with pulmonary artery catheter (PAC) remains the clinical gold standard to measure CO in these patients, however it is associated with ... ...

Abstract	Cardiac output (CO) measurement is mandatory in patients with left ventricular assist devices (LVADs). Thermodilution with pulmonary artery catheter (PAC) remains the clinical gold standard to measure CO in these patients, however it is associated with several complications. Therefore, the agreement between PAC and new, minimally invasive monitoring methods in LVAD needs to be further investigated. The aim of this study was to assess the accuracy and reliability of transpulmonary thermodilution with a PiCCO2 monitor compared with pulmonary artery thermodilution with PAC in a LVAD. Continuous-flow LVADs were implanted in six mini-pigs to assist the left ventricle. We studied two methods of measuring CO-intermittent transpulmonary thermodilution (CO
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.889190
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Article: Inhibition of the NFATc4/ERK/AKT Pathway and Improvement of Thiol-Specific Oxidative Stress by Dronedarone Possibly Secondary to the Reduction of Blood Pressure in an Animal Model of Ventricular Hypertrophy.

Pazó-Sayós, Laia / González, Maria Carmen / Quintana-Villamandos, Begoña

Frontiers in physiology

2020 Volume 11, Page(s) 967

Abstract: Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that ... ...

Abstract	Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertrophy after 14 days of treatment in an experimental study. In this study, we analyze the possible mechanisms responsible for this effect. Ten-month-old male spontaneously hypertensive rats (SHRs,
Language	English
Publishing date	2020-08-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.00967
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Article: New Advances in Monitoring Cardiac Output in Circulatory Mechanical Assistance Devices. A Validation Study in a Porcine Model.

Quintana-Villamandos, Begoña / Barranco, Mónica / Fernández, Ignacio / Ruiz, Manuel / Del Cañizo, Juan Francisco

Frontiers in physiology

2021 Volume 12, Page(s) 634779

Abstract: Cardiac output (CO) measurement by continuous pulmonary artery thermodilution ( ... ...

Abstract	Cardiac output (CO) measurement by continuous pulmonary artery thermodilution (CO
Language	English
Publishing date	2021-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.634779
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Article: Maintenance over Time of the Effect Produced by Esmolol on the Structure and Function of Coronary Arteries in Hypertensive Heart Diseases.

Martín-Oropesa, Raquel / Rodríguez-Rodríguez, Pilar / Pazó-Sayós, Laia / Arnalich-Montiel, Ana / Arribas, Silvia Magdalena / González, Maria Carmen / Quintana-Villamandos, Begoña

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: We previously observed that esmolol treatment for 48 h reduced vascular lesions in spontaneously hypertensive rats (SHRs). Therefore, we investigated whether this beneficial effect is persistent after withdrawal. Fourteen-month-old SHRs (SHR-Es) were ... ...

Abstract	We previously observed that esmolol treatment for 48 h reduced vascular lesions in spontaneously hypertensive rats (SHRs). Therefore, we investigated whether this beneficial effect is persistent after withdrawal. Fourteen-month-old SHRs (SHR-Es) were treated with esmolol (300 μg/kg/min) or a vehicle for 48 h. Two separate groups were also given identical treatment, but they were then monitored for a further 1 week and 1 month after drug withdrawal. We analyzed the geometry and composition of the coronary artery, vascular reactivity and plasma redox status. Esmolol significantly decreased wall thickness (medial layer thickness and cell count), external diameter and cross-sectional area of the artery, and this effect persisted 1 month after drug withdrawal. Esmolol significantly improved endothelium-dependent relaxation by ACh (10
Language	English
Publishing date	2022-10-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11102042
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Article ; Online: Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability.

Quintana-Villamandos, Begoña / Delgado-Martos, María Jesús / Delgado-Baeza, Emilio

BioMed research international

2019 Volume 2019, Page(s) 6374582

Abstract: Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling ... ...

Abstract	Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling induced by chronic hypertension. Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive dronedarone (100 mg/kg) or vehicle. Age-matched male Wistar-Kyoto rats served as controls. After 14 days of treatment, we studied the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis. Nitric oxide (NO) in plasma was analyzed. In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional area, and collagen volume density, as was expected in the experimental model. Dronedarone induced a significant decrease in wall width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR. The values obtained in SHR-D were similar in the WKY control group. We found significantly higher NO levels in plasma in SHR-D than in untreated SHR. Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased nitric oxide bioavailability.
MeSH term(s)	Animals ; Chronic Disease ; Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Dronedarone/pharmacology ; Hypertension/blood ; Hypertension/drug therapy ; Hypertension/pathology ; Hypertension/physiopathology ; Nitric Oxide/blood ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vascular Remodeling/drug effects
Chemical Substances	Nitric Oxide (31C4KY9ESH) ; Dronedarone (JQZ1L091Y2)
Language	English
Publishing date	2019-07-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2019/6374582
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Article ; Online: Early reversal cardiac with esmolol in hypertensive rats: The role of subcellular organelle phenotype.

Quintana-Villamandos, Begoña / Delgado-Martos, María Jesús / Delgado-Baeza, Emilio

Pharmacological reports : PR

2019 Volume 71, Issue 6, Page(s) 1125–1132

Abstract: Background: Our group has previously shown that short-term treatment (48 h) with esmolol reduces left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs). However, we do not know the mechanism that explain this effect. The aim of ... ...

Abstract	Background: Our group has previously shown that short-term treatment (48 h) with esmolol reduces left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs). However, we do not know the mechanism that explain this effect. The aim of this study was to assess the role that the subcellular organelle phenotype plays in early cardiac reverse after short-term treatment with esmolol. Methods: 14-Month-old male SHRs were randomly assigned to receive esmolol (300 μg/kg/min) (SHR-E) or vehicle (SHR). Age-matched male Wistar-Kyoto rats (WKY) served as controls. After 48 h of treatment, an ultrastructural analysis of heart tissue (left ventricle) was performed. We studied cardiomyocyte ultrastructural remodeling of subcellular organelles by electronic microcopy in all groups. Results: SHR group showed significant morphometric and stereological changes in mitochondria and subcellular organelles (cytoplasm and nucleus, myofibril structure, mitochondria structure, Z-Disk, intercalated disk, T-system and cystern), and also changes in the extracellular matrix (collagen) with respect to WKY group. Esmolol significantly improved the morphology and stereology mitochondrial, reduced the organelle phenotype abnormalities but no produced changes in the extracellular matrix with respect to SHR group. Interesantly, parameters of mitochondria (regularity factor, ellipsoidal form factor and density of volume), and all parameters of subcellular organelles returned to the normality in SHR-E. Conclusion: Our results show that left ventricular hypertrophy reversal after short-term treatment with esmolol is associated with reversal of subcellular organelle phenotype.
MeSH term(s)	Animals ; Heart/physiopathology ; Hypertrophy, Left Ventricular/drug therapy ; Hypertrophy, Left Ventricular/physiopathology ; Myocardium/pathology ; Myocardium/ultrastructure ; Organelles/pathology ; Organelles/ultrastructure ; Propanolamines/pharmacology ; Rats, Inbred SHR ; Rats, Inbred WKY
Chemical Substances	Propanolamines ; esmolol (MDY902UXSR)
Language	English
Publishing date	2019-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2186248-5
ISSN	2299-5684 ; 1734-1140
ISSN (online)	2299-5684
ISSN	1734-1140
DOI	10.1016/j.pharep.2019.06.013
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Zs.A 861: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol?

Quintana-Villamandos, Begoña / Delgado-Baeza, Emilio

Medical hypotheses

2016 Volume 87, Page(s) 44–47

Abstract: Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with ... ...

Abstract	Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, calcium channel blockers, and diuretics) has been reported, although only after long-term treatment. Asymmetrical dimethylarginine (ADMA), the most potent endogenous NO synthase inhibitor, is emerging as an important cardiovascular risk factor in patients with arterial hypertension and LVH, and dimethylarginine dimethylaminohydrolase (DDAH) is the mechanism that most frequently leads to accumulation of ADMA (plasma ADMA is cleared in small part by renal excretion, although the bulk of ADMA is degraded by DDAH). Left ventricular mass is strongly modulated by the NO system. As an important inhibitor of the bioavailability of NO, ADMA is an underlying mechanism of LVH. Beta-blockers can induce regression of LVH and reduced plasma ADMA levels. Oxidative stress is increased in patients with LVH, and this in turn increases generation of ADMA. In a previous preclinical study of spontaneously hypertensive rats, we found that short-term treatment (48 h) with esmolol reverses early LVH, increases the bioavailability of NO, and improves antioxidant status in plasma. Therefore, we propose that the ADMA/DDAH/NO pathway could modulate early regression of LVH with esmolol.
MeSH term(s)	Adrenergic beta-1 Receptor Antagonists/therapeutic use ; Amidohydrolases/metabolism ; Animals ; Antihypertensive Agents/therapeutic use ; Arginine/analogs & derivatives ; Arginine/metabolism ; Humans ; Hypertension/drug therapy ; Hypertrophy, Left Ventricular/drug therapy ; Hypertrophy, Left Ventricular/metabolism ; Hypertrophy, Left Ventricular/pathology ; Models, Cardiovascular ; Nitric Oxide/metabolism ; Propanolamines/therapeutic use ; Rats ; Rats, Inbred SHR ; Risk Factors ; Signal Transduction/drug effects ; Ventricular Remodeling/drug effects ; Ventricular Remodeling/physiology
Chemical Substances	Adrenergic beta-1 Receptor Antagonists ; Antihypertensive Agents ; Propanolamines ; Nitric Oxide (31C4KY9ESH) ; N,N-dimethylarginine (63CV1GEK3Y) ; Arginine (94ZLA3W45F) ; Amidohydrolases (EC 3.5.-) ; dimethylargininase (EC 3.5.3.18) ; esmolol (MDY902UXSR)
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2015.12.016
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Zs.A 1132: Show issues

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Article ; Online: Adverse remodeling of the obtuse marginal artery in compensatory hypertrophied myocardium from spontaneously hypertensive rats.

Quintana-Villamandos, Begoña / Delgado-Martos, María Jesús / Delgado-Baeza, Emilio

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

2017 Volume 26, Page(s) 51–54

Abstract: Background: Spontaneously hypertensive rats (SHR) serve as a model of genetic hypertension. Adverse remodeling of a coronary artery has been reported in SHR. This model is used to study new therapies in regression vascular remodeling. However, no data ... ...

Abstract	Background: Spontaneously hypertensive rats (SHR) serve as a model of genetic hypertension. Adverse remodeling of a coronary artery has been reported in SHR. This model is used to study new therapies in regression vascular remodeling. However, no data are available that show remodeling of the intramyocardial branch of the obtuse marginal artery in 10-month-old SHR. This study was designed to assess remodeling (changes in vascular structure and fibrosis) of this coronary artery. Methods and results: The study was performed on 10-month-old male SHR (n=7) and normotensive control Wistar Kyoto rats (WKY) (n=7). Using histology, we show that the external diameter, lumen diameter, wall width, and cross-sectional area of the intramyocardial artery were significantly greater in SHR than in WKY. The wall-to-lumen ratio was similar in SHR and WKY. The collagen volume density of the intramyocardial artery in SHR was significantly greater than in WKY. Conclusions: Our results show hypertrophic outward remodeling in the intramyocardial branch of the obtuse marginal artery of the left ventricle in SHR. This artery can serve as a new vascular bed from adult SHR to study novel therapies in regression coronary artery remodeling.
MeSH term(s)	Animals ; Coronary Vessels/pathology ; Disease Models, Animal ; Hypertension/complications ; Hypertension/pathology ; Hypertension/physiopathology ; Hypertrophy/etiology ; Male ; Myocardium/pathology ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vascular Remodeling
Language	English
Publishing date	2017-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1134600-0
ISSN	1879-1336 ; 1054-8807
ISSN (online)	1879-1336
ISSN	1054-8807
DOI	10.1016/j.carpath.2016.11.002
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Zs.A 3572: Show issues

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Article ; Online: Cardiac and Pulmonary Vascular Dysfunction in Vitamin D-Deficient

Olivencia, Miguel A / Esquivel-Ruiz, Sergio / Callejo, María / Mondéjar-Parreño, Gema / Quintana-Villamandos, Begoña / Barreira, Bianca / Sacedón, Rosa / Cogolludo, Ángel / Perros, Frédéric / Mendes-Ferreira, Pedro / Pérez Vizcaíno, Francisco

American journal of respiratory cell and molecular biology

2022 Volume 67, Issue 3, Page(s) 402–405

MeSH term(s)	Animals ; Bone Morphogenetic Protein Receptors, Type II/genetics ; Heart ; Pulmonary Artery ; Rats ; Vitamin D
Chemical Substances	Vitamin D (1406-16-2) ; Bmpr2 protein, rat (EC 2.7.11.30) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2022-0001LE
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