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  1. Article ; Online: Fetal programming and lactation: modulating gene expression in response to undernutrition during intrauterine life.

    Monedero Cobeta, Ignacio / Gomez Bris, Raquel / Rodríguez-Rodríguez, Pilar / Saez, Angela / Quintana-Villamandos, Begoña / González Granado, Jose Maria / Arribas, Silvia Magdalena

    Pediatric research

    2024  

    Abstract: Background: Adverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of diseases in adulthood. Fetal programming induced by factors like maternal undernutrition leads to low birth ...

    Abstract Background: Adverse environmental conditions during intrauterine life, known as fetal programming, significantly contribute to the development of diseases in adulthood. Fetal programming induced by factors like maternal undernutrition leads to low birth weight and increases the risk of cardiometabolic diseases.
    Methods: We studied a rat model of maternal undernutrition during gestation (MUN) to investigate gene expression changes in cardiac tissue using RNA-sequencing of day 0-1 litters. Moreover, we analyzed the impact of lactation at day 21, in MUN model and cross-fostering experiments, on cardiac structure and function assessed by transthoracic echocardiography, and gene expression changes though qPCR.
    Results: Our analysis identified specific genes with altered expression in MUN rats at birth. Two of them, Agt and Pparg, stand out for being associated with cardiac hypertrophy and fibrosis. At the end of the lactation period, MUN males showed increased expression of Agt and decreased expression of Pparg, correlating with cardiac hypertrophy. Cross-fostering experiments revealed that lactation with control breastmilk mitigated these expression changes reducing cardiac hypertrophy in MUN males.
    Conclusions: Our findings highlight the interplay between fetal programming, gene expression, and cardiac hypertrophy suggesting that lactation period is a potential intervention window to mitigate the effects of fetal programming.
    Impact: Heart remodeling involves the alteration of several groups of genes and lactation period plays a key role in establishing gene expression modification caused by fetal programming. We could identify expression changes of relevant genes in cardiac tissue induced by undernutrition during fetal life. We expose the contribution of the lactation period in modulating the expression of Agt and Pparg, relevant genes associated with cardiac hypertrophy. This evidence reveal lactation as a crucial intervention window for preventing or countering fetal programming.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-024-03042-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  2. Article ; Online: Medtronic electromyographic tracheal tube.

    Vera-Sanchez, M B / Quintana-Villamandos, B

    Anaesthesia

    2017  Volume 72, Issue 10, Page(s) 1282–1283

    MeSH term(s) Airway Obstruction/etiology ; Bronchoscopy ; Electromyography/instrumentation ; Equipment Failure ; Humans ; Intraoperative Complications/etiology ; Intubation, Intratracheal/adverse effects ; Thyroidectomy
    Language English
    Publishing date 2017-09-07
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80033-8
    ISSN 1365-2044 ; 0003-2409
    ISSN (online) 1365-2044
    ISSN 0003-2409
    DOI 10.1111/anae.13986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Cardiac output monitoring with pulmonary versus trans-cardiopulmonary thermodilution in left ventricular assist devices: Interchangeable methods?

    Quintana-Villamandos, Begoña / Barranco, Mónica / Fernández, Ignacio / Ruiz, Manuel / Del Cañizo, Juan Francisco

    Frontiers in physiology

    2022  Volume 13, Page(s) 889190

    Abstract: Cardiac output (CO) measurement is mandatory in patients with left ventricular assist devices (LVADs). Thermodilution with pulmonary artery catheter (PAC) remains the clinical gold standard to measure CO in these patients, however it is associated with ... ...

    Abstract Cardiac output (CO) measurement is mandatory in patients with left ventricular assist devices (LVADs). Thermodilution with pulmonary artery catheter (PAC) remains the clinical gold standard to measure CO in these patients, however it is associated with several complications. Therefore, the agreement between PAC and new, minimally invasive monitoring methods in LVAD needs to be further investigated. The aim of this study was to assess the accuracy and reliability of transpulmonary thermodilution with a PiCCO2 monitor compared with pulmonary artery thermodilution with PAC in a LVAD. Continuous-flow LVADs were implanted in six mini-pigs to assist the left ventricle. We studied two methods of measuring CO-intermittent transpulmonary thermodilution (CO
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.889190
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  4. Article: Inhibition of the NFATc4/ERK/AKT Pathway and Improvement of Thiol-Specific Oxidative Stress by Dronedarone Possibly Secondary to the Reduction of Blood Pressure in an Animal Model of Ventricular Hypertrophy.

    Pazó-Sayós, Laia / González, Maria Carmen / Quintana-Villamandos, Begoña

    Frontiers in physiology

    2020  Volume 11, Page(s) 967

    Abstract: Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that ... ...

    Abstract Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation. Our group previously demonstrated that dronedarone produced an early regression of left ventricular hypertrophy after 14 days of treatment in an experimental study. In this study, we analyze the possible mechanisms responsible for this effect. Ten-month-old male spontaneously hypertensive rats (SHRs,
    Language English
    Publishing date 2020-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00967
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  5. Article: New Advances in Monitoring Cardiac Output in Circulatory Mechanical Assistance Devices. A Validation Study in a Porcine Model.

    Quintana-Villamandos, Begoña / Barranco, Mónica / Fernández, Ignacio / Ruiz, Manuel / Del Cañizo, Juan Francisco

    Frontiers in physiology

    2021  Volume 12, Page(s) 634779

    Abstract: Cardiac output (CO) measurement by continuous pulmonary artery thermodilution ( ... ...

    Abstract Cardiac output (CO) measurement by continuous pulmonary artery thermodilution (CO
    Language English
    Publishing date 2021-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.634779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Maintenance over Time of the Effect Produced by Esmolol on the Structure and Function of Coronary Arteries in Hypertensive Heart Diseases.

    Martín-Oropesa, Raquel / Rodríguez-Rodríguez, Pilar / Pazó-Sayós, Laia / Arnalich-Montiel, Ana / Arribas, Silvia Magdalena / González, Maria Carmen / Quintana-Villamandos, Begoña

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: We previously observed that esmolol treatment for 48 h reduced vascular lesions in spontaneously hypertensive rats (SHRs). Therefore, we investigated whether this beneficial effect is persistent after withdrawal. Fourteen-month-old SHRs (SHR-Es) were ... ...

    Abstract We previously observed that esmolol treatment for 48 h reduced vascular lesions in spontaneously hypertensive rats (SHRs). Therefore, we investigated whether this beneficial effect is persistent after withdrawal. Fourteen-month-old SHRs (SHR-Es) were treated with esmolol (300 μg/kg/min) or a vehicle for 48 h. Two separate groups were also given identical treatment, but they were then monitored for a further 1 week and 1 month after drug withdrawal. We analyzed the geometry and composition of the coronary artery, vascular reactivity and plasma redox status. Esmolol significantly decreased wall thickness (medial layer thickness and cell count), external diameter and cross-sectional area of the artery, and this effect persisted 1 month after drug withdrawal. Esmolol significantly improved endothelium-dependent relaxation by ACh (10
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11102042
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  7. Article ; Online: Perforation of the left ventricle wall due to the insertion of a pulmonary artery catheter. A case report.

    Benito-Saz, P / Garrido, A / Quintana-Villamandos, B / Barrio, J M / Fernandez-Quero, L / Hortal, J

    Revista espanola de anestesiologia y reanimacion

    2019  Volume 66, Issue 10, Page(s) 528–532

    Abstract: Despite the widespread and frequent use in our setting of pulmonary artery catheters for haemodynamic management in critically ill patients, particularly after heart surgery, some experts continue to question the need for these devices. Clinicians need ... ...

    Title translation Perforación de la pared del ventrículo izquierdo por catéter de arteria pulmonar Swan-Ganz. A propósito de un caso.
    Abstract Despite the widespread and frequent use in our setting of pulmonary artery catheters for haemodynamic management in critically ill patients, particularly after heart surgery, some experts continue to question the need for these devices. Clinicians need to weigh up the risks and benefits of pulmonary artery catheters placement and bear in mind the potential complications which, though rare, can be potentially fatal. We present a pulmonary artery catheters-related complication not hitherto described in the literature, involving perforation of the interventricular septum and left ventricular free wall caused by a kink in the pulmonary artery catheters that was not suspected, and only diagnosed by direct vision of the heart after pericardial opening. In the interest of patient safety, we must consider the impact of adverse events; improving our situational awareness and our understanding of the mechanisms behind such events can help reduce the likelihood of repetitions in the future.
    MeSH term(s) Aged ; Aortic Aneurysm/surgery ; Catheterization, Swan-Ganz/adverse effects ; Catheterization, Swan-Ganz/instrumentation ; Echocardiography/methods ; Equipment Failure ; Female ; Heart Injuries/etiology ; Heart Septum/injuries ; Heart Ventricles/injuries ; Humans ; Intraoperative Complications/etiology ; Pulmonary Artery/diagnostic imaging
    Language Spanish
    Publishing date 2019-10-04
    Document type Case Reports ; Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redar.2019.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SEDAR/SECCE ECMO management consensus document.

    Zarragoikoetxea, I / Pajares, A / Moreno, I / Porta, J / Koller, T / Cegarra, V / Gonzalez, A I / Eiras, M / Sandoval, E / Aurelio Sarralde, J / Quintana-Villamandos, B / Vicente Guillén, R

    Revista espanola de anestesiologia y reanimacion

    2021  Volume 68, Issue 8, Page(s) 443–471

    Abstract: ECMO is an extracorporeal cardiorespiratory support system whose use has been increased in the last decade. Respiratory failure, postcardiotomy shock, and lung or heart primary graft failure may require the use of cardiorespiratory mechanical assistance. ...

    Abstract ECMO is an extracorporeal cardiorespiratory support system whose use has been increased in the last decade. Respiratory failure, postcardiotomy shock, and lung or heart primary graft failure may require the use of cardiorespiratory mechanical assistance. In this scenario perioperative medical and surgical management is crucial. Despite the evolution of technology in the area of extracorporeal support, morbidity and mortality of these patients continues to be high, and therefore the indication as well as the ECMO removal should be established within a multidisciplinary team with expertise in the area. This consensus document aims to unify medical knowledge and provides recommendations based on both the recent bibliography and the main national ECMO implantation centres experience with the goal of improving comprehensive patient care.
    MeSH term(s) Consensus ; Extracorporeal Membrane Oxygenation/adverse effects ; Heart Diseases ; Humans ; Respiratory Insufficiency/therapy ; Shock
    Language English
    Publishing date 2021-09-14
    Publishing country Spain
    Document type Practice Guideline ; Journal Article
    ISSN 2341-1929
    ISSN (online) 2341-1929
    DOI 10.1016/j.redare.2020.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability.

    Quintana-Villamandos, Begoña / Delgado-Martos, María Jesús / Delgado-Baeza, Emilio

    BioMed research international

    2019  Volume 2019, Page(s) 6374582

    Abstract: Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling ... ...

    Abstract Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling induced by chronic hypertension. Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive dronedarone (100 mg/kg) or vehicle. Age-matched male Wistar-Kyoto rats served as controls. After 14 days of treatment, we studied the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis. Nitric oxide (NO) in plasma was analyzed. In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional area, and collagen volume density, as was expected in the experimental model. Dronedarone induced a significant decrease in wall width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR. The values obtained in SHR-D were similar in the WKY control group. We found significantly higher NO levels in plasma in SHR-D than in untreated SHR. Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased nitric oxide bioavailability.
    MeSH term(s) Animals ; Chronic Disease ; Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Coronary Vessels/physiopathology ; Dronedarone/pharmacology ; Hypertension/blood ; Hypertension/drug therapy ; Hypertension/pathology ; Hypertension/physiopathology ; Nitric Oxide/blood ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Vascular Remodeling/drug effects
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Dronedarone (JQZ1L091Y2)
    Language English
    Publishing date 2019-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2019/6374582
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  10. Article ; Online: Early reversal cardiac with esmolol in hypertensive rats: The role of subcellular organelle phenotype.

    Quintana-Villamandos, Begoña / Delgado-Martos, María Jesús / Delgado-Baeza, Emilio

    Pharmacological reports : PR

    2019  Volume 71, Issue 6, Page(s) 1125–1132

    Abstract: Background: Our group has previously shown that short-term treatment (48 h) with esmolol reduces left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs). However, we do not know the mechanism that explain this effect. The aim of ... ...

    Abstract Background: Our group has previously shown that short-term treatment (48 h) with esmolol reduces left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHRs). However, we do not know the mechanism that explain this effect. The aim of this study was to assess the role that the subcellular organelle phenotype plays in early cardiac reverse after short-term treatment with esmolol.
    Methods: 14-Month-old male SHRs were randomly assigned to receive esmolol (300 μg/kg/min) (SHR-E) or vehicle (SHR). Age-matched male Wistar-Kyoto rats (WKY) served as controls. After 48 h of treatment, an ultrastructural analysis of heart tissue (left ventricle) was performed. We studied cardiomyocyte ultrastructural remodeling of subcellular organelles by electronic microcopy in all groups.
    Results: SHR group showed significant morphometric and stereological changes in mitochondria and subcellular organelles (cytoplasm and nucleus, myofibril structure, mitochondria structure, Z-Disk, intercalated disk, T-system and cystern), and also changes in the extracellular matrix (collagen) with respect to WKY group. Esmolol significantly improved the morphology and stereology mitochondrial, reduced the organelle phenotype abnormalities but no produced changes in the extracellular matrix with respect to SHR group. Interesantly, parameters of mitochondria (regularity factor, ellipsoidal form factor and density of volume), and all parameters of subcellular organelles returned to the normality in SHR-E.
    Conclusion: Our results show that left ventricular hypertrophy reversal after short-term treatment with esmolol is associated with reversal of subcellular organelle phenotype.
    MeSH term(s) Animals ; Heart/physiopathology ; Hypertrophy, Left Ventricular/drug therapy ; Hypertrophy, Left Ventricular/physiopathology ; Myocardium/pathology ; Myocardium/ultrastructure ; Organelles/pathology ; Organelles/ultrastructure ; Propanolamines/pharmacology ; Rats, Inbred SHR ; Rats, Inbred WKY
    Chemical Substances Propanolamines ; esmolol (MDY902UXSR)
    Language English
    Publishing date 2019-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1016/j.pharep.2019.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 861: Show issues Location:
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