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  1. Article ; Online: Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data.

    Jamieson, Michael J / Byon, Wonkyung / Dettloff, Richard W / Crawford, Matthew / Gargalovic, Peter S / Merali, Samira J / Onorato, Joelle / Quintero, Andres J / Russ, Cristina

    American journal of cardiovascular drugs : drugs, devices, and other interventions

    2022  Volume 22, Issue 6, Page(s) 615–631

    Abstract: Relatively little is known about the influence of extreme body weight on the pharmacokinetics (PK), pharmacodynamics (PD), efficacy, and safety of drugs used in many disease states. While direct oral anticoagulants (DOACs) have an advantage over warfarin ...

    Abstract Relatively little is known about the influence of extreme body weight on the pharmacokinetics (PK), pharmacodynamics (PD), efficacy, and safety of drugs used in many disease states. While direct oral anticoagulants (DOACs) have an advantage over warfarin in that they do not require routine drug monitoring, some may regard this convenience as less compelling in obese patients. Some consensus guidelines discourage using DOACs in patients weighing > 120 kg or with a body mass index > 35-40 kg/m
    MeSH term(s) Humans ; Venous Thromboembolism/drug therapy ; Pyridones/adverse effects ; Warfarin/therapeutic use ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Obesity/complications ; Obesity/drug therapy ; Stroke/epidemiology ; Administration, Oral ; Observational Studies as Topic
    Chemical Substances apixaban (3Z9Y7UWC1J) ; Pyridones ; Warfarin (5Q7ZVV76EI) ; Anticoagulants
    Language English
    Publishing date 2022-05-16
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2052547-3
    ISSN 1179-187X ; 1175-3277
    ISSN (online) 1179-187X
    ISSN 1175-3277
    DOI 10.1007/s40256-022-00524-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5487: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Technical tricks when using the reamer irrigator aspirator technique for autologous bone graft harvesting.

    Quintero, Andres J / Tarkin, Ivan S / Pape, Hans-Christoph

    Journal of orthopaedic trauma

    2010  Volume 24, Issue 1, Page(s) 42–45

    Abstract: This report describes technical tricks for using the reamer irrigator aspirator to harvest autologous bone graft from the femur. This device is a focus of interest in orthopaedics because it can be used to harvest bone graft from the femoral canal and ... ...

    Abstract This report describes technical tricks for using the reamer irrigator aspirator to harvest autologous bone graft from the femur. This device is a focus of interest in orthopaedics because it can be used to harvest bone graft from the femoral canal and medial condyle in voluminous quantities. Moreover, according to some authors, the osteogenic potential of this graft is at least as effective as that of autogenous bone obtained from the iliac crest. The reamer irrigator aspirator device has substantially different design characteristics and technicalities compared with those of a standard reamer. First, a guidewire must be redirected into multiple areas, including the center of the distal femur and into both condyles, to harvest ample bone graft. This is accomplished by prebending the guidewire in a stronger fashion than required for regular reaming in the case of femoral nailing procedures. This bend can increase the risk for eccentric reaming as well as lodging of the suctioning device within the femoral canal. Second, the front and lateral drilling surfaces of this device are very sharp and further cleaned and maintained sharp by the irrigation process to permit the surgeon to obtain significant volumes of graft with a single passage of this device. At the same time, however, this sharp front-end cutting design can increase the risk of iatrogenic fracture if reaming is performed without caution. Third, a powerful suctioning device is connected to the reamer such that the blood loss that can occur during continuous reaming, irrigation, and aspiration must be considered with this technique. We hereby discuss these potential dangers and describe the correct use of this device with technical tricks to minimize the risk of unexpected intraoperative events.
    MeSH term(s) Aged ; Bone Transplantation/instrumentation ; Bone Transplantation/methods ; Cadaver ; Compressive Strength ; Equipment Design ; Equipment Failure Analysis ; Female ; Humans ; Middle Aged ; Suction/instrumentation ; Therapeutic Irrigation/instrumentation ; Tissue and Organ Harvesting/instrumentation
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0b013e3181b2b4eb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2234: Show issues Location:
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  3. Article ; Online: The personal interview: assessing the potential for personality similarity to bias the selection of orthopaedic residents.

    Quintero, Andres J / Segal, Lee S / King, Tonya S / Black, Kevin P

    Academic medicine : journal of the Association of American Medical Colleges

    2009  Volume 84, Issue 10, Page(s) 1364–1372

    Abstract: Purpose: The selection of medical students for training in orthopaedic surgery consists of an objective screening of cognitive skills to secure interviews for the brightest candidates, followed by subjective measures of candidates to confirm whether ... ...

    Abstract Purpose: The selection of medical students for training in orthopaedic surgery consists of an objective screening of cognitive skills to secure interviews for the brightest candidates, followed by subjective measures of candidates to confirm whether applicants are worthy of further consideration. The personal interview and its potential biased impact on the orthopaedic workforce were evaluated.
    Method: During 2004-2006 at the Penn State College of Medicine, the authors performed a prospective cohort study in which 30 consenting interviewers and 135 interviewees completed the Myers-Briggs Type Indicator before the interviews. Completed surveys were evaluated after submitting the resident selection list to the National Residency Matching Program, and candidate rankings based solely on the personal interview were analyzed.
    Results: Clinicians ranked candidates more favorably when they shared certain personality preferences (P = .044) and when they shared the preference groupings of the quadrant extrovert-sensing and either the function pair sensing-thinking (P = .007) or the temperament sensing-judging (P = .003), or the function pair sensing-feeling and the temperament sensing-judging (P = .029). No associations existed between personality preferences and interviewee rankings performed by basic scientists and resident interviewers.
    Conclusions: The results support the hypothesis that, within the department studied, there was a significant association between similarities in personality type and the rankings that individual faculty interviewers assigned to applicants at the completion of each interview session. The authors believe that it is important for the faculty member to recognize that this tendency exists. Finally, promoting diversity within the admission committee may foster a diverse resident body and orthopaedic workforce.
    MeSH term(s) Adult ; Faculty, Medical ; Humans ; Internship and Residency/standards ; Interpersonal Relations ; Interviews as Topic ; Orthopedics/education ; Personality Inventory ; Personnel Selection ; Prejudice ; Prospective Studies ; School Admission Criteria/statistics & numerical data ; Students, Medical/psychology ; Students, Medical/statistics & numerical data
    Language English
    Publishing date 2009-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0b013e3181b6a9af
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 112: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Stem cells for the treatment of skeletal muscle injury.

    Quintero, Andres J / Wright, Vonda J / Fu, Freddie H / Huard, Johnny

    Clinics in sports medicine

    2008  Volume 28, Issue 1, Page(s) 1–11

    Abstract: Skeletal muscle injuries are extremely common, accounting for up to 35%-55% of all sports injuries and quite possibly affecting all musculoskeletal traumas. These injuries result in the formation of fibrosis, which may lead to the development of painful ... ...

    Abstract Skeletal muscle injuries are extremely common, accounting for up to 35%-55% of all sports injuries and quite possibly affecting all musculoskeletal traumas. These injuries result in the formation of fibrosis, which may lead to the development of painful contractures, increases patients' risk for repeat injuries, and limits their ability to return to a baseline or pre-injury level of function. The development of successful therapies for these injuries must consider the pathophysiology of these musculoskeletal conditions. We discuss the direct use of muscle-derived stem cells and some key cell population dynamics as well as the use of clinically applicable modalities that may enhance the local supply of stem cells to the zone of injury by promoting angiogenesis.
    MeSH term(s) Athletic Injuries/surgery ; Fibrosis/physiopathology ; Humans ; Inflammation ; Muscle, Skeletal/injuries ; Muscular Diseases/surgery ; Risk Factors ; Soft Tissue Injuries/surgery ; Stem Cell Transplantation ; Tissue Engineering
    Language English
    Publishing date 2008-09-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 779944-5
    ISSN 1556-228X ; 0278-5919
    ISSN (online) 1556-228X
    ISSN 0278-5919
    DOI 10.1016/j.csm.2008.08.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 797: Show issues Location:
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  5. Article ; Online: Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.

    Ho, Andrew M / Marker, Paul C / Peng, Hairong / Quintero, Andres J / Kingsley, David M / Huard, Johnny

    BMC developmental biology

    2008  Volume 8, Page(s) 35

    Abstract: Background: Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with ... ...

    Abstract Background: Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with weight bearing and muscular activity and decrease with bed rest and disuse. Although the processes of mechanotransduction and functional response of bone to mechanical strain have been extensively studied, the molecular signaling mechanisms that mediate the response of bone cells to mechanical stimulation remain unclear.
    Results: Here, we identify a novel germline mutation at the mouse Bone morphogenetic protein 5 (Bmp5) locus. Genetic analysis shows that the mutation occurs at a site encoding the proteolytic processing sequence of the BMP5 protein and blocks proper processing of BMP5. Anatomic studies reveal that this mutation affects the formation of multiple skeletal features including several muscle-induced skeletal sites in vivo. Biomechanical studies of osteoblasts from these anatomic sites show that the mutation inhibits the proper response of bone cells to mechanical stimulation.
    Conclusion: The results from these genetic, biochemical, and biomechanical studies suggest that BMPs are required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton.
    MeSH term(s) Animals ; Body Patterning ; Bone Morphogenetic Protein 5 ; Bone Morphogenetic Proteins/genetics ; Bone Remodeling/genetics ; Cells, Cultured ; Embryo, Mammalian ; Female ; Fibroblasts/metabolism ; Fluorescent Antibody Technique, Indirect ; Gene Expression ; Genes, Dominant ; Germ-Line Mutation ; In Situ Hybridization ; Male ; Mice ; Mice, Inbred C57BL ; Osteoblasts/metabolism ; Osteogenesis/genetics ; Stress, Mechanical
    Chemical Substances Bmp5 protein, mouse ; Bone Morphogenetic Protein 5 ; Bone Morphogenetic Proteins
    Language English
    Publishing date 2008-04-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1471-213X
    ISSN (online) 1471-213X
    DOI 10.1186/1471-213X-8-35
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Follistatin improves skeletal muscle healing after injury and disease through an interaction with muscle regeneration, angiogenesis, and fibrosis.

    Zhu, Jinhong / Li, Yong / Lu, Aiping / Gharaibeh, Burhan / Ma, Jianqun / Kobayashi, Tetsuo / Quintero, Andres J / Huard, Johnny

    The American journal of pathology

    2011  Volume 179, Issue 2, Page(s) 915–930

    Abstract: Recovery from skeletal muscle injury is often incomplete because of the formation of fibrosis and inadequate myofiber regeneration; therefore, injured muscle could benefit significantly from therapies that both stimulate muscle regeneration and inhibit ... ...

    Abstract Recovery from skeletal muscle injury is often incomplete because of the formation of fibrosis and inadequate myofiber regeneration; therefore, injured muscle could benefit significantly from therapies that both stimulate muscle regeneration and inhibit fibrosis. To this end, we focused on blocking myostatin, a member of the transforming growth factor-β superfamily and a negative regulator of muscle regeneration, with the myostatin antagonist follistatin. In vivo, follistatin-overexpressing transgenic mice underwent significantly greater myofiber regeneration and had less fibrosis formation compared with wild-type mice after skeletal muscle injury. Follistatin's mode of action is likely due to its ability to block myostatin and enhance neovacularization. Furthermore, muscle progenitor cells isolated from follistatin-overexpressing mice were significantly superior to muscle progenitors isolated from wild-type mice at regenerating dystrophin-positive myofibers when transplanted into the skeletal muscle of dystrophic mdx/severe combined immunodeficiency mice. In vitro, follistatin stimulated myoblasts to express MyoD, Myf5, and myogenin, which are myogenic transcription factors that promote myogenic differentiation. Moreover, follistatin's ability to enhance muscle differentiation is at least partially due to its ability to block myostatin, activin A, and transforming growth factor-β1, all of which are negative regulators of muscle cell differentiation. The findings of this study suggest that follistatin is a promising agent for improving skeletal muscle healing after injury and muscle diseases, such as the muscular dystrophies.
    MeSH term(s) Animals ; Cell Line ; Cell Transplantation ; Fibrosis/pathology ; Follistatin/chemistry ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Fluorescence/methods ; Muscle, Skeletal/metabolism ; MyoD Protein/metabolism ; Myogenic Regulatory Factor 5/metabolism ; Myostatin/metabolism ; Neovascularization, Pathologic ; Regeneration ; Transforming Growth Factor beta/metabolism
    Chemical Substances Follistatin ; Myf5 protein, mouse ; MyoD Protein ; Myogenic Regulatory Factor 5 ; Myostatin ; Transforming Growth Factor beta
    Language English
    Publishing date 2011-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2011.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.76: Show issues Location:
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  7. Article ; Online: Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation

    Kingsley David M / Quintero Andres J / Peng Hairong / Marker Paul C / Ho Andrew M / Huard Johnny

    BMC Developmental Biology, Vol 8, Iss 1, p

    2008  Volume 35

    Abstract: Abstract Background Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase ... ...

    Abstract Abstract Background Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with weight bearing and muscular activity and decrease with bed rest and disuse. Although the processes of mechanotransduction and functional response of bone to mechanical strain have been extensively studied, the molecular signaling mechanisms that mediate the response of bone cells to mechanical stimulation remain unclear. Results Here, we identify a novel germline mutation at the mouse Bone morphogenetic protein 5 ( Bmp5 ) locus. Genetic analysis shows that the mutation occurs at a site encoding the proteolytic processing sequence of the BMP5 protein and blocks proper processing of BMP5. Anatomic studies reveal that this mutation affects the formation of multiple skeletal features including several muscle-induced skeletal sites in vivo . Biomechanical studies of osteoblasts from these anatomic sites show that the mutation inhibits the proper response of bone cells to mechanical stimulation. Conclusion The results from these genetic, biochemical, and biomechanical studies suggest that BMPs are required not only for skeletal patterning during embryonic development, but also for bone response and remodeling to mechanical stimulation at specific anatomic sites in the skeleton.
    Keywords Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2008-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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